Research Explorer

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Researcher

Dorien Clarisse

Awards & Distinctions

42 Results

2025

CCR1 inhibition sensitizes multiple myeloma cells to glucocorticoid therapy

Bert LuyckxMaaike Van TrimpontFien DeclerckEleni StaessensAnnick VerheeSara T'SasSven EyckermanFritz OffnerPieter Van VlierbergheSteven Goossens et al.

A1 Journal Article in PHARMACOLOGICAL RESEARCH

PPARα-ERRα crosstalk mitigates metabolic dysfunction-associated steatotic liver disease progression

Milton Boaheng AntwiSander LefereDorien ClarisseLisa KoorneefAnneleen HeldensLouis OnghenaKylian DecroixDaria FijalkowskaJonathan ThommisMadeleine Hellemans et al.

A1 Journal Article in METABOLISM-CLINICAL AND EXPERIMENTAL

Synthesis and functional screening of novel inhibitors targeting the HDAC6 zinc finger ubiquitin-binding domain

Silke GeursEleni StaessensKato BredaelStefaan BorghgraefJordy De RidderLeentje PersoonsSteven De JongheDominique ScholsMandeep K. MannRachel J. Harding et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2024

Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression

Sofie DesmetJonathan ThommisTineke VanderhaeghenEdmee VandenboornDorien ClarisseYunkun LiSteven TimmermansDaria FijalkowskaDariusz RatmanEvelien Van Hamme et al.

A1 Journal Article in MOLECULAR METABOLISM

Glucocorticoid receptor signaling : intricacies and therapeutic opportunities

Dorien ClarisseLaura Van MoortelChloé Van LeeneKris GevaertKarolien De Bosscher

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

Unlocking therapeutic potential : exploring cross-talk among emerging nuclear receptors to combat metabolic dysfunction in steatotic liver disease

Milton Boaheng AntwiAriann JenningsSander LefereDorien ClarisseAnja GeertsLindsey DevisscherKarolien De Bosscher

A2 Journal Article in NPJ METABOLIC HEALTH AND DISEASE

2023

Crosstalk between glucocorticoid and mineralocorticoid receptors boosts glucocorticoid-induced killing of multiple myeloma cells

Dorien ClarisseStefan PrekovicPhilip VlummensEleni StaessensKarlien Van WesemaelJonathan ThommisDaria FijalkowskaGuillaume AckeWilbert ZwartIlse M. Beck et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

HDAC6 : one protein, two domains, diverse therapeutic opportunities : inhibitor synthesis and validation in cellular disease models

Silke GeursMatthias D'hoogheKarolien De BosscherDorien Clarisse

The zinc-binding group effect : lessons from non-hydroxamic acid vorinostat analogs

Silke GeursDorien ClarisseKarolien De BosscherMatthias D'hooghe

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

2022

Approaches towards tissue‐selective pharmacology of the mineralocorticoid receptor

Dorien ClarisseLisa DengKarolien De BosscherAchim Lother

A1 Journal Article in BRITISH JOURNAL OF PHARMACOLOGY

Carboxylic acid bioisosteres in medicinal chemistry : synthesis and properties

Kato BredaelSilke GeursDorien ClarisseKarolien De BosscherMatthias D'hooghe

A1 Journal Article in JOURNAL OF CHEMISTRY

Identification of mercaptoacetamide-based HDAC6 inhibitors via a lean inhibitor strategy : screening, synthesis, and biological evaluation

Silke GeursDorien ClarisseFreya BaeleJorick FranceusTom DesmetKarolien De BosscherMatthias D'hooghe

A1 Journal Article in CHEMICAL COMMUNICATIONS

Novel assays monitoring direct glucocorticoid receptor protein activity exhibit high predictive power for ligand activity on endogenous gene targets

Laura Van MoortelJonathan ThommisBrecht MaertensAn StaesDorien ClarisseDelphine De SutterClaude LibertOnno C. MeijerSven EyckermanKris Gevaert et al.

A1 Journal Article in BIOMEDICINE & PHARMACOTHERAPY

The ubiquitin binding domain of HDAC6 : a key regulator of aggresomal protein disposal and new therapeutic target to combat multiple myeloma

Silke GeursDorien ClarisseEleni StaessensKarolien De BosscherMatthias D'hooghe

The ubiquitin binding domain of HDAC6 : a key regulator of aggresomal protein disposal and new therapeutic target to combat multiple myeloma

Silke GeursEleni StaessensDorien ClarisseKarolien De BosscherMatthias D'hooghe

2021

How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer

Dorien ClarisseKarolien De Bosscher

Editorial material

New tricks of our old friend the glucocorticoid receptor : from combating ulcerative colitis to preventing associated colorectal cancer

Dorien ClarisseIlse Beck

Editorial material

2020

Latest perspectives on glucocorticoid-induced apoptosis and resistance in lymphoid malignancies

Dorien ClarisseFritz OffnerKarolien De Bosscher

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Nuclear receptor crosstalk : defining the mechanisms for therapeutic innovation

Karolien De BosscherSofie DesmetDorien ClarisseEva Estébanez-PerpiñaLuc Brunsveld

A1 Journal Article in NATURE REVIEWS ENDOCRINOLOGY

2018

Effect of combining glucocorticoids with Compound A on glucocorticoid receptor responsiveness in lymphoid malignancies

Dorien ClarisseKarlien Van WesemaelJan TavernierFritz OffnerIlse BeckKarolien De Bosscher

A1 Journal Article in PLOS ONE

Glucocorticoid resistance in multiple myeloma : mechanistic insights and therapeutic considerations

Dorien ClarisseKarolien De BosscherIlse Beck

2017

Coregulator profiling of the glucocorticoid receptor in lymphoid malignancies

Dorien ClarisseJonathan ThommisKarlien Van WesemaelRene HoutmanDariusz RatmanJan TavernierFritz OffnerIlse BeckKarolien De Bosscher

A1 Journal Article in ONCOTARGET

2016

Characterization of the interaction between the dopamine D4 receptor, KLHL12 and β-arrestins

Kamila SkieterskaAo ShenDorien ClarissePieter RondouDasiel Oscar Borroto-EscuelaBéatrice LintermansKjell FuxeYang Kevin XiangKathleen Van Craenenbroeck

A1 Journal Article in CELLULAR SIGNALLING

Dexamethasone induces glucocorticoid receptor (GR)-dependent mineralocorticoid receptor (MR) downregulation

Dorien ClarisseKarolien De BosscherIlse Beck

Selective glucocorticoid receptor-activating adjuvant therapy in cancer treatments

Nora SundahlDorien ClarisseMarc BrackeFritz OffnerWim Vanden BergheIlse Beck

A2 Journal Article in ONCOSCIENCE

The mineralocorticoid receptor is involved in glucocorticoid resistance

Dorien ClarisseFritz OffnerKarolien De BosscherIlse Beck

2015

Combination of dexamethasone with the selective glucocorticoid receptor modulator, Compound A, does not enhance glucocorticoid responsiveness in lymphoid malignancies

Dorien ClarisseFritz OffnerMarc BrackeKarolien De BosscherIlse Beck

Dexamethasone induces glucocorticoid receptor (GR)-dependent mineralocorticoid receptor (MR) downregulation

Dorien ClarisseKarolien De BosscherIlse Beck

Dexamethasone induces glucocorticoid receptor (GR)-dependent mineralocorticoid receptor (MR) downregulation

Dorien ClarisseKarolien De BosscherIlse Beck

Pro-inflammatory cell stress in muscle cells is directed by NFAT5

Sandrine HerbeletJens SchmidtOlivier De WeverEline NysLaurens WeynantsDorien ClarisseGlenn VergauwenBoel De PaepeJan De Bleecker

2014

Cofactor profiling of the glucocorticoid receptor from a cellular environment

Sofie DesmetLien DejagerDorien ClarisseJonathan ThommisDiana MelchersNiek BastiaensenRob RuijtenbeekIlse BeckClaude LibertRenée Houtman et al.

Bookchapter in Steroid receptors : methods and protocols

Determining the cofactor profile of the glucocorticoid receptor in lymphoid malignancies using MARCoNI

Dorien ClarisseSofie DesmetJonathan ThommisIlse BeckKarolien De Bosscher

Determining the coregulator profile of the endogenous glucocorticoid receptor in lymphoid malignancies using MARCoNI

Dorien ClarisseDariusz RatmanSofie DesmetJonathan ThommisRené HoutmanKarolien De BosscherIlse Beck

The increasing complexity of glucocorticoid receptor signaling and regulation

Sofie DesmetIlse BeckNadia BougarneDorien ClarisseJulie DeckersDariusz RatmanJan TavernierKarolien De Bosscher

A2 Journal Article in PROCEEDINGS OF THE BELGIAN ROYAL ACADEMIES OF MEDICINE

2013

Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activation

Ilse BeckZuzanna DrebertRuben Hoya-AriasAli A BaharMichael DevosDorien ClarisseSofie DesmetNadia BougarneBart RuttensValerie Gossye et al.

A1 Journal Article in PLOS ONE

Mitogen- and stress-activated protein kinase 1 (MSK1) regulates glucocorticoid response element (GRE) promoter activity in a glucocorticoid concentration-dependent manner

Ilse BeckDorien ClarisseNadia BougarneSam OkretGuy HaegemanKarolien De Bosscher

Mitogen- and stress-activated protein kinase 1 MSK1 regulates glucocorticoid response element promoter activity in a glucocorticoid concentration-dependent manner

Ilse BeckDorien ClarisseNadia BougarneSam OkretGuy HaegemanKarolien De Bosscher

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACOLOGY

2012

Functional relevance of the KLHL12-mediated D4 dopamine receptor ubiquitination

Kamila SkieterskaPieter RondouDasiel Oscar Borroto-EscuelaDorien ClarisseBéatrice LintermansGuy HaegemanKjell FuxeKathleen Van Craenenbroeck

On the track of function of KLHL12-mediated dopamine D4 receptor ubiquitination

Kamila SkieterskaPieter RondouDasiel Oscar Borroto-EscuelaDorien ClarisseBéatrice LintermansGuy HaegemanKjell FuxeKathleen Van Craenenbroeck

On the track of function of KLHL12-mediated dopamine D4 receptor ubiquitination

Kamila SkieterskaPieter RondouDasiel Oscar Borroto-EscuelaDorien ClarisseBéatrice LintermansGuy HaegemanKjell FuxeKathleen Van Craenenbroeck

The Fukui matrix : Fukui functions exposed!

Patrick BultinckGuillaume AckeDorien ClarisseDimitri Van NeckPaul W Ayers

2011

The Fukui matrix : a simple approach to the analysis of the Fukui function and its positive character

Patrick BultinckDorien ClarissePaul W AyersRamon Carbo-Dorca Carre

A1 Journal Article in PHYSICAL CHEMISTRY CHEMICAL PHYSICS