Research Explorer

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Researcher

Dennis Grimon

Publications & Research Data

Awards & Distinctions

19 Results

2026

Exploiting the natural power of phage lysins as novel enzyme-based antibiotics to treat polymicrobial Gram-negative infections

Gilles VandermarliereGuy HermansDennis GrimonVeronique StoveJan De WaeleRoberto VázquezYves Briers

Systematic engineering of lysins yields serum resistant and in vivo active compounds towards drug-resistant Acinetobacter baumannii

Guy HermansDennis GrimonJens Van LiefferingeLeen Van SimaeyMartijn VerhelstGilles VandermarliereMaria João de Carvalho Maurício da FonsecaKristof Van EmelenYves Briers

2025

Deep eutectic solvent enhances antibacterial activity of a modular lytic enzyme against Acinetobacter baumannii

Aleksandra Maria KocotTomasz SwebockiKarolina CieminskaAdrianna LupkowskaMalgorzata KapustaDennis GrimonEwa LaskowskaAnna-Karina KaczorowskaTadeusz KaczorowskiRabah Boukherroub et al.

A1 Journal Article in SCIENTIFIC REPORTS

Engineering an antimicrobial chimeric endolysin that targets the phytopathogen Pseudomonas syringae pv. actinidiae

Suzanne L. WarringHazel M. SissonGeorge RandallDennis GrimonDorien DamsDiana Gutierrez FernandezMatthias FellnerRobert D. FagerlundYves BriersSimon A. Jackson et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

From design to function : an automation-enabled pipeline for the development of precision lysin therapeutics

Dennis GrimonJens Van LiefferingeLeen Van SimaeyMartijn VerhelstGilles VandermarliereMaria João de Carvalho Maurício da FonsecaBjorn CrielKristof Van EmelenGuy HermansYves Briers

Single-cell analysis of yeast surface display for designer cellulosome applications using a fluorescent protein complex

Babette LamoteEmma CremelieKristel DemeyerePhilippe De GrooteDennis GrimonJulie VanderstraetenEvelyne MeyerMarjan De MeyYves Briers

A1 Journal Article in MICROBIOLOGY SPECTRUM

The new SH3b_T domain increases the structural and functional variability among SH3b-like CBDs from staphylococcal phage endolysins

Roberto VázquezDiana Gutierrez FernandezDennis GrimonLucía FernándezPilar GarcíaAna RodríguezYves Briers

A1 Journal Article in PROBIOTICS AND ANTIMICROBIAL PROTEINS

‘Exquisite specificity’, if the context allows : endolysin evolution is a contingent outcome of phage-host molecular landscapes

Roberto VázquezDiana Gutierrez FernandezZoë DezutterBjorn CrielDennis GrimonRémy GoudeseuneJuan Roque Lizasoain VallejoSeila AgúnYves Briers

2022

Combinatorial assembly and optimisation of designer cellulosomes : a galactomannan case study

Julie VanderstraetenMaria João de Carvalho Maurício da FonsecaPhilippe De GrooteDennis GrimonHans GerstmansAmaranta KahnSarah MoraïsEdward A. BayerYves Briers

A1 Journal Article in BIOTECHNOLOGY FOR BIOFUELS AND BIOPRODUCTS

Rapid and high-throughput evaluation of diverse configura-tions of engineered lysins using the VersaTile technique

Lisa DuyvejonckHans GerstmansMichiel StockDennis GrimonRob LavigneYves Briers

SEVAtile : a standardised DNA assembly method optimised for Pseudomonas

Eveline‐Marie LammensMaarten BoonDennis GrimonYves BriersRob Lavigne

A1 Journal Article in MICROBIAL BIOTECHNOLOGY

2021

Developing Innolysins against Campylobacter jejuni using a novel prophage receptor-binding protein

Athina ZamparaMartine C. Holst SørensenYilmaz Emre GencayDennis GrimonSebastian Hougaard KristiansenLallana Skaarup JørgensenJosephine Rejgaard KristensenYves BriersAnne Elsser-GravesenLone Brøndsted

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

Engineering the modular receptor-binding proteins of Klebsiella phages switches their capsule serotype specificity

Agnieszka ŁątkaSebastien LemireDennis GrimonDorien DamsBarbara MaciejewskaTimothy LuZuzanna Drulis-KawaYves Briers

A1 Journal Article in MBIO

Rapid and high-throughput evaluation of diverse configurations of engineered lysins using the VersaTile technique

Lisa DuyvejonckHans GerstmansMichiel StockDennis GrimonRob LavigneYves Briers

A1 Journal Article in ANTIBIOTICS-BASEL

2020

A VersaTile driven platform for rapid hit-to-lead development of engineered lysins

Hans GerstmansDennis GrimonDiana Gutierrez FernandezCédric LoodAna RodríguezVera van NoortJeroen LammertynRob LavigneYves Briers

A1 Journal Article in SCIENCE ADVANCES

Exploiting phage receptor binding proteins to enable endolysins to kill Gram-negative bacteria

Athina ZamparaMartine C. Holst SørensenDennis GrimonFabio AntenucciAmira Ruslanovna VittValeria BortolaiaYves BriersLone Brøndsted

A1 Journal Article in SCIENTIFIC REPORTS

Lysin LysMK34 of Acinetobacter baumannii bacteriophage PMK34 has a turgor pressure-dependent intrinsic antibacterial activity and reverts colistin resistance

Karim Abdelkader Soufi AbdelkaderDiana Gutierrez FernandezDennis GrimonPatricia Ruas-MadiedoCédric LoodRob LavigneAmal SafaanAhmed S. KhairallaYasser GaberTarek Dishisha et al.

A1 Journal Article in APPLIED AND ENVIRONMENTAL MICROBIOLOGY

2019

VersaTile Platform to create engineered proteins active against the main pathogens implicated in burn wounds

Diana Gutierrez FernandezHans GerstmansDennis GrimonPilar GarciaAna RodriguezRob LavigneYves Briers

2018

High-throughput design and analysis of modular endolysins to develop lead candidates using VersaTile Shuffling

Hans GerstmansDennis GrimonCédric LoodTom CoenyeRob LavigneYves Briers