Research Explorer

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Researcher

Dmitri Krysko

Awards & Distinctions

163 Results

2025

A 3D model for assessing regulated cell death modalities

Robin DemuynckDmitri Krysko

Immunogenic cell death as interplay between physical anticancer modalities and immunotherapy

Yanou EngelenRobin DemuynckJana RamonK. BreckpotStefaan De SmedtGuillaume LajoinieKevin BraeckmansDmitri KryskoIne Lentacker

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Immunogenicity of cell death and cancer immunotherapy with immune checkpoint inhibitors

Elena CatanzaroManuel Beltran-VisiedoLorenzo GalluzziDmitri Krysko

A1 Journal Article in CELLULAR & MOLECULAR IMMUNOLOGY

2024

A guideline on the molecular ecosystem regulating ferroptosis

Enyong DaiXin ChenAndreas LinkermannXuejun JiangRui KangValerian E. KaganHuelya BayirWan Seok YangAna J. Garcia-SaezMaria S. Ioannou et al.

A1 Journal Article in NATURE CELL BIOLOGY

A near-infrared broad-spectrum antimicrobial nanoplatform powered by bacterial metabolic activity for enhanced antimicrobial photodynamic-immune therapy

Jiahao ZhengWangyang MengSuwen ChenZepeng CuiXueying XianJia TianDmitri KryskoBin LiWeian Zhang

A1 Journal Article in ACTA BIOMATERIALIA

CX3CL1 release during immunogenic apoptosis is associated with enhanced anti-tumour immunity

Faye NaessensRobin DemuynckOlga VershininaIuliia EfimovaMariia SaviukGreet De SmetTatiana A. MishchenkoMaria V. VedunovaOlga KryskoElena Catanzaro et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Cytofluorometric analysis of the maturation and activation of bone marrow-derived dendritic cells to assess immunogenic cell death

Faye NaessensIuliia EfimovaMariia SaviukDmitri Krysko

Bookchapter in Immuno-oncology and immunotherapy : part B

Enhancing glioma treatment with 3D scaffolds laden with upconversion nanoparticles and temozolomide in orthotopic mouse model

Tatiana A. MishchenkoMaria O. KlimenkoEvgenii L. GuryevAlexander G. SavelyevDmitri KryskoSergey V. GudkovEvgeny V. KhaydukovAndrei V. ZvyaginMaria V. Vedunova

A1 Journal Article in FRONTIERS IN CHEMISTRY

Glioma : bridging the tumor microenvironment, patient immune profiles and novel personalized immunotherapy

Tatiana A. MishchenkoVictoria D. TurubanovaEkaterina N. GorshkovaOlga KryskoMaria V. VedunovaDmitri Krysko

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Gold standard assessment of immunogenic cell death induced by photodynamic therapy : from in vitro to tumor mouse models and anti-cancer vaccination strategies

Tatiana A MishchenkoIrina V BalalaevaVictoria D TurubanovaMariia SaviukNatalia Yu ShilyaginaOlga KryskoMaria V VedunovaDmitri Krysko

Bookchapter in Cell-based Cancer Immunotherapy

IRONic cell death : unveiling the immunogenicity and efferocytosis of ferroptosis in cancer

Iuliia EfimovaDmitri KryskoAndre Skirtach

Immunogenicity of ferroptosis in cancer : a matter of context?

Elena CatanzaroRobin DemuynckFaye NaessensLorenzo GalluzziDmitri Krysko

A1 Journal Article in TRENDS IN CANCER

Multiple label-free microscopy techniques and machine learning to investigate regulated cancer cell death modalities

Joost VerduijnAndre SkirtachDmitri Krysko

Nanomedicine to aid immunogenic cell death (ICD)-based anticancer therapy

Robin DemuynckYanou EngelenAndre SkirtachStefaan De SmedtIne LentackerDmitri Krysko

A1 Journal Article in TRENDS IN CANCER

New trends in cell death : overview of the International Society of Cell Death (ICDS) annual meeting in Johannesburg South Africa (May 19-22, 2023)

Marianne J. CronjeVarsha GadiyarJerry Edward ChipukTugba Bagci-OnderDmitri KryskoRaymond B. BirgeRichard A. LockshinZahra Zakeri

Editorial material

Optimizing high-intensity focused ultrasound-induced immunogenic cell-death using passive cavitation mapping as a monitoring tool

Yanou EngelenDmitri KryskoIuliia EfimovaKarine BreckpotMichel VersluisStefaan De SmedtGuillaume LajoinieIne Lentacker

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Peripheral blood lymphocytes differ in DNA damage response after exposure to X-rays with different physical properties

Simon SioenLouise D'hondtFien Van HouteRobin DemuynckKlaus BacherCarlos De WagterAnne VralBarbara VanderstraetenDmitri KryskoAns Baeyens

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Photodynamic therapy in cancer : principles, state of the art, and future directions

Dmitri KryskoIrina V. BalalaevaTatiana A. Mishchenko

Editorial material

Targeting immunogenic cell death for glioma immunotherapy

Tatiana A. MishchenkoVictoria D. TurubanovaEkaterina N. GorshkovaOlga KryskoMaria V. VedunovaDmitri Krysko

Editorial material

2023

Apoptotic cell death in disease : current understanding of the NCCD 2023

Ilio VitaleFederico PietrocolaEmma GuilbaudStuart A AaronsonJohn M AbramsDieter AdamMassimiliano AgostiniPatrizia AgostinisEmad S AlnemriLucia Altucci et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Dendritic cells pulsed with tumor lysates induced by tetracyanotetra(aryl)porphyrazines-based photodynamic therapy effectively trigger anti-tumor immunity in an orthotopic mouse glioma model

Tikhon S. RedkinEkaterina E. SleptsovaVictoria D. TurubanovaMariia SaviukSvetlana A. LermontovaLarisa G. KlapshinaNina N. PeskovaIrina V. BalalaevaOlga KryskoTatiana A. Mishchenko et al.

