Research Explorer

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Researcher

Diana Gutierrez Fernandez

Publications & Research Data

Awards & Distinctions

26 Results

2025

Diversity, structure-function relationships and evolution of cell wall-binding domains of staphylococcal phage endolysins

Roberto VázquezDiana Gutierrez FernandezBjorn CrielZoë DezutterYves Briers

A1 Journal Article in INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Engineering an antimicrobial chimeric endolysin that targets the phytopathogen Pseudomonas syringae pv. actinidiae

Suzanne L. WarringHazel M. SissonGeorge RandallDennis GrimonDorien DamsDiana Gutierrez FernandezMatthias FellnerRobert D. FagerlundYves BriersSimon A. Jackson et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The new SH3b_T domain increases the structural and functional variability among SH3b-like CBDs from staphylococcal phage endolysins

Roberto VázquezDiana Gutierrez FernandezDennis GrimonLucía FernándezPilar GarcíaAna RodríguezYves Briers

A1 Journal Article in PROBIOTICS AND ANTIMICROBIAL PROTEINS

‘Exquisite specificity’, if the context allows : endolysin evolution is a contingent outcome of phage-host molecular landscapes

Roberto VázquezDiana Gutierrez FernandezZoë DezutterBjorn CrielDennis GrimonRémy GoudeseuneJuan Roque Lizasoain VallejoSeila AgúnYves Briers

2024

Dissecting the unknown specificity of cell wall-binding domains of phage endolysins

Roberto VázquezDiana Gutierrez FernandezZoë De ZutterBjorn CrielYves Briers

Lessons learned from a systematic structural-functional characterization of cell wall binding domains (CBDs) from phage endolysins

Roberto VázquezDiana Gutierrez FernandezZoë de ZutterBjorn CrielYves Briers

You get what you test for : the killing effect of phage lysins is highly dependent on buffer tonicity and ionic strength

Roberto VázquezDiana Gutierrez FernandezZoë DezutterBjorn CrielPhilippe De GrooteYves Briers

A1 Journal Article in MICROBIAL BIOTECHNOLOGY

2023

Dismantling superbugs : engineering third-generation lysins as enzybiotics for burn wound infections

Vincent De MaesschalckRob LavigneYves BriersJan PaeshuyseDiana Gutierrez Fernandez

Distinct mode of action of a highly stable, engineered phage lysin killing Gram-negative bacteria

Hans GerstmansLisa DuyvejonckRoberto VázquezInes StaesJimmy BorlooKarim Abdelkader Soufi AbdelkaderJeroen LeroyEmma CremelieDiana Gutierrez FernandezHéctor Tamés-Caunedo et al.

A1 Journal Article in MICROBIOLOGY SPECTRUM

Structural and functional diversity of cell wall binding domains in staphylococcal endolysins

Roberto VázquezDiana Gutierrez FernandezBjorn CrielAna RodríguezPilar GarcíaYves Briers

Structural and functional diversity of staphylococcal cell wall binding domains

Roberto VázquezDiana Gutierrez FernandezZoë DezutterBjorn CrielYves Briers

Understanding the RBP modules function of KP32 as a podophage model

Agnieszka ŁątkaDorien DamsFlavia SqueqliaLennert ScholiersAleksandra OtwinowskaSebastian OlejniczakBarbara MaciejewskaDiana Gutierrez FernandezRita BerisioZuzanna Drulis-Kawa et al.

Understanding the RBP modules function of KP32 as a podophage model

Agnieszka ŁątkaDorien DamsFlavia SqueqliaLennert ScholiersAleksandra OtwinowskaSebastian OlejniczakBarbara MaciejewskaDiana Gutierrez FernandezRita BerisioZuzanna Drulis-Kawa et al.

2022

A bioluminescence-based ex vivo burn wound model for real-time assessment of novel phage-inspired enzybiotics

Vincent De MaesschalckDiana Gutierrez FernandezJan PaeshuyseYves BriersGreetje Vande VeldeRob Lavigne

A1 Journal Article in PHARMACEUTICS

Engineering a lysin with intrinsic antibacterial activity (LysMK34) by cecropin a fusion enhances its antibacterial properties against acinetobacter baumannii

Karim Abdelkader Soufi AbdelkaderDiana Gutierrez FernandezHéctor Tamés-CaunedoPatricia Ruas-MadiedoAmal SafaanAhmed S. KhairallaYasser GaberTarek DishishaYves Briers

A1 Journal Article in APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The specific capsule depolymerase of phage PMK34 sensitizes Acinetobacter baumannii to serum killing

Karim Abdelkader Soufi AbdelkaderDiana Gutierrez FernandezAgnieszka ŁątkaDimitri BoeckaertsZuzanna Drulis-KawaBjorn CrielHans GerstmansAmal SafaanAhmed S. KhairallaYasser Gaber et al.

A1 Journal Article in ANTIBIOTICS-BASEL

Unravelling the function of carbohydrate binding domains in a highly specific tailspike of Klebsiella phage KP32

Agnieszka ŁątkaFlavia SqueqliaDorien DamsLennert ScholiersAleksandra OtwinowskaSebastian OlejniczakDiana Gutierrez FernandezBarbara MaciejewskaRita BerisioZuzanna Drulis-Kawa et al.

Unravelling the function of the carbohydrate binding domains in a highly specific tailspike of Klebsiella phage KP32

Agnieszka ŁątkaFlavia SqueqliaDorien DamsLennert ScholiersAleksandra OtwinowskaSebastian OlejniczakDiana Gutierrez FernandezBarbara MaciejewskaRita BerisioZuzanna Drulis-Kawa et al.

2021

Design and selection of engineered lytic proteins with Staphylococcus aureus decolonizing activity

Diana Gutierrez FernandezLorena Rodríguez-RubioPatricia Ruas-MadiedoLucía FernándezAna Belén CampeloYves BriersMartin Weiss NielsenKarl PedersenRob LavignePilar García et al.

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

Lysins breaking down the walls of Gram-negative bacteria, no longer a no-go

Diana Gutierrez FernandezYves Briers

A1 Journal Article in CURRENT OPINION IN BIOTECHNOLOGY

Synergistic action of phage phiIPLA-RODI and lytic protein CHAPSH3b : a combination strategy to target Staphylococcus aureus biofilms

Ana Catarina DuarteLucía FernándezVincent De MaesschalckDiana Gutierrez FernandezAna Belén CampeloYves BriersRob LavigneAna RodríguezPilar García

A1 Journal Article in NPJ BIOFILMS AND MICROBIOMES

2020

A VersaTile driven platform for rapid hit-to-lead development of engineered lysins

Hans GerstmansDennis GrimonDiana Gutierrez FernandezCédric LoodAna RodríguezVera van NoortJeroen LammertynRob LavigneYves Briers

A1 Journal Article in SCIENCE ADVANCES

Advanced engineering of third-generation lysins and formulation strategies for clinical applications

Vincent De MaesschalckDiana Gutierrez FernandezJan PaeshuyseRob LavigneYves Briers

A1 Journal Article in CRITICAL REVIEWS IN MICROBIOLOGY

Developments and opportunities of bacteriophage lytic proteins for therapeutics against gram-negative pathogens

Diana Gutierrez FernandezYves Briers

Bookchapter in Bacterial viruses : exploitation for biocontrol and therapeutics

Lysin LysMK34 of Acinetobacter baumannii bacteriophage PMK34 has a turgor pressure-dependent intrinsic antibacterial activity and reverts colistin resistance

Karim Abdelkader Soufi AbdelkaderDiana Gutierrez FernandezDennis GrimonPatricia Ruas-MadiedoCédric LoodRob LavigneAmal SafaanAhmed S. KhairallaYasser GaberTarek Dishisha et al.

A1 Journal Article in APPLIED AND ENVIRONMENTAL MICROBIOLOGY

2019

VersaTile Platform to create engineered proteins active against the main pathogens implicated in burn wounds

Diana Gutierrez FernandezHans GerstmansDennis GrimonPilar GarciaAna RodriguezRob LavigneYves Briers