Research Explorer

Your browser does not support JavaScript or JavaScript is not enabled. Without JavaScript some functions of this webapplication may be disabled or cause error messages. To enable JavaScript, please consult the manual of your browser or contact your system administrator.

Researcher

Elke Gasthuys

Awards & Distinctions

82 Results

2024

Population pharmacokinetics of lisinopril in hypertensive children and adolescents with normal to mildly reduced kidney function

Louis SandraEva DegraeuwePauline De BruyneSiegrid De BaereSiska CroubelsJan Van BocxlaerAnn RaesJohan Vande WalleElke GasthuysAn Vermeulen

A1 Journal Article in BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Real World Data on the use of Lisinopril over 10 years within Pediatric Nephrology

Eva DegraeuweAnn RaesElke GasthuysEvelien SnauwaertLien DosscheAgnieszka Prytula-Ebelsjoke dehoorneAn VermeulenJohan Vande Walle

The development of the Belgian paediatric clinical trial network

Eva DegraeuweLaura PersijnLieve NuytinckKarel AllegaertLeen De TaeyeElke GasthuysDaphné ChristiaensSevasti KaramariaAnn RaesMark Turner et al.

A1 Journal Article in ACTA CLINICA BELGICA

2023

Building a human physiologically based pharmacokinetic model for aflatoxin B1 to simulate interactions with drugs

Orphélie LootensMarthe De BoevreJia NingElke GasthuysJan Van BocxlaerSarah De SaegerAn Vermeulen

A1 Journal Article in PHARMACEUTICS

Building a physiologically based pharmacokinetic model for a carcinogenic food contaminant

Orphélie LootensMarthe De BoevreAn VermeulenJia NingElke GasthuysJan Van BocxlaerSarah De Saeger

Building a physiologically based pharmacokinetic model for a carcinogenic food contaminant

Orphélie LootensMarthe De BoevreJia NingElke GasthuysJan Van BocxlaerSarah De SaegerAn Vermeulen

CO2-driven nebulization of pH-sensitive supramolecular polymers for intraperitoneal hydrogel formation and the treatment of peritoneal metastasis

Helena BraetPeter-Paul FransenRemco MariënGiovanna LolloWim CeelenChris VervaetLieve BalcaenFrank VanhaeckeChristian VanhoveStefan van der Vegte et al.

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

Comparison of monoclonal antibody disposition predictions between different PBPK platforms

Pieter-Jan De SutterElke GasthuysAn Vermeulen

Predicting volume of distribution in neonates : performance of physiologically based pharmacokinetic modelling

Pieter-Jan De SutterPhebe RossignolLien BreënsElke GasthuysAn Vermeulen

A1 Journal Article in PHARMACEUTICS

Predictive performance of physiologically based pharmacokinetic modelling of beta-lactam antibiotic concentrations in adipose, bone and muscle tissues

Pieter-Jan De SutterPieter De CockTN JohnsonH MustherElke GasthuysAn Vermeulen

A1 Journal Article in DRUG METABOLISM AND DISPOSITION

Real-world evidence of lisinopril in pediatric hypertension and nephroprotective management : a 10-year cohort study

Eva DegraeuweAnn RaesElke GasthuysEvelien SnauwaertLien DosscheAgnieszka Prytula-EbelsJo DehoorneAn VermeulenJohan Vande Walle

2022

Accuracy of PBPK-predicted tissue concentrations : a case study of beta-lactam antibiotics in fat, bone and muscle

Pieter-Jan De SutterPieter De CockTrevor N JohnsonHelen MustherElke GasthuysAn Vermeulen

Altered intravenous drug disposition in people living with cystic fibrosis : a meta‐analysis integrating top‐down and bottom‐up data

Pieter-Jan De SutterMaxime Van HaeverbekeEva Van BraeckelStephanie Van BiervlietJan Van BocxlaerAn VermeulenElke Gasthuys

A1 Journal Article in CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

Challenges of creating a patient engagement group in a pediatric setting

Eva DegraeuweMaria CavallerLaura PersijnElke GasthuysEvelien SnauwaertLieve NuytinckJohan Vande WalleAnn Raes

Determination of pharmacokinetic parameters of efavirenz an aflatoxin B1 : an approach to unravel possible interactions

Orphélie LootensAn VermeulenElke GasthuysJan Van BocxlaerSarah De SaegerMarthe De Boevre

Determination of pharmacokinetic parameters of efavirenz and aflatoxin B1 : an approach to unravel possible interactions

Orphélie LootensAn VermeulenElke GasthuysJan Van BocxlaerSarah De SaegerMarthe De Boevre

Johan Vande WalleElke GasthuysLien Dossche

Extensive review of pharmacokinetic and pharmacodynamic properties of ACE-inhibitors and angiotensin receptor blockers in hypertensive children

Eva DegraeuweLouis SandraPaulien De VosAn VermeulenAnn RaesJohan Vande WalleElke Gasthuys

Extensive review of pharmacokinetic and pharmacodynamic properties of ace-inhibitors and angiotensin receptor blockers in children with renal impairment

Eva DegraeuweLouis SandraPaulien DevosElke GasthuysEvelien SnauwaertAnn RaesJohan Vande Walle

Extensive review of trial methodology investigating therapeutics ACE-inhibitors and angiotensin receptor blockers in hypertensive paediatric patients

Eva DegraeuweLouis SandraPaulien DevosAn VermeulenAnn RaesJohan Vande WalleElke Gasthuys

General clinical and methodological considerations on the extrapolation of pharmacokinetics and optimization of study protocols for small molecules and monoclonal antibodies in children

Naim BouazzaAristides DokoumetzidisCatherijne A. J. KnibbeSaskia N. de WildtClaire AmberyPieter De CockElke GasthuysFrantz FoissacSaik UrienAnna-Karin Hamberg et al.

A1 Journal Article in BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

High throughput analytical report writing in R : a case study of validating an LC-MS method for the quantification of amoxicillin in human plasma

Pieter-Jan De SutterElke GasthuysAn VermeulenJan Van Bocxlaer

Investing in sustainable European paediatric trial networks : the value of a Young Investigator Community

Eva DegraeuweTessa van der GeestRicardo FernandesPaul MalenfantLieve NuytinckElke GasthuysAnn RaesJohan Vande WalleRégis HankardMark Turner

Nocturnal enuresis : non responders : how to optimize therapy in refractory cases

Johan Vande WalleLien DosscheElke Gasthuys

Patient engagement in a pediatric clinical trials : current state and perspectives in Belgium

Eva DegraeuweJohan Vande WalleAnn RaesElke GasthuysEvelien Snauwaert

Lecture / Speech

Phase I study of intraperitoneal aerosolized nanoparticle albumin based paclitaxel (NAB-PTX) for unresectable peritoneal metastases

Wim CeelenLouis SandraLeen Van de SandeM GraversenMB MortensenAn VermeulenElke GasthuysDries ReyndersSarah CosynsAnne Hoorens et al.

A1 Journal Article in EBIOMEDICINE

Physiologically based pharmacokinetic models for the prediction of beta-lactam antibiotic concentrations in perfusion-limited tissues

Pieter-Jan De SutterPieter De CockElke GasthuysAn Vermeulen

Population pharmacokinetics and Bayesian estimations of lisinopril at steady state in hypertensive children with mild to moderate renal impairment

Louis SandraEva DegraeuweElke GasthuysAn VermeulenPauline De BruyneAnn RaesJohan Vande Walle

Unravelling the pharmacokinetics of aflatoxin B1 : in vitro determination of Michaelis-Menten constants, intrinsic clearance and the metabolic contribution of CYP1A2 and CYP3A4 in pooled human liver microsomes

Orphélie LootensMarthe De BoevreElke GasthuysJan Van BocxlaerAn VermeulenSarah De Saeger

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

2021

Bayesian population approach to determine lisinopril exposure in hypertensive paediatric patients with mild to moderate renal impairment

Louis SandraEva DegraeuweElke GasthuysPaulien De BruyneAn VermeulenAnn RaesJohan Vande Walle

Desmopressin oral lyophilisate in young children : new insights in pharmacokinetics and pharmacodynamics

Lien DosscheRobin MicheletPauline De BruyneCharlotte Van HerzeeleElke GasthuysSøren RittigAn VermeulenJohan Vande Walle

A1 Journal Article in ARCHIVES OF DISEASE IN CHILDHOOD

European paediatric clinical trial networks beyond the Atlantic : the collaboration between I-ACT for Children (US) and the Belgian National Network

Eva DegraeuweMark TurnerLieve NuytinckDaphné ChristiaensElke GasthuysCollin HovingaCallie HaetonDinah StormJohan Vande Walle

How to improve paediatric clinical trial design : a sponsor’s perspective

Eva DegraeuweLieve NuytinckElke GasthuysAnn RaesJohan Vande WalleMark Turner

Interregional internationlisation initiative for research group paediatrics and paediatric nephrology

Eva DegraeuweAnn RaesKristof VandenkerckhoveJoke DehoorneElke GasthuysLieve NuytinckEvelien SnauwaertJohan Vande Walle

Investing in sustainable Pediatric European Trial Networks : the value of a young investigator’s community

Eva DegraeuweTessa Van der GeestRicardo FernandesPaul MalenfantLieve NuytinckElke GasthuysAnn RaesMark TurnerJohan Vande WalleRégis Hankard

Paediatric adaptations for clinical trial site preparation in pharmacological research

Eva DegraeuweLieve NuytinckElke GasthuysAnn RaesJohan Vande WalleMark Turner

Paediatric adaptations in the ethical committee and national authority approval process for pharmacological research

Eva DegraeuweLieve NuytinckElke GasthuysAnn RaesJohan Vande WalleMark Turner

Paediatric pharmacological development through a European clinical trial network conect4children (c4c) : activities of the Belgian National Network and its progression

Eva DegraeuweMark TurnerLieve NuytinckDaphné ChristiaensSimon VanderschaegheElke GasthuysSevasti KaramariaCatherine Van Der StraetenJohan Vande Walle

Pharmacokinetics and blood pressure effects of ACE-inhibitors in children with hypertension

Louis SandraEva DegraeuweElke GasthuysAn VermeulenPauline De BruyneAnn RaesJohan Vande Walle

Population pharmacokinetic modeling of lisinopril at steady-state in hypertensive paediatric patients with mild to moderate renal impairement

Eva DegraeuweLouis SandraElke GasthuysPaulien De BruyneAnn RaesJohan Vande WalleAn Vermeulen

Population pharmacokinetics of lisinopril in hypertensive children with mild to moderate renal impairment

Louis SandraEva DegraeuweElke GasthuysAn VermeulenPaulien De BruyneAnn RaesJohan Vande Walle

The European Paediatric Clinical Trials Network beyond the Atlantic : the collaboration between I-ACT for Children (US) and European Network Activity

Eva DegraeuweLeen De TaeyeMark TurnerLieve NuytinckDaphné ChristiaensElke GasthuysCollin HovingaChristina StanleyJohan Vande Walle

The European Paediatric Clinical Trials Network conect4children : activities of the Belgium National Network and its progression

Eva DegraeuweLeen De TaeyeMark TurnerLieve NuytinckDaphné ChristiaensSimon VanderschaegheElke GasthuysSevasti KaramariaCatherine Van Der StraetenJohan Vande Walle

2020

An integrated paediatric population PK/PD analysis of dDAVP : how do PK differences translate to clinical outcomes?

Robin MicheletLien DosscheCharlotte Van HerzeelePauline De BruyneElke GasthuysJan Van BocxlaerJohan Vande WalleAn Vermeulen

A1 Journal Article in CLINICAL PHARMACOKINETICS

Desmopressin resistant monosymptomatic nocturnal enuresis : new pathophysiological and pharmacological insights

Lien DosscheJohan Vande WalleSören RittigElke Gasthuys

Enuresis : evaluation and treatment

Johan Vande WalleLien DosscheElke Gasthuys

Ontogeny and cross species comparison of pathways involved in drug absorption, distribution, metabolism and excretion in neonates (review) : KIDNEY

Ruud BuetersAn BaelElke GasthuysConnie ChenMichiel F SchreuderKendall S Frazier

A1 Journal Article in DRUG METABOLISM AND DISPOSITION

Pediatric pharmacology of desmopressin in children with enuresis : a comprehensive review

Elke GasthuysLien DosscheRobin MicheletJens Peter NorgaardMathias DevreeseSiska CroubelsAn VermeulenJan Van BocxlaerJohan Vande Walle

A1 Journal Article in PEDIATRIC DRUGS

Pharmacokinetics in patients with cystic fibrosis : a systematic review of data published between 1999 and 2019

Pieter-Jan De SutterElke GasthuysEva Van BraeckelPetra SchelstraeteStephanie Van BiervlietJan Van BocxlaerAn Vermeulen

A1 Journal Article in CLINICAL PHARMACOKINETICS

Simultaneous measurement of glomerular filtration rate, effective renal plasma flow and tubular secretion in different poultry species by single intravenous bolus of iohexol and para-aminohippuric acid

Lenka StroobantSiska CroubelsLaura DhondtJoske MillecamSiegrid De BaereElke GasthuysJ MorrensGunther Antonissen

A1 Journal Article in ANIMALS

2019

Comparative physiology of glomerular filtration rate by plasma clearance of exogenous creatinine and exo-iohexol in six different avian species

Elke GasthuysAndrés MontesinosNele CaekebekeMathias DevreeseSiegrid De BaereMaria ArdiacaDominique PaepeSiska CroubelsGunther Antonissen

A1 Journal Article in SCIENTIFIC REPORTS

Development of an in vivo lipopolysaccharide inflammation model to study the pharmacodynamics of COX-2 inhibitors celecoxib, mavacoxib, and meloxicam in cockatiels (Nymphicus hollandicus)

Elke GasthuysRenée HoubenRoel HaesendonckSiegrid De BaereStanislas SysJoachim MorrensGunther Antonissen

A1 Journal Article in JOURNAL OF AVIAN MEDICINE AND SURGERY

Developmental pharmacokinetics and safety of ibuprofen and its enantiomers in the conventional pig as potential pediatric animal model

Joske MillecamThomas van BergenStijn SchauvliegeGunther AntonissenAnn MartensKoen ChiersRonette GehringElke GasthuysJohan Vande WalleSiska Croubels et al.

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Insights into in vivo absolute oral bioavailability, biotransformation, and toxicokinetics of zearalenone, α-zearalenol, β-zearalenol, zearalenone-14-glucoside, and zearalenone-14-sulfate in pigs

Amelie CatteuwNathan BroekaertSiegrid De BaereMarianne LauwersElke GasthuysBart HuybrechtsAlfons CallebautLada IvanovaSilvio UhligMarthe De Boevre et al.

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

SAFEPEDRUG : safer pediatric drugs for children: what have we learned?

Elke GasthuysJohan Vande WalleLien DosscheLieve NuytinckRobin MicheletAn VermeulenSevasti Karamaria

Setting up a Belgian paediatric clinical research network

Johan Vande WalleLeen De TaeyeElke GasthuysDaphne ChristaensSevasti KaramariaLieve Nuytinck

A2 Journal Article in BELGIAN JOURNAL OF PAEDIATRICS

Survey by TEDDY European Network of Excellence for Paediatric Clinical Research demonstrates potential for Europe‐wide trials

Lucia RuggieriDonato BonifaziAnnalisa LandiFedele BonifaziFranco BartoloniMary CostelloMaria Grazia FelisiElke GasthuysAnila GodoFederico Martinon Torres et al.

A1 Journal Article in ACTA PAEDIATRICA

2018

A novel approach in paediatric drug research : the development of a juvenile conventional pig model for pharmacokinetic/pharmacodynamic studies, using desmopressin as case

Editorial material

A novel approach in paediatric drug research : the development of a juvenile pig model for pharmacokinetic/pharmacodynamic studies, using desmopressin as case 1

Elke GasthuysJoske MillecamMathias DevreeseAn VermeulenPauline De BruyneJohan Vande WalleJoris DelangheSiska Croubels

Conventional growing piglets as potential juvenile animal model for preclinical pharmaceutical research : postnatal maturation of the glomerular filtration rate

Elke GasthuysJoske MillecamMathias DevreeseJoris DelangheJohan Vande WalleMarjolein HeyndrickxSiska Croubels

Desmopressin what is new? : paediatric drug development : towards maturity

Elke GasthuysRobin MicheletLien DosscheJohan Vande Walle

Le project Européen c4c

Johan Vande WalleFranz SchaeferElke GasthuysLieve Nuytinck

Maturation of hepatic cytochrome P450 enzymes in conventional pigs : fact or fiction?

Joske MillecamLaura De ClerckElisabeth GovaertMathias DevreeseElke GasthuysWim SchelstraeteDieter DeforceLies De BockJan Van BocxlaerStanislas Sys et al.

Maturation of hepatic cytochrome P450 enzymes in conventional pigs : the added value of proteomics

Joske MillecamLaura De ClerckElisabeth GovaertMathias DevreeseElke GasthuysWim SchelstraeteDieter DeforceLies De BockJan Van BocxlaerStanislas Sys et al.

Maturation of hepatic cytochrome P450 enzymes in conventional pigs as model for preclinical paediatric drug research

Joske MillecamLaura De ClerckElisabeth GovaertMathias DevreeseElke GasthuysWim SchelstraeteDieter DeforceLies De BockJan Van BocxlaerStanislas Sys et al.

PK/PD studies in pigs leading to optimization of treatment dose in MNE?

Elke GasthuysLien DosscheSiska CroubelsPauline De BruyneMathias DevreeseAn VermeulenJohan Vande Walle

Pediatric drug development: towards maturity : desmopressin as a case

Elke GasthuysRobin MicheletLien DosschePauline De BruyneJohan Vande WalleAn VermeulenMathias DevreeseSiska Croubels

Population pharmacokinetic modeling of a desmopressin oral lyophilisate in growing piglets as a model for the pediatric population

Elke GasthuysAn VermeulenSiska CroubelsJoske MillecamStijn SchauvliegeThomas van BergenPauline De BruyneJohan Vande WalleMathias Devreese

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Population pharmacokinetic modeling of a desmopressin oral lyophilisate in growing piglets as a model for the pediatric population

Elke GasthuysAn VermeulenSiska CroubelsPauline De BruyneJoske MillecamJohan Vande WalleMathias Devreese

The development of a juvenile conventional pig model for PK/PD studies, using desmopressin as case

The ontogeny of cytochrome P450 enzyme activity and protein abundance in conventional pigs in support of preclinical pediatric drug research

Joske MillecamLaura De ClerckElisabeth GovaertMathias DevreeseElke GasthuysWim SchelstraeteDieter DeforceLies De BockJan Van BocxlaerStanislas Sys et al.

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

2017

A new approach in pediatric drug design : the development of a pediatric pig model, part II : the maturation of hepatic cytochrome P450 enzymes using enzyme activity and proteomics

Joske MillecamElke GasthuysMathias DevreeseDieter DeforceLies De BockJan Van BocxlaerSiska Croubels

A novel approach in paediatric drug design : the conventional pig as juvenile animal model

Joske MillecamElke GasthuysMathias DevreeseSiska Croubels

A novel approach in paediatric drug research : the development of a juvenile conventional pig model for pharmacokinetic/pharmacodynamic studies, using desmopressin as case

Elke GasthuysSiska CroubelsMathias Devreese

Population pharmacokinetic modeling of the glomerular filtration rate in growing piglets using iohexol

Elke GasthuysJoske MillecamSiska CroubelsRonette GehringMathias Devreese

Postnatal maturation of the glomerular filtration rate in conventional growing piglets as potential juvenile animal model for preclinical pharmaceutical research

Elke GasthuysMathias DevreeseJoske MillecamStanislas SysKatrien VanderperrenJoris DelangheJohan Vande WalleMarjolein HeyndrickxSiska Croubels

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Repetitive urine and blood sampling in neonatal and weaned piglets for pharmacokinetic and pharmacodynamic modelling in drug discovery : a pilot study

Elke GasthuysStijn SchauvliegeThomas van BergenJoske MillecamIlaria CerasoliAnn MartensFrank GasthuysTim VandecasteelePieter CornillieWim Van Den Broeck et al.

A1 Journal Article in LABORATORY ANIMALS

The conventional pig as PK/PD/toxicity model for the pediatric subpopulation : development of urine and blood sampling strategies in growing piglets

Elke GasthuysThomas van BergenStijn SchauvliegeJoske MillecamSiska CroubelsMathias Devreese

The ontogeny of hepatic cytochrome P450 enzymes in conventional pigs using enzyme activity and proteomics

Joske MillecamElke GasthuysMathias DevreeseDieter DeforceJan Van BocxlaerSiska Croubels

2016

The potential use of piglets as human pediatric surrogate for preclinical pharmacokinetic and pharmacodynamic drug testing

Elke GasthuysTim VandecasteelePauline De BruyneJohan Vande WallePatrick De BackerPieter CornillieMathias DevreeseSiska Croubels

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

2015

Comparison of iohexol and endogenous creatinine clearance as estimators of glomerular filtration rate in piglets at different age categories

Elke GasthuysMathias DevreeseJoske MillecamPatrick De BackerSiska Croubels

The ontogeny of hepatic CYP3A, CYP2C and CYP2E enzyme activity in conventional pigs

Joske MillecamMathias DevreeseLies De BockJan Van BocxlaerElke GasthuysPatrick De BackerSiska Croubels