Research Explorer

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Researcher

Fernand Lambein

Awards & Distinctions

154 Results

2019

Grass pea (Lathyrus sativus L.) : orphan crop, nutraceutical or just plain food?

Fernand LambeinSilvia TravellaYu-Haey KuoMarc Van MontaguMarc Heijde

A1 Journal Article in PLANTA

On the prevention of konzo, lessons learned from neurolathyrism

Fernand LambeinDelphin Diasolua Ngudi

Editorial material

Scientific innovation for the sustainable development of African agriculture

Silvia TravellaDulce De OliveiraSylvie De BuckFernand LambeinDelphin Diasolua NgudiVanessa De BauwGodelieve GheysenMarc Van MontaguMarc Heijde

A2 Journal Article in AFRIKA FOCUS

2018

Is grass pea (Lathyrus sativus L.) taking the stage in a world with changing climate?

Fernand LambeinDelphin Diasolua Ngudi

Editorial material

2017

Fernand LambeinDelphin Diasolua Ngudi

Editorial material

Plant toxin β-ODAP activates integrin β1 and focal adhesion : a critical pathway to cause neurolathyrism

Rui-Yue TanGeng-Yan XingGuang-Ming ZhouFeng-Min LiWen-Tao HuFernand LambeinJun-Lan XiongSheng-Xiang ZhangHai-Yan KongHao Zhu et al.

A1 Journal Article in SCIENTIFIC REPORTS

Remembering Vapniarca (Sept. 1942-May 1943), doctor Kessler (1903-2000), Professor dr Dan Cohn (1931-2017)

Fernand Lambein

A4 Journal Article in CCDN NEWS

2016

Beyond the Millenium Development Goals: new agenda

Delphin Diasolua NgudiFernand Lambein

Editorial material

Is stress a factor in the susceptibility to neurolathyrism?

Kuniko Kusama-EguchiFumio IkegamiFernand Lambein

A4 Journal Article in CCDN NEWS

2015

Fernand LambeinDelphin Diasolua Ngudi

Editorial material

Lathyrus sativus L. (grass pea) toxic plant or nutraceutical?

Fernand Lambein

A4 Journal Article in CCDN NEWS

2014

Crippling konzo in DRC, three generations later

Delphin Diasolua NgudiJean-Pierre Banea MayambuFernand Lambein

A4 Journal Article in CCDN NEWS

Fernand Lambein

Editorial material

2013

Experimental model of neurolathyrism : role of heme oxygenase-1 in the vascular insult associated with hind-leg paraparesis

Kimino KawaguchiKuniko Kusama-EguchiFernand Lambein

Lathyrus sativus: to eat or not to eat?

Fernand LambeinYu-Haey Kuo

A4 Journal Article in CCDN NEWS

2012

Is chronic exposure of the blood-brain barrier to relatively low L-β-ODAP concentrations a possible entry point of L-β-ODAP into the central nervous system?

Marijke Van MoorhemM CulotM KuntzElke DecrockMarijke De BockNan WangKatharina D'HerdeFernand LambeinLuc Leybaert

Lathyrus sativus: from royal funeral offering to toxic plant to wonder crop?

Fernand LambeinYu-Haey Kuo

Research on motor neuron diseases konzo and neurolathyrism : trends from 1990 to 2010

Delphin Diasolua NgudiYu-Haey KuoMarc Van MontaguFernand Lambein

A1 Journal Article in PLOS NEGLECTED TROPICAL DISEASES

Vascular insult accompanied by overexpressed heme oxygenase-1 as a pathophysiological mechanism in experimental neurolathyrism with hind-leg paraparesis

Kimino KawaguchiFernand LambeinKuniko Kusama-Eguchi

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

2011

Climatic, edaphic and altitudinal factors affecting yield and toxicity of Lathyrus sativus grown at five locations in Ethiopia

Woldemedhin Asnake FikreTesgera NegwoYu-Haey KuoFernand LambeinSeid Ahmed

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

Effect of environmental factors on the biosynthesis of the neuro-excitatory amino acid beta-ODAP (beta-N-oxalyl-L-alpha, beta-diaminopropionic acid) in callus tissue of lathyrus sativus

