Research Explorer

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Researcher

Elke Decrock

93 Results

2021

X-irradiation induces acute and early term inflammatory responses in atherosclerosis-prone ApoE-/- mice and in endothelial cells

Raghda RamadanEllen CocquytElke DecrockSarah BaatoutLuc Leybaert

A1 Journal Article in MOLECULAR MEDICINE REPORTS

2020

Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage

Raghda RamadanDelphine HoorelbekeElke DecrockSarah BaatoutLuc Leybaert

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Cx43 channels and signaling via IP3/Ca2+, ATP, and ROS/NO propagate radiation-induced DNA damage to non-irradiated brain microvascular endothelial cells

Delphine HoorelbekeElke DecrockMaarten De SmetMarijke De BockBenedicte DescampsValérie Van HaverTinneke DelvaeyeDmitri KryskoChristian VanhoveLuc Leybaert

A1 Journal Article in CELL DEATH & DISEASE

2019

Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock

Tinneke DelvaeyeMaarten De SmetStijn VerwaerdeElke DecrockAleksandra CzekajRoosmarijn VandenbrouckeKelly LemeireAmanda GonçalvesWim DeclercqPeter VandenabeeleDmitri KryskoLuc Leybaert

A1 Journal Article in SCIENTIFIC REPORTS

Single and fractionated ionizing radiation induce alterations in endothelial connexin expression and channel function

Raghda RamadanElke DecrockSarah BaatoutLuc Leybaert

A1 Journal Article in SCIENTIFIC REPORTS

2018

Calcium, a pivotal player in photodynamic therapy?

Delphine HoorelbekeElke DecrockValérie Van HaverMarijke De BockLuc Leybaert

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Noninvasive whole-body imaging of phosphatidylethanolamine as a cell death marker using 99mTc-duramycin during TNF-induced SIRS

Tinneke DelvaeyeKelly LemeireAmanda GonçalvesElke DecrockLuc LeybaertPeter VandenabeeleDmitri Krysko

A1 Journal Article in JOURNAL OF NUCLEAR MEDICINE

Species-dependent extracranial manifestations of a brain seeking breast cancer cell line

Valerie De MeulenaereSara NeytBert VandeghinstePieter MolletOlivier De WeverElke DecrockLuc LeybaertIngeborg GoethalsChristian VanhoveBenedicte DescampsKarel Deblaere

A1 Journal Article in PLOS ONE

2017

At the cross-point of connexins, calcium, and ATP : blocking hemichannels inhibits vasoconstriction of rat small mesenteric arteries

Mélissa BolNan WangMarijke De BockElke DecrockAshish Kumar GadicherlaKatrijn DecaluweBert VanheelDmitri KryskoJohan Van de VoordeLuc Leybaert

A1 Journal Article in CARDIOVASCULAR RESEARCH

Blocking connexin channels improves embryo development of vitrified bovine blastocysts

Nerea Ortiz EscribanoKatarzyna Joanna Szymańska-VandendriesscheMélissa BolLynn VandenbergheElke DecrockMario Van PouckeLuc PeelmanEtienne Van den AbbeelAnn Van SoomLuc Leybaert

A1 Journal Article in BIOLOGY OF REPRODUCTION

Calcium, oxidative stress and connexin channels, a harmonious orchestra directing the response to radiotherapy treatment?

Elke DecrockDelphine HoorelbekeRaghda RamadanTinneke DelvaeyeMarijke De BockNan WangDmitri KryskoSarah BaatoutLuc Leybaert

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Connexin hemichannel inhibition reduces acetaminophen-induced liver injury in mice

Elke DecrockLuc Leybaert

A1 Journal Article in TOXICOLOGY LETTERS

Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice

Elke DecrockLuc Leybaert

A1 Journal Article in SCIENTIFIC REPORTS

Multimodal imaging in an experimental rat model for brain metastasis

Valerie De MeulenaereChristian VanhoveElke DecrockOlivier De WeverBenedicte Descamps

Pannexin1 as mediator of inflammation and cell death

Elke DecrockMarijke De BockLuc Leybaert

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The BH4 domain of Bcl-2 orthologues from different classes of vertebrates can act as an evolutionary conserved inhibitor of IP3 receptor channels

Elke DecrockLuc Leybaert

A1 Journal Article in CELL CALCIUM

2016

Connexins and their channels in inflammation

Elke DecrockNan WangLuc Leybaert

A1 Journal Article in CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Electroporation loading and dye transfer : a safe and robust method to probe gap junctional coupling

Elke DecrockMarijke De BockDiego De BaereDelphine HoorelbekeNan WangLuc Leybaert

Bookchapter in Gap junction protocols

Into rather unexplored terrain : transcellular transport across the blood-brain barrier

Marijke De BockValérie Van HaverRoosmarijn VandenbrouckeElke DecrockNan WangLuc Leybaert

A1 Journal Article in GLIA

2015

18F-fluoromethylcholine (FCho), 18F-fluoroethyltyrosine (FET), and 18F-fluorodeoxyglucose (FDG) for the discrimination between high-grade glioma and radiation necrosis in rats: a PET study

Julie BolcaenBenedicte DescampsKarel DeblaereTom BoterbergFilip De VosJean-Pierre Kalala OkitoElke DecrockLuc LeybaertChristian VanhoveIngeborg Goethals

A1 Journal Article in NUCLEAR MEDICINE AND BIOLOGY

Connexin and pannexin signaling pathways, an architectural blueprint for CNS physiology and pathology?

Elke DecrockMarijke De BockNan WangLuc Leybaert

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Effect of Cx-mimetic peptide administration on breast cancer brain metastasis development: a preclinical serial MRI study

Valerie De MeulenaereElke DecrockSara NeytOlivier De WeverFilip De VosChristian VanhoveHannelore DenysBenedicte DescampsKarel Deblaere

Effect of GAP27 on breast cancer brain metastasis development: initial results

Valerie De MeulenaereElke DecrockSara NeytOlivier De WeverFilip De VosChristian VanhoveHannelore DenysBenedicte DescampsKarel Deblaere

Electroporation loading and flash photolysis to investigate intra- and intercellular Ca2+ signaling

Elke DecrockMarijke De BockNan WangMélissa BolAshish Kumar GadicherlaLuc Leybaert

A2 Journal Article in COLD SPRING HARBOR PROTOCOLS

Electroporation loading of membrane-impermeable molecules to investigate intra- and intercellular Ca2+ signaling

Elke DecrockMarijke De BockNan WangMélissa BolAshish Kumar GadicherlaLuc Leybaert

A2 Journal Article in COLD SPRING HARBOR PROTOCOLS

Flash photolysis of caged IP3 to trigger intercellular Ca2+ waves

Elke DecrockMarijke De BockNan WangMélissa BolAshish Kumar GadicherlaLuc Leybaert

A2 Journal Article in COLD SPRING HARBOR PROTOCOLS

Intracellular cleavage of the Cx43 C-terminal domain by matrix-metalloproteases : a novel contributor to inflammation?

Marijke De BockNan WangElke DecrockLuc Leybaert

A1 Journal Article in MEDIATORS OF INFLAMMATION

Multi-modality imaging in a pre-clinical model of developing rat brain metastases: initial results

Valerie De MeulenaereBenedicte DescampsSara NeytElke DecrockOlivier De WeverFilip De VosChristian VanhoveKarel Deblaere

Multi-modality imaging in a pre-clinical model of developing rat brain metastases: initial results

Valerie De MeulenaereBenedicte DescampsSara NeytOlivier De WeverElke DecrockFilip De VosChristian VanhoveKarel Deblaere

Multi-modality imaging in a pre-clinical model of developing rat brain metastases: initial results

Valerie De MeulenaereBenedicte DescampsSara NeytOlivier De WeverElke DecrockFilip De VosChristian VanhoveKarel Deblaere

Ryanodine receptors are targeted by anti-apoptotic Bcl-X-L involving its BH4 domain and Lys87 from its BH3 domain

Irma LemmensElien VandermarliereElke DecrockLennart MartensLuc LeybaertJan Tavernier

A1 Journal Article in SCIENTIFIC REPORTS

Structure, regulation and function of gap junctions in liver

Elke DecrockNan WangLuc Leybaert

A1 Journal Article in CELL COMMUNICATION AND ADHESION

The BH4 domain of anti-apoptotic Bcl-XL, but not that of the related Bcl-2, limits the voltage-dependent anion channel 1 (VDAC1)-mediated transfer of pro-apoptotic Ca2+ signals to mitochondria

Elke DecrockLuc Leybaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2014

A new angle on blood–CNS interfaces: a role for connexins?

Marijke De BockRoosmarijn VandenbrouckeElke DecrockLuc Leybaert

A1 Journal Article in FEBS LETTERS

Bcl-2 binds to and inhibits ryanodine receptors

Elke DecrockLuc Leybaert

A1 Journal Article in JOURNAL OF CELL SCIENCE

Connexin and pannexin (hemi)channels in the liver

Elke DecrockLuc Leybaert

A1 Journal Article in FRONTIERS IN PHYSIOLOGY

MRI-guided 3D conformal arc micro-irradiation of a F98 glioblastoma rat model using the Small Animal Radiation Research Platform (SARRP)

Julie BolcaenBenedicte DescampsKarel DeblaereTom BoterbergGiorgio HallaertElke DecrockAnne VralLuc LeybaertChristian VanhoveIngeborg Goethals

A1 Journal Article in JOURNAL OF NEURO-ONCOLOGY

Molecular MRI in preclinical research

Benedicte DescampsSara NeytFilip De VosValerie De MeulenaereElke DecrockJulie BolcaenIngeborg GoethalsOlivier De WeverTom BoterbergKarel DeblaereChristian Vanhove

Molecular MRI in preclinical research

Benedicte DescampsSara NeytFilip De VosValerie De MeulenaereElke DecrockJulie BolcaenIngeborg GoethalsOlivier De WeverTom BoterbergKarel DeblaereChristian Vanhove

Targeting radiation-induced neuroinflammation using ICAM-MPIO

Benedicte DescampsSara NeytCaroline DumolynFilip De VosElke DecrockValerie De MeulenaereJulie BolcaenIngeborg GoethalsTom BoterbergChristian VanhoveKarel Deblaere

Targeting radiation-induced neuroinflammation using ICAM-MPIO

Benedicte DescampsSara NeytCaroline DumolynFilip De VosElke DecrockValerie De MeulenaereJulie BolcaenIngeborg GoethalsTom BoterbergChristian VanhoveKarel Deblaere

The dual face of connexin-based astroglial Ca2+ communication: a key player in brain physiology and a prime target in pathology

Marijke De BockElke DecrockNan WangMélissa BolLuc Leybaert

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

2013

Alpha-helical destabilization of the Bcl-2-BH4-domain peptide abolishes its ability to inhibit the IP3 receptor

Elke DecrockLuc Leybaert

A1 Journal Article in PLOS ONE

Connexin targeting peptides as inhibitors of voltage- and intracellular Ca2+-triggered Cx43 hemichannel opening

Nan WangMarijke De BockElke DecrockMélissa BolAshish Kumar GadicherlaLuc Leybaert

A1 Journal Article in NEUROPHARMACOLOGY

Endothelial calcium dynamics, connexin channels and blood-brain barrier function

Marijke De BockNan WangElke DecrockMélissa BolAshish Kumar GadicherlaLuc Leybaert

A1 Journal Article in PROGRESS IN NEUROBIOLOGY

IP₃, a small molecule with a powerful message

Elke DecrockMarijke De BockNan WangAshish Kumar GadicherlaMélissa BolTinneke DelvaeyePeter VandenabeeleDmitri KryskoLuc Leybaert

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

In vivo magnetic resonance imaging of acute radiation induced inflammation using ICAM1 targeted micron-sized particles of iron oxide (ICAM-MPIO)

Benedicte DescampsSara NeytElke DecrockFilip De VosCaroline DumolynJulie BolcaenIngeborg GoethalsTom BoterbergChristian VanhoveKarel Deblaere

Inhibiting connexin channels protects against cryopreservation-induced cell death in human blood vessels

Mélissa BolCaroline Van GeytElke DecrockNan WangMarijke De BockAshish Kumar GadicherlaCaren RandonHilde BeeleMaria CornelissenLuc Leybaert

A1 Journal Article in EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Proteomic and metabolomic responses to connexin43 silencing in primary hepatocyte cultures

Elke DecrockLuc LeybaertAn StaesKris Gevaert

A1 Journal Article in ARCHIVES OF TOXICOLOGY

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury

Nan WangElke De VuystJoris WaumanMarijke De BockElke DecrockMélissa BolJan TavernierLuc Leybaert

A1 Journal Article in BASIC RESEARCH IN CARDIOLOGY

2012

Connexin 43 hemichannels contribute to cytoplasmic Ca2+ oscillations by providing a bimodal Ca2+-dependent Ca2+ entry pathway

Marijke De BockNan WangMélissa BolElke DecrockLuc Leybaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca2+ elevation

Nan WangMarijke De BockAshish Kumar GadicherlaMélissa BolElke DecrockLuc Leybaert

A1 Journal Article in BASIC RESEARCH IN CARDIOLOGY

Connexin-based intercellular signaling in cell death, to live or let die?

Elke DecrockLuc LeybaertKatharina D'Herde

Connexin43 signaling contributes to spontaneous apoptosis in cultures of primary hepatocytes

Elke DecrockLuc Leybaert

A1 Journal Article in TOXICOLOGICAL SCIENCES

Is chronic exposure of the blood-brain barrier to relatively low L-β-ODAP concentrations a possible entry point of L-β-ODAP into the central nervous system?

Marijke Van MoorhemElke DecrockMarijke De BockNan WangKatharina D'HerdeFernand LambeinLuc Leybaert

Low extracellular Ca2+ conditions induce an increase in brain endothelial permeability that involves intercellular Ca2+ waves

Marijke De BockNan WangElke DecrockMélissa BolLuc Leybaert

A1 Journal Article in BRAIN RESEARCH

Non-channel functions of connexins in cell growth and cell death

Elke DecrockLuc Leybaert

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Paracrine signaling through plasma membrane hemichannels

Nan WangMarijke De BockElke DecrockMélissa BolAshish Kumar GadicherlaLuc Leybaert

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl

Elke DecrockLuc Leybaert

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Transfer of IP3 through gap junctions is critical, but not sufficient, for the spread of apoptosis

Elke DecrockDmitri KryskoAgnieszka KaczmarekMélissa BolNan WangMarijke De BockElke De VuystPeter VandenabeeleLuc Leybaert

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2011

Calcium and connexin-based intercellular communication, a deadly catch?

Elke DecrockMélissa BolKatharina D'HerdePeter VandenabeeleDmitri KryskoLuc Leybaert

A1 Journal Article in CELL CALCIUM

Characterization of spontaneous cell death in monolayer cultures of primary hepatocytes

Elke DecrockElke De VuystLuc Leybaert

A1 Journal Article in ARCHIVES OF TOXICOLOGY

Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood brain barrier permeability

Marijke De BockNan WangMélissa BolElke DecrockElke De VuystIne DauweGaspard De LeyLuc Leybaert

A1 Journal Article in JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Connexins: sensors and regulators of cell cycling

Elke DecrockElke De VuystLuc Leybaert

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

L-β-N-oxalyl-α,β-diaminopropionic acid toxicity in motor neurons

Marijke Van MoorhemElke DecrockElke De VuystMarijke De BockNan WangFernand LambeinLuc Leybaert

A1 Journal Article in NEUROREPORT

Memichannels contribute to Ca2+ dynamics and contractility of smooth muscle cells in acutely isolated small mesenteric arteries

Mélissa BolMarijke De BockNan WangElke DecrockBert Vanheel

2010

Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death

Elke DecrockElke De VuystMarijke De BockRoosmarijn VandenbrouckeBruno De GeestJo DemeesterNiek SandersLuc LeybaertVera Rogiers

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

DNA methyltransferase 3a expression decreases during apoptosis in primary cultures of hepatocytes

Elke DecrockLuc Leybaert

A1 Journal Article in TOXICOLOGY IN VITRO

Hemichannel involvement in CA2+ dynamics and contractility of smooth muscle cells in acutely isolated small mesenteric arteries

Mélissa BolMarijke De BockElke De VuystNan WangElke DecrockJhon Jairo Monsalvo CastañoKelly DecaluwéBert VanheelJohan Van de VoordeLuc Leybaert

L-β-ODAP alters mitochondrial Ca2+ handling as an early event in excitotoxicity

Marijke Van MoorhemElke DecrockElke De VuystKatleen VranckxMarijke De BockNan WangKatharina D'HerdeFernand LambeinLuc Leybaert

A1 Journal Article in CELL CALCIUM

2009

Biochemical characterisation of an in vitro model of hepatocellular apoptotic cell death.

Elke DecrockElke De VuystLuc Leybaert

A1 Journal Article in ATLA-ALTERNATIVES TO LABORATORY ANIMALS

Ca2+ regulation of connexin 43 hemichannels in C6 glioma and glial cells

Elke De VuystNan WangElke DecrockMarijke De BockMarijke Van MoorhemLuc Leybaert

A1 Journal Article in Cell Calcium

Calcium regulation of connexin-43 hemichannel-mediated ATP release in glial cells

Elke De VuystMarijke De BockNan WangElke DecrockMarijke Van MoorhemVera RogiersLuc Leybaert

Cell death communication via connexin channels investigated in a C6 glioma cell model

Elke DecrockMarijke Van MoorhemElke De VuystNan WangMarijke De BockLuc Leybaert

Cell-cell communication of apoptosis via connexin channels in a C6 glioma cell model.

Elke DecrockMarijke Van MoorhemElke De VuystNan WangMarijke De BockMélissa BolKatharina D'HerdeLuc Leybaert

Connexin 43 hemichannels contribute to the propagation of apoptotic cell death in a rat C6 glioma cell model.

Elke DecrockElke De VuystMarijke Van MoorhemKatleen VranckxNan WangMarijke De BockKatharina D'HerdeVera RogiersLuc Leybaert

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Connexin-related signaling in cell death: to live or let die?

Elke DecrockElke De VuystDmitri KryskoKatharina D'HerdePeter VandenabeeleVera RogiersLuc Leybaert

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Epigenetic regulation of gap junctional intercellular communication: more than a way to keep cells quiet?

Elke DecrockElke De VuystLuc Leybaert

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Gap junctional intercellular communication as a target for liver toxicity and carcinogenicity

Elke DecrockLuc LeybaertVera Rogiers

A1 Journal Article in CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Hemichannels contribute to Ca2+ dynamics in smooth muscle cells in acutely isolated small mesenteric arteries

Mélissa BolMarijke De BockElke De VuystNan WangElke DecrockMarijke Van MoorhemBert VanheelLuc Leybaert

Inhibition of connexin 43 hemichannel responses with high cytoplasmic calcium concentrations is mediated by mechanisms different from calcium activation of hemichannel responses

Nan WangElke De VuystMarijke De BockElke DecrockMarijke Van MoorhemLuc Leybaert

Involvement of connexin hemichannels in dynamic calcium changes and permeability of blood-brain barrier endothelial cells

Marijke De BockElke De VuystNan WangElke DecrockMarijke Van MoorhemLuc Leybaert

Neuro- and gliotoxicity of the excitatory amino acid beta-ODAP involves impaired free radical defence

Marijke Van MoorhemElke DecrockMarijke De BockNan WangElke De VuystFernand LambeinLuc Leybaert

Neuro- and gliotoxicity of the excitatory amino acid beta-ODAP involves impaired free radical difference

Marijke Van MoorhemElke DecrockMarijke De BockNan WangElke De VuystFernand LambeinLuc Leybaert

2008

Cx43 hemichannel regulation by intracellular calcium: involvement of different signaling pathways

Elke De VuystMarijke De BockElke DecrockMarijke Van MoorhemLuc Leybaert

Gliotransmitter release via Connexin 43 hemichannels: role of cytoplasmic changes

Elke De VuystMarijke De BockNan WangMarijke Van MoorhemElke Decrock

In situ bipolar Electroporation for localized cell loading with reporter dyes and investigating gap junctional coupling

Elke De VuystMarijke De BockElke DecrockMarijke Van MoorhemCyriel MabildeLuc Leybaert

A1 Journal Article in BIOPHYSICAL JOURNAL

Inhibition of Cx43 hemichannel responses with High Ca2+i is mediated by mechanisms different from calcium activation of hemichannel responses

Nan WangElke De VuystMarijke De BockElke Decrock

2007

Connexin channels mediate propagation of apoptosis in a C6 glioma cell model

Elke DecrockMarijke Van MoorhemMarijke De BockElke De VuystKatharina D'HerdeLuc Leybaert

Connexin hemichannels and gap junction channels are differentially influenced by lipopolysaccharide and basic fibroblast growth factor

Elke De VuystElke DecrockMarijke De BockLuc Leybaert

A1 Journal Article in MOLECULAR BIOLOGY OF THE CELL

Neurobarrier coupling in the brain: Adjusting glucose entry with demand

Luc LeybaertMarijke De BockMarijke Van MoorhemElke DecrockElke De Vuyst

A1 Journal Article in JOURNAL OF NEUROSCIENCE RESEARCH

2006

Connexin channels, possible mediators in apoptosis spread in a glioma cell model

Elke DecrockMarijke Van MoorhemMarijke De BockElke De VuystKatharina D'HerdeLuc Leybaert

Intracellular calcium changes trigger connexin 32 hemichannel opening

Elke De VuystElke DecrockLuc Leybaert

A1 Journal Article in EMBO JOURNAL