Research Explorer

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Researcher

Fabian Hulpia

Awards & Distinctions

58 Results

2024

Mapping the transporter-substrate interactions of the Trypanosoma cruzi NB1 nucleobase transporter reveals the basis for its high affinity and selectivity for hypoxanthine and guanine and lack of nucleoside uptake

Mustafa M. AldferFabian HulpiaSerge Van CalenberghHarry P. De Koning

A1 Journal Article in MOLECULAR AND BIOCHEMICAL PARASITOLOGY

2022

A Toxoplasma gondii oxopurine transporter binds nucleobases and nucleosides using different binding modes

Gustavo D. CampagnaroHamza A. A. ElatiSofia BalaskaMaria Esther Martin AbrilManal J. NattoFabian HulpiaKelly LeeLilach SheinerSerge Van CalenberghHarry P. de Koning

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ex vivo feedback control of neurotransmission using a photocaged adenosine A1 receptor agonist

Erine CraeyFabian HulpiaJeroen SpanogheSimona ManzellaLars Emil LarsenMathieu SprengersDimitri De BundelIlse SmoldersEvelien CarretteJean Delbeke et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exploration of 6-methyl-7-(hetero)aryl-7-deazapurine ribonucleosides as antileishmanial agents

Cai LinIzet KaralicAn MatheeussenPim-Bart FeijensFabian HulpiaLouis MaesGuy CaljonSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nucleoside analogues for the treatment of animal trypanosomiasis

Dorien MabilleKayhan IlbeigiSarah HendrickxMarzuq A. UngogoFabian HulpiaCai LinLouis MaesHarry P. de KoningSerge Van CalenberghGuy Caljon

A1 Journal Article in INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE

Phenethyl-4-ANPP : a marginally active byproduct suggesting a switch in illicit fentanyl synthesis routes

Marthe VandeputteAlex J. KrotulskiFabian HulpiaSerge Van CalenberghChristophe Stove

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

Phenotypic evaluation of nucleoside analogues against Trypanosoma cruzi infection : in vitro and in vivo approaches

Ludmila F. de A. FiuzaDenise G. J. BatistaRoberson D. GirãoFabian HulpiaPaula Finamore-AraújoMustafa M. AldferEhab Kotb ElmahallawyHarry P. De KoningOtacílio MoreiraSerge Van Calenbergh et al.

A1 Journal Article in MOLECULES

2021

2-((3,5-Dinitrobenzyl)thio)quinazolinones : potent antimycobacterial agents activated by deazaflavin (F420)-dependent nitroreductase (Ddn)

Yanlin JianHe Eun ForbesFabian HulpiaMartijn RisseeuwGuy CaljonHélène Munier-LehmannHelena I. M. BoshoffSerge Van Calenbergh

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

4E interacting protein as a potential novel drug target for nucleoside analogues in Trypanosoma brucei

Dorien MabilleCamila Cardoso SantosRik HendrickxMathieu ClaesPeter TakacChristine ClaytonSarah HendrickxFabian HulpiaLouis MaesSerge Van Calenbergh et al.

A1 Journal Article in MICROORGANISMS

6-Methyl-7-deazapurine nucleoside analogues as broad-spectrum antikinetoplastid agents

Cai LinFabian HulpiaIzet KaralicLaurens De SchepperLouis MaesGuy CaljonSerge Van Calenbergh

A1 Journal Article in INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE

6‐methyl‐7‐aryl‐7‐deazapurine nucleosides as anti‐trypanosoma cruzi agents : structure‐activity relationship and in vivo efficacy

Cai LinLudmila Ferreira de Almeida FiuzaCamila Cardoso SantosDaniela Ferreira NunesOtacílio Cruz MoreiraJakob BoutonIzet KaralicLouis MaesGuy CaljonFabian Hulpia et al.

A1 Journal Article in CHEMMEDCHEM

7-Aryl-7-deazapurine 3 '-deoxyribonucleoside derivative as a novel lead for Chagas' disease therapy : in vitro and in vivo pharmacology

Camila Cardoso-SantosLudmila Ferreira de Almeida FiuzaCristiane Franca da SilvaAna Lia MazzetiRoberson Donola GiraoGabriel Melo de OliveiraDenise da Gama Jaen BatistaOtacilio Cruz MoreiraNatalia Lins da Silva GomesLouis Maes et al.

A2 Journal Article in JAC-ANTIMICROBIAL RESISTANCE

Deazapurine nucleoside analogues for the treatment of Trichomonas vaginalis

Manal J. NattoFabian HulpiaEric R. KalkmanSusan BaillieAmani AlhejeliYukiko MiyamotoLars EckmannSerge Van CalenberghHarry P. de Koning

A1 Journal Article in ACS INFECTIOUS DISEASES

Optical control of excitatory transmission in hippocampal slices with photoactive adenosine A1 receptor agonist

Erine CraeyFabian HulpiaSerge Van CalenberghLars Emil LarsenCharlotte MathysInge Van ColenJean DelbekeKristl VonckPaul BoonWytse Wadman et al.

Optical control of excitatory transmission in hippocampal slices with photoactive adenosine A1 receptor agonist

Erine CraeyFabian HulpiaSerge Van CalenberghLars Emil LarsenCharlotte MathysInge Van ColenJean DelbekeKristl VonckPaul BoonWytse Wadman et al.

Report on a new opioid NPS : chemical and in vitro functional characterization of a structural isomer of the MT-45 derivative diphenpipenol

Annelies CannaertFabian HulpiaMartijn RisseeuwKatleen Van UytfangheEric DeconinckSerge Van CalenberghPeter BlanckaertChristophe Stove

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors

Lijun SongRomain MerceronFabian HulpiaAinhoa LuciaBegona GraciaYanlin JianMartijn RisseeuwToon VerstraelenPaul CosJose A. Ainsa et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of 3′-fluorinated 7-deazapurine nucleosides as antikinetoplastid agents

Jakob BoutonArno Furquim d'AlmeidaLouis MaesGuy CaljonSerge Van CalenberghFabian Hulpia

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2020

1-(1-Arylethylpiperidin-4-yl)thymine analogs as antimycobacterial TMPK inhibitors

Yanlin JianFabian HulpiaMartijn RisseeuwHe Eun ForbesGuy CaljonHélène Munier-LehmannHelena I. M. BoshoffSerge Van Calenbergh

A1 Journal Article in MOLECULES

3'-Deoxyribofuranosyl 7-deazapurine nucleoside analogues : a new class of highly potent antitrypanosomal agents

Fabian HulpiaDorien MabilleGustavo Daniel CampagnaroLouis MaesHarry P de KoningGuy CaljonSerge Van Calenbergh

6-O-alkylated 7-deazainosine nucleoside analogues : discovery of potent and selective anti-sleeping sickness agents

Fabian HulpiaJakob BoutonGustavo D. CampagnaroIbrahim A. AlfayezDorien MabilleLouis MaesHarry P. de KoningGuy CaljonSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Deazapurine nucleoside analogues as potent anti-Trypanosoma cruzi agents

Fabian HulpiaCai LinChristiane França da SilvaDenise da Gama Jean BatistaCamilla Cardoso-SantosLouis MaesGuy CaljonMaria de Nazaré C. SoeiroSerge Van Calenbergh

Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents

Yanlin JianRomain MerceronSteven De MunckHe Eun ForbesFabian HulpiaMartijn RisseeuwKristof Van HeckeSavvas SavvidesHélène Munier-LehmannHelena I. M. Boshoff et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

First report on brorphine : the next opioid on the deadly new psychoactive substance horizon?

Nick VerougstraeteMarthe VandeputteCathelijne LyphoutAnnelies CannaertFabian HulpiaSerge Van CalenberghAlain VerstraeteChristophe Stove

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

Ali H. AlghamdiJane C. MundayGustavo D. CampagnaroDominik GurvicFredrik SvenssonChinyere E. OkparaArvind KumarJuan F. QuintanaMaria Esther Martin AbrilPatrik Milić et al.

A1 Journal Article in ELIFE

Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

Ali H. AlghamdiJane C. MundayGustavo D. CampagnaroDominik GurvicFredrik SvenssonChinyere E. OkparaArvind KumarJuan F. QuintanaMaria Esther Martin AbrilPatrik Milić et al.

Report on a novel emerging class of highly potent benzimidazole NPS opioids : chemical and in vitro functional characterization of isotonitazene

Peter BlanckaertAnnelies CannaertKatleen Van UytfangheFabian HulpiaEric DeconinckSerge Van CalenberghChristophe Stove

A1 Journal Article in DRUG TESTING AND ANALYSIS

Structure-activity relationship exploration of 3’-deoxy-7-deazapurine nucleoside analogues as anti-Trypanosoma brucei agents

Fabian HulpiaGustavo Daniel CampagnaroKhalid J. AlzahraniIbrahim A. AlfayezMarzuq A. UngogoDorien MabilleLouis MaesHarry P. de KoningGuy CaljonSerge Van Calenbergh

A1 Journal Article in ACS INFECTIOUS DISEASES

Synthesis and structure activity relationships of cyanopyridone based anti-tuberculosis agents

Yanlin JianFabian HulpiaMartijn RisseeuwHe Eun ForbesHélène Munier-LehmannGuy CaljonHelena I. M. BoshoffSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2019

3’-Deoxy-3’-fluoro-7-deazapurine nucleosides : synthesis and evaluation against kinetoplastid parasites

Jakob BoutonFabian HulpiaLouis MaesGuy CaljonSerge Van Calenbergh

Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

Fabian HulpiaDorien MabilleGustavo Daniel CampagnaroGabriela SchumanLouis MaesIsabel RoditiAnders HoferHarry P de KoningGuy CaljonSerge Van Calenbergh

A1 Journal Article in NATURE COMMUNICATIONS

Design and synthesis of trypanocidal purine nucleoside analogues : discovery of lead compounds for the treatment of sleeping sickness

Fabian HulpiaSerge Van Calenbergh

Discovery of 7-aryl-7-deazapurine 3'-deoxyribofuranosyl nucleoside analogues as anti-Trypanosoma cruzi agents

Fabian HulpiaLouis MaesGuy CaljonMaria de Nazaré SoeiroSerge Van Calenbergh

Discovery of pyrrolo[2,3-b]pyridine (1,7-dideazapurine) nucleoside analogues as anti-Trypanosoma cruzi agents

Cai LinFabian HulpiaCristiane França da SilvaDenise da Gama Jaén BatistaKristof Van HeckeLouis MaesGuy CaljonMaria de Nazaré Correia SoeiroSerge Van Calenbergh

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Discovery of pyrrolo[2,3-b]pyridine nucleoside analogues as anti-Trypanosoma cruzi agents

Cai LinFabian HulpiaKristof Van HeckeLouis MaesGuy CaljonMaria de Nazaré C. SoeiroSerge Van Calenbergh

New fluoroethyl phenylalanine analogues as potential LAT1-targeting PET tracers for glioblastoma

Jeroen VerhoevenFabian HulpiaKen KersemansJulie BolcaenStef De LombaerdeJan GoemanBenedicte DescampsGiorgio HallaertCaroline Van den BroeckeKarel Deblaere et al.

A1 Journal Article in SCIENTIFIC REPORTS

Novel pyrazolo[3,4-d]pyrimidine nucleosides : promising hits for Chagas disease and Leishmaniasis

Jakob BoutonFabian HulpiaSerge Van CalenberghGuy CaljonLouis Maes

Purine nucleoside analogs as highly potent leads for the treatment of human African trypanosomiasis

Fabian HulpiaLouis MaesHarry P de KoningGuy CaljonSerge Van Calenbergh

Purine nucleoside analogs as highly potent leads for the treatment of human African trypanosomiasis

Fabian HulpiaLouis MaesHarry P. de KoningGuy CaljonSerge Van Calenbergh

Revisiting tubercidin against kinetoplastid parasites : aromatic substitutions at position 7 improve activity and reduce toxicity

