Research Explorer

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Researcher

Filip Matthijssens

Awards & Distinctions

56 Results

2024

A dual role for PSIP1/LEDGF in T cell acute lymphoblastic leukemia

Lisa DemoenFilip MatthijssensLindy ReunesBruno PalhaisBéatrice LintermansSara T'SasIgor FijalkowskiJoachim TaminauMuluembet Z. AkeleSiska Van Belle et al.

A1 Journal Article in SCIENCE ADVANCES

CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia

Bruno A. CardosoMafalda DuqueAna GírioRita FragosoMariana L. OliveiraJames R. AllenLeila R. MartinsNádia C. CorreiaAndré Bortolini SilveiraAlexandra Veloso et al.

A1 Journal Article in HAEMATOLOGICA

2022

The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency

Sigrid WahlenFilip MatthijssensWouter Van LoockeSylvie TaveirneLaura KiekensEva PersynEls Van AmmelZenzi De VosStijn De MunterPatrick Matthys et al.

A1 Journal Article in ELIFE

2021

Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells

Despoina KerselidouBushra Saeed DohaiDavid R. NelsonSarah DaakourNicolas De CockZahra Al Oula HassounDae-Kyum KimJulien OlivetDiana C. El AssalAshish Jaiswal et al.

A1 Journal Article in SCIENCE ADVANCES

Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice

Tim PietersSara T'SasStijn VanheeAndré Pedro Pinto De AlmeidaYasmine DriegeJuliette RoelsWouter Van LoockeWillem DaneelsMathijs BaensArnaud Marchand et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis

E. G. GarciaA. VelosoM. L. OliveiraJ. R. AllenS. LoontiensD. BrunsonD. DoC. YanR. MorrisS. Iyer et al.

A1 Journal Article in LEUKEMIA

RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia

Filip MatthijssensNitesh D. SharmaMonique NysusChristian K. NicklHuining KangDominique R. PerezBéatrice LintermansWouter Van LoockeJuliette RoelsSofie Peirs et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Unlike its paralog LEDGF/p75, HRP-2 is dispensable for MLL-R leukemogenesis but important for leukemic cell survival

Siska Van BelleSara El AshkarKateřina ČermákováFilip MatthijssensSteven GoossensAlessandro CanellaCourtney H. HodgesFrauke ChristJan De RijckPieter Van Vlierberghe et al.

A1 Journal Article in CELLS

2020

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia

Juliette RoelsMorgan ThénozBronislawa SzarzynskaMattias LandforsStien De ConinckLisa DemoenLien ProvezAnna KuchmiySteven StrubbeLindy Reunes et al.

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia

Juliette RoelsMorgan ThénozB SzarzyńskaM LandforsStien De ConinckLisa DemoenLien ProvezAnna KuchmiySteven StrubbeLindy Reunes et al.

A2 Journal Article in BLOOD CANCER DISCOVERY

PHF6 expression levels impact human hematopoietic stem cell differentiation

Siebe LoontiensAnne-Catherine DolensSteven StrubbeInge Van de WalleFinola E. MooreLisa DepestelSuzanne VanhauwaertFilip MatthijssensDavid M. LangenauFranki Speleman et al.

A1 Journal Article in FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

2019

Genetic characterization and therapeutic targeting of MYC-rearranged T cell acute lymphoblastic leukaemia

Gloria MilaniFilip MatthijssensWouter Van LoockeKaat DurinckJuliette RoelsSofie PeirsMorgan ThénozTim PietersLindy ReunesBéatrice Lintermans et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies

Tim PietersSara T'SasLisa DemoenAndré Pedro Pinto De AlmeidaLieven HaenebalckeFilip MatthijssensKelly LemeireJinke D'HontFrédérique VanrockeghemTino Hochepied et al.

A1 Journal Article in SCIENTIFIC REPORTS

Purification of high-quality RNA from a small number of fluorescence activated cell sorted zebrafish cells for RNA sequencing purposes

Siebe LoontiensLisa DepestelSuzanne VanhauwaertGivani DewynCharlotte GistelinckKaren VerboomWouter Van LoockeFilip MatthijssensAndy WillaertJo Vandesompele et al.

A1 Journal Article in BMC GENOMICS

2018

A novel t(8;14)(q24;q11) rearranged human cell line as a model for mechanistic and drug discovery studies of NOTCH1-independent human T-cell leukemia

Valeria ToselloGloria MilaniAnnalisa MartinesNadia MacriWouter Van LoockeFilip MatthijssensBarbara BuldiniSonia MinuzzoDeborah BongiovanniRichard Fabian Schumacher et al.

A1 Journal Article in CELLS

Isolation of high-quality RNA from fluorescent activated cell sorted (FACS) zebrafish cells for RNA sequencing purposes

Siebe LoontiensSuzanne VanhauwaertLisa DepestelGivani DewynCharlotte GistelinckKaren VerboomEls JanssensFilip MatthijssensAndy WillaertJo Vandesompele et al.

Pre-clinical evaluation of second generation PIM inhibitors for the treatment of T-cell acute lymphoblastic leukemia and lymphoma

Renate De SmedtSofie PeirsJulie MorscioFilip MatthijssensJuliette RoelsLindy ReunesBéatrice LintermansSteven GoossensTim LammensNadine Van Roy et al.

A1 Journal Article in HAEMATOLOGICA

2017

Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia

Steven GoossensSofie PeirsWouter Van LoockeJueqiong WangMina TakawyFilip MatthijssensStefan E SondereggerKatharina HaighThao NguyenNiels Vandamme et al.

A1 Journal Article in BLOOD

Oxidative stress

Bart BraeckmanPatricia BackFilip Matthijssens

Bookchapter in Ageing : lessons from C. elegans

Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia

Sofie PeirsV FrismantasFilip MatthijssensW Van LoockeTim PietersNiels VandammeBéatrice LintermansMP DobayGeert BerxBruce Poppe et al.

A1 Journal Article in LEUKEMIA

The TLX1 oncogene modulates the enhancer RNA landscape in T-ALL

Karen VerboomKaat DurinckMatthias De DeckerWouter Van LoockeFilip MatthijssensJean-Jacques SoulierWouter De LaatTom TaghonPieter Van VlierbergheFranki Speleman

2016

BRD4 inhibition improves the efficacy of ABT-199 in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensTim PietersNiels VandammeGeert BerxBruce PoppePieter Van Vlierberghe

BRD4 inhibition improves the efficacy of ABT-199 in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensTim PietersNiels VandammeGeert BerxBruce PoppePieter Van Vlierberghe

Fast generation of conditional ROSA26-based mouse models that recapitulate genomic events in human T-ALL

Tim PietersSteven GoossensSara T'SasLieven HaenebalckeTino HochepiedBéatrice LintermansSofie PeirsFilip MatthijssensJ HaighGeert Berx et al.

Genetic characterization and therapeutic targeting of MYC translocated pediatric T-cell acute lymphoblastic leukemia

Gloria MilaniKaat DurinckFilip MatthijssensSofie PeirsTim PietersLindy ReunesBéatrice LintermansNiels VandammeTim LammensYunlei Li et al.

Long noncoding RNA signatures define oncogenic subtypes in T-cell acute lymphoblastic leukemia

Annelynn WallaertKaat DurinckWouter Van LoockeInge Van de WalleFilip MatthijssensPieter-Jan VoldersFrancisco Avila CobosDries RombautPieter RondouPieter Mestdagh et al.

A1 Journal Article in LEUKEMIA

Targeting BET family proteins improves the efficacy of ABT-199 in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensBéatrice LintermansTim PietersNiels VandammeGeert BerxBruce PoppePieter Van Vlierberghe

Targeting BET family proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia

Sofie PeirsViktoras FrismantasFilip MatthijssensBéatrice LintermansTim PietersNiels VandammeWouter Van LoockeGeert BerxBruce PoppeJean-Pierre Bourquin et al.

The T-ALL oncogene TLX1 controls enhancer lncRNA expression

Karen VerboomKaat DurinckWouter Van LoockeFilip MatthijssensInge Van de WalleAnnelynn WallaertPieter-Jan VoldersNadine Van RoyYves BenoitBruce Poppe et al.

The combination of ABT-199 and JQ1 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensTim PietersNiels VandammeBéatrice LintermansLindy ReunesGeert BerxBruce PoppePieter Van Vlierberghe

2015

CRISPR/Cas9-mediated genome editing in primed versus naïve human embryonic stem cells

Eva JacobsSharat WarrierEva D'haeneFilip MatthijssensMargot Van der JeughtBjörn HeindryckxBjörn MentenSarah Vergult

Novel biological insights in T-cell acute lymphoblastic leukemia

Kaat DurinckSteven GoossensSofie PeirsAnnelynn WallaertWouter Van LoockeFilip MatthijssensTim PietersGloria MilaniTim LammensPieter Rondou et al.

A1 Journal Article in EXPERIMENTAL HEMATOLOGY

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

Joni Van der MeulenViraj SanghviKonstantinos MavrakisKaat DurinckFang FangFilip MatthijssensPieter RondouMonica RosenTim PietersPeter Vandenberghe et al.

A1 Journal Article in BLOOD

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Steven GoossensEnrico RadaelliOdile BlanchetKaat DurinckJoni Van der MeulenSofie PeirsTom TaghonCedric S TremblayMagdaline CostaMorvarid Farhang Ghahremani et al.

A1 Journal Article in NATURE COMMUNICATIONS

2014

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensInge Van de WalleKatia RuggeroCharles E de BockSandrine DegryseKirsten Canté-BarrettDelphine BriotEmmanuelle Clappier et al.

A1 Journal Article in BLOOD

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in early immature T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensKirsten Canté-BarrettTim LammensBarbara De MoerlooseYves BenoitJean SoulierBruce PoppeTom Taghon et al.

ABT-199 mediated inhibition of BCL2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensCharles De BockKirsten Canté-BarrettTim LammensInge Van de WalleBarbara De MoerlooseYves BenoitBruce Poppe et al.

2013

Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans

Cassandra CoburnErik AllmanParag MahantiAlexandre BenedettoFilipe CabreiroZachary PincusFilip MatthijssensCaroline AraizAbraham MandelManolis Vlachos et al.

A1 Journal Article in PLOS BIOLOGY

2012

A simplified hydroethidine method for fast and accurate detection of superoxide production in isolated mitochondria

Patricia BackFilip MatthijssensJacques VanfleterenBart Braeckman

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

Exploring ROS and redox biology in aging Caenorhabditis elegans

Patricia BackBart BraeckmanFilip Matthijssens

Exploring real-time in vivo redox biology of developing and aging Caenorhabditis elegans

Patricia BackWinnok De VosGeert DepuydtFilip MatthijssensJacques VanfleterenBart Braeckman

A1 Journal Article in FREE RADICAL BIOLOGY AND MEDICINE

ROS in aging Caenorhabditis elegans: damage or signaling?

Patricia BackBart BraeckmanFilip Matthijssens

A1 Journal Article in OXIDATIVE MEDICINE AND CELLULAR LONGEVITY

2010

DamID in C. elegans reveals longevity-associated targets of DAF-16/FoxO

Eugene SchusterJoshua J McElweeJennifer MA TulletRyan DoonanFilip MatthijssensJohn S Reece-HoyesIan A HopeJacques VanfleterenJanet M ThorntonDavid Gems

A1 Journal Article in MOLECULAR SYSTEMS BIOLOGY

Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans

Kristel BrysNatascha CasteleinFilip MatthijssensJacques VanfleterenBart Braeckman

A1 Journal Article in BMC BIOLOGY

Effects of sod gene overexpression and deletion mutation on the expression profiles of reporter genes of major detoxification pathways in Caenorhabditis elegans

Patricia BackFilip MatthijssensCaroline VlaeminckBart BraeckmanJacques Vanfleteren

A1 Journal Article in EXPERIMENTAL GERONTOLOGY

2008

Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

Ryan DoonanJoshua McElweeFilip MatthijssensGlenda WalkerKoen HouthoofdPatricia BackAndrea MatscheskiJacques VanfleterenDavid Gems

A1 Journal Article in Genes and Development

Prooxidant activity of the superoxide dismutase (SOD)-mimetic EUK-8 in proliferating and growth-arrested Escherichia coli cells

Filip MatthijssensPatricia BackBart BraeckmanJacques Vanfleteren

A1 Journal Article in Free Radical Biology and Medicine

Selection and validation of a set of reliable reference genes for quantitative sod gene expression analysis in C-elegans

David HoogewijsKoen HouthoofdFilip MatthijssensJo VandesompeleJacques Vanfleteren

A1 Journal Article in BMC MOLECULAR BIOLOGY

2007

Evaluation of different methods for assaying protein carbonylation

Filip MatthijssensBart BraeckmanJacques Vanfleteren

A1 Journal Article in CURRENT ANALYTICAL CHEMISTRY

2005

DAF-2 pathway mutations and food restriction in aging Caenorhabditis elegans differentially affect metabolism

Koen HouthoofdBart BraeckmanIsabelle LenaertsKristel BrysFilip MatthijssensAnna De VreeseSylvie Van EygenJacques Vanfleteren

A1 Journal Article in NEUROBIOLOGY OF AGING

Metabolism, physiology and stress defense in three aging Ins/IGF-1 mutants of the nematode Caenorhabditis elegans

Koen HouthoofdMA FIDALGODavid HoogewijsBart BraeckmanIsabelle LenaertsKristel BrysFilip MatthijssensAnna De VreeseSylvie Van EygenMJ MUNOZ et al.

A1 Journal Article in AGING CELL

2004

Caloric restriction, Ins/IGF-1 signalling and longevity in the nematode Caenorhabditis elegans

Koen HouthoofdBart BraeckmanAnna De VreeseSylvie Van EygenIsabelle LenaertsKristel BrysFilip MatthijssensJacques Vanfleteren

A1 Journal Article in BELGIAN JOURNAL OF ZOOLOGY

Superoxide dismutase mimetics elevate superoxide dismutase activity in vivo but do not retard aging in the nematode Caenorhabditis elegans

M KEANEYFilip MatthijssensM SHARPEJacques VanfleterenD GEMS

A1 Journal Article in FREE RADICAL BIOLOGY AND MEDICINE

2003

A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas ligand

Geert van LooSaskia LippensM HAHNEFilip MatthijssensWim DeclercqXavier SaelensPeter Vandenabeele

A1 Journal Article in CYTOKINE

2002

A high-throughput microtiter plate assay for superoxide dismutase based on lucigenin chemiluminescence.

Isabelle LenaertsBart BraeckmanFilip MatthijssensJacques Vanfleteren

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

Caspases are not localized in mitochondria during life or death

Geert van LooXavier SaelensFilip MatthijssensPeter SchotteRudi BeyaertWim DeclercqPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION