Research Explorer

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Researcher

Frank Loontiens

Awards & Distinctions

11 Results

2002

Base-sequence specificity of Hoechst 33258 and DAPI binding to five (A/T)(4) DNA sites with kinetic evidence for more than one high-affinity Hoechst 33258-AATT complex.

SY BREUSEGEMRM CLEGGFrank Loontiens

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

2001

Experimental precedent for the need to involve the primary hydration layer of DNA in lead drug design.

SY BREUSEGEMSE SADAT-EBRAHIMIKT DOUGLASEV BICHENKOVARM CLEGGFrank Loontiens

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Increased stability and lifetime of the complex formed between DNA and meta-phenyl-substituted Hoechst dyes as studied by fluorescence titrations and stopped-flow kinetics.

SY BREUSEGEMSE SADAT-EBRAHIMIKT DOUGLASRM CLEGGFrank Loontiens

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Kinetics of binding of hoechst dyes to DNA studied by stopped-flow fluorescence techniques.

SY BREUSEGEMFrank LoontiensP REGENFUSSRM CLEGG

A1 Journal Article in DRUG-NUCLEIC ACID INTERACTIONS

1995

Rational ligand design for the minor groove: testing the predictability of putative desgined binding interactions for Hoechst 33258 analogues. Ninth Conversation in the Discipline of Biomolecular Stereodynamics, June 20-24 Albany New York

S SADAT-EBRAHIMIJK EMBREYKT DOUGLASJA PARKINSONFrank LoontiensRM CLEGG

A2 Journal Article in Journal Biomolec. Struc. Dvnamics, 12, a202

1993

Modification by site-directed mutagenesis of the specificity of Erythrina corrallodendron lectin for galactose derivatives with bulky substituents at C-2.

R ARANGOE RODRIGUEZARANGOR ADARD BELENKYFrank LoontiensS ROZENBLATTN SHARON

A1 Journal Article in FEBS LETTERS

1992

SYNTHESIS OF METHYL ALPHA-N-DANSYL-D-GALACTOSAMINIDES AND BETA-N-DANSYL-D-GALACTOSAMINIDES, PROBES FOR THE COMBINING SITES OF N-ACETYL-D-GALACTOSAMINE-SPECIFIC LECTINS.

WR KINZYDM BELENKYFrank LoontiensN SHARON

A1 Journal Article in GLYCOCONJUGATE JOURNAL

1980

A temperature-jump relaxation study on the binding of fluorescent 4-methylumbelliferyl chito-oligosaccarides to wheat-germ-agglutinin

RM CleggFrank LoontiensAnita Van LandschootN SharonClement De BruyneTM Jovin

1978

KINETICS OF BINDING OF 4-METHYLUMBELLIFERYL ALPHA-MANNOBIOSIDE TO CONCANAVALIN - STOPPED-FLOW MEASUREMENTS.

Anita Van LandschootRM CLEGGFrank LoontiensTM JOVIN

1977

Binding of 4-methylumbelliferyl glycosides of alpha-mannobiose and mannotriose to tetrameric Concanavalin A: equilibrium and fast kinetic studies using fluorescence quenching

Anita Van LandschootRobert M CleggFrank LoontiensThomas M Jovin

Synthesis of methyl a- and b-N-dansyl-D-galactosaminides, probes for the combining sites of N-acetyl-D-galactosamine-specific lectins. Glycoconjugate J., 1992, 9, pp. 225-227.

WR KINZYD BELENKYFrank LoontiensN SHARON

A2 Journal Article