Research Explorer

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Researcher

Fien De Leersnyder

Awards & Distinctions

15 Results

2019

A Quality by Design strategy for a continuous pharmaceutical manufacturing process of tablets based on wet granulation

Fien De LeersnyderThomas De BeerEric Ziemons

Evaluation of an in-line NIR spectroscopic method for the determination of the residence time in a tablet press

Fien De LeersnyderValérie VanhoorneAshish KumarChris VervaetThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Modeling of semicontinuous fluid bed drying of pharmaceutical granules with respect to granule size

Michael GhijsElisabeth SchäferAshish KumarPhilippe CappuynsIvo Van AsscheFien De LeersnyderValérie VanhoorneThomas De BeerIngmar Nopens

A1 Journal Article in JOURNAL OF PHARMACEUTICAL SCIENCES

2018

Breakage and drying behaviour of granules in a continuous fluid bed dryer : influence of process parameters and wet granule transfer

Fien De LeersnyderValérie VanhoorneH BekaertJurgen VercruysseMichael GhijsNils BostijnMaxim VerstraetenP CappuynsI Van AsscheY Vander Heyden et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Development and validation of an in-line NIR spectroscopic method for continuous blend potency determination in the feed frame of a tablet press

Fien De LeersnyderElisabeth PeetersHasna DjalabiValérie VanhoorneBernd Van SnickKe HongStephen HammondAngela Yang LiuEric ZiemonsChris Vervaet et al.

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Liquid-to-solid ratio control as an advanced process control solution for continuous twin-screw wet granulation

Niels NicolaïFien De LeersnyderDana CopotMichiel StockClara-Mihaela IonescuKrist V GernaeyIngmar NopensThomas De Beer

A1 Journal Article in AICHE JOURNAL

2017

Multivariate statistical process control of a continuous pharmaceutical twin-screw granulation and fluid bed drying process

Ana Tavares da SilvaMC SarraguçaMargot FonteyneJurgen VercruysseFien De LeersnyderValérie VanhoorneNils BostijnMaxim VerstraetenChris VervaetJean Paul Remon et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2016

Blend uniformity evaluation during continuous mixing in a twin screw granulator by in-line NIR using a moving F-test

Margot FonteyneJurgen VercruysseFien De LeersnyderRut BesselingAd GerichWim OostraJean Paul RemonChris VervaetThomas De Beer

A1 Journal Article in ANALYTICA CHIMICA ACTA

Development of a controlled release formulation by continuous twin screw granulation : influence of process and formulation parameters

Valérie VanhoorneBrecht VanbillemontJ VercruysseFien De LeersnyderP GomesThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Development of a process map : a step towards a regime map for steady-state high shear wet twin screw granulation

Ashish KumarJens DhondtJurgen VercruysseFien De LeersnyderValérie VanhoorneChris VervaetJean Paul RemonKrist V. GernaeyThomas De BeerIngmar Nopens

A1 Journal Article in POWDER TECHNOLOGY

Linking granulation performance with residence time and granulation liquid distributions in twin-screw granulation : an experimental investigation

Ashish KumarMaija AlakarjulaValérie VanhoorneMaunu ToiviainenFien De LeersnyderJurgen VercruysseMikko JuutiJarkko KetolainenChris VervaetJean Paul Remon et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Model-based process analysis in continuous manufacturing of pharmaceuticals : calibration of a fluid bed dryer model

Michael GhijsFien De LeersnyderDaan Van HauwermeirenValérie VanhoorneJurgen VercruyssePhilippe CappuynsSéverine MortierThomas De BeerKrist GernaeyIngmar Nopens

2015

Development of regime map for steady-state high shear wet twin-screw granulation

Ashish KumarJens DhondtJurgen VercruysseFien De LeersnyderValérie VanhoorneKrist V GernaeyThomas De BeerIngmar Nopens

Evaluation of an in-line particle imaging tool for monitoring twin-screw granulation performance

Ashish KumarJens DhondtFien De LeersnyderJurgen VercruysseValérie VanhoorneChris VervaetJean Paul RemonKrist V GernaeyThomas De BeerIngmar Nopens

A1 Journal Article in POWDER TECHNOLOGY

Process analytical technology for continuous manufacturing of solid-dosage forms

Margot FonteyneJurgen VercruysseFien De LeersnyderBernd Van SnickChris VervaetJean Paul RemonThomas De Beer

A1 Journal Article in TRAC-TRENDS IN ANALYTICAL CHEMISTRY