Research Explorer

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Researcher

Fien Martens

Publications & Research Data

Awards & Distinctions

4 Results

2026

Targeting replication stress in neuroblastoma by exploiting the synergistic potential of second generation RRM2 and CHK1 inhibitors

Iris NelenSoetkin LeysSarah-Lee BekaertFanny De VloedFien MartensEllen SandersAngeline Praveena Enton RajAnnika JeschkeShunya OhmuraThomas G P Grünewald et al.

A1 Journal Article in CELL DEATH & DISEASE

2025

Second-generation AURKA-targeting PROTACs : structural optimization toward in vivo degradation in neuroblastoma

Simon KrolsMuhammad RishfiFien MartensAnouk Van HauwermeirenEllen SandersPieter-Jan De SutterAn VermeulenKaat De WeverSarah-Lee BekaertM. Emmy M. Dolman et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Synergistic inhibition of CHK1 and MUS81 to combat replication stress resistance in high-risk neuroblastoma

Elien HilgertChristophe Van NesteSarah-Lee BekaertFien MartensSuzanne VanhauwaertEllen SandersPeter VerstraelenMartijn RisseeuwEllen M. WesterhoutMark A. Grannetia et al.

A1 Journal Article in SCIENTIFIC REPORTS

2023

Targeted AURKA degradation : towards new therapeutic agents for neuroblastoma

Muhammad RishfiSimon KrolsFien MartensSarah-Lee BekaertEllen SandersAline EggermontFanny De VloedJoshua Robert GouldingMartijn RisseeuwJan Molenaar et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY