Research Explorer

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Researcher

Evelien Naessens

Awards & Distinctions

27 Results

2024

A cGAS-mediated type I interferon response in human CD4+T cells depends on productive infection and is conserved over HIV types and strains

Marija JanevskaTimothy CammaertEvelien NaessensBruno Verhasselt

A1 Journal Article in JOURNAL OF VIROLOGY

2016

HIV triggers a cGAS-dependent, Vpu- and Vpr-regulated type I interferon response in CD4+ T cells

JOLIEN VERMEIREFerdinand RoeschDaniel SauterRéjane RuaDominik HotterAnouk Van NuffelHanne VanderstraetenEvelien NaessensVeronica IannucciAlessia Landi et al.

A1 Journal Article in CELL REPORTS

HIV-1 Vpr N-terminal tagging affects alternative splicing of the viral genome

Ann BaeyensEvelien NaessensAnouk Van NuffelKarin WeeningAnne-Marie ReillyEva ClaeysWim TrypsteenLinos VandekerckhoveSven EyckermanKris Gevaert et al.

A1 Journal Article in SCIENTIFIC REPORTS

Mimicking the tumour microenvironment of chronic lymphocytic leukaemia in vitro critically depends on the type of B-cell receptor stimulation

Ans RomboutSofie LustFritz OffnerEvelien NaessensBruno VerhasseltJan Philippé

A1 Journal Article in BRITISH JOURNAL OF CANCER

The human immunodeficiency virus (HIV) Rev-binding protein (HRB) is a co-factor for HIV-1 Nef-mediated CD4 downregulation

Alessia LandiCristina García TimermansEvelien NaessensHanne VanderstraetenVeronique StoveBruno Verhasselt

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

2015

Lipoprotein lipase SNPs rs13702 and rs301 correlate with clinical outcome in chronic lymphocytic leukemia patients

Ans RomboutBasile StamatopoulosLaurence LagneauxSofie LustFritz OffnerEvelien NaessensHanne VanderstraetenBruno VerhasseltJan Philippé

A1 Journal Article in PLOS ONE

Mimicking the tumor microenvironment of chronic lymphocytic leukemia in vitro critically depends on the type of B cell receptor stimulation

Ans RomboutSofie LustFritz OffnerEvelien NaessensBruno VerhasseltJan Philippé

Vpx-independent lentiviral transduction and shRNA-mediated protein knock-down in monocyte-derived dendritic cells

Wojciech WitkowskiJOLIEN VERMEIREAlessia LandiEvelien NaessensHanne VanderstraetenHans NauwynckHerman FavoreelBruno Verhasselt

A1 Journal Article in PLOS ONE

2014

Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation

Alessia LandiJOLIEN VERMEIREVeronica IannucciHanne VanderstraetenEvelien NaessensMostafa BentahirBruno Verhasselt

A1 Journal Article in RETROVIROLOGY

2013

CLL cells respond to B-cell receptor stimulation with a microRNA/mRNA signature associated with MYC activation and cell cycle progression

Valerie PedeAns RomboutJOLIEN VERMEIREEvelien NaessensPieter MestdaghNore RobberechtHanne VanderstraetenNadine Van RoyJo VandesompeleFranki Speleman et al.

A1 Journal Article in PLOS ONE

Efficient, Vpx independent shRNA transduction of monocyte derived dendritic cells as a tool for studying HIV transmission to primary T-cells

Wojciech WitkowskiVeronica IannucciEvelien NaessensHanne VanderstraetenBruno Verhasselt

Expression of ZAP70 in chronic lymphocytic leukaemia activates NF-κB signalling

Valerie PedeAns RomboutJOLIEN VERMEIREEvelien NaessensHanne VanderstraetenJan PhilippéBruno Verhasselt

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

HIV-1 infection induces a type I IFN response in primary CD4(+) T cells

JOLIEN VERMEIREVeronica IannucciEvelien NaessensKathleen Van LandeghemHanne VanderstraetenJo Van DammeBruno Verhasselt

New host factors and pathways involved in CD4 downregulation in HIV-1 infected cells

Alessia LandiJOLIEN VERMEIREVeronica IannucciHanne VanderstraetenEvelien NaessensMostafa BentahirBruno Verhasselt

Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms

Anouk Van NuffelKevin AriënVeronique StoveMichael SchindlerEduardo O'NeillJan SchmökelInge Van de WalleEvelien NaessensHanne VanderstraetenKathleen Van Landeghem et al.

