Research Explorer

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Researcher

Filip Van Hauwermeiren

Awards & Distinctions

32 Results

2022

Bacillus anthracis induces NLRP3 inflammasome activation and caspase-8-mediated apoptosis of macrophages to promote lethal anthrax

Filip Van HauwermeirenNina Van OpdenboschHanne Van GorpNathalia de VasconcelosGeert van LooPeter VandenabeeleThirumala-Devi KannegantiMohamed Lamkanfi

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSDMD drives canonical inflammasome-induced neutrophil pyroptosis and is dispensable for NETosis

Dhruv ChauhanDieter DemonLieselotte Vande WalleOonagh PaerewijckAnnalisa ZecchinLeslie BosselerKarin SantoniRemi PlanesSilvia Ribó GenéAmelie Fossoul et al.

A1 Journal Article in EMBO REPORTS

2021

Nanoparticle-sensitized photoporation enables inflammasome activation studies in targeted single cells dagger

Aranit HarizajFilip Van HauwermeirenStephan StremerschRiet De RyckeHerlinde De KeersmaeckerToon BransJuan FraireKarolien GrauwenStefaan De SmedtIne Lentacker et al.

A1 Journal Article in NANOSCALE

2019

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

Lieselotte Vande WalleIrma B StowePavel SachaBettina L LeeDieter DemonAmelie FossoulFilip Van HauwermeirenPedro Henrique Viana SaavedraPetr SimonVladimir Subrt et al.

A1 Journal Article in PLOS BIOLOGY

Structure of S-layer protein Sap reveals a mechanism for therapeutic intervention in anthrax

Antonella FioravantiFilip Van HauwermeirenSander E Van der VerrenWim JonckheereAmanda GonçalvesEls PardonJan SteyaertHenri De GreveMohamed LamkanfiHan Remaut

A1 Journal Article in NATURE MICROBIOLOGY

2017

Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4

Nina Van OpdenboschHanne Van GorpMaarten VerdoncktPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosAmanda GonçalvesLieselotte Vande WalleDieter DemonMagdalena MatusiakFilip Van Hauwermeiren et al.

A1 Journal Article in CELL REPORTS

Nlrp6-and ASC-dependent inflammasomes do not shape the commensal gut microbiota composition

Michail MamantopoulosFrancesca RonchiFilip Van HauwermeirenSara Vieira-SilvaBahtiyar YilmazLiesbet MartensYvan SaeysStefan K DrexlerAmir S YazdiJeroen Raes et al.

A1 Journal Article in IMMUNITY

2016

Does caspase-12 suppress inflammasome activation?

Lieselotte Vande WalleDaniel Jiménez FernandezDieter DemonNaomi Van LaethemFilip Van HauwermeirenHanne Van GorpNina Van OpdenboschNobuhiko KayagakiMohamed Lamkanfi

A1 Journal Article in NATURE

Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

Hanne Van GorpPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosNina Van OpdenboschLieselotte Vande WalleMagdalena MatusiakGiusi PrencipeAntonella InsalacoFilip Van HauwermeirenDieter Demon et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammasomes in inflammatory disease

Hanne Van GorpPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosNina Van OpdenboschLieselotte Vande WalleMagdalena MatusiakFilip Van HauwermeirenG. PrencipeDelfien BogaertMelissa Dullaers et al.

The NEK-sus of the NLRP3 inflammasome

Filip Van HauwermeirenMohamed Lamkanfi

Editorial material

2015

Determining differentially expressed miRNAs and validating miRNA-target relationships using the SPRET/Ei mouse strain

Steven TimmermansFilip Van HauwermeirenLeen PuimègeLien DejagerElien Van WonterghemValerie VanhoorenPieter MestdaghClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in MAMMALIAN GENOME

Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1

Sophie SteelandLeen PuimègeRoosmarijn VandenbrouckeFilip Van HauwermeirenJurgen HaustraeteNick DevoogdtPaco HulpiauGeert Leroux-RoelsDebby LaukensPhilip Meuleman et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1

Leen PuimègeFilip Van HauwermeirenSophie SteelandSara Van RyckeghemJolien VandewalleSofie LodensLien DejagerSofie VandevyverJan StaelensSteven Timmermans et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation

Lien DejagerKaren DendonckerMelanie EggermontJolien SouffriauFilip Van HauwermeirenMonique WillartElien Van WonterghemThomas NaessensMarlies BallegeerSofie Vandevyver et al.

A1 Journal Article in MUCOSAL IMMUNOLOGY

TNFR1-induced lethal inflammation is mediated by goblet and Paneth cell dysfunction

Filip Van HauwermeirenRoosmarijn VandenbrouckeLynda GrineSofie LodensElien Van WonterghemRiet De RyckeN De GeestB HassanClaude Libert

A1 Journal Article in MUCOSAL IMMUNOLOGY

2014

Antisense oligonucleotides against TNFR1 prevent toxicity of TNF/IFNγ treatment in mouse tumor models

Filip Van HauwermeirenRoosmarijn VandenbrouckeLynda GrineLeen PuimègeElien Van WonterghemHong ZhangClaude Libert

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

NOD-like receptors interfacing the immune and reproductive systems

Hanne Van GorpAnna KuchmiyFilip Van HauwermeirenMohamed Lamkanfi

A1 Journal Article in FEBS JOURNAL

Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation

Roosmarijn VandenbrouckeIneke VanlaereFilip Van HauwermeirenElien Van WonterghemC WilsonClaude Libert

A1 Journal Article in MUCOSAL IMMUNOLOGY

Regulation and dysregulation of tumor necrosis factor receptor-1

Leen PuimègeClaude LibertFilip Van Hauwermeiren

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

2013

LPS resistance of SPRET/Ei mice is mediated by Gilz, encoded by the Tsc22d3 gene on the X chromosome

Iris PinheiroLien DejagerIoanna PettaSofie VandevyverLeen PuimègeTina MahieuMarlies BallegeerFilip Van HauwermeirenCarlo RiccardiMarnik Vuylsteke et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF

Roosmarijn VandenbrouckeEline DejonckheereFilip Van HauwermeirenSofie LodensRiet De RyckeElien Van WonterghemAn StaesKris GevaertCarlos López-OtinClaude Libert

A1 Journal Article in EMBO MOLECULAR MEDICINE

Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium

Filip Van HauwermeirenMarietta ArmakaNiki KaragianniKsanthi KranidiotiRoosmarijn VandenbrouckeSonja LogesMaarten Van RoyenJan StaelensLeen PuimègeAjay Palagani et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

2012

Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases

Roosmarijn VandenbrouckeEline DejonckheerePhilippe Van LintDelphine DemeestereElien Van WonterghemIneke VanlaereLeen PuimègeFilip Van HauwermeirenRiet De RyckeConor Mc Guire et al.

A1 Journal Article in JOURNAL OF NEUROSCIENCE

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

Nozomi TakahashiLinde DuprezSasker GrootjansAnje CauwelsWim NerinckxJB DuHadawayVera GoossensRia RoelandtFilip Van HauwermeirenClaude Libert et al.

A1 Journal Article in CELL DEATH & DISEASE

2011

New strategies to prevent TNF-induced toxicity in TNF/IFNγ-based anti-tumor models

Filip Van HauwermeirenClaude Libert

RIP Kinase-dependent necrosis drives lethal systemic inflammatory response syndrome

Linde DuprezNozomi TakahashiFilip Van HauwermeirenBenjamin VandendriesscheVera GoossensTom Vanden BergheWim DeclercqClaude LibertAnje CauwelsPeter Vandenabeele

A1 Journal Article in IMMUNITY

Strategies to inhibit the toxicity of systemic TNF treatment

Filip Van HauwermeirenLeen PuimègeSofie VandevyverTom Van BogaertIneke VanlaereLiesbeth HuysLien DejagerClaude Libert

A1 Journal Article in Advances in Experimental Medicine and Biology

Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1

Filip Van HauwermeirenRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

Tumor necrosis factor Inhibits glucocorticoid receptor function in mice a strong signal toward lethal shock

Tom Van BogaertSofie VandevyverLien DejagerFilip Van HauwermeirenIris PinheiroIoanna PettaDavid EngblomAnna KleymanGuenther SchutzJan Tuckermann et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2009

Type I interferon drives tumor necrosis factor-induced lethal shock

Liesbeth HuysFilip Van HauwermeirenLien DejagerEline DejonckheereStefan LienenklausSiegfried WeissGeorges LeclercqClaude Libert

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2007

Endothelial outgrowth cells are not derived from CD133(+) cells or CD45(+) hematopoietic precursors

Frank TimmermansFilip Van HauwermeirenMagda De SmedtRobrecht RaedtFRANK PLASSCHAERTMarc De BuyzereThierry GillebertJean PlumBart Vandekerckhove

A1 Journal Article in ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY