Research Explorer

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Researcher

Dieter Demon

Publications & Research Data

Awards & Distinctions

35 Results

2024

Caspase-12 is expressed in Purkinje neurons and prevents psychiatric-like behavior in mice

Lin-Yan HuangYi-Ning LiuJie ChenHai-Xue ZhuLi-Li LiZhi-Yan LiangJin-Xiu SongYu-Jie LiZhao-Li HuDieter Demon et al.

A1 Journal Article in MOLECULAR NEUROBIOLOGY

2023

The autoinflammation-associated NLRC4<SUP>V341A</SUP> mutation increases microbiota-independent IL-18 production but does not recapitulate human autoinflammatory symptoms in mice

Elien EeckhoutTomoko AsaokaHanne Van GorpDieter DemonCharlotte Girard-Guyonvarc'hVanessa AndriesLars VereeckeCem GabayMohamed LamkanfiGeert van Loo et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2022

GSDMD drives canonical inflammasome-induced neutrophil pyroptosis and is dispensable for NETosis

Dhruv ChauhanDieter DemonLieselotte Vande WalleOonagh PaerewijckAnnalisa ZecchinLeslie BosselerKarin SantoniRemi PlanesSilvia Ribó GenéAmelie Fossoul et al.

A1 Journal Article in EMBO REPORTS

2019

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

Lieselotte Vande WalleIrma B StowePavel SachaBettina L LeeDieter DemonAmelie FossoulFilip Van HauwermeirenPedro Henrique Viana SaavedraPetr SimonVladimir Subrt et al.

A1 Journal Article in PLOS BIOLOGY

2017

Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4

Nina Van OpdenboschHanne Van GorpMaarten VerdoncktPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosAmanda GonçalvesLieselotte Vande WalleDieter DemonMagdalena MatusiakFilip Van Hauwermeiren et al.

A1 Journal Article in CELL REPORTS

Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections

M HassaneDieter DemonD SoulardJ FontaineLE KellerEC PatinR PorteI PrinzB RyffelA Kadioglu et al.

A1 Journal Article in MUCOSAL IMMUNOLOGY

2016

Complementarity and redundancy of IL-22-producing innate lymphoid cells

Lucille C RankinMathilde JH Girard-MadouxCyril SeilletLisa A MielkeYann KerdilesAurore FenisElisabeth WieduwildTracy PutoczkiStanislas MondotOlivier Lantz et al.

A1 Journal Article in NATURE IMMUNOLOGY

Does caspase-12 suppress inflammasome activation?

Lieselotte Vande WalleDaniel Jiménez FernandezDieter DemonNaomi Van LaethemFilip Van HauwermeirenHanne Van GorpNina Van OpdenboschNobuhiko KayagakiMohamed Lamkanfi

A1 Journal Article in NATURE

Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

Hanne Van GorpPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosNina Van OpdenboschLieselotte Vande WalleMagdalena MatusiakGiusi PrencipeAntonella InsalacoFilip Van HauwermeirenDieter Demon et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2015

Escherichia coli α-hemolysin counteracts the anti-virulence innate immune response triggered by the Rho GTPase activating toxin CNF1 during bacteremia

Mamady DiabatePatrick MunroElsa GarciaArnaud JacquelGregory MichelSandrine ObbaDiogo GoncalvesCarmelo LuciSandrine MarchettiDieter Demon et al.

A1 Journal Article in PLOS PATHOGENS

Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes

Elke YdensDieter DemonGuillaume LornetVicky De WinterVincent TimmermanMohamed LamkanfiSophie Janssens

A1 Journal Article in JOURNAL OF NEUROINFLAMMATION

Protective and detrimental roles of inflammasomes in disease

Pedro Henrique Viana SaavedraDieter DemonHanne Van GorpMohamed Lamkanfi

A1 Journal Article in SEMINARS IN IMMUNOPATHOLOGY

2014

Adaptation of an intraductal mouse mastitis model to study the effect of inflammation in breast cancer metastasis

Koen BreyneSofie DeniesDieter DemonNiek SandersEvelyne Meyer

Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis

Dieter DemonAnna KuchmiyAmelie FossoulQ ZhuT-D KannegantiMohamed Lamkanfi

A1 Journal Article in MUCOSAL IMMUNOLOGY

Non-classical ProIL-1beta activation during mammary gland infection is pathogen-dependent but caspase-1 independent

Koen BreyneSteven CoolDieter DemonKristel DemeyereTom VandenberghePeter VandenabeeleHarald CarlsenWim Van Den BroeckNiek SandersEvelyne Meyer

Non-classical ProIL-1beta activation during mammary gland infection is pathogen-dependent but caspase-1 independent

Koen BreyneSteven CoolDieter DemonKristel DemeyereTom VandenberghePeter VandenabeeleHarald CarlsenWim Van Den BroeckNiek SandersEvelyne Meyer

A1 Journal Article in PLOS ONE

Optimalization and characterization of a novel intraductal mouse mammary tumor model

Koen BreyneSofie DeniesDieter DemonNiek SandersEvelyne Meyer

Sensing the enemy within: how macrophages detect intracellular Gram-negative bacteria

Dieter DemonLieselotte Vande WalleMohamed Lamkanfi

Editorial material

Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock

Tom Vanden BergheDieter DemonPieter BogaertBenjamin VandendriesscheAlain GoethalsBart DepuydtMarnik VuylstekeRia RoelandtElien Van WonterghemJill Vandenbroecke et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

2013

An inactivating caspase-11 passenger mutation muddles sepsis research

Tom Vanden BergheAlain GoethalsDieter DemonPieter BogaertTak W MakAnje CauwelsPeter Vandenabeele

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Escherichia coli induces bovine neutrophil cell death independent from caspase-3/-7/-1, but with phosphatidylserine exposure prior to membrane rupture

Kristel DemeyereQuinten RemijsenDieter DemonKoen BreyneSofie NotebaertFilip BoyenChristopher J GuérinPeter VandenabeeleEvelyne Meyer

A1 Journal Article in VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Short communication: Antimicrobial efficacy of intramammary treatment with a novel biphenomycin compound against Staphylococcus aureus, Streptococcus uberis, and Escherichia coli-induced mouse mastitis

Dieter DemonKoen BreyneGuido SchifferEvelyne Meyer

A1 Journal Article in JOURNAL OF DAIRY SCIENCE

2012

Chitinase-like proteins are candidate biomarkers for sepsis-induced acute kidney injury

Bert MaddensBart GhesquièreRaymond VanholderDieter DemonJ VanmassenhoveKris GevaertEvelyne Meyer

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Flow cytometric immunophenotyping of the bacterially infected murine mammary gland

Koen BreyneKristel DemeyereDieter DemonHoward KendrickWim Van Den BroeckMatthew SmalleyEvelyne Meyer

Severity of sepsis-induced acute kidney injury in a novel mouse model is age dependent

Bert MaddensBenjamin VandendriesscheDieter DemonRaymond VanholderKoen ChiersAnje CauwelsEvelyne Meyer

A1 Journal Article in CRITICAL CARE MEDICINE

The intramammary efficacy of first generation cephalosporins against Staphylococcus aureus mastitis in mice

Dieter DemonCarolin LudwigKoen BreyneDavid GuédéJulia-Charlotte DönerRobrecht FroymanEvelyne Meyer

A1 Journal Article in VETERINARY MICROBIOLOGY

Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)-mediated caspase-11 protease production integrates toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens

Prajwal GurungRK Subbarao MalireddiParas K AnandDieter DemonLieselotte Vande WalleZhiPing LiuPeter VogelMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2011

Immunophenotyping of mammary gland cells in an acute mouse mastitis model

Koen BreyneDieter DemonKristel DemeyereEvelyne Meyer

In vitro characterization of bovine neutrophil cell death following Escherichia coli phagocytosis

Sofie NotebaertKristel DemeyereDieter DemonFilip BoyenChris GuerinPeter VandenabeeleEvelyne Meyer

The in vivo role of executioner caspase-3 and -7 in the Escherichia coli-infected mammary gland

Koen BreyneDieter DemonTom Vanden BerghePeter VandenabeeleEvelyne Meyer

2010

Role of caspase-7 during early involution of the Escherichia coli- or the Staphylococcus aureus-infected mammary gland

Koen BreyneDieter DemonTom Vanden BerghePeter VandenabeeleEvelyne Meyer

Validation of immunoassays for the candidate renal markers C-reactive protein, immunoglobulin G, thromboxane B₂ and retinol binding protein in canine urine

Bert MaddensSylvie DaminetKristel DemeyereDieter DemonPascale SmetsEvelyne Meyer

A1 Journal Article in VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

2009

Caspase substrates: easily caught in deep waters?

Dieter DemonPetra Van DammeTom Vanden BergheJoël VandekerckhoveWim DeclercqKris GevaertPeter Vandenabeele

A1 Journal Article in TRENDS IN BIOTECHNOLOGY

Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity

Dieter DemonPetra Van DammeTom Vanden BergheAnnelies DeceuninckJoost Van DurmeJelle VerspurtenKenny HelsensFrancis ImpensMagdalena WejdaJoost Schymkowitz et al.

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

2008

Inflammatory mediators in Escherichia coli-induced mastitis in mice

Sofie NotebaertDieter DemonTom Vanden BerghePeter VandenabeeleEvelyne Meyer

A1 Journal Article in COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES