Research Explorer

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Researcher

Frank Peelman

Awards & Distinctions

94 Results

2024

Biallelic RXFP2 variants lead to congenital bilateral cryptorchidism and male infertility, supporting a role of RXFP2 in spermatogenesis

Hannes SyrynJulie Van De VeldeGriet De ClercqHannah VerdinAnnelies DheedeneFrank PeelmanAndrew SinclairKatie L AyersRoss A D BathgateMartine Cools et al.

U Journal Article in HUMAN REPRODUCTION

Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression

Sofie DesmetJonathan ThommisTineke VanderhaeghenEdmee VandenboornDorien ClarisseYunkun LiSteven TimmermansDaria FijalkowskaDariusz RatmanEvelien Van Hamme et al.

A1 Journal Article in MOLECULAR METABOLISM

2023

Deep mutational scanning of proteins in mammalian cells

Stefanie MaesNick DeploeyFrank PeelmanSven Eyckerman

A2 Journal Article in CELL REPORTS METHODS

Harnessing deep mutational scanning for faster mapping of protein-protein interaction interfaces

Stefanie MaesFrank PeelmanNico Callewaert

RXFP2 : validating its role in autosomal recessive bilateral cryptorchidism and a novel association with male infertility

Hannes SyrynHannah VerdinJulie Van De VeldeFrank PeelmanMarianne BeckerCecile BrachetMarieke den BrinkerSylvia DepoorterJulie FudvoyeDaniel Klink et al.

The biologist’s guide to the glucocorticoid receptor’s structure

Nick DeploeyLaura Van MoortelInez RogatskyFrank PeelmanKarolien De Bosscher

A1 Journal Article in CELLS

2021

An affinity-enhanced, broadly neutralizing heavy chain-only antibody protects against SARS-CoV-2 infection in animal models

Bert SchepensLoes van SchieWim NerinckxKenny RooseWander Van BreedamDaria FijalkowskaSimon DevosWannes WeytsSieglinde De CaeSandrine Vanmarcke et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

Selective IL-1 activity on CD8+ T cells empowers antitumor immunity and synergizes with neovasculature-targeted TNF for full tumor eradication

Bram Van Den EeckhoutLeander HuygheSandra Van LintElianne BurgStéphane PlaisanceFrank PeelmanAnje CauwelsGilles UzéNiko KleySarah Gerlo et al.

A1 Journal Article in JOURNAL FOR IMMUNOTHERAPY OF CANCER

2020

Functional characterization of the first missense variant in CEP78, a founder allele associated with cone‐rod dystrophy, hearing loss and reduced male fertility

Giulia AscariFrank PeelmanPietro FarinelliToon RosseelNina LambrechtsKirsten A. WunderlichMatias WagnerKonstantinos NikopoulosPernille MartensIrina Balikova et al.

A1 Journal Article in HUMAN MUTATION

Safe eradication of large established tumors using neovasculature-targeted tumor necrosis factor-based therapies

Leander HuygheAlexander Van ParysAnje CauwelsSandra Van LintStijn De MunterJennyfer BultinckLennart ZabeauJeroen HostensAn GoethalsNele Vanderroost et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Selected IL-1 activity on CD8+ T cells allows for safe enhancement of cellular immune responses

Bram Van Den EeckhoutLien Van HoeckeElianne BurgSandra Van LintFrank PeelmanNiko KleyGilles UzéXavier SaelensJan TavernierSarah Gerlo

Specific targeting of IL-1β activity to CD8+ T cells allows for safe use as a vaccine adjuvant

Bram Van Den EeckhoutLien Van HoeckeElianne BurgSandra Van LintFrank PeelmanNiko KleyGilles UzéXavier SaelensJan TavernierSarah Gerlo

A1 Journal Article in NPJ VACCINES

2019

Biallelic sequence and structural variants in RAX2 are a novel cause for autosomal recessive inherited retinal disease

Stijn Van de SompeleClaire SmithMarianthi KaraliMarta CortonKristof Van SchilFrank PeelmanTimothy CherryToon RosseelHannah VerdinJulien Derolez et al.

A1 Journal Article in GENETICS IN MEDICINE

Expansion of the role and functional characterization of a missense variant in CEP78 associated with cone-rod dystrophy and hearing loss

Giulia AscariFrank PeelmanPietro FarinelliToon RosseelNina LambrechtsIrina BalikovaLara DeryckeGabriële HoltappelsOlga KryskoThalia Van Laethem et al.

Expansion of the role and functional characterization of a missense variant in CEP78 associated with cone-rod dystrophy and hearing loss

Giulia AscariFrank PeelmanNina LambrechtsThalia Van LaethemToon RosseelPietro FarinelliDavid CreytensIrina BalikovaJan GerrisClaus Bachert et al.

The N‐terminal p.(Ser38Cys) TIMP3 mutation underlying Sorsby fundus dystrophy is a founder mutation disrupting an intramolecular disulfide bond

Sarah NaessensJulie De ZaeytijdDelfien SyxRoosmarijn VandenbrouckeFrédéric SmeetsCaroline Van CauwenberghBart LeroyFrank PeelmanFrauke Coppieters

A1 Journal Article in HUMAN MUTATION

Towards the use of interleukin-1β as vaccine adjuvant

Bram Van Den EeckhoutLien Van HoeckeElianne BurgSandra Van LintFrank PeelmanXavier SaelensJan TavernierSarah Gerlo

2018

Biallelic and monoallelic ESR2 variants associated with 46,XY disorders of sex development

Dorien BaetensTülay GüranBerenice B MendoncaNathalia L GomesLode De CauwerFrank PeelmanHannah VerdinMarnik VuylstekeMalaïka Van der LindenHans Stoop et al.

A1 Journal Article in GENETICS IN MEDICINE

Biallelic loss-of-function variants in RAX2, encoding a homeobox-containing Rax transcription factor, cause autosomal recessive inherited retinal disease

Stijn Van de SompeleClaire SmithMarianthi KaraliMarta CortonKristof Van SchilFrank PeelmanTimothy CherryToon RosseelHannah VerdinJulien Derolez et al.

Functional characterization of N-terminal TIMP3 mutation underlying Sorsby fundus dystrophy in Belgian and French pedigrees

Sarah NaessensDelfien SyxFrank PeelmanRoosmarijn VandenbrouckeSarah De JaegereFrédéric SmeetsJulie De ZaeytijdBart LeroyElfride De BaereFrauke Coppieters

Germline gain-of-function myeloid differentiation primary response gene-88 (MYD88) mutation in a child with severe arthritis

Keith A SikoraJoshua R BennettLaurens VynckeZuoming DengWanxia Li TsaiEwald PauwelsGerlinde Layh-SchmittApril BrundidgeFatemeh NavidKristien JM Zaal et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-1β AcTaleukins : towards potent yet safe adjuvants for tumor vaccination

Bram Van Den EeckhoutElianne BurgAnje CauwelsFrank PeelmanSandra Van LintJan TavernierSarah Gerlo

Structural and functional analysis of TIR domains in health and disease

Laurens VynckeFrank PeelmanJan Tavernier

2017

IL-1β AcTaleukins : towards potent yet safe adjuvants for tumor vaccination

Bram Van Den EeckhoutElianne BurgAnje CauwelsFrank PeelmanSandra Van LintJan TavernierSarah Gerlo

NR5A1 is a novel disease gene for 46,XX testicular and ovotesticular disorders of sex development

Dorien BaetensHans StoopFrank PeelmanAnne-Laure TodeschiniToon RosseelFrauke CoppietersReiner VeitiaLeendert LooijengaElfride De BaereMartine Cools

A1 Journal Article in GENETICS IN MEDICINE

RNF41 interacts with the VPS52 subunit of the GARP and EARP complexes

Delphine MasschaeleLeentje De CeuninckJoris WaumanDieter DefeverFrank StennerSam LievensFrank PeelmanJan Tavernier

A1 Journal Article in PLOS ONE

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

Kenneth VerstraeteFrank PeelmanHarald BraunJuan LopezDries Van RompaeyAnn DansercoerIsabel VandenbergheKris PauwelsJan TavernierBart Lambrecht et al.

A1 Journal Article in NATURE COMMUNICATIONS

TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity

Raffaele MoriJoris WaumanLaura IcardiJosé Van Der HeydenLode De CauwerFrank PeelmanKarolien De BosscherJan Tavernier

A1 Journal Article in SCIENTIFIC REPORTS

Virtual screening for inhibitors of the human TSLP:TSLPR interaction

Dries Van RompaeyKenneth VerstraeteFrank PeelmanSavvas SavvidesKoen AugustynsPieter Van Der VekenHans De Winter

A1 Journal Article in SCIENTIFIC REPORTS

2016

Isolated and syndromic retinal dystrophy caused by biallelic mutations in RCBTB1, a gene implicated in ubiquitination

Frauke CoppietersGiulia AscariKatharina DannhausenKonstantinos NikopoulosFrank PeelmanMarcus KarlstetterMingchu XuCécile BrachetIsabelle MeunierMiltiadis K Tsilimbaris et al.

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

Reconstructing the TIR side of the myddosome: a paradigm for TIR-TIR interactions

Laurens VynckeCelia BovijnEwald PauwelsTim Van AckerElien RuyssinckElianne BurgJan TavernierFrank Peelman

A1 Journal Article in STRUCTURE

2015

Leptin's metabolic and immune functions can be uncoupled at the ligand/receptor interaction level

Lennart ZabeauCathy J JensenSylvie SeeuwsKoen VenkenAnnick VerheeDominiek CatteeuwGeert van LooHui ChenKen WalderJacob Hollis et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Leptin: from structural insights to the design of antagonists

Lennart ZabeauFrank PeelmanJan Tavernier

A1 Journal Article in LIFE SCIENCES

Reconstructing the TIR side of the Myddosome: a paradigm for TIR-TIR interactions?

Laurens VynckeCelia BovijnEwald PauwelsTim Van AckerElien RuyssinckJan TavernierFrank Peelman

2014

20 Years of leptin: insights into signaling assemblies of the leptin receptor

Frank PeelmanLennart ZabeauKedar MoharanaSavvas SavvidesJan Tavernier

A1 Journal Article in JOURNAL OF ENDOCRINOLOGY

Antagonizing leptin: current status and future directions

Lennart ZabeauFrank PeelmanJan Tavernier

A1 Journal Article in BIOLOGICAL CHEMISTRY

Structural and mechanistic paradigm of leptin receptor activation revealed by complexes with wild-type and antagonist leptins

Kedar MoharanaLennart ZabeauFrank PeelmanPhilippe RinglerHenning StahlbergJan TavernierSavvas Savvides

A1 Journal Article in STRUCTURE

Structural basis of the proinflammatory signaling complex mediated by TSLP

Kenneth VerstraeteLoes van SchieLaurens VynckeYehudi BlochJan TavernierEwald PauwelsFrank PeelmanSavvas Savvides

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

The small GTPase Arf6 is essential for TLR4 signaling in multiple (path)ways

Tim Van AckerFrank PeelmanJan Tavernier

The small GTPase Arf6 is essential for the Tram/Trif pathway in RLR4 signaling

Tim Van AckerSven EyckermanLieselotte Vande WalleSarah GerloMarc GoethalsMohamed LamkanfiCelia BovijnJan TavernierFrank Peelman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2013

Identification of binding sites for myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 in MyD88 adapter-like (Mal)

Celia BovijnAnn-Sophie DesmetIsabel UyttendaeleTim Van AckerJan TavernierFrank Peelman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Reciprocal cross-regulation between RNF41 and USP8 controls cytokine receptor sorting and processing

Leentje De CeuninckJoris WaumanDelphine MasschaeleFrank PeelmanJan Tavernier

A1 Journal Article in JOURNAL OF CELL SCIENCE

2012

Identification of interaction sites for dimerization and adapter recruitment in Toll/interleukin-1 receptor (TIR) domain of Toll-like receptor 4

Celia BovijnPeter UlrichtsAnne-Sophie De SmetDominiek CatteeuwRudi BeyaertJan TavernierFrank Peelman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of protein-protein interaction sites in the TLR4/Mal/MyD88 complex

Celia BovijnFrank PeelmanJan Tavernier

MAPPIT analysis of medically relevant protein-protein interactions

Isabel UyttendaeleJan TavernierFrank Peelman

Random mutagenesis MAPPIT analysis identifies binding sites for Vif and Gag in both cytidine deaminase domains of Apobec3G

Isabel UyttendaeleDelphine LavensDominiek CatteeuwIrma LemmensCelia BovijnJan TavernierFrank Peelman

A1 Journal Article in PLoS ONE

Selection of non-competitive leptin antagonists using a random nanobody-based approach

Lennart ZabeauAnnick VerheeDominiek CatteeuwLiesbeth FaesSylvie SeeuwsTine DecruyDirk ElewautFrank PeelmanJan Tavernier