A1 Journal Article in PHARMACEUTICS

Differential protease content of mast cells and the processing of IL-33 in Alternaria alternata induced allergic airway inflammation in mice

Olga KryskoDarya KorsakovaAndrea Renate TeufelbergerAmse De MeyerJill SteelsNatalie De RuyckJudith van OvostSharon Van NevelGabriële HoltappelsFrauke Coppieters et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Ferroptosis : friend or foe in cancer immunotherapy?

Robin DemuynckIuliia EfimovaElena CatanzaroDmitri Krysko

Editorial material

High-throughput mechano-cytometry as a method to detect apoptosis, necroptosis, and ferroptosis

Louis Van der MeerenJoost VerduijnDmitri KryskoAndre Skirtach

A1 Journal Article in CELL PROLIFERATION

In vitro transcribed RNA-based platform vaccines : past, present, and future

Alexey D. PerenkovAlena D. SergeevaMaria V. VedunovaDmitri Krysko

A1 Journal Article in VACCINES

Mechanobiology dynamics in regulated cell death : cells under pressure

Louis Van der MeerenAndre SkirtachDmitri Krysko

Mechanobiology of ferroptotic cancer cells as a novel 'eat-me' signal : regulating efferocytosis through layer-by-layer coating

Louis Van der MeerenIuliia EfimovaRobin DemuynckBogdan ParakhonskiyDmitri KryskoAndre Skirtach

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

The alpha-adrenergic antagonist prazosin promotes cytosolic siRNA delivery from lysosomal compartments

Thijs Van de VyverCristina MunteanIuliia EfimovaDmitri KryskoLynn De BackerStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Trial watch : chemotherapy-induced immunogenic cell death in oncology

Jenny SprootenRaquel S LaureanoIsaure VanmeerbeekJannes GovaertsStefan NaulaertsDaniel M BorrasLisa KingetJitka FucikovaRadek SpisekLenka Palova Jelinkova et al.

A1 Journal Article in ONCOIMMUNOLOGY

2022

DC vaccines loaded with glioma cells killed by photodynamic therapy induce Th17 anti-tumor immunity and provide a four-gene signature for glioma prognosis

Maria VedunovaVictoria TurubanovaOlga VershininaMariia SaviukIuliia EfimovaTatiana MishchenkoRobrecht RaedtAnne VralChristian VanhoveDaria Korsakova et al.

A1 Journal Article in CELL DEATH & DISEASE

Far-red fluorescent murine glioma model for accurate assessment of brain tumor progression

Tatiana A. MishchenkoIrina V. BalalaevaMaria O. KlimenkoAnna A. BrilkinaNina N. PeskovaEvgenii L. GuryevDmitri KryskoMaria V. Vedunova

A1 Journal Article in CANCERS

Immunogenic cell death and role of nanomaterials serving as therapeutic vaccine for personalized cancer immunotherapy

Elena CatanzaroOlivier FeronAndre SkirtachDmitri Krysko

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

In vitro veritas : from 2D cultures to organ-on-a-chip models to study immunogenic cell death in the tumor microenvironment

Dmitri KryskoRobin DemuynckIuliia EfimovaFaye NaessensOlga KryskoElena Catanzaro

A1 Journal Article in CELLS

Perillaldehyde is a new ferroptosis inducer with a relevant clinical potential for acute myeloid leukemia therapy

Elena CatanzaroEleonora TurriniTessa KerreSimon SioenAns BaeyensAlessandra GuerriniMohamed Lamin Abdi BellauGianni SacchettiGuglielmo PaganettoDmitri Krysko et al.

A1 Journal Article in BIOMEDICINE & PHARMACOTHERAPY

Severity of SARS-CoV-2 infection is associated with high numbers of alveolar mast cells and their degranulation

Olga KryskoJoshua H. BourneElena KondakovaElena A. GalovaKatharine WhitworthMaddy L. NewbyClaus BachertHarriet HillMax CrispinZania Stamataki et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Unraveling of functional activity of primary hippocampal neuron-glial networks in photodynamic therapy based on tetracyanotetra(aryl)porphyrazines

Maria O. SavyukVictoria D. TurubanovaTatiana A. MishchenkoSvetlana A. LermontovaLarisa G. KlapshinaDmitri KryskoMaria V. Vedunova

A1 Journal Article in CELLS

Which cell death modality wins the contest for photodynamic therapy of cancer?

Tatiana MishchenkoIrina BalalaevaAnastasia GorokhovaMaria VedunovaDmitri Krysko

A1 Journal Article in CELL DEATH & DISEASE

2021

Analysis of immunogenic cell death in the tumor microenvironment of tumor spheroids

Robin DemuynckIuliia EfimovaOlga KryskoHeidi DeclercqDmitri Krysko

Analysis of the immune responses in photo-dependent immunogenic cell death

Victoria TurubanovaDmitri KryskoMaria Vedunova

Artificial intelligence predicts severity of COVID-19 based on correlation of exaggerated monocyte activation, excessive organ damage and hyperinflammatory syndrome : a prospective clinical study

Olga KryskoElena KondakovaOlga VershininaElena GalovaAnna BlagonravovaEkaterina GorshkovaClaus BachertMikhail IvanchenkoDmitri KryskoMaria Vedunova

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Cell death stage dictates the immunogenicity of ferroptotic cancer cells

Iuliia EfimovaElena CatanzaroRobin DemuynckLouis Van der MeerenFrauke CoppietersClaus BachertAndre SkirtachOlga KryskoDmitri Krysko

Cyanoarylporphyrazines with high viscosity sensitivity : a step towards dosimetry-assisted photodynamic cancer treatment

Irina V. BalalaevaTatiana A. MishchenkoVictoria D. TurubanovaNina N. PeskovaNatalia Y. ShilyaginaVladimir I. PlekhanovSvetlana A. LermontovaLarisa G. KlapshinaMaria V. VedunovaDmitri Krysko

A1 Journal Article in MOLECULES

Deep learning with digital holographic microscopy discriminates apoptosis and necroptosis

Joost VerduijnLouis Van der MeerenDmitri KryskoAndre Skirtach

A1 Journal Article in CELL DEATH DISCOVERY

Early but not late ferroptotic cancer cells are immunogenic in vitro and in vivo

Iuliia EfimovaElena CatanzaroLouis Van der MeerenClaus BachertAndre SkirtachOlga KryskoDmitri Krysko

Encapsulation of cells in gold nanoparticle functionalized hybrid Layer-by-Layer (LbL) hybrid shells : remote effect of laser light

Louis Van der MeerenJoost VerduijnJie LiEllen VerweeDmitri KryskoBogdan ParakhonskiyAndre Skirtach

A2 Journal Article in APPLIED SURFACE SCIENCE ADVANCES

Ferroptosis and photodynamic therapy synergism : enhancing anticancer treatment

Tatiana A. MishchenkoIrina V. BalalaevaMaria V. VedunovaDmitri Krysko

Editorial material

Immunogenic cell death in photodynamic-induced tumor cells based on photosens and photodithazine

Viktoria TurubanovaIuliia EfimovaTatiana MishchenkoElena CatanzaroIrina BalalaevaClaus BachertOlga KryskoMaria VedunovaDmitri Krysko

Immunogenic cell death induced by PDT : a new approach for cancer therapy

Dmitri KryskoVictoria TurubanovaTatiana MishchenkoIrina BalalaevaIuliia EfimovaOlga KryskoMaria Vedunova

Immunogenic ferroptosis and where to find it?

Robin DemuynckIuliia EfimovaFaye NaessensDmitri Krysko

A1 Journal Article in JOURNAL FOR IMMUNOTHERAPY OF CANCER

Novel porphyrazine-based photodynamic anti-cancer therapy induces immunogenic cell death

Victoria D. TurubanovaTatiana A. MishchenkoV Balalaeva, IrinaIuliia EfimovaNina N. PeskovaLarisa G. KlapshinaSvetlana A. LermontovaClaus BachertOlga KryskoMaria V. Vedunova et al.

A1 Journal Article in SCIENTIFIC REPORTS

Targeting immunogenic cancer cell death by photodynamic therapy : past, present and future

Razan AlzeibakTatiana A. MishchenkoNatalia Y. ShilyaginaIrina V. BalalaevaMaria V. VedunovaDmitri Krysko

A1 Journal Article in JOURNAL FOR IMMUNOTHERAPY OF CANCER

2020

A 3D cell death assay to quantitatively determine ferroptosis in spheroids

Robin DemuynckIuliia EfimovaAbraham LinHeidi DeclercqDmitri Krysko

A1 Journal Article in CELLS

AFM analysis enables differentiation between apoptosis, necroptosis, and ferroptosis in murine cancer cells

Louis Van der MeerenJoost VerduijnDmitri KryskoAndre Skirtach

A1 Journal Article in ISCIENCE

Classification of analytics, sensorics, and bioanalytics with polyelectrolyte multilayer capsules

Louis Van der MeerenJie LiBogdan ParakhonskiyDmitri KryskoAndre Skirtach

A1 Journal Article in ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Curcumin-1,2,3-Triazole Conjugation for Targeting the Cancer Apoptosis Machinery

Francesca SeghettiRita Maria Concetta Di MartinoElena CatanzaroAlessandra BisiSilvia GobbiAngela RampaBarbara CanonicoMariele MontanariDmitri KryskoStefano Papa et al.

A1 Journal Article in MOLECULES

Cx43 channels and signaling via IP3/Ca2+, ATP, and ROS/NO propagate radiation-induced DNA damage to non-irradiated brain microvascular endothelial cells

Delphine HoorelbekeElke DecrockMaarten De SmetMarijke De BockBenedicte DescampsValérie Van HaverTinneke DelvaeyeDmitri KryskoChristian VanhoveGeert Bultynck et al.