Rabiul HaqueYu-Haey KuoFernand LambeinMohammed Hussain

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

Konzo and dietary pattern in cassava-consuming populations of Popokabaka, democratic republic of Congo

Delphin Diasolua NgudiJean-Pierre Banea-MayambuFernand LambeinPatrick Kolsteren

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

Konzo and neurolathyrism: similarities and dissimilarities between these crippling neurodegenerative diseases of the poor

J Howard BradburyFernand Lambein

Editorial material

L-β-N-oxalyl-α,β-diaminopropionic acid toxicity in motor neurons

Marijke Van MoorhemElke DecrockElke De VuystMarijke De BockNan WangFernand LambeinLudo Van Den BoschLuc Leybaert

A1 Journal Article in NEUROREPORT

Neurolathyrism in Ethiopia: preliminary data

Asnake FikreDelphin Diasolua NgudiFernand Lambein

A4 Journal Article in CCDN NEWS

On the molecular mechanisms of konzo and neurolathyrism

Fernand LambeinDelphin Diasolua NgudiMarijke Van MoorhemYu-Haey Kuo

A4 Journal Article in CCDN NEWS

Soya, human nutrition and health

Sylvia BurssensIne PertryDelphin Diasolua NgudiYu-Haey KuoMarc Van MontaguFernand Lambein

Bookchapter in Soybean and nutrition

Studies on neurolathyrism in Ethiopia: dietary habits, perception of risk and prevention

Asnake FikreMarijke Van MoorhemSeid AhmedFernand LambeinGodelieve Gheysen

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

Study of the etiology of neurolathyrism, a human neurodegenerative disease with nutritional causes

Marijke Van MoorhemLuc LeybaertFernand Lambein

Sulfur amino acids deficiency caused by grass pea diet plays an important role in the toxicity of L-beta-ODAP by increasing the oxidative stress: studies on a motor neuron cell line

Kuniko Kusama-EgichiNaduki YoshinoAi MinouraKazuko WatanabeTadashi KusamaFernand LambeinFumio Ikegami

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

Unraveling the mechanism of β-N-oxalyl-α,β-diaminopropionic acid (β-ODAP) induced excitotoxicity and oxidative stress, relevance for neurolathyrism prevention

Marijke Van MoorhemFernand LambeinLuc Leybaert

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

2010

Can we meet the first Millenium Development Goal in konzo and lathyrism settings by 2015?

Delphin Diasolua NgudiFernand Lambein

A4 Journal Article in CCDN NEWS

Effect of methionine supplement on physical responses and neurological symptoms in broiler chicks fed grass pea (Lathyrus sativus)-based starter ration

Asnake FikreAlemu YamiYu-Haey KuoSeid AhmedGodelieve GheysenFernand Lambein

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

Hind-limb paraparesis in a rat model for neurolathyrism associated with apoptosis and an impaired vascular endothelial growth factor system in the spinal cord

Kuniko Kusama-EguchiYoshiko YamazakiTadashi UedaAtsuhiro SudaYukari HirayamaFumio IkegamiKazuko WatanabeMike MayFernand LambeinTadashi Kusama

A1 Journal Article in JOURNAL OF COMPARATIVE NEUROLOGY

L-β-ODAP alters mitochondrial Ca2+ handling as an early event in excitotoxicity

Marijke Van MoorhemElke DecrockEvelyne CousseeLiesbeth FaesElke De VuystKatleen VranckxMarijke De BockNan WangKatharina D'HerdeFernand Lambein et al.

A1 Journal Article in CELL CALCIUM

Lathyrus sativus and human health

Fernand LambeinSylvia BurssensYu-Haey Kuo

Progress in prevention of toxico-nutritional neurodegenerations

Fernand LambeinDelphin Diasolua NgudiYu-Haey Kuo

A4 Journal Article in AFRICAN TECHNOLOGY DEVELOPMENT FORUM JOURNAL

Why are neurolathyrism and konzo neglected diseases?

Delphin Diasolua NgudiFernand Lambein

A4 Journal Article in CCDN NEWS

2009

An improved neurolathyrism rat model : impaired VEGF systems have a critical role in the degeneration of motor neurons

Kuniko Kusama-EguchiYoshiko YamazakiFumio IkegamiFernand LambeinTadashi Kusama

Effect of agro-ecological factors on the accumulation of neurotoxin and other amino acids in Lathyrus sativus

Rabiul HaqueYu-Haey KuoFernand Lambein

Grain legumes and human health

Fernand LambeinYu-Haey KuoFumio IkegamiKuniko Kusama-EguchiDirk Enneking

Is lathyrism still endemic in northern Ethiopia? : the case of Legambo Woreda (district) in the South Wollo Zone, Amhara National Regional State

Redda Tekle-HaimanotAmsalu FelekeFernand Lambein

Konzo and dietary pattern in cassava-consuming populations of Popokabaka, Democratic Republic of Congo

Delphin Diasolua NgudiJP Banea-MayambuFernand LambeinPatrick Kolsteren

Fernand LambeinYu-Haey Kuo

Neuro- and gliotoxicity of the excitatory amino acid beta-ODAP involves impaired free radical defence

Marijke Van MoorhemElke DecrockMarijke De BockNan WangElke De VuystGeert CallewaertLudo Van Den BoschFernand LambeinLuc Leybaert

Neuro- and gliotoxicity of the excitatory amino acid beta-ODAP involves impaired free radical difference

Marijke Van MoorhemElke DecrockMarijke De BockNan WangElke De VuystGeert CallewaertLudo Van den BoschFernand LambeinLuc Leybaert

Nutritional improvement of grass pea and cassava to prevent neurolathyrism and konzo

Fernand LambeinYu-Haey Kuo

Preliminary attempts in molecular breeding of Ethiopian grass pea (Lathyrus sativus L.): productive regeneration and genetic transformation

Dejene GirmaAsnake FikreNancy TerrynYu-Haey KuoFernand Lambein

Study on climatic, edaphic and altitudinal factors affecting yield and toxicity of grass pea grown in Ethiopia

Asnake FikreFernand LambeinMillion EscheteYu-Haey KuoSeid Ahmed

The Lathyrus/lathyrism controversy

Fernand Lambein

Editorial material

Unraveling the mechanism of beta-ODAP induced excitotoxicity and oxidative stress, relevance for neurolathyrism prevention

Marijke Van MoorhemFernand LambeinLuc Leybaert

Workshop on toxico-nutritional neurodegenerations konzo and lathyrism

Workshop on toxico-nutritional neurodegenerations konzo and lathyrism: foreword

J Howard BradburyFernand Lambein

Editorial material

2008

The contents of the neuro-excitatory amino acid beta-ODAP (beta-N-oxalyl-L-alpha,beta-diaminopropionic acid), and other free and protein amino acids in the seeds of different genotypes of grass pea (Lathyrus sativus L.)

A FIKREL KORBUYu-Haey KuoFernand Lambein

A1 Journal Article in FOOD CHEMISTRY

2007

3-N-oxalyl-L-2,3-diaminopropanoic acid, a multifunctional plant metabolite of toxic reputation

Fernand LambeinYu-Haey KuoKuniko Kusama-EguchiFumio Ikegami

A1 Journal Article in ARKIVOC

Comparison of urinary amino acids and trace elements (copper, zinc and manganese) of recent neurolathyrism patients and healthy controls from Ethiopia

Yu-Haey KuoBARBARA DEFOORTH GETAHUNRT HAIMANOTFernand Lambein

A1 Journal Article in CLINICAL BIOCHEMISTRY

Quantitative analysis of the motor neuron death in the neurolathyrism model rat

Y YAMAZAKIK KUSAMA-EGUCHIK SHIMOJIMAH OMORIM YAMADAA SUDAF IKEGAMIFernand LambeinT KUSAMAK WATANABE

2006

Kinetics of free protein amino acids, free non-protein amino acids and trigonelline in soybean (Glycine max L.) and lupin (Lupinus angustifolius L.) sprouts

C MARTINEZ-VILLALUENGAYu-Haey KuoFernand LambeinJ FRIASC VIDAL-VALVERDE

A1 Journal Article in EUROPEAN FOOD RESEARCH AND TECHNOLOGY

Lathyrus improvement for resistance against biotic and abiotic stresses: From classical breeding to marker assisted selection

MCV PATTOB SKIBAECK PANGSJ OCHATTFernand LambeinD RUBIALES

A1 Journal Article in EUPHYTICA

2005

Is lathyrism still endemic in northern Ethiopia?: the case of the Legambo Woreda (district) in the South Wollo Zone, Amhara National Regional State