A1 Journal Article in BIOCHEMICAL JOURNAL

2011

High prevalence of mutations in LCAT in patients with low HDL cholesterol levels in The Netherlands: identification and characterization of eight novel mutations

Adriaan G HolleboomJan A KuivenhovenFrank PeelmanAlinda W SchimmelJorge PeterJoep C DefescheJohn JP KasteleinG Kees HovinghErik S StroesMohammad Mahdi Motazacker

A1 Journal Article in HUMAN MUTATION

MAPPIT: a protein interaction toolbox built on insights in cytokine receptor signaling

Sam LievensFrank PeelmanKarolien De BosscherIrma LemmensJan Tavernier

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

2010

Abnormal LPL release leads to chylomicronemia in the presence of GPIHBP1 defects

BJ ArsenaultAP BeigneuxFrank PeelmanR FranssenJ HertecantSG YoungGM Dallinga-Thie

Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site

Peter UlrichtsCelia BovijnSam LievensRudi BeyaertJan TavernierFrank Peelman

A1 Journal Article in JOURNAL OF CELL SCIENCE

Chylomicronemia with low Postheparin Lipoprotein Lipase levels in the setting of GPIHBP1 defects

Remco FranssenStephen G YoungFrank PeelmanJozef HertecantJeroen A SiertsAlida WM SchimmelAndre BensadounJohn JP KasteleinLoren G FongGeesje M Dallinga-Thie et al.

A1 Journal Article in CIRCULATION-CARDIOVASCULAR GENETICS

Definition of the interacting interfaces of Apobec3G and HIV-1 Vif using MAPPIT mutagenesis analysis

Delphine LavensFrank PeelmanJosé Van Der HeydenIsabel UyttendaeleDominiek CatteeuwAnnick VerheeB Van SchoubroeckJ KurthS HallenbergerR Clayton et al.

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Definition of the interacting interfaces of Apobec3G and HIV-1 Vif using MAPPIT mutagenesis analysis

Delphine LavensFrank PeelmanJosé Van Der HeydenIsabel UyttendaeleDominiek CatteeuwBertrand Van SchouwbroeckJulia KurthSabine HallenbergerReginald ClaytonJan Tavernier

The metabolism of triglyceride-rich lipoproteins revisited: new players, new insight

Geesje M Dallinga-ThieRemco FranssenHans L MooijMaartje E VisserH Carlijne HassingFrank PeelmanJohn JP KasteleinMiklos PeterfyMax Nieuwdorp

A1 Journal Article in ATHEROSCLEROSIS

2009

Chemical inhibition of a subset of Arabidopsis thaliana GSK3-like kinases activates brassinosteroid signaling

Bert De RybelDominique AudenaertGrégory VertWilfried RozhonJuliane MayerhoferFrank PeelmanSilvie CoutuerTinneke DenayerLeentje JansenLong Nguyen et al.

A1 Journal Article in CHEMISTRY & BIOLOGY

2008

Elongin B/C recruitment regulates substrate binding by CIS

Julie PiessevauxLeentje De CeuninckDominiek CatteeuwFrank PeelmanJan Tavernier

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Functional characterization of naturally occurring pathogenic mutations in the human leptin receptor

Wendy KimberFrank PeelmanXavier PrieurTheresia WangensteenStephen O'RahillyJan TavernierI. Sadaf Farooq

A1 Journal Article in ENDOCRINOLOGY

HyperISGylation of old world monkey ISG15 in human cells

Els PattynAnnick VerheeIsabel UyttendaeleJulie PiessevauxEvy TimmermanKris GevaertJoël VandekerckhoveFrank PeelmanJan Tavernier

A1 Journal Article in PLOS ONE

Multiple roles for the SOCS box

Julie PiessevauxDelphine LavensFrank PeelmanJan Tavernier

The many faces of the SOCS box

Julie PiessevauxDelphine LavensFrank PeelmanJan Tavernier

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

2007

MAPPIT analysis of TLR adaptor complexes

Peter UlrichtsFrank PeelmanRudi BeyaertJan Tavernier

A1 Journal Article in FEBS LETTERS

Mammalian protein-protein interaction trap (MAPPIT) analysis of STAT5, CIS, and SOCS2 interactions with the growth hormone receptor

Isabel UyttendaeleIrma LemmensAnnick VerheeAnne-Sophie De SmetJoël VandekerckhoveDelphine LavensFrank PeelmanJan Tavernier

A1 Journal Article in MOLECULAR ENDOCRINOLOGY

The C-terminus of CIS defines its interaction pattern

Delphine LavensPeter UlrichtsDominiek CatteeuwKris GevaertJoël VandekerckhoveFrank PeelmanSven EyckermanJan Tavernier

A1 Journal Article in BIOCHEMICAL JOURNAL

2006

Caenorhabditis elegans expresses three functional profilins in a tissue-specific manner

Debby PoletAnja LambrechtsK ONOA MAHFrank PeelmanJoël VandekerckhoveDL BAILLIEChristophe AmpeS ONO

A1 Journal Article in CELL MOTILITY AND THE CYTOSKELETON

Functional cross-modulation between SOCS proteins can stimulate cytokine signaling

Julie PiessevauxDelphine LavensT MONTOYEJoris WaumanDominiek CatteeuwJoël VandekerckhoveD BELSHAMFrank PeelmanJan Tavernier

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping of binding site III in the leptin receptor and modeling of a hexameric leptin center dot leptin receptor complex

Frank PeelmanHannes IserentantAnne-Sophie De SmetJoël VandekerckhoveLennart ZabeauJan Tavernier

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Techniques: New pharmacological perspectives for the leptin receptor

Frank PeelmanC COUTURIERJ DAMLennart ZabeauJan TavernierR JOCKERS

A1 Journal Article in TRENDS IN PHARMACOLOGICAL SCIENCES

2005

Leptin receptor activation depends on critical cysteine residues in its fibronectin type III subdomains

Lennart ZabeauD DEFEAUH ISERENTANTJoël VandekerckhoveFrank PeelmanJan Tavernier

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Leptin, immune responses and autoimmune disease. Perspectives on the use of leptin antagonists

Frank PeelmanHannes IserentantSven EyckermanLennart ZabeauJan Tavernier

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

Mapping of the interface between leptin and the leptin receptor CRH2 domain

H ISERENTANTFrank PeelmanD DEFEAUJoël VandekerckhoveLennart ZabeauJan Tavernier

A1 Journal Article in JOURNAL OF CELL SCIENCE

2004

Expression and activity of the nucleotide-binding domains of the human ABCA1 transporter

Stein RoosbeekH CASTERQZ LIUPF BERNEN DUVERGERBart ChristiaensJoël VandekerckhoveFrank PeelmanChristine LabeurMaryvonne Rosseneu

A1 Journal Article in PROTEIN EXPRESSION AND PURIFICATION

Leptin: linking adipocyte metabolism with cardiovascular and autoimmune diseases

Frank PeelmanWim WaelputHannes IserentantDelphine LavensSven EyckermanLennart ZabeauJan Tavernier

A1 Journal Article in PROGRESS IN LIPID RESEARCH

Mapping of the leptin binding sites and design of a leptin antagonist

Frank PeelmanKatrien Van BenedenLennart ZabeauHannes IserentantPeter UlrichtsDelphine DefeauAnnick VerheeDominiek CatteeuwDirk ElewautJan Tavernier

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation by protein kinase CK2 modulates the activity of the ATP binding cassette A1 transporter

Stein RoosbeekFrank PeelmanAnnick VerheeChristine LabeurH CASTERMarc LensinkC CIRULLIJohan GrootenC COCHETJoël Vandekerckhove et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the ABCA1 transporter activity by protein kinase CK2

R STEINFrank PeelmanJan TavernierMaryvonne Rosseneu

2003

Characterization of the ABCA transporter subfamily: Identification of prokaryotic and eukaryotic members, phylogeny and topology

Frank PeelmanChristine LabeurBerlinda VanlooStein RoosbeekC DEVAUDN DUVERGERP DENEFLEM ROSIERJoël VandekerckhoveMaryvonne Rosseneu

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Structure and regulation of the ABCA transporters

Maryvonne RosseneuStein RoosbeekFrank PeelmanMarc LensinkJan Tavernier

The ins and outs of leptin receptor activation

Lennart ZabeauDelphine LavensFrank PeelmanSven EyckermanJoël VandekerckhoveJan Tavernier

A1 Journal Article in FEBS LETTERS

2002

Activation of lecithin cholesterol acyl transferase (LCAT) by apolipoproteins

Stein RoosbeekFrank PeelmanMaryvonne Rosseneu

2001

A hydrophobic cluster at the surface of the human plasma phospholipid transfer protein is critical for activity on high density lipoproteins.

C DESRUMAUXChristine LabeurA VERHEEJan TavernierJoël VandekerckhoveMaryvonne RosseneuFrank Peelman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of mutations of N- and C-terminal charged residues on the activity of LCAT.

Frank PeelmanBerlinda VanlooJean-Luc VerscheldeChristine LabeurH CASTERJ TAVEIRNEA VERHEEN DUVERGERJoël VandekerckhoveJan Tavernier et al.

A1 Journal Article in JOURNAL OF LIPID RESEARCH

Three arginine residues in apolipoprotein A-I are critical for activation of lecithin: cholesterol acyltransferase.

Stein RoosbeekBerlinda VanlooN DUVERGERH CASTERJ BREYNEI DE BEUNH PATELJoël VandekerckhoveC SHOULDERSMaryvonne Rosseneu et al.

A1 Journal Article in JOURNAL OF LIPID RESEARCH

2000

Characterization of recombinant wild type and site-directed mutations of apolipoprotein C-III: Lipid binding, displacement of ApoE, and inhibition of lipoprotein lipase.

HQ LIUPJ TALMUDL LINSR BRASSEURG OLIVECRONAFrank PeelmanJoël VandekerckhoveMaryvonne RosseneuChristine Labeur

A1 Journal Article in BIOCHEMISTRY

Headgroup specificity of lecithin cholesterol acyltransferase for monomeric and vesicular phospholipids.

Bart ChristiaensBerlinda VanlooC GOUYETTEInge Van VyncktH CASTERJ TAVEIRNEA VERHEEChristine LabeurFrank PeelmanJoël Vandekerckhove et al.

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Relationship between structure and biochemical phenotype of lecithin: cholesterol acyltransferase (LCAT) mutants causing fish-eye disease.

Berlinda VanlooFrank PeelmanKristof DeschuymereJ TAVEIRNEA VERHEEC GOUYETTEChristine LabeurJoël VandekerckhoveJan TavernierMaryvonne Rosseneu

A1 Journal Article in JOURNAL OF LIPID RESEARCH

Structure and function of lecithin cholesterol acyl transferase: new insights from structural predictions and animal models.

Frank PeelmanJoël VandekerckhoveMaryvonne Rosseneu

A1 Journal Article in CURRENT OPINION IN LIPIDOLOGY

1999

Characterisation of functional residues in the interfacial recognition domain of lecithin cholesterol acyltransferase.

Berlinda VanlooFrank PeelmanChristine LabeurJoël VandekerckhoveJan TavernierMaryvonne Rosseneu

Characterization of functional residues in the interfacial recognition domain of lecithin cholesterol acyltransferase (LCAT).

Frank PeelmanB VANLOOO PEREZ-MENDEZA DECOUTJL VERSCHELDEChristine LabeurN VINAIMONTA VERHEEN DUVERGERR BRASSEUR et al.

A1 Journal Article in PROTEIN ENGINEERING

Effects of natural mutations in lecithin:cholesterol acyltransferase on the enzyme structure and activity

Frank PeelmanJean-Luc VerscheldeBerlinda VanlooChristophe AmpeChristine LabeurJan TavernierJoël VandekerckhoveMaryvonne Rosseneu

A1 Journal Article in JOURNAL OF LIPID RESEARCH

LCAT defects and low HDL levels.

Maryvonne RosseneuFrank PeelmanJL VERSCHELDEB VANLOOChristine LabeurJan TavernierJoël Vandekerckhove

A1 Journal Article in ATHEROSCLEROSIS

1998

A proposed architecture for lecithin cholesterol acyl transferase (LCAT): Identification of the catalytic triad and molecular modeling.

Frank PeelmanN VINAIMONTA VERHEEB VANLOOJL VERSCHELDEChristine LabeurS SEGURET-MACEN DUVERGERG HUTCHINSONJoël Vandekerckhove et al.

A1 Journal Article in PROTEIN SCIENCE

Contribution of the hydrophobicity gradient of an amphipathic peptide to its mode of association with lipids.

O PEREZ-MENDEZB VANLOOA DECOUTM GOETHALSFrank PeelmanJoël VandekerckhoveR BRASSEURMaryvonne Rosseneu

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

1997

Structural and functional properties of the 154-171 wild-type and variant peptides of human lecithin-cholesterol acyltransferase.

Frank PeelmanM GOETHALSB VANLOOChristine LabeurR BRASSEURJoël VandekerckhoveMaryvonne Rosseneu

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY