Research Explorer

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Researcher

Frank Bosmans

Publications & Research Data

Awards & Distinctions

83 Results

2026

Decoding pain sensitization : GPR35 tunes sensory neuron excitability through the elusive Nav1.9 channel

Margaux TheysFrank Bosmans

2025

A robust expression system reveals distinct gating mechanisms and calmodulin regulation of NaV1.9 channels

Margaux TheysJolien De WaeleSharang GarudKatrien WillegemsFilip Van PetegemFrank Bosmans

A1 Journal Article in SCIENCE ADVANCES

Biallelic truncating variants in SCN3B encoding Nav channel subunit β3 lead to neurodevelopmental phenotype with and without epilepsy and ataxia

Nathan RoutledgeMaxime LammensReza MaroofianBakht BelandDavid MurphyAsif MirZia UllahJaveria Reza AlviTipu SultanStephanie Efthymiou et al.

A1 Journal Article in ANNALS OF NEUROLOGY

CARD14 signaling in intestinal epithelial cells induces intestinal inflammation and intestinal transit delay

Aigerim AidarovaMarieke CarelsMira HaegmanYasmine DriegeSteven TimmermansEline Van DammeJavier Aguilera-LizarragaMaria Francesca ViolaRita de Cassia de Oliveira CollacoJoan Manils et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Gene expression, purification, and functional characterization of recombinant conotoxin μ-TIIIA and TIIIAlaMut in Escherichia coli with clinical evaluation of antiwrinkle efficacy

Diana MikiewiczAnna Mazurkiewicz-PisarekMagdalena JanczewskaJolien De WaeleAlina MazurkiewiczAgata StefanekFrank BosmansAgnieszka Lew-MirskaPrzemysław StyczeńTomasz Ciach

A2 Journal Article in BIOTECHNOLOGIA (POZNAŃ)

2024

Anxiety and dysautonomia symptoms in patients with a NaV1.7 mutation and the potential benefits of low-dose short-acting guanfacine

Rita de Cassia de Oliveira CollacoMaxime LammensCarley BlevinsKristen RodgersAndrei GurauSuguru YamauchiChristine KimJeannine ForresterEdward LiuJinny Ha et al.

A1 Journal Article in CLINICAL AUTONOMIC RESEARCH

Exploring cardiac sympathetic denervation as a treatment approach for recurrent ventricular arrhythmias : a concise review

Andrei GurauFrank BosmansAndreas BarthMalcolm V BrockJinny S Ha

A2 Journal Article in JOURNAL OF CLINICAL & EXPERIMENTAL CARDIOLOGY

2023

Structure-function relationship of new peptides activating human Nav1.1

Ludivine LopezStephan De WaardHervé MeudalCécile CaumesKuldip KhakhSteve PeigneurBarbara Oliveira-MendesSophia LinJolien De WaeleJérôme Montnach et al.

A1 Journal Article in BIOMEDICINE & PHARMACOTHERAPY

Understanding the physiological role of NaV1.9 : challenges and opportunities for pain modulation

Wayra BrackxRita de Cassia de Oliveira CollacoMargaux TheysJolien Vander CruyssenFrank Bosmans

A1 Journal Article in PHARMACOLOGY & THERAPEUTICS

2022

In vivo spatiotemporal control of voltage-gated ion channels by using photoactivatable peptidic toxins

Jérôme MontnachLaila Ananda BlömerLudivine LopezLuiza FilipisHervé MeudalAude LafouxSébastien NicolasDuong ChuCécile CaumesRémy Béroud et al.

A1 Journal Article in NATURE COMMUNICATIONS

N-type inactivation variances in honeybee and Asian giant hornet Kv channels

Shahid HussainJolien De WaeleMaxime LammensFrank Bosmans

A2 Journal Article in BIOELECTRICITY

Neonatal Nav1.5 : pharmacological distinctiveness of a cancer‐related voltage‐gated sodium channel splice variant

Scott P. FraserRustem OnkalMargaux TheysFrank BosmansMustafa B. A. Djamgoz

A1 Journal Article in BRITISH JOURNAL OF PHARMACOLOGY

2021

Getting stoned : characterisation of the coagulotoxic and neurotoxic effects of reef stonefish (Synanceia verrucosa) venom

Richard J. HarrisNicholas J. YoungmanWeili ChanFrank BosmansKaren L. CheneyBryan G. Fry

A1 Journal Article in TOXICOLOGY LETTERS

Homozygous SCN1B variants causing early infantile epileptic encephalopathy 52 affect voltage-gated sodium channel function

Marcello ScalaStephanie EfthymiouTipu SultanJolien De WaeleMarta PanciroliVincenzo SalpietroReza MaroofianPasquale StrianoFilip Van PetegemHenry Houlden et al.

A1 Journal Article in EPILEPSIA

The dragon’s paralysing spell : evidence of sodium and calcium ion channel binding neurotoxins in Helodermatid and Varanid lizard venoms

James S. DobsonRichard J. HarrisChristina N. ZdenekTam HuynhWayne C. HodgsonFrank BosmansRudy FourmyAude VioletteBryan G. Fry

A1 Journal Article in TOXINS

2020

Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predators

V HerzigK SunagarDTR WilsonSS PinedaMR IsraelS DutertreBS McFarlandEAB UndheimWC HodgsonPF Alewood et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biophysical investigation of sodium channel interaction with β-subunit variants associated with arrhythmias

José P. LlonguerasSamir DasJolien De WaeleLucio CapulziniAntonio SorgenteFilip Van PetegemFrank Bosmans

A2 Journal Article in BIOELECTRICITY

Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1.7

Darshani B. RupasingheVolker HerzigIrina VetterZoltan DekanJohn GilchristFrank BosmansPaul F. AlewoodRichard J. LewisGlenn F. King

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2019

Chemical synthesis, proper folding, Nav channel selectivity profile and analgesic properties of the spider peptide phlotoxin 1

S NicolasC ZoukimianFrank BosmansJ MontnachS DiochotE CuypersS De WaardR BéroudD MebsD Craik et al.

A1 Journal Article in TOXINS

Structural basis of α-scorpion toxin action on Nav channels

Thomas ClairfeuilleAlexander CloakeDaniel T InfieldJosé P LlonguerasChristopher P ArthurZhong Rong LiYuwen JianMarie-France Martin-EauclairePierre E BougisClaudio Ciferri et al.

A1 Journal Article in SCIENCE

2018

A disease mutation reveals a role for Nav1.9 in acute itch

Juan SalvatierraMarcelo Diaz-BustamanteJames MeixiongElaine TierneyXinzhong DongFrank Bosmans

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Nav1.1 inhibition can reduce visceral hypersensitivity

Juan SalvatierraJoel CastroAndelain EricksonQian LiJoão BrazJohn GilchristLuke GrundyGrigori Y RychkovAnnemie DeiterenRana Rais et al.

A1 Journal Article in JCI INSIGHT

Spider toxin inhibits gating pore currents underlying periodic paralysis

Roope MännikköZakhar O ShenkarevMichael G ThorAntonina A BerkutMikhail Yu MyshkinAlexander S ParamonovDmitrii S KulbatskiiDmitry A KuzminMarisol Sampedro CastañedaLouise King et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using voltage-sensor toxins and their molecular targets to investigate Nav1.8 gating

John GilchristFrank Bosmans

A1 Journal Article in JOURNAL OF PHYSIOLOGY-LONDON

2017

Insect-active toxins with promiscuous pharmacology from the African theraphosid spider Monocentropus balfouri

Jennifer J SmithVolker HerzigMaria P IkonomopoulouSlawomir DziemborowiczFrank BosmansGraham M NicholsonGlenn F King

A1 Journal Article in TOXINS

Pharmacological characterisation of the highly Nav1.7 selective spider venom peptide Pn3a

Jennifer R DeuisZoltan DekanJoshua S WingerdJennifer J SmithNehan R MunasingheRebecca F BholaWendy L ImlachVolker HerzigDavid A ArmstrongK Johan Rosengren et al.

A1 Journal Article in SCIENTIFIC REPORTS

Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes

Jerremiah D OsteenKevin SampsonVivek IyerDavid JuliusFrank Bosmans

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sodium channel Nav1.8 underlies TTX-resistant axonal action potential conduction in somatosensory C-fibers of distal cutaneous nerves

Amanda H KleinAlina VyshnevskaTimothy V HartkeRoberto De ColJoseph L MankowskiBrian TurnquistFrank BosmansPeter W ReehMartin SchmelzRichard W Carr et al.

A1 Journal Article in JOURNAL OF NEUROSCIENCE

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity

Joshua S WingerdChristine A MozarChristine A UssingSwetha S MuraliYanni K-K ChinBen Cristofori-ArmstrongThomas DurekJohn GilchristChristopher W VaughanFrank Bosmans et al.

A1 Journal Article in SCIENTIFIC REPORTS

2016

A painful tale about synthetic scorpion toxins

Juan SalvatierraFrank Bosmans

Editorial material

Binary architecture of the Nav1.2-β2 signaling complex

Samir DasJohn GilchristFrank BosmansFilip Van Petegem

A1 Journal Article in ELIFE

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide

Soohyun KwonFrank BosmansQuentin KaasOlivier ChenevalAnne C ConibearK Johan RosengrenConan K WangChristina I SchroederDavid J Craik

A1 Journal Article in BIOTECHNOLOGY AND BIOENGINEERING

Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix

Maria P IkonomopoulouJennifer J SmithVolker HerzigSandy S PinedaSlawomir DziemborowiczSing-Yan ErThomas DurekJohn GilchristPaul F AlewoodGraham M Nicholson et al.

A1 Journal Article in TOXICON

Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami

Volker HerzigMaria IkonomopoulouJennifer J SmithSlawomir DziemborowiczJohn GilchristLucia Kuhn-NentwigFernanda Oliveira RezendeLuciano Andrade MoreiraGraham M NicholsonFrank Bosmans et al.

A1 Journal Article in SCIENTIFIC REPORTS

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

Jeremiah D OsteenVolker HerzigJohn GilchristJoshua J EmrickChuchu ZhangXidao WangJoel CastroSonia Garcia-CaraballoLuke GrundyGrigori Y Rychkov et al.

A1 Journal Article in NATURE

The hitchhiker's guide to the voltage-gated sodium channel galaxy

Christopher A AhernJian PayandehFrank BosmansBaron Chanda

A1 Journal Article in JOURNAL OF GENERAL PHYSIOLOGY

The scorpion toxin Bot IX is a potent member of the α-like family and has a unique N-terminal sequence extension

Marie-France Martin-EauclaireJuan SalvatierraPascal MansuelleFrank BosmansPierre E Bougis

A1 Journal Article in FEBS LETTERS

2015

A surface plasmon resonance approach to monitor toxin interactions with an isolated voltage-gated sodium channel paddle motif

Marie-France Martin-EauclaireGeraldine FerracciFrank BosmansPierre E Bougis

A1 Journal Article in JOURNAL OF GENERAL PHYSIOLOGY

From foe to friend: using animal toxins to investigate ion channel function.

Jeet KaliaMirela MilescuJuan SalvatierraJordan WagnerJulie K KlintGlenn F KingBaldomero M OliveraFrank Bosmans

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

MmTX1 and MmTX2 from coral snake venom potently modulate GABAa receptor activity

Jean-Pierre RossoJürgen R SchwarzMarcelo Diaz-BustamanteBrigitte CéardJosé M GutiérrezMatthias KneusselOlaf PongsFrank BosmansPierre E Bougis

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Seven novel modulators of the analgesic target Nav1.7 uncovered using a high-throughput venom-based discovery approach

Julie K KlintJennifer J SmithIrina VetterDarshani B RupasingheSing Yan ErSebastian SenffVolker HerzigMehdi MobliRichard J LewisFrank Bosmans et al.

A1 Journal Article in Br J Pharmacol

The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop

Niraj S BendeSlawomir DziemborowiczVolker HerzigVenkatraman RamanujamGeoffrey W BrownFrank BosmansGraham M NicholsonGlenn F KingMehdi Mobli

A1 Journal Article in FEBS JOURNAL

The scorpion toxin Tf2 from Tityus fasciolatus promotes Nav1.3 opening

Thalita S CamargosFrank BosmansSolange C RegoCaroline BF MourãoElisabeth F Schwartz

A1 Journal Article in PLOS ONE

2014

A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a

Niraj S BendeSlawomir DziemborowiczMehdi MobliVolker HerzigJohn GilchristJordan WagnerGraham M NicholsonGlenn F KingFrank Bosmans

A1 Journal Article in NATURE COMMUNICATIONS

A first exploration of the venom of the Buthus occitanus scorpion found in southern France

Marie-France Martin-EauclaireFrank BosmansBrigitte CéardSylvie DiochotPierre E Bougis

A1 Journal Article in TOXICON

Animal toxins influence voltage-gated sodium channel function

John GilchristBaldomero M OliveraFrank Bosmans

Bookchapter in Voltage gated sodium channels

Nav1.1 modulation by a novel triazole compound attenuates epileptic seizures in rodents

John GilchristStacey DuttonMarcelo Diaz-BustamanteAnnie McPhersonNicolas OlivaresJeet KaliaAndrew EscaygFrank Bosmans

A1 Journal Article in ACS CHEMICAL BIOLOGY

2013

Crystallographic insights into sodium-channel modulation by the β4 subunit

John GilchristSamir DasFilip Van PetegemFrank Bosmans

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New rule(r)s for FRET

The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels

Niraj S BendeEunji KangVolker HerzigFrank BosmansGraham M NicholsonMehdi MobliGlenn F King

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2012

Animal toxins can alter the function of Nav1.8 and Nav1.9

John GilchristFrank Bosmans

A1 Journal Article in TOXINS

2011

Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensors

Frank BosmansMichelino PuopoloMarie-France Martin-EauclaireBruce P BeanKenton J Swartz

A1 Journal Article in JOURNAL OF GENERAL PHYSIOLOGY

Palmitoylation influences the function and pharmacology of sodium channels

Frank BosmansMirela MilescuKenton J Swartz

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2010

Targeting voltage sensors in sodium channels with spider toxins

Frank BosmansKenton J Swartz

A1 Journal Article in TRENDS IN PHARMACOLOGICAL SCIENCES

2009

Insecticidal peptides from the theraposid spider Brachypelma albiceps : an NMR-based model of Ba2

Gerardo CorzoCedric BernardHerlinda ClementElba VillegasFrank BosmansJan TytgatLourival D PossaniHervé DarbonAlejandro Alagón

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Interactions between lipids and voltage sensor paddles detected with tarantula toxins

Mirela MilescuFrank BosmansSeungkyu LeeAbdulRasheed A AlabiJae Il KimKenton J Swartz

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

2008

Animal peptides targeting voltage-activated sodium channels.

Bert BillenFrank BosmansJan Tytgat

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

Biochemical characterization of cysteine-rich peptides from Oxyopes sp. venom that block calcium ion channels

Elba VillegasSatomi Adachi-AkahaneFrank BosmansJan TytgatTerumi NakajimaGerardo Corzo

A1 Journal Article in TOXICON

Deconstructing voltage sensor function and pharmacology in sodium channels

Frank BosmansMarie-France Martin-EauclaireKenton J Swartz

A1 Journal Article in NATURE

2007

Differential effects of five 'classical' scorpion beta-toxins on rNav1.2a and DmNav1 provide clues on species-selectivity

Frank BosmansMarie-France Martin-EauclaireJan Tytgat

A1 Journal Article in TOXICOLOGY AND APPLIED PHARMACOLOGY

Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na+ channels

Frank BosmansJan Tytgat

A1 Journal Article in TOXICON

Solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channels

Gerardo CorzoJennifer K SaboFrank BosmansBert BillenElba VillegasJan TytgatRaymond S Norton

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Spider peptide toxins as leads for drug development

Pierre EscoubasFrank Bosmans

A1 Journal Article in EXPERT OPINION ON DRUG DISCOVERY

Voltage-gated sodium channel modulation by scorpion α-toxins

Frank BosmansJan Tytgat

A1 Journal Article in TOXICON

2006

Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes

Frank BosmansL RashS ZhuS DiochotM LazdunskiP EscoubasJ Tytgat

A1 Journal Article in MOLECULAR PHARMACOLOGY

The first potassium channel toxin from the venom of the Iranian scorpion Odonthobuthus doriae

Yousra Abdel-MottalebElke ClynenAmir JalaliFrank BosmansHossein VatanpourLiliane SchoofsJan Tytgat

A1 Journal Article in FEBS LETTERS

2005

BjαIT : a novel scorpion α-toxin selective for insects : unique pharmacological tool

Tal ArnonTamara PotikhaDaniel SherMenashe ElazarWenfu MaoTzachy TalFrank BosmansJan TytgatNissim Ben-ArieEliahu Zlotkin

A1 Journal Article in INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Expression, renaturation and functional analysis of an excitatory insect-specific toxin from scorpion Buthus martensii Karsch

C LiW LiuFrank BosmansRH ZhuJ TytgatDC Wang

A1 Journal Article in PROTEIN AND PEPTIDE LETTERS

Molecular basis of the mammalian potency of the scorpion α-like toxin, BmK M1

LH LiuFrank BosmansC MaertensRH ZhuDC WangJ Tytgat

A1 Journal Article in FASEB JOURNAL

New 'Birtoxin analogs' from Androctonus australis venom

MF Martin-EauclaireB CeardFrank BosmansJP RossoJ TytgatPE Bougis

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

OD1, the first toxin isolated from the venom of the scorpion Odonthobuthus doriae active on voltage-gated Na+ channels

A JalaliFrank BosmansM AmininasabE ClynenE CuypersA ZaremirakabadiMN SarboloukiL SchoofsH VatanpourJ Tytgat

A1 Journal Article in FEBS LETTERS

Pharmacological comparison of two different insect models using the scorpion α-like toxin BmK M1 from Buthus martensii Karsch

Frank BosmansB BrôneYM SunRH ZhuYM XiongDC WangE Van KerkhoveJ Tytgat

A1 Journal Article in PROTEIN AND PEPTIDE LETTERS

Solution structure of two insect-specific spider toxins and their pharmacological interaction with the insect voltage-gated Na+ channel

G FerratFrank BosmansJ TytgatC PimentelB ChagotN GillesT NakajimaH DarbonG Corzo

A1 Journal Article in PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structural basis for the voltage-gated Na+ channel selectivity of the scorpion α-like toxin BmK M1

X YeFrank BosmansC LiY ZhangDC WangJ Tytgat

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

The depressant scorpion neurotoxin LqqIT2 selectively modulates the insect voltage-gated sodium channel

Frank BosmansMarie-France Martin-EauclaireJan Tytgat

A1 Journal Article in TOXICON

2004

Adaptive evolution of scorpion sodium channel toxins.

SY ZhuFrank BosmansJ Tytgat

A1 Journal Article in JOURNAL OF MOLECULAR EVOLUTION

Phaiodotoxin, a novel structural class of insect-toxin isolated from the venom of the Mexican scorpion Anuroctonus phaiodactylus

Norma A Valdez-CruzCesar VF BatistaFernando Z ZamudioFrank BosmansJan TytgatLourival D Possani

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

The poison Dart frog's batrachotoxin modulates Nav1.8

Frank BosmansC MaertensF VerdonckJ Tytgat

A1 Journal Article in FEBS LETTERS

2003

Characterization of Amm VIII from Androctonus mauretanicus mauretanicus : a new scorpion toxin that discriminates between neuronal and skeletal sodium channels

M AlamiH VacherFrank BosmansC DevauxJP RossoPE BougisJ TytgatH DarbonMF Martin-Eauclaire

A1 Journal Article in BIOCHEMICAL JOURNAL

Function and solution structure of hainantoxin-I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana

Dongling LiYucheng XiaoWeijun HuJinyun XieFrank BosmansJan TytgatSongping Liang

A1 Journal Article in FEBS LETTERS

Importance of the conserved aromatic residues in the scorpion α-like toxin BmK M1 : the hydrophobic surface region revisited

YM SunFrank BosmansRH ZhuC GoudetYM XiongJ TytgatDC Wang

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2002

The sea anemone Bunodosoma granulifera contains surprisingly efficacious and potent insect-selective toxins

Frank BosmansA AneirosJ Tytgat

A1 Journal Article in FEBS LETTERS

1998

Liquid chromatographic method for separation of lincomycin from its related substances

Jennifer OrwaFrank BosmansS DepuydtE RoetsJos Hoogmartens

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY A