Research Explorer

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Researcher

Evelien Wynendaele

Awards & Distinctions

172 Results

2024

BrainPepPass : a framework based on supervised dimensionality reduction for predicting blood-brain barrier-penetrating peptides

Ewerton Cristhian Limade OliveiraHannah HirmzEvelien WynendaeleJuliana Auzier Seixas FeioIgor Matheus MoreiraKauê Santana da CostaAnderson H. LimaBart De SpiegeleerClaudomiro de Souza de Sales Júnior

A1 Journal Article in JOURNAL OF CHEMICAL INFORMATION AND MODELING

Food-based biomaterials : pH-responsive alginate/gellan gum/ carboxymethyl cellulose hydrogel beads for lactoferrin delivery

Lin CaoDavy Van de WalleHannah HirmzEvelien WynendaeleKoen DewettinckBogdan ParakhonskiyAndre Skirtach

A1 Journal Article in BIOMATERIALS ADVANCES

Streptococcal quorum sensing peptide CSP-7 contributes to muscle inflammation and wasting

Anton De SpiegeleerAmélie DescampsEvelien WynendaelePetar NaumovskiLiesbeth CrombezMarta PlanasLidia FeliuDaniel KnappeVincent MoulyAnne Bigot et al.

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The continuing challenge of drug recalls: insights from a ten-year FDA data analysis

Seppe GhijsEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

2023

Bacterial quorum-sensing peptides as immune modulators present in systemic circulation

Anton De SpiegeleerAmélie DescampsSrinath GovindarajanJulie CoudenysKevin Van der borghtHannah HirmzNele Van Den NoortgateDirk ElewautBart De SpiegeleerEvelien Wynendaele

A1 Journal Article in BIOMOLECULES

Emerging pharmaceutical therapies of Ascidian-derived natural products and derivatives

Kris CooremanBart De SpiegeleerChristof Van PouckeDavid VanavermaeteDaan DelbareEvelien WynendaeleBavo De Witte

A1 Journal Article in ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Environment-functionality-cost balance of an analytical reagent

Hannah HirmzFrederick VerbekeBartosz WielgomasChristophe FurmanEmmanuelle LipkaBart De SpiegeleerEvelien Wynendaele

A1 Journal Article in SUSTAINABLE CHEMISTRY AND PHARMACY

Evaluation of greenness and analytical performances of separative methods for chiral separation of novel lactam-based P2RX7-antagonists

Lorenzo AvigoChristophe FurmanAlina GhinetTeodora SanduEvelien WynendaeleBartosz WielgomasBart De SpiegeleerEmmanuelle Lipka

A1 Journal Article in ELECTROPHORESIS

Peptidomics : LC-MS operational parameters do matter

Amélie DescampsKevin Van der borghtAnton De SpiegeleerEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Potential role of statins in treatment of acute sarcopenia

Anton De SpiegeleerHasan KahyaLiesbeth CrombezAmélie DescampsRoland RösslerReto W. KressigBruno LapauwEvelien WynendaeleDirk ElewautBart De Spiegeleer et al.

A1 Journal Article in MEDICAL HYPOTHESES

Quantification and stability assessment of urinary phenolic and acidic biomarkers of non-persistent chemicals using the SPE-GC/MS/MS method

Anna KlimowskaEvelien WynendaeleBartosz Wielgomas

A1 Journal Article in ANALYTICAL AND BIOANALYTICAL CHEMISTRY

2022

A bioanalytical screening method for Enterococcus faecalis RNPP-type quorum sensing peptides in murine feces

Frederick VerbekeNathan DebunneYorick JanssensBart De SpiegeleerEvelien Wynendaele

A1 Journal Article in BIOANALYSIS

A fit-for-purpose LC-MS/MS method for the analysis of selected Streptococcal quorum sensing peptides in human saliva

Frederick VerbekeKevin Van der borghtAnton De SpiegeleerNathan DebunneYorick JanssensEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Degradation kinetics of artesunate for the development of an ex-tempore intravenous injection

Fanta Gashe FufaEvelien WynendaeleBart De SpiegeleerSultan Suleman

A1 Journal Article in MALARIA JOURNAL

Exploring the in-vivo role of quorum sensing peptides : preclinical and bioanalytical contributions

Frederick VerbekeBart De SpiegeleerEvelien Wynendaele

Liquid chromatography-mass spectrometry (LC-MS) analysis of bioactive peptides

Evelien WynendaeleKevin Van der borghtNathan DebunneBart De Spiegeleer

Bookchapter in Bioactive peptides from food : aources, analysis, and functions

Quality-by-design principles applied to the establishment of a pharmaceutical quality control laboratory in a resource-limited setting : the lab water

Sultan SulemanSileshi Belew YohannesDereje KebebeMarkos DugumaHenok TeshomeGemmechu HasenEvelien WynendaeleLuc DuchateauBart De Spiegeleer

A1 Journal Article in INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY

Sarcopenia : a gut-feeling for quorum sensing peptides and natural killer T cells

Anton De SpiegeleerNele Van Den NoortgateDirk ElewautEvelien Wynendaele

Statin intake and all-cause mortality among older nursing home residents

Anton De SpiegeleerJordi Van MigerodeAntoon BronselaerEvelien WynendaeleMilan PeelmanFilip VandaeleGeert ByttebierGuy De TréLuc BelmansChristophe Van De Wiele et al.

A1 Journal Article in GERONTOLOGY

The bacterial quorum sensing peptide iAM373 is a novel inducer of sarcopenia

Anton De SpiegeleerEvelien WynendaeleAmélie DescampsNathan DebunneBart BraeckmanMarjan De MeyJulie CoudenysLiesbeth CrombezFrederick VerbekeYorick Janssens et al.

A1 Journal Article in CLINICAL AND TRANSLATIONAL MEDICINE

The quorum sensing peptide EntF* promotes colorectal cancer metastasis in mice : a new factor in the host-microbiome interaction

Evelien WynendaeleNathan DebunneYorick JanssensAnton De SpiegeleerFrederick VerbekeLiesa TackSophie Van WeldenEvy GoossensDaniel KnappeRalf Hoffmann et al.

A1 Journal Article in BMC BIOLOGY

2021

Acute sarcopenia changes following hospitalization : influence of pre-admission care dependency level

Anton De SpiegeleerHasan KahyaDolores Sanchez-RodriguezKarolina PiotrowiczMurielle SurquinEster MarcoCeline DetremerieDhurgham HusseinSuzy HopeDhayana Dallmeier et al.

A1 Journal Article in AGE AND AGEING

Applications in medicine : mental health

Yorick JanssensEvelien WynendaeleKurt AudenaertBart De Spiegeleer

Bookchapter in Biologically active peptides : from basic science to applications for human health

BBPpred : sequence-based prediction of blood-brain barrier peptides with feature representation learning and logistic regression

Ruyu DaiWei ZhangWending TangEvelien WynendaeleQizhi ZhuYannan BinBart De SpiegeleerJunfeng Xia

A1 Journal Article in JOURNAL OF CHEMICAL INFORMATION AND MODELING

Conformational stability as a quality attribute for the cell therapy raw material human serum albumin

Evelien WynendaeleGamaliel Junren MaXiaolong XuNam-Joon ChoBart De Spiegeleer

A1 Journal Article in RSC ADVANCES

Cov-MS : a community-based template assay for mass-spectrometry-based protein detection in SARS-CoV-2 patients

Bart Van PuyveldeKatleen Van UytfangheOlivier TytgatLaurence Van OudenhoveRalf GabrielsRobbin BouwmeesterSimon DaledTim Van Den BosschePathmanaban RamasamySigrid Verhelst et al.

A2 Journal Article in JACS AU

Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1

Aaron G. PothFrancis C.K. ChiuSofie StalmansBrett R. HamiltonYen-Hua HuangDavid M. ShacklefordRahul PatilThao T. LeMeng-Wei KanThomas Durek et al.

A2 Journal Article in MEDICINE IN DRUG DISCOVERY

Environmental risk assessment of the anthelmintic albendazole in Eastern Africa, based on a systematic review

Sileshi BelewSultan SulemanEvelien WynendaeleLuc DuchateauBart De Spiegeleer

A1 Journal Article in ENVIRONMENTAL POLLUTION

Hospital mortality in COVID-19 patients in Belgium treated with statins, ACE inhibitors and/or ARBs

Geert ByttebierLuc BelmansMyriam AlexanderBo E. H. SaxbergBart De SpiegeleerAnton De SpiegeleerNick DevrekerJens Van PraetKarolien VanhoveReinhilde Reybrouck et al.

A1 Journal Article in HUMAN VACCINES & IMMUNOTHERAPEUTICS

PapRIV : a BV-2 microglial cell activating quorum sensing peptide

Yorick JanssensNathan DebunneAnton De SpiegeleerEvelien WynendaeleMarta PlanasLidia FeliuAlessandra QuartaChristel ClaesDebby Van DamPeter Paul De Deyn et al.

A1 Journal Article in SCIENTIFIC REPORTS

Quorum sensing peptides as a novel microbiomal causative factor in promoting colorectal cancer metastasis : the EntF metabolite case

Nathan DebunneBart De SpiegeleerEvelien Wynendaele

Sustainability in drug discovery

Evelien WynendaeleChristophe FurmanBartosz WielgomasPer LarssonEelko HakThomas BlockSerge Van CalenberghNicolas WillandMichal MarkuszewskiLuke R. Odell et al.

A2 Journal Article in MEDICINE IN DRUG DISCOVERY

2020

A role for iNKT cells in sarcopenia

Anton De SpiegeleerHasan KahyaNele Van Den NoortgateEvelien WynendaeleTine DecruySrinath GovindarajanDirk Elewaut

A simplified checklist for the visual inspection of finished pharmaceutical products : a way to empower frontline health workers in the fight against poor-quality medicines

B. SchiavettiEvelien WynendaeleV MelotteJ. Van der ElstBart De SpiegeleerR. Ravinetto

A2 Journal Article in JOURNAL OF PHARMACEUTICAL POLICY AND PRACTICE

An unexpected role for iNKT cells in skeletal muscle homeostasis

Anton De SpiegeleerHasan KahyaNele Van Den NoortgateEvelien WynendaeleTine DecruySrinath GovindarajanDirk Elewaut

Blood-brain barrier transport kinetics of NOTA-modified proteins : the somatropin case

Nathalie BrackeYorick JanssensEvelien WynendaeleLiesa TackAlex MaesChristophe Van De WieleMike SathekgeBart De Spiegeleer

A1 Journal Article in QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Development of a dissolution method for lumefantrine and artemether in immediate release fixed dose artemether/lumefantrine tablets

Sileshi Belew YohannesSultan SulemanMarkos DugumaHenok TeshomeEvelien WynendaeleLuc DuchateauBart De Spiegeleer

A1 Journal Article in MALARIA JOURNAL

Influence of blood collection methods and long-term plasma storage on quorum-sensing peptide stability

Nathan DebunneAnton De SpiegeleerDorian DepuydtYorick JanssensAmélie DescampsEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in ACS OMEGA

LC-MS compatible antiadsorption diluent for peptide analysis

Frederick VerbekeNathalie BrackeNathan DebunneEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in ANALYTICAL CHEMISTRY

MEK1/2 inhibition in murine heart and aorta after oral administration of refametinib supplemented drinking water

Felke SteijnsNathalie BrackeMarjolijn RenardJulie De BackerPatrick SipsNathan DebunneEvelien WynendaeleFrederick VerbekeBart De SpiegeleerLaurence Campens

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Quorum sensing molecules as a novel microbial factor impacting muscle cells

Anton De SpiegeleerDirk ElewautNele Van Den NoortgateYorick JanssensNathan DebunneSelien Van LangenhoveSrinath GovindarajanBart De SpiegeleerEvelien Wynendaele

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Quorum sensing peptides and their interactions with the host

Evelien WynendaeleNathan DebunneFrederick VerbekeYorick JanssensAnton De SpiegeleerBart De Spiegeleer

Bookchapter in Quorum sensing : microbial rules of life

Quorum sensing peptides as possible brain-influencing microbiome mediators

Yorick JanssensBart De SpiegeleerEvelien Wynendaele

Structural study of L-ascorbic acid 2-phosphate magnesium, a raw material in cell and tissue therapy

Xiaolong XuMagdalena WozniczkaKristof Van HeckeDieter BuystDimitrije MaraChris VervaetKaren HermanEvelien WynendaeleEric DeconinckBart De Spiegeleer

A1 Journal Article in JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

The effects of ARBs, ACEis, and statins on clinical outcomes of COVID-19 infection among nursing home residents

Anton De SpiegeleerAntoon BronselaerJames T. TeoGeert ByttebierGuy De TréLuc BelmansRichard DobsonEvelien WynendaeleChristophe Van de WieleFilip Vandaele et al.

A1 Journal Article in JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION

Thermal sensitivity as a quality control attribute for biotherapeutics : the L‐asparaginase case

Han YaoEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in DRUG TESTING AND ANALYSIS

2019

A Surface Acoustic Wave (SAW) biosensor method for functional quantification of E. coli l-asparaginase

Han YaoCristina Soto FernándezXiaolong XuEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in TALANTA

Bacterial quorum sensing peptides as mediators of the gut-brain axis

Yorick JanssensEvelien WynendaeleNathan DebunneKurt AudenaertDebby Van DamAlessandra QuartaPeter PonsaertsBart De Spiegeleer

Biological characterisation of somatropin-derived cryptic peptides

Liesa TackNathalie BrackeFrederick VerbekeEvelien WynendaeleEwald PauwelsAlex MaesChristophe Van de WieleMike SathekgeBart De Spiegeleer

A1 Journal Article in INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS

Disbiome : a database describing microbiome alterations in different disease states

Yorick JanssensAntoon BronselaerEvelien WynendaeleGuy De TréBart De Spiegeleer

Bookchapter in Reference module in biomedical sciences

Hot-melt preparation of a non-biodegradable peptide implant : a proof of principle

Matthias D'HondtFrederick VerbekePieter WuytensAndre SkirtachBart De SpiegeleerEvelien Wynendaele

A1 Journal Article in PROTEIN AND PEPTIDE LETTERS

Peptides as epigenetic modulators : therapeutic implications

Yorick JanssensEvelien WynendaeleWim Vanden BergheBart De Spiegeleer

A1 Journal Article in CLINICAL EPIGENETICS

Pharmaceutical compounding of orphan active ingredients in Belgium : how community and hospital pharmacists can address the needs of patients with rare diseases

Valérie VanhoorneE PeetersInge Van TongelenKoen BousseryEvelien WynendaeleBart De SpiegeleerJean Paul RemonChris Vervaet

A1 Journal Article in ORPHANET JOURNAL OF RARE DISEASES

Quality of fixed dose artemether/lumefantrine products in Jimma Zone, Ethiopia

Sileshi Belew YohannesSultan SulemanTesfaye MohammedYimer MekonnenMarkos DugumaHenok TeshomeBikila BayisaEvelien WynendaeleMathias D'HondtLuc Duchateau et al.

A1 Journal Article in MALARIA JOURNAL

Residual active pharmaceutical ingredient on the primary packaging of medicines : a valuable GMP-marker

Evelien WynendaeleMiguel ColpaertNathan DebunneAnne KosgeiBart De Spiegeleer

A1 Journal Article in TALANTA

Zwitterionic-hydrophilic interaction liquid chromatography for L-ascorbic acid 2-phosphate magnesium, a raw material in cell therapy

Xiaolong XuJonas UrlaubMagdalena WoźniczkaEvelien WynendaeleKaren HermanCurd SchollmayerBernd DiehlSerge Van CalenberghUlrike HolzgrabeBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

2018

Analysis of iodinated quorum sensing peptides by LC-UV/ESI ion trap mass spectrometry

Yorick JanssensFrederick VerbekeNathan DebunneEvelien WynendaeleKathelijne PeremansBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL ANALYSIS

Characterisation of magnesium ascorbyl phosphate, a raw material in cell therapy

Xiaolong XuMagdalena WoźniczkaToon VerstraelenKristof Van HeckePatrick BultinckCarl MenschDieter BuystEric DeconinckEvelien WynendaeleKaren Herman et al.

Chromatography of quorum sensing peptides : an important functional class of the bacterial peptidome

Nathan DebunneFrederick VerbekeYorick JanssensEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in CHROMATOGRAPHIA

Circular dichroism in functional quality evaluation of medicines

Han YaoEvelien WynendaeleXiaolong XuAnne KosgeiBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Detection and quantification of Enterococcus faecalis RNPP-type quorum sensing peptides in bacterial culture media by UHPLC-MS

Frederick VerbekeNathan DebunneYorick JanssensLiesa TackEvelien WynendaelePetra RigoleTom CoenyeBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Development of a capillary zone electrophoresis method to quantify E. coli L-asparaginase and its acidic variants

Han YaoJana VandenbosscheCari E Sänger-van de GriendYorick JanssensCristina Soto FernándezXiaolong XuEvelien WynendaeleGovert Willem SomsenRob HaselbergBart De Spiegeleer

A1 Journal Article in TALANTA

Disbiome database : linking the microbiome to disease

Yorick JanssensJoachim NielandtAntoon BronselaerNathan DebunneFrederick VerbekeEvelien WynendaeleFilip Van ImmerseelYves-Paul VandewynckelGuy De TréBart De Spiegeleer

A1 Journal Article in BMC MICROBIOLOGY

Do quorum sensing peptides play a role in psychiatric disorders?

Evelien WynendaeleYorick JanssensNathan DebunneKurt AudenaertBart De Spiegeleer

Is there a role for quorum sensing peptides in cancer?

Evelien WynendaeleYorick JanssensNathan DebunneOlivier De WeverBart De Spiegeleer

Quality of anthelminthic medicines available in Jimma Ethiopia

Sileshi Belew YohannesSultan SulemanEvelien WynendaeleMatthias D'HondtAnne KosgeiLuc DuchateauBart De Spiegeleer

A1 Journal Article in ACTA TROPICA

Quality of isotopically labelled internal standards for peptide quantification

Nathan DebunneFrederick VerbekeYorick JanssensLiesa TackEvelien WynendaeleBart De Spiegeleer

Regulatory status of N-alkylamide containing health products

Evelien WynendaeleBart De SpiegeleerBert GevaertYorick JanssensSultan SulemanSteven CattoorJimmy SaundersLieselotte Veryser

A1 Journal Article in REGULATORY TOXICOLOGY AND PHARMACOLOGY

Residual API on the packaging : a GMP-marker?

Evelien WynendaeleMiguel ColpaertAnne KosgeiNathan DebunneBart De Spiegeleer

Screening of quorum sensing peptides for biological effects in neuronal cells

Yorick JanssensEvelien WynendaeleFrederick VerbekeNathan DebunneBert GevaertKurt AudenaertChristophe Van De WieleBart De Spiegeleer

A1 Journal Article in PEPTIDES

The quality of medicines used in children and supplied by private pharmaceutical wholesalers in Kinshasa, Democratic Republic of Congo : a prospective survey

Benedetta SchiavettiEvelien WynendaeleBart De SpiegeleerGeremie J MbinzeNicodème KalendaRoland MariniVera MelotteEpco HaskerBruno MeessenRaffaella Ravinetto et al.

A1 Journal Article in AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide

Joshua A JackmanVivian V CostaSoohyun ParkAna Luiza CV RealJae Hyeon ParkPablo L CardozoAbdul Rahim FerhanIsabella G OlmoThaiane P MoreiraJordana L Bambirra et al.

A1 Journal Article in NATURE MATERIALS

Treatment of malaria and related symptoms using traditional herbal medicine in Ethiopia

Sultan SulemanTakele Beyene TufaDereje KebebeSileshi BelewYimer MekonnenFanta GasheSeid MussaEvelien WynendaeleLuc DuchateauBart De Spiegeleer

A1 Journal Article in JOURNAL OF ETHNOPHARMACOLOGY

2017

Analysis of illegal peptide drugs via HILIC-DAD-MS

Steven JanvierEvelien De SutterEvelien WynendaeleBart De SpiegeleerCeline VanheeEric Deconinck

A1 Journal Article in TALANTA

Analytics in microbiome : investigating quorum sensing peptides

Nathan DebunneFrederick VerbekeEvelien WynendaeleYorick JanssensBart De Spiegeleer

Chemical classification of cyclic depsipeptides

Lien TaevernierEvelien WynendaeleBert GevaertBart De Spiegeleer

A1 Journal Article in CURRENT PROTEIN AND PEPTIDE SCIENCE

Faecal microbiota transplantation : a regulatory hurdle?

Frederick VerbekeYorick JanssensEvelien WynendaeleBart De Spiegeleer

Editorial material

Hydrophilic interaction liquid chromatography method development and validation for the assay of HEPES zwitterionic buffer

Xiaolong XuBert GevaertNathalie BrackeHan YaoEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Identification and quantification of falsified peptide drugs via HILIC-DAD-MS

Steven JanvierEvelien De SutterEvelien WynendaeleBart De SpiegeleerCeline VanheeEric Deconinck

In vitro functional quality characterization of NOTA-modified somatropins

Nathalie BrackeHan YaoEvelien WynendaeleFrederick VerbekeXiaolong XuBert GevaertAlex MaesChristophe Van De WieleMike SathekgeSarah De Saeger et al.

A1 Journal Article in ANALYTICAL CHEMISTRY

N-alkylamide profiling of Achillea ptarmica and Achillea millefolium extracts by liquid and gas chromatography-mass spectrometry

Lieselotte VeryserLien TaevernierEvelien WynendaeleYannick VerheustAnn DumoulinBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL ANALYSIS

Peptides as quorum sensing molecules : measurement techniques and obtained levels in vitro and in vivo

Frederick VerbekeSeverine De CraemerNathan DebunneYorick JanssensEvelien WynendaeleChristophe Van de WieleBart De Spiegeleer

A1 Journal Article in FRONTIERS IN NEUROSCIENCE

Poor dissolution of anthelminthic medicines : a risk for reduced efficacy

B SileshiS SultanEvelien WynendaeleKaat AnnéLuc DuchateauBart De SpiegeleerBruno Levecke

2016

An analytical quality by design (aQbD) approach for a L-asparaginaseactivity method

Han YaoJochem VancoillieMatthias D'HondtEvelien WynendaeleNathalie BrackeBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Bacterial quorum sensing peptides and the inter-kingdom communication with human cancer cells

Frederick VerbekeEvelien WynendaeleYorick JanssensBart De Spiegeleer

Blood-brain barrier transport kinetics of the cyclic depsipeptide mycotoxins beauvericin and enniatins

Lien TaevernierNathalie BrackeLieselotte VeryserEvelien WynendaeleBert GevaertKathelijne PeremansBart De Spiegeleer

A1 Journal Article in TOXICOLOGY LETTERS

Blood-brain barrier transport kinetics of the neuromedin peptides NMU, NMN, NMB and NT

Bert GevaertEvelien WynendaeleSofie StalmansNathalie BrackeMatthias D'HondtIlse SmoldersAnn Van EeckhautBart De Spiegeleer

A1 Journal Article in NEUROPHARMACOLOGY

Do cyclic depsipeptide mycotoxins beauvericin and enniatins cross the blood-brain barrier?

Lien TaevernierNathalie BrackeLieselotte VeryserEvelien WynendaeleBart De Spiegeleer

Exploration of the medicinal peptide space

Bert GevaertSofie StalmansEvelien WynendaeleLien TaevernierNathalie BrackeMatthias D'HondtBart De Spiegeleer

A1 Journal Article in PROTEIN AND PEPTIDE LETTERS

Fish hydrolysates : a regulatory perspective of bioactive peptides

Bert GevaertLieselotte VeryserFrederick VerbekeEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in PROTEIN AND PEPTIDE LETTERS

Hydrophilic interaction liquid chromatography method development and validation for the assay of HEPES zwitterionic buffer

Xiaolong XuBert GevaertNathalie BrackeHan YaoEvelien WynendaeleBart De Spiegeleer

Implementation of UHPLC-single quad MS platform : the next level transforming pharmaceutical quality control laboratories

Evelien WynendaeleBert GevaertLieselotte VeryserXiaolong XuFrederick VerbekeBart De Spiegeleer

Implementation of a single quad MS detector in routine QC analysis of peptide drugs

Matthias D'HondtBert GevaertEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL ANALYSIS

Impurity profiling of L-asparaginase preparation

Han YaoNathalie BrackeBert GevaertXiaolong XuEvelien WynendaeleRob HaselbergGovert SomsenBart De Spiegeleer

Mucosal and blood-brain barrier transport kinetics of the plant N-alkylamide spilanthol using in vitro and in vivo models

Lieselotte VeryserLien TaevernierTanmayee JoshiPratima TatkeEvelien WynendaeleNathalie BrackeSofie StalmansKathelijne PeremansChristian Paul G. BurvenichMartijn Risseeuw et al.

A1 Journal Article in BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE

Pre-clinical pharmacokinetics of selected quorum sensing peptides

Yorick JanssensEvelien WynendaeleFrederick VerbekeBart De Spiegeleer

Quality control of cationic cell-penetrating peptides

Sofie StalmansBert GevaertFrederick VerbekeMatthias D'HondtNathalie BrackeEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Quantitative in vitro and in vivo evaluation of intestinal and blood-brain barrier transport kinetics of the plant N-alkylamide pellitorine

Lieselotte VeryserNathalie BrackeEvelien WynendaeleTanmayee JoshiPratima TatkeLien TaevernierBart De Spiegeleer

A1 Journal Article in BIOMED RESEARCH INTERNATIONAL

Quorum sensing peptides: the missing link between microbiome and disease?

Evelien WynendaeleFrederick VerbekeYorick JanssensNathan DebunneBart De Spiegeleer

Regulatory development of geriatric medicines : to GIP or not to GIP?

Bart De SpiegeleerEvelien WynendaeleNathalie BrackeLieselotte VeryserLien TaevernierAgnes DegrooteSofie Stalmans

A1 Journal Article in AGEING RESEARCH REVIEWS

The effects of quorum sensing peptides on colon cancer cells: implications for the role of the gut microbiome

Yorick JanssensEvelien WynendaeleFrederick VerbekeAn HendrixOlivier De WeverMarc BrackeBart De Spiegeleer

The human microbiota in health and disease: the role of quorum sensing peptides

Evelien WynendaeleFrederick VerbekeYorick JanssensBart De Spiegeleer

The mycotoxin definition reconsidered towards fungal cyclic depsipeptides

Lien TaevernierEvelien WynendaeleLeen De VreeseChristian Paul G. BurvenichBart De Spiegeleer

A1 Journal Article in JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

2015

An analytical quality-by-design (aQbD) approach for a L-asparaginase activity method

Han YaoJochem VancoillieMatthias D'HondtEvelien WynendaeleNathalie BrackeBart De Spiegeleer

Analytical quality-by-design approach for sample treatment of BSA-containing solutions

Lien TaevernierEvelien WynendaeleMatthias D'HondtBart De Spiegeleer

A2 Journal Article in JOURNAL OF PHARMACEUTICAL ANALYSIS

Assessment of efficacy and quality of two albendazole brands commonly used against soil-transmitted helminth infections in school children in Jimma Town, Ethiopia

Sileshi Belew YohannesMestawet GetachewSultan Suleman WegaTesfaye MohammedHabetewold DetiMatthias D'HondtEvelien WynendaeleZeleke Mekonnen KurmaneJozef VercruysseLuc Duchateau et al.

A1 Journal Article in PLOS NEGLECTED TROPICAL DISEASES

Blood–brain transfer and antinociception of linear and cyclic N-methyl-guanidine and thiourea-enkephalins

Mathieu VerbekenEvelien WynendaeleElodie MauchaufféeNathalie BrackeSofie StalmansEngin BojnikSandor BenyheKathelijne PeremansIngeborgh PolisChristian Paul G. Burvenich et al.

A1 Journal Article in PEPTIDES

Cell-penetrating peptides selectively cross the blood-brain barrier in vivo

Sofie StalmansNathalie BrackeEvelien WynendaeleBert GevaertKathelijne PeremansChristian Paul G. BurvenichIngeborgh PolisBart De Spiegeleer

A1 Journal Article in PLOS ONE

Classification of peptides according to their blood-brain barrier influx

Sofie StalmansBert GevaertEvelien WynendaeleJoachim NielandtGuy De TréKathelijne PeremansChristian Paul G. BurvenichBart De Spiegeleer

A1 Journal Article in PROTEIN AND PEPTIDE LETTERS

Communication of quorum sensing peptides with breast cancer cells

Frederick VerbekeEvelien WynendaeleMarianne LauwersAn HendrixChristian Paul G. BurvenichOlivier De Wevermarc brackeBart De Spiegeleer

Crosstalk between the microbiome and cancer cells by quorum sensing peptides

Evelien WynendaeleFrederick VerbekeMatthias D'HondtAn HendrixChristophe Van De WieleChristian Paul G. BurvenichKathelijne PeremansOlivier De Wevermarc brackeBart De Spiegeleer

A1 Journal Article in PEPTIDES

Evaluation of local tolerance of a plant extract by the slug mucosal irritation (SMI) assay

Lieselotte VeryserJoke LenoirJente BoonenNathalie BrackeEvelien WynendaeleEls AdriaensHans NelisBram De WeverJean Paul RemonBart De Spiegeleer

A2 Journal Article in JOURNAL OF TOXICOLOGICAL EDUCATION

Exploring the chemical space of quorum sensing peptides

Evelien WynendaeleBert GevaertSofie StalmansFrederick VerbekeBart De Spiegeleer

A1 Journal Article in BIOPOLYMERS

Gas chromatographic method for the determination of lumefantrine in antimalarial finished pharmaceutical products

Sultan Suleman WegaYannick VerheustAnn DumoulinEvelien WynendaeleMatthias D'HondtKirsten VandercruyssenLieselotte VeryserLuc DuchateauBart De Spiegeleer

A1 Journal Article in JOURNAL OF FOOD AND DRUG ANALYSIS

Peptide profiling of internet obtained Cerebrolysin using HPLC-ESI-IT & UHPLC-Q-IM-TOF mass spectrometry

Bert GevaertMatthias D'HondtNathalie BrackeHan YaoEvelien WynendaeleJohannes Petrus Cornelis VissersMartin De CeccoJan ClaereboudtBart De Spiegeleer

Peptide profiling of internet-obtained cerebrolysin using high performance liquid chromatography–electrospray ionization ion trap and ultra high performance liquid chromatography–ion mobility–quadrupole time of flight mass spectrometry

Bert GevaertMatthias D'HondtNathalie BrackeHan YaoEvelien WynendaeleJohannes Petrus Cornelis VissersMartin De CeccoJan ClaereboudtBart De Spiegeleer

A1 Journal Article in DRUG TESTING AND ANALYSIS

Quality evaluation of synthetic quorum sensing peptides used in R&D

Frederick VerbekeEvelien WynendaeleSarah BraetMatthias D'HondtBart De Spiegeleer

A2 Journal Article in JOURNAL OF PHARMACEUTICAL ANALYSIS

Quorum sensing peptides selectively penetrate the blood-brain barrier

Evelien WynendaeleFrederick VerbekeSofie StalmansBert GevaertYorick JanssensChristophe Van De WieleKathelijne PeremansChristian Paul G. BurvenichBart De Spiegeleer

A1 Journal Article in PLOS ONE

Surface acoustic wave biosensor as a functional quality method in pharmaceutics

Nathalie BrackeSophia BarhdadiEvelien WynendaeleBert GevaertMatthias D'HondtBart De Spiegeleer

A1 Journal Article in SENSORS AND ACTUATORS B-CHEMICAL

The blood-brain barrier (BBB) permeability properties of plant N-alkylamides

Lieselotte VeryserEvelien WynendaeleNathalie BrackeBart De Spiegeleer

The quorum sensing peptides PhrG, CSP and EDF promote angiogenesis and invasion of breast cancer cells in vitro

Bart De SpiegeleerFrederick VerbekeMatthias D'HondtAn HendrixChristophe Van De WieleChristian Paul G. BurvenichKathelijne PeremansOlivier De Wevermarc brackeEvelien Wynendaele

A1 Journal Article in PLOS ONE

The use of UHPLC coupled to single quad MS detection in Franz diffusion cell methodologies

Lieselotte VeryserLien TaevernierEvelien WynendaeleNathalie RocheBart De Spiegeleer

2014

An in silico approach for modelling T-helper polarizing iNKT cell agonists

Anton De SpiegeleerEvelien WynendaeleMatthias VandekerckhoveSofie StalmansMaxime BoucartNele Van Den NoortgateKoen VenkenSerge Van CalenberghSANDRINE ASPESLAGHDirk Elewaut

A1 Journal Article in PLOS ONE

Analytical characterisation of NOTA-modified somatropins

Nathalie BrackeEvelien WynendaeleMatthias D'HondtRob HaselbergGovert W SomsenEwald PauwelsChristophe Van De WieleBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Are plant N-alkylamide cosmenutriceuticals also active in the central nervous system?

Lieselotte VeryserEvelien WynendaeleLien TaevernierFrederick VerbekeTanmayee JoshiPratima TatkeBart De Spiegeleer

Blood-brain barrier transport of short proline-rich antimicrobial peptides

Sofie StalmansEvelien WynendaeleNathalie BrackeDaniel KnappeRalf HoffmannKathelijne PeremansIngeborgh PolisChristian Paul G. BurvenichBart De Spiegeleer

A1 Journal Article in PROTEIN AND PEPTIDE LETTERS

Crosstalk between mammalian cells and the microbiome through quorum sensing peptides, influencing cancer metastasis

Evelien WynendaeleFrederick VerbekeMatthias D'HondtAn HendrixChristophe Van De WieleChristian Paul G. BurvenichKathelijne PeremansOlivier De Wevermarc brackeBart De Spiegeleer

Derringer desirability and kinetic plot LC-column comparison approach for MS-compatible lipopeptide analysis

Matthias D'HondtFrederick VerbekeSofie StalmansBert GevaertEvelien WynendaeleBart De Spiegeleer

A2 Journal Article in JOURNAL OF PHARMACEUTICAL ANALYSIS

Development of peptide and protein based radiopharmaceuticals

Evelien WynendaeleNathalie BrackeSofie StalmansBart De Spiegeleer

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

Do cell-penetrating peptides cross the blood-brain barrier

Sofie StalmansEvelien WynendaeleNathalie BrackeBart De Spiegeleer

Exploration of quorum sensing peptides: the missing link between microbiome and cancer outcome?

Evelien WynendaeleBart De Spiegeleer

Exploration of the peptide drug space

Bert GevaertEvelien WynendaeleMathieu VerbekenMatthias D'HondtSofie StalmansKathelijne PeremansChristian Paul G. BurvenichCatherine DelesalleBart De Spiegeleer

How does the human microbiome affect cancer outcome?

Evelien WynendaeleFrederick VerbekeMatthias D'HondtAn HendrixChristophe Van De WieleChristian Paul G. BurvenichKathelijne PeremansOlivier De Wevermarc brackeBart De Spiegeleer

How the exploration of the chemical space of cell-penetrating peptides helps to understand their functionality

Sofie StalmansEvelien WynendaeleBart De Spiegeleer

Identification of a microscopically selected microorganism in milk samples

Nathalie BrackeMario Van PouckeBram BaertEvelien WynendaeleLobke De BelsWim Van Den BroeckLuc PeelmanChristian Paul G. BurvenichBart De Spiegeleer

A1 Journal Article in JOURNAL OF DAIRY SCIENCE

Investigation of active pharmaceutical ingredient loss in pharmaceutical compounding of capsules

Matthias D'HondtEvelien WynendaeleKirsten VandercruyssenTieneke BautersJohan VandenbrouckeSteven MullensChris VervaetJean Paul RemonBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

N-alkylamides : from plant to brain

Lieselotte VeryserEvelien WynendaeleLien TaevernierFrederick VerbekeTanmayee JoshiPratima TatkeBart De Spiegeleer

A2 Journal Article in FUNCTIONAL FOODS IN HEALTH AND DISEASE

Quality of medicines commonly used in the treatment of soil transmitted helminths and Giardia in Ethiopia: a nationwide survey

Sultan Suleman WegaGemechu ZelekeHabtewold DetiZeleke Mekonnen KurmaneLuc DuchateauBruno LeveckeJozef VercruysseMatthias D'HondtEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in PLOS NEGLECTED TROPICAL DISEASES

Quorum sensing peptides: missing link between microbiome and health?

Evelien WynendaeleFrederick VerbekeMatthias D'HondtAn HendrixChristophe Van De WieleChristian Paul G. BurvenichKathelijne PeremansOlivier De Wevermarc brackeBart De Spiegeleer

Related impurities in peptide medicines

Matthias D'HondtNathalie BrackeLien TaevernierBert GevaertFrederick VerbekeEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Surface acoustic wave biosensor as a functional-quality method in pharmaceutics

Nathalie BrackeEvelien WynendaeleBert GevaertBart De Spiegeleer

Surface acoustic wave biosensor as an analytical tool in pharmaceutics : a quality by design approach

Nathalie BrackeEvelien WynendaeleBert GevaertBart De Spiegeleer

The possible role of somatropin derivatives as a theranostic in oncology

Nathalie BrackeEvelien WynendaeleSophia BarhdadiChristophe Van De WieleBart De Spiegeleer

2013

A computational high-throughput screening approach of iNKT-agonists: a novel tool to find optimized iNKT cell ligands

Anton De SpiegeleerEvelien WynendaeleSofie StalmansNele Van Den NoortgateMatthias VandekerckhoveSerge Van CalenberghSANDRINE ASPESLAGHKoen VenkenDirk Elewaut

A rapid stability-indicating, fused-core HPLC method for simultaneous determination of β-artemether and lumefantrine in anti-malarial fixed dose combination products

Sultan Suleman WegaKirsten VandercruyssenEvelien WynendaeleMatthias D'HondtNathalie BrackeLuc DuchateauChristian Paul G. BurvenichKathelijne PeremansBart De Spiegeleer

A1 Journal Article in MALARIA JOURNAL

Chemical-functional diversity in cell-penetrating peptides

Sofie StalmansEvelien WynendaeleNathalie BrackeBert GevaertMatthias D'HondtKathelijne PeremansChristian Paul G. BurvenichBart De Spiegeleer

A1 Journal Article in PLOS ONE

Quorumpeps database : chemical space, microbial origin and functionality of quorum sensing peptides

Evelien WynendaeleAntoon BronselaerJoachim NielandtMatthias D'HondtSofie StalmansNathalie BrackeFrederick VerbekeChristophe Van De WieleGuy De TréBart De Spiegeleer

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Reversed-phase fused-core HPLC modeling of peptides

Matthias D'HondtBert GevaertSofie StalmansSylvia Van DorpeEvelien WynendaeleKathelijne PeremansChristian Paul G. BurvenichBart De Spiegeleer

A2 Journal Article in JOURNAL OF PHARMACEUTICAL ANALYSIS

Somatropin (rhGH) functional quality characterization by LC/CE-MS and SAW (Surface Acoustic Wave) biosensor techniques

Nathalie BrackeEvelien WynendaeleRob HaselbergGovert SomsenSophia BarhdadiBart De Spiegeleer

Surface acoustic wave technology as a tool for functional quality characterization of new compounds and biosimilars

Nathalie BrackeEvelien WynendaeleChristophe Van De WieleBart De Spiegeleer

2012

Brainpeps: the blood-brain barrier peptide database

Sylvia Van DorpeAntoon BronselaerJoachim NielandtSofie StalmansEvelien WynendaeleKurt AudenaertChristophe Van De WieleChristian Paul G. BurvenichKathelijne PeremansHung Hsuchou et al.

A1 Journal Article in BRAIN STRUCTURE & FUNCTION

Exploring the Brainpeps database

Sofie StalmansMatthias D'HondtEvelien WynendaeleNathalie BrackeBart De Spiegeleer

Exploring the chemical-functional space of cell-penetrating peptides

Sofie StalmansEvelien WynendaeleBart De Spiegeleer

In vitro metabolic stability of iodinated obestatin peptides

Bart De SpiegeleerSylvia Van DorpeValentijn VergoteEvelien WynendaeleEwald PauwelsChristophe Van De WielePablo Garcia-SolisJuan Carlos Solis-Sainz

A1 Journal Article in PEPTIDES

Influence of variability in starting materials quality on stability of finished drug products: a quality-by-design factor and response

Matthias D'HondtEvelien WynendaeleTieneke BautersJohan VandenbrouckeHugo RobaysBart De Spiegeleer

Receptor and blood-brain barrier characterisation of opioid peptides in drug research and early development

Bart De SpiegeleerSofie StalmansEvelien WynendaeleNathalie BrackeMathieu VerbekenKathelijne PeremansIngeborgh PolisChristian Paul G. Burvenich

Receptor and blood-brain barrier characterization of opioid peptides in drug research and early development

Mathieu VerbekenSofie StalmansEvelien WynendaeleNathalie BrackeBert GevaertKathelijne PeremansIngeborgh PolisChristian Paul G. BurvenichBart De Spiegeleer

Targeting the S1 and S3 subsite of trypsin with unnatural cationic amino acids generates antimicrobial peptides with potential for oral administration

Rasmus KarstadGeir IsaksenEvelien WynendaeleYngve GuttormsenBart De SpiegeleerBjorn-Olav BrandsdalJohn Sigurd SvendsenJohan Svenson

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

The influence of peptide impurity profiles on functional tissue-organ bath response: the 11-mer peptide INSL6[151-161] case

Mathieu VerbekenEvelien WynendaeleRomain LefebvreEls GoossensBart De Spiegeleer

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

The potential role of quorum-sensing peptides in oncology

Evelien WynendaeleEwald PauwelsChristophe Van De WieleChristian Paul G. BurvenichBart De Spiegeleer

A1 Journal Article in MEDICAL HYPOTHESES

Variation of the net charge, lipophilicity, and side chain flexibility in Dmt¹-DALDA: effect on opioid activity and biodistribution

Alexandre NovoaSylvia Van DorpeEvelien WynendaeleMariana SpeteaNathalie BrackeSofie StalmansCecilia BettiNga N ChungCarole LemieuxJohannes Zuegg et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

2011

ADME behaviour of some Dmt-DALDA-peptide derivatives

Sylvia Van DorpeIris VandenbroeckEvelien WynendaeleMathieu VerbekenAlexandre NovoaDirk TourwéSteven BalletBart De Spiegeleer

Blood-brain barrier and ADME properties of selected DALDA-peptide derivatives

Sylvia Van DorpeEvelien WynendaeleChristian Paul G. BurvenichAlexandre NovoaDirk TourwéSteven BalletBart De Spiegeleer

Classification of quorum-sensing peptides

Evelien WynendaeleEwald PauwelsChristophe Van De WieleAntoon BronselaerGuy De TréBart De Spiegeleer

Development of a quorum-sensing peptide database: quorumpeps

Evelien WynendaeleAntoon BronselaerGuy De TréEwald PauwelsMaxime BoucartChristophe Van De WieleBart De Spiegeleer

Dry heat stress stability evaluation of casein peptide mixture

Matthias D'HondtWim DemaréSylvia Van DorpeEvelien WynendaeleChristian Paul G. BurvenichKathelijne PeremansBart De Spiegeleer

A1 Journal Article in FOOD CHEMISTRY

Purity profiling of peptide drugs

Sylvia Van DorpeMathieu VerbekenEvelien WynendaeleBart De Spiegeleer

A2 Journal Article in JOURNAL OF BIOANALYSIS AND BIOMEDICINE

Structural modification and biological evaluation of Dmt1-DALDA analogues

Alexandre NovoaSylvia Van DorpeEvelien WynendaeleNga ChungCarole LemieuxPeter W SchillerDirk TourwéBart De SpiegeleerSteven Ballet

2010

Characterisation of modified pharmaceutical proteins: the somatropin case

Evelien WynendaeleDaphne WiskerkeBart De Spiegeleer

HPLC-MS characterisation of chelate modified somatropin

Evelien WynendaeleEwald PauwelsSylvia Van DorpeValentijn VergoteChristophe Van De WieleBart De Spiegeleer

LC-MS characterization and cell-binding properties of chelate modified somatropin

Evelien WynendaeleKoen MertensEwald PauwelsChristophe Van De WieleBart De Spiegeleer

LC-MS quality control of modified pharmaceutical proteins : the somatropin case

Evelien WynendaeleEwald PauwelsChristophe Van De WieleSylvia Van DorpeBart De Spiegeleer