A1 Journal Article in CELL DEATH & DISEASE

Effect of novel porphyrazine photosensitizers on normal and tumor brain cells

Tatiana A MishchenkoVictoria D TurubanovaElena V MitroshinaRazan AlzeibakNina N PeskovaSvetlana A LermontovaLarisa G KlapshinaIrina V BalalaevaMaria V VedunovaDmitri Krysko

A1 Journal Article in JOURNAL OF BIOPHOTONICS

Identification of a novel pathway in immune response towards S. aureus protease like protein D

Olga KryskoAndrea Renate TeufelbergerSharon Van NevelSzanne De GraevePaco HulpiauM. NordengruenB. M. BroekerDmitri KryskoClaus Bachert

Immunodominant AH1 antigen-deficient necroptotic, but not apoptotic, murine cancer cells induce antitumor protection

Tania Love AaesHanne VerschuereAgnieszka KaczmarekLiesbeth HeyndrickxBartosz WiernickiIris DelrueBram De CraeneJoachim TaminauTinneke DelvaeyeMathieu Bertrand et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Mouse strain-dependent difference toward the staphylococcus aureus allergen serine protease-like protein D reveals a novel regulator of IL-33

Andrea Renate TeufelbergerSharon Van NevelPaco HulpiauMaria NordengrünSavvas SavvidesSarah De GraeveSrinivas AkulaGabriële HoltappelsNatalie De RuyckWim Declercq et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Necroptosis in immuno-oncology and cancer immunotherapy

Jenny SprootenPieter De WijngaertIsaure VanmeerbeekShaun MartinPeter VangheluweSusan SchlennerDmitri KryskoJan B. ParysGeert BultynckPeter Vandenabeele et al.

A1 Journal Article in CELLS

Targeting topoisomerase II with trypthantrin derivatives : discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer

Elena CatanzaroNibal BetariJose M. ArencibiaSerena MontanariClaudia SissiAngela De SimoneIvano VassuraAlan SantiniVincenza AndrisanoVincenzo Tumiatti et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity

Iuliia EfimovaElena CatanzaroLouis Van der MeerenVictoria TurubanovaHamida HammadTatiana MishchenkoMaria VedunovaCarmela FimognariClaus BachertFrauke Coppieters et al.

A1 Journal Article in JOURNAL FOR IMMUNOTHERAPY OF CANCER

2019

An emerging role for nanomaterials in increasing immunogenicity of cancer cell death

Tatiana MishchenkoElena MitroshinaIrina BalalaevaOlga KryskoMaria VedunovaDmitri Krysko

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock

Tinneke DelvaeyeMaarten De SmetStijn VerwaerdeElke DecrockAleksandra CzekajRoosmarijn VandenbrouckeKelly LemeireAmanda GonçalvesWim DeclercqPeter Vandenabeele et al.

A1 Journal Article in SCIENTIFIC REPORTS

Effect of photosensitizers photosens, photodithazine and hypericin on glioma cells and primary neuronal cultures : a comparative analysis

Tatiana MishchenkoElena MitroshinaViktoria TurubanovaRozan Alzeibakirina BalalaevaMaria VedunovaDmitri Krysko

A2 Journal Article in SOVREMENNYE TEHNOLOGII V MEDICINE

Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion

Jose Pedro Friedmann AngeliDmitri KryskoMarcus Conrad

A1 Journal Article in NATURE REVIEWS CANCER

Immunogenic cell death induced by a new photodynamic therapy based on photosens and photodithazine

Victoria D TurubanovaIrina V BalalaevaTatiana A MishchenkoElena CatanzaroRazan AlzeibakNina N PeskovaIuliia EfimovaClaus BachertElena V MitroshinaOlga Krysko et al.

A1 Journal Article in JOURNAL FOR IMMUNOTHERAPY OF CANCER

Protease/antiprotease network in allergy : the role of Staphylococcus aureus protease-like proteins

Olga KryskoAndrea Renate TeufelbergerSharon Van NevelDmitri KryskoClaus Bachert

A1 Journal Article in ALLERGY

Redox (phospho)lipidomics of signaling in inflammation and programmed cell death

YY TyurinaCM St CroixSC WatkinsAM WatsonMW EpperlyTS AnthonymuthuER KisinII VlasovaOlga KryskoDmitri Krysko et al.

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Staphylococcus aureus orchestrates type 2 airway diseases

Andrea Renate TeufelbergerBarbara M. BrökerDmitri KryskoClaus BachertOlga Krysko

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

2018

Fabrication of prevascularized spheroids for bioprinting

Lise De MoorIdriz MerovciSarah BaetensBieke BekaertJulien VerstraetenPaulina KowalskaSandra Van VlierberghePeter DubruelDmitri KryskoWinnok De Vos et al.

Generation and bioprinting of prevascularized spheroids using a photo-crosslinkable gelatin

Lise De MoorIdriz MerovciSarah BaetensBieke BekaertJulien VerstraetenPaulina KowalskaSandra Van VlierberghePeter DubruelDmitri KryskoWinnok De Vos et al.