Fabian HulpiaGustavo Daniel CampagnaroMirko ScortichiniKristof Van HeckeLouis MaesHarry P de KoningGuy CaljonSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of 3’-deoxy-3’-fluoro-7-deazapurine nucleosides as antikinetoplastid agents

Jakob BoutonFabian HulpiaGuy CaljonLouis MaesSerge Van Calenbergh

2018

C7 substituted 7-deaza adenosines : design and synthesis of nucleosides with potent antitrypanosomal activity

Fabian HulpiaSerge Van Calenbergh

Design and synthesis of a purine nucleoside library : phenotypic discovery of antikinetoplastid agents

Fabian HulpiaSerge Van Calenbergh

Discovery of novel 7-aryl 7-deazapurine 3'-deoxy-ribofuranosyl nucleosides with potent activity against Trypanosoma cruzi

Fabian HulpiaKristof Van HeckeCristiane Franca da SilvaDenise da Gama Jaen BatistaLouis MaesGuy CaljonMaria de Nazare C SoeiroSerge Van Calenbergh

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Structure guided lead generation toward nonchiral M. tuberculosis thymidylate kinase inhibitors

Lijun SongRomain MerceronBegoña GraciaAinhoa Lucía QuintanaMartijn RisseeuwFabian HulpiaPaul CosJosé A AínsaHélène Munier-LehmannSavvas Savvides et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of a 3'-C-ethynyl-β-D-ribofuranose purine nucleoside library : discovery of C7-deazapurine analogs as potent antiproliferative nucleosides

Fabian HulpiaSam NoppenDominique ScholsGraciela AndreiRobert SnoeckSandra LiekensPeter VervaekeSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2017

Novel 3'-deoxy purine nucleoside analogs as highly potent leads for human African trypanosomiasis

Fabian HulpiaSerge Van Calenbergh

2016

C-3’-ethynylnucleosides: an old modification going viral

Fabian HulpiaJan BalzariniDominique ScholsSerge Van Calenbergh

Exploring the purine core of 3'-C-ethynyladenosine (EAdo) in search of novel nucleoside therapeutics

Fabian HulpiaJan BalzariniDominique ScholsGraciela AndreiRobert SnoeckSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel nucleoside therapeutics :'Min(d)ing the gap'

Fabian HulpiaSerge Van Calenbergh

Phenotypic screening of a focused nucleoside library

Fabian HulpiaSerge Van Calenbergh

Purine-mimicking 3'-ethynylribofuranose nucleosides: new opportunities for an old sugar modification

Fabian HulpiaJan BalzariniDominique ScholsSerge Van Calenbergh

Purine-mimicking 3’-ethynylribofuranose nucleosides : new opportunities for an old sugar modification

Fabian HulpiaJan BalzariniDominique ScholsSerge Van Calenbergh

Synthesis, in vitro and in vivo small-animal SPECT evaluation of novel technetium labeled bile acid analogues to study (altered) hepatic transporter function

Sara NeytMaarten VliegenBjorn VerreetStef De LombaerdeKim BraeckmanChristian VanhoveMaarten Thomas HuismanCaroline DumolynKen KersemansFabian Hulpia et al.

A1 Journal Article in NUCLEAR MEDICINE AND BIOLOGY

The design and synthesis of inhibitors of Mycobacterium tuberculosis thymidylate kinase (MtTMPK)

Lijun SongMartijn RisseeuwFabian HulpiaRomain MerceronSavvas SavvidesHélène Munier-LehmannSerge Van Calenbergh

The design and synthesis of inhibitors of Mycobacterium tuberculosis thymidylate kinase (MtTMPK)

Lijun SongMartijn RisseeuwFabian HulpiaHélène Munier-LehmannSerge Van Calenbergh

2015

In search of novel nucleoside therapeutics: exploring the purine core of 3'-C-ethynyladenosine

Fabian HulpiaJan BalzariniDominique ScholsSerge Van Calenbergh

The design and synthesis of inhibitors of Mycobacterium tuberculosis thymidylate kinase (MtTMPK)

Lijun SongMartijn RisseeuwFabian HulpiaHélène Munier-LehmannSerge Van Calenbergh