A1 Journal Article in RETROVIROLOGY

Vpr content of HIV-1 virions determines infection of resting peripheral blood CD4⁺ lymphocytes

Anouk Van NuffelFrancis ImpensAnn BaeyensStijn VanheeWojciech WitkowskiElien VandermarliereHanne VanderstraetenEvelien NaessensKathleen Van LandeghemSophie Vermaut et al.

2012

Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function

Pieter MeuwissenBettina StolpVeronica IannucciJOLIEN VERMEIREEvelien NaessensKalle SakselaMatthias GeyerGuido VanhamKevin AriënOliver T Fackler et al.

A1 Journal Article in RETROVIROLOGY

Quantification of reverse transcriptase activity by real-time PCR as a fast and accurate method for titration of HIV, lenti- and retroviral vectors

JOLIEN VERMEIREEvelien NaessensHanne VanderstraetenAlessia LandiVeronica IannucciAnouk Van NuffelTom TaghonMassimo PizzatoBruno Verhasselt

A1 Journal Article in PLOS ONE

2010

Rho GTPase Cdc42 is essential for human T-cell development

Kaatje SmitsVeronica IannucciVeronique StovePeter Van HauweEvelien NaessensPieter MeuwissenKevin AriënMostafa BentahirJean PlumBruno Verhasselt

A1 Journal Article in HAEMATOLOGICA-THE HEMATOLOGY JOURNAL

2008

Efficient gene transfer in CLL by mRNA electroporation

FEMKE VAN BOCKSTAELEValerie PedeEvelien NaessensStefanie Van CoppernolleV VAN TENDELOOBruno VerhasseltJan Philippé

A1 Journal Article in LEUKEMIA

2007

Tumor necrosis factor promotes T-cell at the expense of B-cell lymphoid development from cultured human CD34(+) cord blood cells

K SMITSMagda De SmedtEvelien NaessensGreet De SmetVeronique StoveTom TaghonJean PlumBruno Verhasselt

A1 Journal Article in EXPERIMENTAL HEMATOLOGY

2006

Multiple gene knock-down by a single lentiviral vector expressing an array of short hairpin RNAs

Veronique StoveKaatje SmitsEvelien NaessensJean PlumBruno Verhasselt

A1 Journal Article in ELECTRONIC JOURNAL OF BIOTECHNOLOGY

2005

Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8 alpha beta

Veronique StoveInge Van de WalleEvelien NaessensElisabeth CoeneChristophe StoveJean PlumBruno Verhasselt

A1 Journal Article in JOURNAL OF VIROLOGY

2003

Generation of transgenic T cells from human CD34+ cord blood cells

Bruno VerhasseltEvelien NaessensVeronique Stove

Bookchapter in Cytokines and Colony Stimulating Factors.

Signaling but not trafficking function of HIV-1 protein Nef is essential for Nef-induced defects in human intrathymic T-cell development

Veronique StoveEvelien NaessensChristophe StoveT SWIGUTJean PlumBruno Verhasselt

A1 Journal Article in BLOOD

1999

Human immunodeficiency virus nef gene expression affects generation and function of human T cells, but not dendritic cells

Bruno VerhasseltEvelien NaessensChris VerhofstedeMagda De SmedtSigrid SchollenTessa KerreDominique VanheckeJean Plum

A1 Journal Article in BLOOD

Thymic repopulation by CD34+ human cord blood cells after expansion in stroma-free culture

Bruno VerhasseltTessa KerreEvelien NaessensDominique VanheckeMagda De SmedtBart VandekerckhoveJean Plum

A1 Journal Article in BLOOD