High-throughput fabrication of vascularized spheroids for bioprinting

Lise De MoorIdriz MerovciSarah BaetensJulien VerstraetenPaulina KowalskaDmitri KryskoWinnok De VosHeidi Declercq

A1 Journal Article in BIOFABRICATION

Lipid homeostasis and inflammatory activation are disturbed in classically activated macrophages with peroxisomal β-oxidation deficiency

Ivana GericYulia Y TyurinaOlga KryskoDmitri KryskoEvelyn De SchryverValerian E KaganPaul P Van VeldhovenMyriam BaesSimon Verheijden

A1 Journal Article in IMMUNOLOGY

Macrophages regulate the clearance of living cells by calreticulin

Dmitri KryskoKodi RavichandranPeter Vandenabeele

Editorial material

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

Behrouz HassanniaBartosz WiernickiIrina IngoldFeng QuSimon Van HerckYulia Y. TyurinaHülya BayırBehnaz A. AbhariJose Pedro Friedmann AngeliSze Men Choi et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Noninvasive whole-body imaging of phosphatidylethanolamine as a cell death marker using 99mTc-duramycin during TNF-induced SIRS

Tinneke DelvaeyeLeonie wyffelsSteven DeleyeKelly LemeireAmanda GonçalvesElke DecrockSteven StaelensLuc LeybaertPeter VandenabeeleDmitri Krysko

A1 Journal Article in JOURNAL OF NUCLEAR MEDICINE

Radiation-induced leukemia : response of hematopoietic stem cells and progenitor cells to clinical therapy beams

Bram VerstraeteAnne VralDmitri KryskoAns Baeyens

The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus-derived serine protease-like protein D

Andrea Renate TeufelbergerMaria NordengrünHarald BraunTania MaesKatrien De GroveGabriële HoltappelsClara O'BrienSharen ProvoostHamida HammadAmanda Gonçalves et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The interplay of the staphylococcal protease SplD and IL-33 in the development of allergic asthma in mice

Andrea Renate TeufelbergerClaus BachertOlga KryskoDmitri Krysko

The pathological role of Cx43 and MLKL in TNF-induced systemic inflammatory response syndrome

Tinneke DelvaeyePeter VandenabeeleLuc LeybaertDmitri Krysko

Therapeutic targeting of connexin channels : new views and challenges

Tinneke DelvaeyePeter VandenabeeleGeert BultynckLuc LeybaertDmitri Krysko

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

2017

At the cross-point of connexins, calcium, and ATP : blocking hemichannels inhibits vasoconstriction of rat small mesenteric arteries

Mélissa BolNan WangMarijke De BockBenjamin WacquierElke DecrockAshish GadicherlaKatrijn DecaluweBert VanheelHarold Victor Maria van RijenDmitri Krysko et al.

A1 Journal Article in CARDIOVASCULAR RESEARCH

Calcium, oxidative stress and connexin channels, a harmonious orchestra directing the response to radiotherapy treatment?

Elke DecrockDelphine HoorelbekeRaghda RamadanTinneke DelvaeyeMarijke De BockNan WangDmitri KryskoSarah BaatoutGeert BultynckAn Aerts et al.

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ferroptosis : oxidized PEs trigger death

Katharina D'HerdeDmitri Krysko

Ionizing radiation-induced cell death

Sandy Adjemian CataniKatrien VandecasteeleSofie MartensBartosz WiernickiTania Love AaesDmitri KryskoPeter Vandenabeele

Low concentration of uncouplers of oxidative phosphorylation decreases the TNF-induced endothelial permeability and lethality in mice

Vlada V ZakharovaOlga Yu PletjushkinaIvan I GalkinRoman A ZinovkinBoris V ChernyakDmitri KryskoClaus BachertOlga KryskoVladimir P SkulachevEkaterina N Popova

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial Cx43 hemichannels contribute to mitochondrial calcium entry and cell death in the heart

Ashish GadicherlaNan WangMarco BulicEsperanza Agullo-PascualAlessio LissoniMaarten De SmetMario DelmarGeert BultynckDmitri KryskoAmadou Camara et al.

A1 Journal Article in BASIC RESEARCH IN CARDIOLOGY

Modulation of Cx43 hemichannels by TNFα in HeLa cells overexpressing Cx43

Stijn VerwaerdeMaarten De SmetTinneke DelvaeyeAlessio LissoniPeter VandenabeeleDmitri KryskoLuc Leybaert

Necroptotic cell death in anti-cancer therapy

Olga KryskoTania Love AaesValerian E KaganKatharina D'HerdeClaus BachertLuc LeybaertPeter VandenabeeleDmitri Krysko

A1 Journal Article in IMMUNOLOGICAL REVIEWS

Role of necroptotic cancer cells in anti-cancer immunity

Dmitri KryskoTania Love AaesPeter Vandenabeele

The impact of cell death modalities on the immunogenicity of cancer cells

Tania Love AaesPeter VandenabeeleDmitri Krysko

2016

A real-time fluorometric method for the simultaneous detection of cell death type and rate

Sasker GrootjansBehrouz HassanniaIris DelrueVera GoossensBartosz WiernickiYves DondelingerMathieu BertrandDmitri KryskoMarnik VuylstekePeter Vandenabeele et al.

A1 Journal Article in NATURE PROTOCOLS

Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice

Simon D PouwelsG Jan ZijlstraMarco van der ToornLaura HesseRenee GrasNick HT ten HackenDmitri KryskoPeter VandenabeeleMaaike de VriesAntoon JM van Oosterhout et al.

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Extracellular ATP and P₂X₇ receptor exert context-specific immunogenic effects after immunogenic cancer cell death

AD GargDmitri KryskoPeter VandenabeeleP Agostinis

A1 Journal Article in CELL DEATH & DISEASE

Immunogenic apoptotic cell death and anticancer immunity

Peter VandenabeeleKatrien VandecasteeleClaus BachertOlga KryskoDmitri Krysko

A1 Journal Article in Advances in Experimental Medicine and Biology

Necroptosis: a novel cell death modality and its potential relevance for critical care medicine

Gabriel Moreno-GonzalezPeter VandenabeeleDmitri Krysko

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role and contribution of mitochondrial connexin43, complex I and calcium sensitive potassium channels in cardiac ischemia-reperfusion injury

Ashish GadicherlaLuc LeybaertAlexander PanfilovDmitri Krysko

The protease SplD provides a link between asthma and mucosal S. aureus colonization

Andrea Renate TeufelbergerS StentzelHarald BraunTania MaesGabriële HoltappelsSharen ProvoostKatrien De GroveRudi BeyaertDmitri KryskoB Broeker et al.

Vaccination with necroptotic cancer cells induces efficient anti-tumor immunity

Tania Love AaesAgnieszka KaczmarekTinneke DelvaeyeBram De CraeneStefaan De KokerLiesbeth HeyndrickxIris DelrueJoachim TaminauBartosz WiernickiPhilippe De Groote et al.

A1 Journal Article in CELL REPORTS

2015

Molecular and translational classifications of DAMPs in immunogenic cell death

Abhishek D GargLorenzo GalluzziLionel ApetohThais BaertRaymond B BirgeJosé Manuel Bravo-San PedroKarine BreckpotDavid BroughRicardo ChaurioMara Cirone et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal

Abhishek D GargSanne ElsenDmitri KryskoPeter VandenabeelePeter de WittePatrizia Agostinis

A1 Journal Article in ONCOTARGET

Wavelet modeling and prediction of the stability of states: the Roman Empire and the European Union

Tatyana Y YaroshenkoDmitri KryskoVitalii DobriyanMaksim V ZhigalovHendrik VosPeter VandenabeeleVadim A Krysko

A1 Journal Article in COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION

2014

BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton

H MaesS Van EygenDmitri KryskoPeter VandenabeeleK NysK RillaertsAD GargT VerfaillieP Agostinis

A1 Journal Article in CELL DEATH & DISEASE

Consensus guidelines for the detection of immunogenic cell death

Oliver KeppLaura SenovillaIlio VitaleErika VacchelliSandy AdjemianPatrizia AgostinisLionel ApetohFernando ArandaVincenzo BarnabaNorma Bloy et al.

A1 Journal Article in ONCOIMMUNOLOGY

DAMPs activating innate and adaptive immune responses in COPD

SD PouwelsIH HeijinkNHT ten HackenPeter VandenabeeleDmitri KryskoMC NawijnAJM van Oosterhout

A1 Journal Article in MUCOSAL IMMUNOLOGY

2013

Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells

Kristof SchuttersDennis HM KustersMartijn LL ChatrouTrinidad Montero-MelendezMarjo DonnersNiko M DeckersDmitri KryskoPeter VandenabeeleMauro PerrettiLeon J Schurgers et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Determination of apoptotic and necrotic cell death in vitro and in vivo

Tom Vanden BergheSasker GrootjansVera GoossensYves DondelingerDmitri KryskoNozomi TakahashiPeter Vandenabeele

A1 Journal Article in METHODS

IP₃, a small molecule with a powerful message

Elke DecrockMarijke De BockNan WangAshish GadicherlaMélissa BolTinneke DelvaeyePeter VandenabeeleMathieu VinkenGeert BultynckDmitri Krysko et al.

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inducers of immunogenic cancer cell death

Aleksandra M DudekAbhishek D GargDmitri KryskoDirk De RuysscherPatrizia Agostinis

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

Inhibition of necroptosis reduces cigarette smoke-induced epithelial cell-death and damage associated molecular pattern release in vitro and airway neutrophilia in mice

J ZijlstraM Van der ToornD PouwelsNHT Ten HackenDmitri KryskoIH HeijinkMC NawijnAJM Van Oosterhout

Many faces of DAMPs in cancer therapy

Olga KryskoTania Love AaesClaus BachertPeter VandenabeeleDmitri Krysko

A1 Journal Article in CELL DEATH & DISEASE

Necroptosis: the release of damage-associated molecular patterns and its physiological relevance

Agnieszka KaczmarekPeter VandenabeeleDmitri Krysko

A1 Journal Article in IMMUNITY

Peroxisomal multifunctional protein-2 deficiency causes neuroinflammation and degeneration of Purkinje cells independent of very long chain fatty acid accumulation

Simon VerheijdenAstrid BottelbergsOlga KryskoDmitri KryskoLien BeckersStephanie De MunterPaul P Van VeldhovenSabine WynsWim KulikKlaus-Armin Nave et al.

A1 Journal Article in NEUROBIOLOGY OF DISEASE

ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death

Abhishek D GargAleksandra M DudekGabriela B FerreiraTom VerfailliePeter VandenabeeleDmitri KryskoChantal MathieuPatrizia Agostinis

A1 Journal Article in AUTOPHAGY

Sensing of apoptotic and necroptotic cell death by the innate immune system

Agnieszka KaczmarekPeter VandenabeeleDmitri Krysko

TNF/TNF-R1 pathway is involved in doxorubicin-induced acute sterile inflammation

Agnieszka KaczmarekOlga KryskoLiesbeth HeyndrickxTania Love AaesTinneke DelvaeyeClaus BachertLuc LeybaertPeter VandenabeeleDmitri Krysko

A1 Journal Article in CELL DEATH & DISEASE

The adjuvant-like activity of staphylococcal enterotoxin B in a murine asthma model is independent of IL-1R signaling

Olga KryskoTania MaesMaud PlantingaGabriële HoltappelsRosina ImiruPeter VandenabeeleGuy JoosDmitri KryskoClaus Bachert

A1 Journal Article in ALLERGY

2012

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

Abhishek D GargDmitri KryskoTom VerfaillieAgnieszka KaczmarekGabriela B FerreiraThiery MarysaelNoemi RubioMalgrozata FirczukChantal MathieuAnton JM Roebroek et al.

A1 Journal Article in EMBO JOURNAL

ATP release from dying autophagic cells and their phagocytosis are crucial for inflammasome activation in macrophages

Gizem AynaDmitri KryskoAgnieszka KaczmarekGoran PetrovskiPeter VandenabeeleLászló Fésüs

A1 Journal Article in PLOS ONE

Contribution of ER stress to immunogenic cancer cell death

Abhishek D GargDmitri KryskoJakub GolabPeter VandenabeelePatrizia Agostinis

Bookchapter in Endoplasmic reticulum stress in health and disease

Damage-associated molecular patterns : revealing the molecular communication between dying cancer cells and the immune system

Abhishek GargPatrizia AgostinisDmitri Krysko

ER stress and inflammation

Abhsihek D GargAgnieszka KaczmarekDmitri KryskoPeter Vandenabeele

Bookchapter in Endoplasmic reticulum stress in health and disease

ER stress-induced inflammation: does it aid or impede disease progression?

Abhishek GargAgnieszka KaczmarekOlga KryskoPeter VandenabeeleDmitri KryskoPatrizia Agostinis

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

Growth inhibition of pancreatic cancer by experimental treatment with 4-phenylbutyrate is associated with increased expression of connexin 43

Dmitriy I DovzhanskiyWerner HartwigNóra G LázárAlexandra SchmidtKlaus FelixBeate K StraubThilo HackertDmitri KryskoJens Werner

A1 Journal Article in ONCOLOGY RESEARCH

Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin

Abhishek D GargDmitri KryskoPeter VandenabeelePatrizia Agostinis

A1 Journal Article in CANCER IMMUNOLOGY IMMUNOTHERAPY

Immunogenic cell death and DAMPs in cancer therapy

Dmitri KryskoAbhishek D GargAgnieszka KaczmarekOlga KryskoPatrizia AgostinisPeter Vandenabeele

A1 Journal Article in NATURE REVIEWS CANCER

Immunogenic cell death and emission of damps: calreticulin and ATP

Editorial material

Impact of the histone deacetylase inhibitor 4-phenylbutyrate on the clearance of apoptotic pancreatic carcinoma cells by human macrophages

Lena WelschThilo WelschDmitriy I DovzhanskiyKlaus FelixNathalia A GieseDmitri KryskoJens Werner

A1 Journal Article in INTERNATIONAL JOURNAL OF ONCOLOGY

Severity of doxorubicin-induced small intestinal mucositis is regulated by the TLR-2 and TLR-9 pathways

Agnieszka KaczmarekBrigitta BrinkmanLiesbeth HeyndrickxPeter VandenabeeleDmitri Krysko

A1 Journal Article in JOURNAL OF PATHOLOGY

The emergence of phox-ER stress induced immunogenic apoptosis

Abhishek D GargDmitri KryskoPeter VandenabeelePatrizia Agostinis

Editorial material

Transfer of IP3 through gap junctions is critical, but not sufficient, for the spread of apoptosis

Elke DecrockDmitri KryskoMathieu VinkenAgnieszka KaczmarekGiulia CrispinoMélissa BolNan WangMarijke De BockElke De VuystChristian C Naus et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2011

Alternatively activated macrophages and impaired phagocytosis of S-aureus in chronic rhinosinusitis

Olga KryskoGabriële HoltappelsNan ZhangMalgorzata KubicaKim DeswarteLara DeryckeSofie ClaeysHamida HammadGuy BrussellePeter Vandenabeele et al.

A1 Journal Article in ALLERGY

Calcium and connexin-based intercellular communication, a deadly catch?

Elke DecrockMathieu VinkenMélissa BolKatharina D'HerdeVera RogiersPeter VandenabeeleDmitri KryskoGeert BultynckLuc Leybaert

A1 Journal Article in CELL CALCIUM

DAMPs and PDT-mediated photo-oxidative stress: exploring the unknown

Abhishek D GargDmitri KryskoPeter VandenabeelePatrizia Agostinis

A1 Journal Article in PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Effect of LPS, dsRNA or interferons on the phagocytosis of dying cells or mycobacteria by macrophages

Frederic VanzemberghGreet BrouckaertFlorence NazéSteven Van GuchtTom Vanden BergheDmitri KryskoPeter VandenabeeleMichael Kalai

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

Dmitri KryskoPatrizia AgostinisOlga KryskoAbhishek D GargClaus BachertBart LambrechtPeter Vandenabeele

A1 Journal Article in TRENDS IN IMMUNOLOGY

TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation

Dmitri KryskoAgnieszka KaczmarekOlga KryskoLiesbeth HeyndrickxJerzy WoznickiPieter BogaertAnje CauwelsNozomi TakahashiS MagezClaus Bachert et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2010

Clearance of dead cells: mechanisms, immune responses and implication in the development of diseases

Dmitri KryskoPeter Vandenabeele

Editorial material

Immunogenic cell death, DAMPs and anticancer therapeutics: An emerging amalgamation

AD GargD NowisJ GolabPeter VandenabeeleDmitri KryskoP Agostinis

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Impairment of phagocytosis of apoptotic cells and its role in chronic airway diseases

Olga KryskoPeter VandenabeeleDmitri KryskoClaus Bachert

A1 Journal Article in APOPTOSIS

MYD88, TLR-2, TLR-9 and TNFR1-dependent signaling is essential for the sterile inflammatory response triggered by doxorubicin

Dmitri KryskoAgnieszka KaczmarekJerzy WoznickiStefan MagezOlga KryskoPieter BogaertPeter Vandenabeele

Биотехнология: современные аспекы

A4 Journal Article in NOVUS TREND

2009

Connexin-related signaling in cell death: to live or let die?

Elke DecrockMathieu VinkenElke De VuystDmitri KryskoKatharina D'HerdeTamara VanhaeckePeter VandenabeeleVera RogiersLuc Leybaert

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Mitotic catastrophe as a prestage to necrosis in mouse liver cells treated with Helicobacter pullorum sonicates

Liesbeth M CeelenFreddy HaesebrouckKatharina D'HerdeDmitri KryskoHerman FavoreelPeter VandenabeeleRichard DucatelleAnnemie Decostere

A1 Journal Article in JOURNAL OF MORPHOLOGY

Molecular pathways of different types of cell death: many roads to death

Dmitri KryskoAgnieszka KaczmarekPeter Vandenabeele

Bookchapter in Phagocytosis of dying cells: from molecular mechanisms to human diseases

Phagocytosis of dying cells: from molecular mechanisms to human diseases

2008

Apoptosis and necrosis: Detection, discrimination and phagocytosis

Dmitri KryskoTom Vanden BergheKatharina D'HerdePeter Vandenabeele

A1 Journal Article in METHODS

From regulation of dying cell engulfment to development of anti-cancer therapy

Dmitri KryskoPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Life and death of female gametes during oogenesis and folliculogenesis

Dmitri KryskoAraceli Diez FraileGodelieve CrielAndrei SvistunovPeter VandenabeeleKatharina D'Herde

A1 Journal Article in Apoptosis

Methods for distinguishing apoptotic from necrotic cells and measuring their clearance

Dmitri KryskoTom Vanden BergheEef ParthoensKatharina D'HerdePeter Vandenabeele

A1 Journal Article in METHODS IN ENZYMOLOGY

Molecular mechanisms and pathophysiology of necrotic cell death

Nele VanlangenakkerTom Vanden BergheDmitri KryskoNele FestjensPeter Vandenabeele

A1 Journal Article in CURRENT MOLECULAR MEDICINE

2007

Cell death types at a glance

Dmitri KryskoPeter VandenabeeleKatharina D'Herde

Bookchapter in Cell Apoptosis Research Advances

2006

Cell death: initiation, propagation and clearance

Dmitri KryskoKatharina D'HerdePeter Vandenabeele

Clearance of apoptotic and necrotic cells and its immunological consequences

Dmitri KryskoKatharina D'HerdePeter Vandenabeele

A1 Journal Article in APOPTOSIS

Macrophages use different internalization mechanisms to clear apoptotic and necrotic cells

Dmitri KryskoGeertrui DeneckerNele FestjensSofie GabriëlsEef ParthoensKatharina D'HerdePeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2005

Gap junctions and the propagation of cell survival and cell death signals

Dmitri KryskoLuc LeybaertPeter VandenabeeleKatharina D'Herde

A1 Journal Article in APOPTOSIS

2004

Gap junctional communication and connexin43 expression in relation to apoptotic cell death and survival of granulosa cells

Dmitri KryskoSylvie MusscheLuc LeybaertKatharina D'Herde

A1 Journal Article in JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

More than one way to die: methods to determine TNF-induced apoptosis and necrosis

Tom Vanden BergheGeertrui DeneckerGreet BrouckaertDmitri KryskoKatharina D'HerdePeter Vandenabeele

A4 Journal Article in METHODS IN MOLECULAR MEDICINE

Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production

Greet BrouckaertMichaël KalaiDmitri KryskoXavier SaelensDominique VercammenMatladi NdlovuGuy HaegemanKatharina D'HerdePeter Vandenabeele

A1 Journal Article in MOLECULAR BIOLOGY OF THE CELL

2003

Mechanisms of internalization of apoptotic and necrotic L929 cells by a macrophage cell line studied by electron microscopy

Dmitri KryskoGreet BrouckaertMichaël KalaiPeter VandenabeeleKatharina D'Herde

A1 Journal Article in JOURNAL OF MORPHOLOGY

2001

Mitochondrial transmembrane potential changes support the concept of mitochondrial heterogeneity during apoptosis

Dmitri KryskoFrank RoelsLuc LeybaertKatharina D'Herde

A1 Journal Article in JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY