Research Explorer

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Researcher

Esther Hoste

Publications & Research Data

Awards & Distinctions

54 Results

2025

ATG9A-mediated autophagy prevents inflammatory skin disease by limiting TNFR1-driven STING activation and ZBP1-dependent cell death

Dario PriemJon HuygheBarbara GilbertSimon VerdonckTom DelangheBruno VerstraetenEsther HostePeter VandenabeeleJonathan MaelfaitGeert van Loo et al.

A1 Journal Article in IMMUNITY

2024

Cell death as an architect of adult skin stem cell niches

Kim LecomteAnnagiada TonioloEsther Hoste

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer's disease

Sahana SrinivasanDaliya KanchevaSofie De RenTakashi SaitoMaude JansFleur BooneCharysse VandendriesscheIne PaesmansHerve MaurinRoosmarijn Vandenbroucke et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Laser-induced vapor nanobubbles for B16-F10 melanoma cell killing and intracellular delivery of chemotherapeutics

Jana RamonYanou EngelenHerlinde De KeersmaeckerIlia GoemaereDeep PunjJulián Mejía MoralesCédric BonteGeert BerxEsther HosteStephan Stremersch et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

OTULIN as a crucial regulator of keratinocyte death, stem cell identity and Wnt signaling

Kim LecomteGeert van LooEsther Hoste

Oxylipins and metabolites from pyroptotic cells act as promoters of tissue repair

Parul MehrotraSophia MaschalidiLaura BoeckaertsChristian MaueröderRochelle TixeiraJonathan PinneyJavier BurgoaVladimir SukhovYunus IncikChristopher Anderson et al.

A1 Journal Article in NATURE

Women in STEM becoming independent : our shared motivation and enthusiasm are our driving force

Liudmila AndreevaLidia BosurgiShu Zhen ChongCoco ChuYejing GeEsther HosteKellie A JuradoJette LengefeldArchita MishraStefanie Wculek et al.

Editorial material

2023

Autophagy critically controls skin inflammation and apoptosis-induced stem cell activation

Lisette Van HoveAnnagiada TonioloMohammad GhiaslooKim LecomteFleur BooneMaarten CiersKris RaaijmakersNiels VandammeJana RoelsSophia Maschalidi et al.

A1 Journal Article in AUTOPHAGY

Glycyrrhizin-based hydrogels accelerate wound healing of normoglycemic and diabetic mouse skin

Maarten A. MeesFleur BooneThomas BouwenFrederik VanaerschotCharlotte TitecaHanna-Kaisa VikkulaLeen CatrysseAnja VananroyeErin KoosStelios Alexandris et al.

A1 Journal Article in PHARMACEUTICS

Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice

Karel Van DammePieter HertensArne MartensElisabeth GilisDario PriemInge BruggemanAmelie FossoulJozefien DeclercqHelena Catharine AegerterAndy Wullaert et al.

A1 Journal Article in SCIENTIFIC REPORTS

2022

A20 controls RANK-dependent osteoclast formation and bone physiology

Arne MartensPieter HertensDario PriemVagelis RinotasTheodore MeletakosMeropi GennadiLisette Van HoveEls LouagieJulie CoudenysAmélie De Muynck et al.

A1 Journal Article in EMBO REPORTS

Activation of fibroblasts in skin cancer

Lisette Van HoveEsther Hoste

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

ATG9A prevents TNF cytotoxicity by an unconventional lysosomal targeting pathway.

Jon HuygheDario PriemLisette Van HoveBarbara GilbertJ FritschY UchiyamaEsther HosteGeert van LooMathieu Bertrand

A1 Journal Article in SCIENCE

Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes

Sophia MaschalidiParul MehrotraBurcu Nur KeçeliHannah De CleeneKim LecomteRenée Van der CruyssenPauline JanssenJonathan PinneyGeert van LooDirk Elewaut et al.

A1 Journal Article in NATURE

2021

A20 deficiency in myeloid cells protects mice from diet-induced obesity and insulin resistance due to increased fatty acid metabolism

Leen CatrysseBastiaan MaesParul MehrotraArne MartensEsther HosteLiesbet MartensChristian MaueröderAnneleen RemmerieAnna BujkoKarolina Slowicka et al.

A1 Journal Article in CELL REPORTS

Fibrotic enzymes modulate wound-induced skin tumorigenesis

Lisette Van HoveKim LecomteJana RoelsNiels VandammeHanna-Kaisa VikkulaIsabelle HoorensKatia OngenaeTino HochepiedGiacomo DonatiYvan Saeys et al.

A1 Journal Article in EMBO REPORTS

OTULIN in NF-κB signaling, cell death, and disease

Lien VerboomEsther HosteGeert van Loo

A1 Journal Article in TRENDS IN IMMUNOLOGY

OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity

Esther HosteKim LecomteKarl AnnusverNiels VandammeJana RoelsSophia MaschalidiLien VerboomHanna-Kaisa VikkulaMozes SzeLisette Van Hove et al.

A1 Journal Article in NATURE COMMUNICATIONS

Stem cells remember insults : wounding mobilizes stem cells that accumulate epigenetic memories and regenerate skin

Editorial material

Unravelling molecular mechanisms mediating skin inflammation and tumour formation

Lisette Van HoveGeert van LooEsther Hoste

2020

OTULIN prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated hepatocyte apoptosis

Lien VerboomArne MartensDario PriemEsther HosteMozes SzeHanna-Kaisa VikkulaLisette Van HoveSofie VoetJana RoelsJonathan Maelfait et al.

A1 Journal Article in CELL REPORTS

Publisher correction : Zeb2 drives invasive and microbiota-dependent colon carcinoma

Karolina SlowickaIoanna PettaGillian BlanckeEsther HosteEmilie DumasMozes SzeHanna-Kaisa VikkulaEnrico RadaelliJody J. HaighSven Jonckheere et al.

Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities

Arne MartensDario PriemEsther HosteJessica VettersSofie RennenLeen CatrysseSofie VoetLaura DeelenMozes SzeHanna-Kaisa Vikkula et al.

A1 Journal Article in NATURE IMMUNOLOGY

Zeb2 drives invasive and microbiota-dependent colon carcinoma

Karolina SlowickaIoanna PettaGillian BlanckeEsther HosteEmilie DumasMozes SzeHanna-Kaisa VikkulaEnrico RadaelliJody J. HaighSven Jonckheere et al.

A1 Journal Article in NATURE CANCER

2019

Epithelial HMGB1 delays skin wound healing and drives tumor initiation by priming neutrophils for NET formation

Esther HosteChristian MaueröderLisette Van HoveLeen CatrysseHanna-Kaisa VikkulaMozes SzeBastiaan MaesDyah KarjosukarsoLiesbet MartensAmanda Gonçalves et al.

A1 Journal Article in CELL REPORTS

Mutant Lef1 controls Gata6 in sebaceous gland development and cancer

Bénédicte OulèsEmanuel RognoniEsther HosteGeorgina GossRyan FiehlerKen NatsugaSven QuistRemco MentinkGiacomo DonatiFiona M Watt

A1 Journal Article in EMBO JOURNAL

2018

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

Sofie VoetConor Mc GuireNora HagemeyerArne MartensAnna SchroederPeter WieghoferCarmen DaemsOri StaszewskiLieselotte Vande WalleMarta Joana Costa Jordao et al.

A1 Journal Article in NATURE COMMUNICATIONS

Langerhans cells : sensing the environment in health and disease

Julie DeckersHamida HammadEsther Hoste

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis

Tamara MuliaditanJonathan CaronMary OkesolaJames W OpzoomerParis KostiMirella GeorgouliPeter GordonSharanpreet LallDesislava M KuzevaLuisa Pedro et al.

A1 Journal Article in NATURE COMMUNICATIONS

2017

Epicutaneous sensitization to house dust mite allergen requires interferon regulatory factor 4-dependent dermal dendritic cells

Julie DeckersDorine SichienMaud PlantingaJustine Van MoorleghemManon VanheerswynghelsEsther HosteBernard MalissenDavid DombrowiczMartin GuilliamsKarolien De Bosscher et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

S100B is a potential disease activity marker in nonsegmental vitiligo

Reinhart SpeeckaertSofie VoetEsther HosteNanja van Geel

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Stabilization of beta-catenin does not increase dermal papilla cell number in the hair follicle : reply

Grace KaushalEmanuel RognoniBeate M LichtenbergerRyan R DriskellKai KretzschmarEsther HosteFiona M Watt

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Wounding induces dedifferentiation of epidermal Gata6⁺ cells and acquisition of stem cell properties

Giacomo DonatiEmanuel RognoniToru HiratsukaKifayathullah Liakath-AliEsther HosteGozde KarMelis KayikciRoslin RussellKai KretzschmarKlaas W Mulder et al.

A1 Journal Article in NATURE CELL BIOLOGY

2015

Fate of Prominin-1 expressing dermal papilla cells during homeostasis, wound healing and Wnt activation

Grace S. KaushalEmanuel RognoniBeate M. LichtenbergerRyan R. DriskellKai KretzschmarEsther HosteFiona M. Watt

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Innate sensing of microbial products promotes wound-induced skin cancer

Esther HosteEsther N. ArwertRohit LalAndrew P. SouthJulio C. Salas-AlanisDedee F. MurrellGiacomo DonatiFiona M. Watt

A1 Journal Article in NATURE COMMUNICATIONS

Understanding allergy and cancer risk : what are the barriers?

Esther HosteSara CipolatFiona M. Watt

Editorial material

2014

Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility

Sara CipolatEsther HosteKen NatsugaSven R. QuistFiona M. Watt

A1 Journal Article in ELIFE

2013

Caspase-14-deficient mice are more prone to the development of parakeratosis

Esther HosteGeertrui DeneckerBarbara GilbertFilip Van NieuwerburghLeslie van der FitsBob AsselberghRiet De RyckeJean-Pierre HachemDieter DeforceErrol P Prens et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Distinct fibroblast lineages determine dermal architecture in skin development and repair

Ryan R. DriskellBeate M. LichtenbergerEsther HosteKai KretzschmarBen D. SimonsMarika CharalambousSacri R. FerronYann HeraultGuillaume PavlovicAnne C. Ferguson-Smith et al.

A1 Journal Article in NATURE

2012

Epidermal Cadm1 expression promotes autoimmune alopecia via enhanced T cell adhesion and cytotoxicity

Adam GiangrecoEsther HosteYoshimi TakaiIan RosewellFiona M. Watt

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Epithelial stem cells, wound healing and cancer

Esther N. ArwertEsther HosteFiona M. Watt

A1 Journal Article in NATURE REVIEWS CANCER

Filaggrin degradation by caspase-14 is required for UVB photoprotection but does not influence allergic sensitization in a mouse model of atopic dermatitis

Michael DevosJanne PrawittDelphine Staumont-SalleEsther HosteSebastién FleuryEmmanuel BouchaertBarbara GilbertSaskia LippensPeter VandenabeeleDavid Dombrowicz et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Upregulation of CD26 expression in epithelial cells and stromal cells during wound-induced skin tumour formation

E. N. ArwertR. A. MentinkR. R. DriskellEsther HosteS. J. GoldieS. QuistF. M. Watt

A1 Journal Article in ONCOGENE

2011

Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin

Esther HostePatrick KempermanMichael DevosGeertrui DeneckerSanja KezicNico YauBarbara GilbertSaskia LippensPhilippe De GrooteRia Roelandt et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cell death in the skin

Saskia LippensEsther HostePeter VandenabeeleWim Declercq

Bookchapter in Apoptosis : physiology and pathology

2010

Study of the role of caspase-14 in epidermal cornification

Esther HosteWim DeclercqPeter Vandenabeele

2009

Cell death in the skin

Saskia LippensEsther HostePeter VandenabeelePatrizia AgostinisWim Declercq

A1 Journal Article in APOPTOSIS

2007

Caspase-14 protects against epidermal UVB photo-damage and water loss

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensC VAN DEN BROUCKEPetra Van DammeKatharina D'HerdeJ HACHEM et al.

Caspase-14 protects against epidermal UVB photo-damage and water loss.

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensC VAN DEN BROUCKEPetra Van DammeKatharina D'HerdeJ HACHEM et al.

Caspase-14 protects against epidermal UVB photodamage and water loss

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensCaroline Van den broeckePetra Van DammeKatharina D'HerdeJP HACHEM et al.

A1 Journal Article in NATURE CELL BIOLOGY

Generation of active recombinant human caspase-14

Philippe De GrootePetra OvaereEsther HosteGeertrui DeneckerSaskia LippensPeter VandenabeeleWim Declercq

Identification and characterization of filaggrin as a caspase-14 substrate

Esther HosteGeertrui DeneckerPetra Van DammeRB PRESLANDJoël VandekerckhoveKris GevaertPeter VandenabeeleWim Declercq

2006

Role of caspase-14 in terminal differentiation of keratinocytes

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensCaroline VandenbrouckeKatharina D'HerdePeter VandenabeeleWim Declercq

The secret life of caspase-14

Geertrui DeneckerEsther HosteT HOCHPIEDBarbara GilbertPetra OvaereKatharina D'HerdeCaroline VandenbrouckeSaskia LippensLore SchoonjansClaude Libert et al.