Research Explorer

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Researcher

Els Demecheleer

Publications & Research Data

Awards & Distinctions

18 Results

2025

Aberrant strand transfer events across multiple stages of reverse transcription shape the heterogeneous landscape of the HIV-1 reservoir

Jarryt HardyVirginie MortierYiannis De MeersmanDelfien StaelensEls DemecheleerMarlies SchauvliegeCiel VermeerschElizaveta PadalkoChris Verhofstede

A1 Journal Article in COMMUNICATIONS BIOLOGY

2024

Reverse transcription of plasma-derived HIV-1 RNA generates multiple artifacts through tRNA(Lys-3)-priming

Jarryt HardyEls DemecheleerMarlies SchauvliegeDelfien StaelensVirginie MortierChris Verhofstede

A1 Journal Article in MICROBIOLOGY SPECTRUM

2020

High frequency of new recombinant forms in HIV-1 transmission networks demonstrated by full genome sequencing

Laura HebberechtVirginie MortierKenny DauweMarlies SchauvliegeDelfien StaelensEls DemecheleerKarolien StoffelsFien VanroyeMarie-Luce DelforgeEllen Vancutsem et al.

A1 Journal Article in INFECTION GENETICS AND EVOLUTION

2019

Single genome sequencing of near full-length HIV-1 RNA using a limiting dilution approach

Laura HebberechtLeen VancoillieMarlies SchauvliegeDelfien StaelensEls DemecheleerJarryt HardyVirginie MortierChris Verhofstede

A1 Journal Article in JOURNAL OF VIROLOGICAL METHODS

2018

Meticulous plasma isolation is essential to avoid false low-level viraemia in Roche Cobas HIV-1 viral load assays

Virginie MortierLeen VancoillieKenny DauweDelfien StaelensEls DemecheleerMarlies SchauvliegeSylvie DinakisTom Van MaerkenGéraldine DessillyJean Ruelle et al.

A1 Journal Article in ANTIVIRAL THERAPY

Quantification of total HIV-1 DNA in buffy coat cells, feasibility and potential added value for clinical follow-up of HIV-1 infected patients on ART

Virginie MortierEls DemecheleerDelfien StaelensMarlies SchauvliegeKenny DauweSylvie DinakisLaura HebberechtLeen VancoillieChris Verhofstede

A1 Journal Article in JOURNAL OF CLINICAL VIROLOGY

2017

Longitudinal sequencing of HIV-1 infected patients with low-level viremia for years while on ART shows no indications for genetic evolution of the virus

Leen VancoillieLaura HebberechtKenny DauweEls DemecheleerSylvie DinakisDries VaneechoutteVirginie MortierChris Verhofstede

A1 Journal Article in VIROLOGY

2015

Drug resistance is rarely the cause or consequence of long-term persistent low-level viraemia in HIV-1-infected patients on ART

Leen VancoillieVirginie MortierEls DemecheleerMarlies SchauvliegeLinos VandekerckhoveDirk VogelaersChris Verhofstede

A1 Journal Article in ANTIVIRAL THERAPY

2014

Markers associated with persisting low-level viraemia under antiretroviral therapy in HIV-1 infection

Leen VancoillieEls DemecheleerSteven CallensDirk VogelaersLinos VandekerckhoveVirginie MortierChris Verhofstede

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

2012

Impact of triplicate testing on HIV genotypic tropism prediction in routine clinical practice

J SymonsLinos VandekerckhoveR ParedesChris VerhofstedeR BellidoEls DemecheleerPM van HamSFL van LelyveldAJ StamD van Versendaal et al.

A1 Journal Article in CLINICAL MICROBIOLOGY AND INFECTION

2011

Comparison of phenotypic and genotypic tropism determination in triple-class-experienced HIV patients eligible for maraviroc treatment

Linos VandekerckhoveChris VerhofstedeEls DemecheleerStephane De WitEric FlorenceKatrien FransenMichel MoutschenWendy MostmansKabamba KabeyaNicola Mackie et al.

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

2010

Effect of triplicate testing on genotypic tropism prediction in routine clinical practice

J SymonsLinos VandekerckhoveR ParedesChris VerhofstedeR BellidoEls DemecheleerPaulyn Van HammeSFL van LelyveldAL StamD van Versendaal et al.

2009

CXCR4-using HIV type 1 variants are more commonly found in peripheral blood mononuclear cell DNA than in plasma RNA

Chris VerhofstedeLinos VandekerckhoveVeerle Van EygenEls DemecheleerIna VandenbrouckeBart WintersJean PlumDirk VogelaersLieven Stuyver

A1 Journal Article in JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

2008

Impact of Delta 32-CCR5 heterozygosity on HIV-1 genetic evolution and variability - A study of 4 individuals infected with closely related HIV-1 strains

Kristen ChalmetFilip Van WanzeeleEls DemecheleerKenny DauweJolanda PelgromBeatrijs Van Der GuchtDirk VogelaersJean PlumLieven StuyverLinos Vandekerckhove et al.

A1 Journal Article in Virology

2007

Feasibility of detecting human immunodeficiency virus type 1 drug resistance in DNA extracted from whole blood or dried blood spots

K SteegenStanley LüchtersEls DemecheleerKenny DauweK MandaliyaW JaokoJean PlumMarleen TemmermanChris Verhofstede

A1 Journal Article in JOURNAL OF CLINICAL MICROBIOLOGY

2006

A sensitive in-house RT-PCR genotyping system for combined detection of plasma HIV-1 and assessment of drug resistance

Kim SteegenEls DemecheleerNancy De CabooterD NGESMarleen TemmermanP NDUMBEK MANDALIYAJean PlumChris Verhofstede

A1 Journal Article in JOURNAL OF VIROLOGICAL METHODS

2004

Drug-resistant variants that evolve during nonsuppressive therapy persist in HIV-1-infected peripheral blood mononuclear cells after long-term highly active antiretroviral therapy

Chris VerhofstedeAnne NoëEls DemecheleerNancy De CabooterFilip Van WanzeeleBeatrijs Van Der GuchtDirk VogelaersJean Plum

A1 Journal Article in JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

2003

Diversity of the human immunodeficiency virus type 1 (HIV-1) env sequence after vertical transmission in mother-child pairs infected with HIV-1 subtype A

Chris VerhofstedeEls DemecheleerNancy De CabooterP GAILLARDF MWANYUMBAPatricia ClaeysV. CHOHANK MANDALIYAMarleen TemmermanJean Plum

A1 Journal Article in JOURNAL OF VIROLOGY