R TEKLE HAIMANOTA FELEKEFernand Lambein

A2 Journal Article in ETHIOPIAN JOURNAL OF HEALTH DEVELOPMENT

Konzo and cassava toxicity: a study of associated nutritional factors in the Popokabaka district, Democratic Republic of Congo

Delphin Diasolua NgudiPatrick KolsterenFernand Lambein

Neurolathyrism risk depends on type of grass pea preparation and on mixing with cereals and antioxidants

H GETAHUNFernand LambeinM VANHOORNEPatrick Van Der Stuyft

A1 Journal Article in TROPICAL MEDICINE & INTERNATIONAL HEALTH

2004

Development of a model rat of the motor neuron death

K KUSAMA-EGUCHIM YAMAMOTOA SUDAT KUSAMAF IKEGAMIK IGARASHIFernand LambeinY ITOK WATANABE

Effects of different germination conditions on the contents of free protein and non-protein amino acids of commercial legumes

Yu-Haey KuoPascale RozanFernand LambeinJ FRIASC VIDAL-VALVERDE

A1 Journal Article in FOOD CHEMISTRY

Partial involvement of group I metabotropic glutamate receptors in the neurotoxicity of 3-N-oxalyl-L-2,3-diaminopropanoic acid (L-beta-ODAP)

K KUSAMA-EGUCHIT KUSAMAA SUDAT MASUKOM YAMAMOTOF IKEGAMIK IGARASHIYu-Haey KuoFernand LambeinK WATANABE

A1 Journal Article in BIOLOGICAL & PHARMACEUTICAL BULLETIN

2003

Amino acid profiles and protein quality of cooked cassava leaves or 'saka-saka'

Delphin Diasolua NgudiYu-Haey KuoFernand Lambein

A1 Journal Article in JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Cassava cyanogens and free amino acids in raw and cooked leaves

Delphin Diasolua NgudiYu-Haey KuoFernand Lambein

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

Cassava leaves, a non negligible source of dietary exposure to cyanogens

Delphin Diasolua NgudiYu-Haey KuoFernand Lambein

A4 Journal Article in CCDN NEWS

Food-aid cereals to reduce neurolathyrism related to grass-pea preparations during famine

H GETAHUNFernand LambeinMichel VanhoornePatrick Van Der Stuyft

A1 Journal Article in LANCET

Neuroactive and other free amino acids in seed and young plants of Panax ginseng

Yu-Haey KuoF IKEGAMIFernand Lambein

A1 Journal Article in PHYTOCHEMISTRY

2002

ABO blood groups, grass pea preparation, and neurolathyrism in Ethiopia

H GETAHUNFernand LambeinPatrick Van Der Stuyft

A1 Journal Article in TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Food safety and amino acid balance in processed cassava 'Cossettes'

Delphin Diasolua NgudiYu-Haey KuoFernand Lambein

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Mechanism of ODAP oxicity in one-day-old chicks.

MZ SHAMINMS HOSSAINK ISLAMHKM YUSUFFernand Lambein

A2 Journal Article in DHAKA UNIVERSITY JOURNAL OF BIOLOGICAL SCIENCES

Neurolathyrism in Ethiopia: assessment and comparison of knowledge and attitude of health workers and rural inhabitants

H GETAHUNFernand LambeinMichel Vanhoorne

A1 Journal Article in SOCIAL SCIENCE & MEDICINE

New functional foods by germination: Effect on the nutritive value of beans, lentils and peas.

C VIDAL-VALVERDEJ FRIASI SIERRAI BLAZQUEZFernand LambeinYu-Haey Kuo

A1 Journal Article in EUROPEAN FOOD RESEARCH AND TECHNOLOGY

Pattern and associated factors of the neurolathyrism epidemic in Ethiopia.

H GETAHUNFernand LambeinMichel VanhoornePatrick Van Der Stuyft

A1 Journal Article in TROPICAL MEDICINE & INTERNATIONAL HEALTH

Prolific regeneration of fertile plants from green nodular callus induced from meristematic tissues in Lathyrus sativus L. (grass pea)

Mukund ZambreBishan ChowdhuryYu-Haey KuoMarc Van MontaguGeert AngenonFernand Lambein

A1 Journal Article in PLANT SCIENCE

2001

Amino acids in seeds and seedlings of the genus Lens.

Pascale RozanYu-Haey KuoFernand Lambein

A1 Journal Article in PHYTOCHEMISTRY

Identification and quantification of natural isoxazolinone compounds by capillary zone electrophoresis.

B CHOWDHURYPascale RozanYu-Haey KuoM SUMINOFernand Lambein

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY A

Non-protein amino acids and food safety

Fernand LambeinYu-Haey KuoPascale RozanF IKEGAMI

Non-protein amino acids in edible lentil and garden pea seedlings.

Pascale RozanYu-Haey KuoFernand Lambein

A1 Journal Article in AMINO ACIDS

2000

Free amino acids present in commercially available seedlings sold for human consumption. A potential hazard for consumers.

Pascale RozanYu-Haey KuoFernand Lambein

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Reduction efficiency of the neurotoxin beta-ODAP in low-toxin varieties of Lathyrus sativus seeds by solid state fermentation with Aspergillus oryzae and Rhizopus microsporus var chinensis.

Yu-Haey KuoHM BAUPascale RozanB CHOWDHURYFernand Lambein

A1 Journal Article in JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

1999

Enzymatic formation of 2,3-diaminopropionic acid, the direct precursor of the neurotoxin beta-ODAP, in Lathyrus sativus.

F IKEGAMIA YAMAMOTOYu-Haey KuoFernand Lambein

A1 Journal Article in BIOLOGICAL & PHARMACEUTICAL BULLETIN

Epidemic of neurolathyrism in Ethiopia.

H GETAHUNA MEKONNENR TEKLE-HAIMANOTFernand Lambein

A1 Journal Article in LANCET

1998

Metabolic routes of beta-(isoxazolin-5-on-2-yl)-L-alanine (BIA), the precursor of the neurotoxin ODAP (beta-N-oxalyl-L-alpha,beta,-diaminopropionic acid), in different legume seedlings.

Yu-Haey KuoF IKEGAMIFernand Lambein

A1 Journal Article in PHYTOCHEMISTRY

1997

Chemotaxonomy based on non protein amino acids applied to questions of authenticity of food

Fernand LambeinM TATE

Evidence of Osteolathyrism among patients suffering from Neurolathyrism in Bangladesh.

A HAQUEM HOSSAINFernand LambeinEA BELL

A2 Journal Article in NATURAL TOXINS

Inhibitory activity of a naturally occurring heterocyclic beta-substituted alanine, beta-(isoxazolin-5-on-4-yl)-L-alanine, on the L-glutamate/L-aspartate transporter (GLAST) expressed in Xenopus oocytes.

K KUSAMAEGUCHIT KUSAMAF IKEGAMIFernand LambeinK WATANABE

A1 Journal Article in MOLECULAR BRAIN RESEARCH

Is ß-ODAP the only cause for human neurolathyrism?

Fernand LambeinYu-Haey KuoB CHOWDHURYF IKEGAMIC BRIGGS

Lathyrus and lathyrism: a Decade of Progress: proceedings of an international conference.

Lathyrus sativus, a neolithic crop with a modern future?: an overview of the present situation.

Fernand LambeinYu-Haey Kuo

Mechanism of ODAP toxicity in one-day-old chicks.

HKM YUSUFMK HAQUEMA UDDINBC ROYMZ SHAMINMS HOSSAINFernand Lambein

Serum zinc levels in lathyrism patients.

A HAQUEFernand Lambein

1996

Effects of beta-ODAP and its biosynthetic precursor on the electrophysiological activity of cloned glutamate receptors.

K KUSAMA-EGUCHIF IKEGAMIT KUSAMAFernand LambeinK WATANABE

A1 Journal Article in ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Enzymatic synthesis of two isoxazolylalanine isomers by cysteine synthases in Lathyrus species.

F IKEGAMIM KAMIYAYu-Haey KuoFernand LambeinI MURAKOSHI

A1 Journal Article in BIOLOGICAL & PHARMACEUTICAL BULLETIN

Epidemiological study of lathyrism in northwestern districts of Bangladesh.

A HAQUEM HOSSAINGuido WoutersFernand Lambein

A1 Journal Article in NEUROEPIDEMIOLOGY

Salinity tolerance and accumulation of neurotoxin and excitatory amino acids in Lathyrus sativus

R HOQUEM HUSSAINYu-Haey KuoFernand Lambein

A2 Journal Article in BANGLADESH JOURNAL OF BIOCHEMISTRY

Symptomatic treatment of neurolathyrism with Tolperisone.HCL (Mydocalm): a randomized double blind and placebo controlled drug trial.

A MELKAR TEKLE-HAIMANOTFernand Lambein

A2 Journal Article in Ethiopian Medical Journal

1995

Biosynthesis in vitro of some Lathyrus toxins

F IKEGAMIYu-Haey KuoFernand LambeinI MURAKOSHI

Biosynthesis in vivo of the neurotoxin ß-ODAP in Lathyrus sativus

Yu-Haey KuoJK KHANFernand Lambein

Biosynthesis of the neurotoxin ß-ODAP in callus tissue of Lathyrus sativus, incorporation of [^N]- and ['^CJ-precursors

Yu-Haey KuoFernand LambeinLC MELLORRM ADLINGTONJE BALDWIN

Collaborative projects on Lathyrus and human lathyrism coordinated by the University of Ghent, Belgium: prospects for further research

Fernand Lambein

Detoxification of Lathyrus sativus meal by fermentation without loss of nutritive value

Yu-Haey KuoHM BAUJK KHANFernand Lambein

High-performance liquid chromatographic separation of the toxins and some non-protein amino acids in Lathyrus sativus

JK KHANN KEBEDEYu-Haey KuoFernand Lambein

Homoarginine antagonizes the toxicity of Lathyrus toxin in 1-day-old-chicks.

HKM YUSUFK HOQUEA UDDINBC ROYFernand Lambein

A2 Journal Article in BANGLADESH JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

In vitro Toxicological Investigations of Isoxazolinone Amino Acids of Lathyrus sativus

M RIEPEPS SPENCERFernand LambeinAC LUDOLPHCN ALLEN

A2 Journal Article in NATURAL TOXINS

Influence of nutrient status for cultivation of Lathyrus sativus and level of the neurotoxin ODAP: a link between environment and toxicity?

N KEBEDEYu-Haey KuoJK KHANFernand Lambein

Inhibitory and excitatory amino-acids in cerebrospinal-fluid of neurolathyrism patients, a highly prevalent motorneurone disease.

JK KHANYu-Haey KuoA HAQUEFernand Lambein

A1 Journal Article in ACTA NEUROLOGICA SCANDINAVICA

Interaction of some heterocyclic beta-substituted alanines of plants with rat-brain N-METHYL-D-ASPARTATE (NMDA) receptors.

F IKEGAMIK KUSAMAEGUCHIE SUGIYAMAK WATANABEFernand LambeinI MURAKOSHI

A1 Journal Article in BIOLOGICAL & PHARMACEUTICAL BULLETIN

Lathyrus sativus and human lathyrism: progress and prospects from international collaborators: proceedings of the Second International Colloquium on Lathyrus/Lathyrism, Dhaka, December 10-12, 1993

Neurotransmitters in the cerebrospinal fluid and serum of neurolathyrism patients

JK KHANYu-Haey KuoA HAQUEFernand Lambein

Progress and Prospects in the Bangladesh/Belgium Inter-university project.

Guido WoutersFernand LambeinA HAQUEM HUSSAINH YUSUF

SOLID-STATE FERMENTATION OF LATHYRUS-SATIVUS SEEDS USING ASPERGILLUS-ORYZAE AND RHIZOPUS-OLIGOSPORUS SP T-3 TO ELIMINATE THE NEUROTOXIN BETA-ODAP WITHOUT LOSS OF NUTRITIONAL-VALUE.

Yu-Haey KuoHM BAUB QUEMENERJK KHANFernand Lambein

A1 Journal Article in JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

STUDY OF HTLV-I ANTIBODIES IN CSF AND SERUM OF NEUROLATHYRISM PATIENTS IN BANGLADESH.

A HAQUEJK KHANGuido WoutersM HOSSAINFernand Lambein

A1 Journal Article in ANNALES DE LA SOCIETE BELGE DE MEDECINE TROPICALE

Study of some socio-economic aspects of lathyhrism patients in two northwestern districts of Bangladesh

A HAQUEM HOSSAINGuido WoutersYu-Haey KuoFernand Lambein

1994

Appearance of the neurotoxinß-N-oxalyl-L-oc.ß-diaminopropionic acid (ß-ODAP) and of homoarginine in systemic blood and urine following the consumption of cooked Lathyrus sativus by human volunteers

NP NunnC PereraEA BellFernand Lambein

Biochemical diversity in the genus Lathyrus

Yu-Haey KuoF IKEGAMIC BRIGGSC CAMPBELLFernand Lambein

Biosynthesis of the neurotoxin-beta-ODAP in developing pods of Lathyrus sativus.

Yu-Haey KuoJK KHANFernand Lambein

A1 Journal Article in PHYTOCHEMISTRY

Conformation of the Lathyrus neurotoxin ß-ODAP and its neurochemical implications

André De BruynF IkegamiFernand Lambein

Determination of non-protein amino acids and toxins in Lathyrus sativus by high-performance liquid chromatography with precolumn phenyl isothiocyanate derivatisation.

JK KHANYu-Haey KuoN KEBEDEFernand Lambein

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY A

From soil to brain: zinc deficiency increases the neurotoxicity of Lathyrus sativus and may affect the susceptibility for the motorneurone disease neurolathyrism.

Fernand LambeinR HAQUEJK KHANN KEBEDEYu-Haey Kuo

A1 Journal Article in TOXICON

New findings and symptomatic treatment for neurolathyrism, a motor neuron disease occuring in North West Bangladesh

A HAQUEM HUSSAINJK KHANYu-Haey KuoFernand LambeinJacques De Reuck

A1 Journal Article in PARAPLEGIA

Recent progress in the Bangladesh-Belgium inter-university project

Fernand LambeinGuido WoutersA HAQUEM HUSSAINH YUSUF

Reduction of the neurotoxin ODAP from Lathyrus sativus meal by double fermentation

Yu-Haey KuoHM BAUFernand Lambein

Ring-nitrogen of beta-isoxazolinone-alanine is incorporated into the neurotoxin, beta-N-oxalyl-L-a, beta-diaminopropionic acid, in callus tissue of Lathyrus-sativus.

Yu-Haey KuoFernand LambeinLC MELLORRM ADLINGTONJE BALDWIN

A1 Journal Article in PHYTOCHEMISTRY

Study of Lathyrism: some new findings

A HAQUEFernand LambeinM HUSSAINJK KHANGuido WoutersJacques De Reuck

The mechanism of the rearrangement of the neurotoxin β-ODAP to α-ODAP

André De BruynC BecuFernand LambeinN KebedeB AbegazPB Nunn

A1 Journal Article in PHYTOCHEMISTRY

Thermal isomerization of N-oxalyl derivatives of diamino acids

BM AbegazPB NunnAndré De BruynFernand Lambein

1993

Analysis of the neurotoxin β-ODAP and its α-isomer by precolumn derivatization with phenylisothiocyanate

JK KhanN KebedeYu-Haey KuoFernand LambeinAndré De Bruyn

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

Analysis, quantitation and characterisation of cyanobacterial heterocyst-type glycolipids

Mark DaveyFernand Lambein

Biosynthesis in vitro of 2-(3-amino-3-carboxy-propyl)-isoxazolin-5-one, the neurotoxic amino acid in Lathyrus odoratus.

F IKEGAMIR SAKAIT ISHIKAWAYu-Haey KuoFernand LambeinI MURAKOSHI

A1 Journal Article in BIOLOGICAL & PHARMACEUTICAL BULLETIN

Biosynthesis of beta-(isoxazolin-5-on-2-yl)-L-alanine by cysteine synthase in Lathyrus sativus.

F IKEGAMIG ONGENAR SAKAIS ITAGAKIM KOBORIT ISHIKAWAYu-Haey KuoFernand LambeinI MURAKOSHI

A1 Journal Article in PHYTOCHEMISTRY

Chemical properties of the natural neurotoxin of Lathyrus sativus 3-N-oxalyl-2,3-diamino-propanoic acid (β-ODAP), its nontoxic 2-N-oxalyl isomer, and its hydrolysis product 2,3-diamino-propanoic acid (DAPRO) by 1H- and 13C-NMR spectroscopy

André De BruynDirk Van HaverFernand LambeinBM Abegaz

A2 Journal Article in NATURAL TOXINS

Chemistry of grass pea toxin and related N-oxalyl amino acids

B ABEGAZAndré De BruynN KEBEDEFernand LambeinP NUNN

Thermal isomerization of N-oxalyl derivatives of diamino acids

BM AbegazPB NunnAndré De BruynFernand Lambein

A1 Journal Article in PHYTOCHEMISTRY

Toxins in the seedlings of some varieties of grass pea (Lathyrus sativus)

Fernand LambeinJK KAHNYu-Haey KuoCG CAMPBELLCJ BRIGGS

A2 Journal Article in NATURAL TOXINS

1992

Beta-isoxazolinone-alanine and lathyrism research: optimisation of its isolation and purification

J KHANFernand LambeinH YUSUP

A2 Journal Article in Dhaka University Studies

Characterization of γ-glutamyl-β-(isoxazolinonyl)-alanine from Lathyrus sativus and its decarboxylation product from Lathyrus odoratus

Fernand LambeinJ KhanC BecuAndré De Bruyn

A1 Journal Article in PHYTOCHEMISTRY

Chemistry of natural occurring isoxazolin-5-ones

Fernand LambeinYu-Haey KuoAndré De Bruyn

A4 Journal Article in PHYTOCHEMISTRY (LIFE SCIENCES ADVANCES)

Free amino acids and toxins in Lathyrus-sativus seedlings.

Fernand LambeinJK KHANYu-Haey Kuo

A1 Journal Article in PLANTA MEDICA

Identification of new isoxazolinone derivatives in lathyrus species by 1H and 13C NMR.

André De BruynFernand Lambein

Mechanism for the photolysis of the naturally occuring isoxazolin-5-ones and the link with the Lathyrus toxins

André De BruynG VerheggeFernand Lambein

A1 Journal Article in PLANTA MEDICA

Metabolism of ß-(isoxazolin-5-on-2-yl)-alanine to the neurotoxin ODAP in callus tissue of Lathyrus sativus

Yu-Haey KuoFernand Lambein

Purification and some properties of cysteine synthases from Lathyrus sativus

G ONGENAF IKEGAMIS ITAGAKIYu-Haey KuoFernand LambeinI MURAKOSM

Quantitative derivatization and high-performance liquid chromatographic analysis of cyanobacterial heterocyst-type glycolipids.

MW DAVEYFernand Lambein

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

Recent developments in the biochemistry of the Lathyrus toxins

Fernand LambeinYu-Haey Kuo

A4 Journal Article in Lathyrus Lathyrism Newsletters

Semipreparative isolation of individual cyanobacterial heterocyst type glycolipids by reverse-phase high-performance liquid chromatography.

MW DAVEYFernand Lambein

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

The biosynthesis of the Lathyrus toxins

Fernand LambeinYu-Haey Kuo

Toxic non-coding amino acids in the genus Lathyrus

Fernand LambeinYu-Haey KuoG ONGENAF IKEGAMII MURAKOSHI

1991

1H and 13C NMR data for the basic naturally occurring isoxazolin-5-one derivatives

André De BruynG VerheggeFernand Lambein

A1 Journal Article in MAGNETIC RESONANCE IN CHEMISTRY

Biosynthesis of beta-(isoxazolin-5-on-2-yl)alanine, the precursor of the neurotic amino-acid beta-N-oxalyl-L-alpha,beta-diaminopropionic acid.

F IKEGAMIS ITAGAKIT ISHIKAWAG ONGENAYu-Haey KuoFernand LambeinI MURAKOSHI

A1 Journal Article in CHEMICAL AND PHARMACEUTICAL BULLETIN

Biosynthesis of the neurotoxin beta-N-oxalyl-alpha,beta-diaminopropionic acid in callus tissue of Lathyrus sativus.

Yu-Haey KuoFernand Lambein

A1 Journal Article in PHYTOCHEMISTRY

Recent development in the biochemistry of the Lathyrus toxins

Fernand LambeinYu-Haey Kuo