Research Explorer

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Researcher

Debby Laukens

158 Results

2022

A randomized placebo controlled clinical trial with 5-hydroxytryptophan in patients with quiescent Inflammatory Bowel Disease and fatigue (Trp-IBD)

Marie TruyensTriana Lobatón OrtegaAnneleen PeetersMarc FerranteSéverine VermeirePeter BossuytLieven PouillonPieter DewintAnneline CremerHarald PeetersGuy LambrechtEdouard LouisJean-Francois RahierOlivier DewitVinciane MulsTom HolvoetLiv VandermeulenGerard GonzalesDebby LaukensMartine De Vos

Metallothioneins alter macrophage phenotype and represent novel therapeutic targets for acetaminophen-induced liver injury

Lindsey DevisscherSanne Van CampenhoutSander LefereSarah RaevensLaurentijn TillemanFilip Van NieuwerburghHannelore P. Van EeckhoutteAnne HoorensMichael A. LynesAnja GeertsDebby LaukensHans Van Vlierberghe

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Role of integrin expression in the prediction of response to vedolizumab : a prospective real‐life multicentre cohort study

Cara De GalanGerard GonzalesSophie Van WeldenSimon TavernierTriana Lobatón OrtegaWouter Van MoerkerckeBeatrijs StrubbeHarald PeetersElisabeth MackenMartine De VosDebby LaukensPieter Hindryckx

A1 Journal Article in CLINICAL AND TRANSLATIONAL MEDICINE

The role of albumin and the extracellular matrix on the pathophysiology of oedema formation in severe malnutrition

Gerard GonzalesJames M. NjungeBonface M GichukiBijun WenMoses NgariIsabel PotaniJohnstone ThitiriDebby LaukensWieger VoskuijlRobert BandsmaJill VanmassenhoveJames A Berkley

A1 Journal Article in EBIOMEDICINE

2021

A discriminative metabolic profile in the sera of Crohn's disease patients with fibrostenosis

Simon BosMartine De VosPieter HindryckxTriana Lobatón OrtegaLynn VanhaeckeDebby Laukens

Can serum metabolomics discriminate the Crohn’s disease fibrostenotic phenotype?

Simon BosSophie Van WeldenMartine De VosPieter HindryckxTriana Lobatón OrtegaLynn VanhaeckeDebby Laukens

Early prediction of response to vedolizumab in patients with active inflammatory bowel disease : a prospective real-life multicentre cohort study

Cara De GalanGerard Bryan GonzalesSophie Van WeldenSimon TavernierTriana Lobatón OrtegaWouter Van MoerkerckeBeatrijs StrubbeHarald PeetersElisabeth MackenMartine De VosDebby LaukensPieter Hindryckx

Long-term environmental hypoxia does not impact experimental Crohn's like ileitis

Cara De GalanSophie Van WeldenTriana Lobatón OrtegaPieter HindryckxMartine De VosDebby Laukens

Long-term environmental hypoxia exposure and haematopoietic prolyl hydroxylase-1 deletion do not impact experimental Crohn's like ileitis

Cara De GalanMartine De VosPieter HindryckxDebby LaukensSophie Van Welden

A1 Journal Article in BIOLOGY-BASEL

Magnetization transfer MRI and T2-weighted MRI texture analysis allow non-invasive detection of intestinal fibrosis in a fibrosis-inducing chronic colitis mouse model

Simon BosIsabelle De KockLouke DelruePieter HindryckxMartine De VosGeert VilleirsDebby Laukens

Prevalence of fatigue and unrecognized depression in patients with inflammatory bowel disease in remission under immunosuppressants and biologicals

Marie TruyensElodie De RuyckGerard Bryan GonzalesSimon BosDebby LaukensMartine De Vos

A1 Journal Article in JOURNAL OF CLINICAL MEDICINE

Versatile human in vitro triple coculture model coincubated with adhered gut microbes reproducibly mimics pro-inflammatory host-microbe interactions in the colon

Annelore BeteramsKim De PaepeLaure MaesIndia Jane WiseHerlinde De KeersmaeckerAndreja RajkovicDebby LaukensTom Van de WieleMarta Calatayud Arroyo

A1 Journal Article in FASEB JOURNAL

Versatile human in vitro triple coculture model coincubated with adhered gut microbes reproducibly mimics pro-inflammatory host-microbe interactions in the colon

Annelore BeteramsKim De PaepeLaure MaesIndia Jane WiseHerlinde De KeersmaeckerAndreja RajkovicDebby LaukensTom Van de WieleMarta Calatayud Arroyo

A1 Journal Article in FASEB JOURNAL

2020

Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction

Joeri TulkensGlenn VergauwenJan Van DeunEdward GeeurickxBert DhondtLien LippensMarie-Angélique De ScheerderIlkka MiinalainenPekka RappuBruno De GeestKatrien VandecasteeleDebby LaukensLinos VandekerckhoveHannelore DenysJo VandesompeleOlivier De WeverAn Hendrix

A1 Journal Article in GUT

Integrin expression changes on the T cells subsets influence the response to vedolizumab in inflammatory bowel disease patients

Cara De GalanSophie Van WeldenSimon BosSimon TavernierTriana Lobatón OrtegaGerard GonzalesWouter Van MoerkerckeBeatrijs StrubbeHarald PeetersElisabeth MackenMartine De VosDebby LaukensPieter Hindryckx

Metabolic modulation during intestinal fibrosis

Simon BosDebby Laukens

A1 Journal Article in JOURNAL OF DIGESTIVE DISEASES

Translational research into the effects of cigarette smoke on inflammatory mediators and epithelial TRPV1 in Crohn’s disease

Liesbeth AllaisStephanie VerschuereTania MaesRebecca De SmetSarah DevrieseGerard GonzalesHarald PeetersKoen Van CrombruggenClaus BachertMartine De VosGuy BrusselleKen BrackeClaude CuvelierDebby Laukens

A1 Journal Article in PLOS ONE

2019

Cellular diversity in the colon : another brick in the wall

Isabelle CleynenDebby Laukens

Editorial material

Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

Alberto RomagnoniSimon JégouKristel Van SteenGilles WainribJean-Pierre Hugotthe International Inflammatory Bowel Disease Genetics Consortium (IIBDGC)Harald PeetersDebby Laukens

A1 Journal Article in SCIENTIFIC REPORTS

Integrin expression changes on the T cell subsets influence the response to vedolizumab in inflammatory bowel disease patients

Cara De GalanSophie Van WeldenSimon BosSimon TavernierTriana Lobatón OrtegaGerard GonzalesWouter Van MoerkerckeBeatrijs StrubbeHarald PeetersElisabeth MackenMartine De VosDebby LaukensPieter Hindryckx

2018

IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

Yukihide MomozawaJulia DmitrievaEmilie TheatreValerie DeffontaineSouad RahmouniBenoit CharloteauxFrancois CrinsElisa DocampoMahmoud ElansaryAnn-Stephan GoriChristelle LecutRob MarimanMyriam MniCecile OuryIlya AltukhovDmitry AlexeevYuri AulchenkoLeila AmininejadGerd BoumaFrank HoentjenMark LowenbergBas OldenburgMarieke J PierikAndrea E vander Meulen-de JongC Janneke van der WoudeMarijn C VisschedijkMark LathropJean-Pierre HugotRinse K WeersmaMartine De VosDenis FranchimontSeverine VermeireMichiaki KuboEdouard LouisMichel GeorgesClara AbrahamJean-Paul AchkarTariq AhmadAshwin N AnanthakrishnanVibeke AndersenCarl A AndersonJane M AndrewsVito AnneseGuy AumaisLeonard BaidooRobert N BaldassanoPeter A BamptonMurray BarclayJeffrey C BarrettTheodore M BaylessJohannes BethgeAlain BittonGabrielle BoucherStephan BrandBerenice BrandtSteven R BrantCarsten BueningAngela ChewJudy H ChoIsabelle CleynenAriella CohainAnthony CroftMark J DalyMauro D'AmatoSilvio DaneseDirk De JongGoda DenapieneLee A DensonKathy L. DevaneyOlivier DewitRenata D'IncaMarla DubinskyRichard H DuerrCathryn EdwardsDavid EllinghausJonah EssersLynnette R FergusonEleonora A FestenPhilip FleshnerTim FlorinAndre FrankeKarin FransenRichard GearryChristian GiegerJuergen GlasPhilippe GoyetteTodd GreenAnne M GriffithsStephen L GutheryHakon HakonarsonJonas HalfvarsonKatherine HaniganTalin HarituniansAilsa HartChris HawkeyNicholas K HaywardMatija HedlPaul HendersonXinli HuHailiang HuangKen Y HuiMarcin ImielinskiAndrew IppolitiLaimas JonaitisLuke JostinsTom H KarlsenNicholas A KennedyMohammed Azam KhanGediminas KiudelisKrupa KrishnaprasadSubra KugathasanLimas KupcinskasAnna LatianoDebby LaukensIan C LawranceJames C LeeCharlie W LeesMarcis LejaJohan Van LimbergenPaolo LionettiJimmy Z LiuGillian MahyJohn MansfieldDunecan MasseyChristopher G MathewDermot P.B McGovernRaquel MilgromMitja MitrovicGrant W MontgomeryCraig MowatWilliam NewmanAylwin NgSiew C NgSok Meng Evelyn NgSusanna NikolausKaida NingMarkus NoethenIoloannis OikonomouOrazio PalmieriMiles ParkesAnne PhillipsCyriel Y PonsioenUros PotocnikNatalie J PrescottDeborah D ProctorGraham Radford-SmithJean-Francois RahierSoumya RaychaudhuriMiguel RegueiroFlorian RiederJohn D RiouxStephan RipkeRebecca RobertsRichard K RussellJeremy D SandersonMiguel SansJack SatsangiEric E SchadtStefan SchreiberDominik SchulteL Philip SchummRegan ScottMark SeielstadYashoda SharmaMark S SilverbergLisa A. SimmsJurgita SkiecevicieneSarah L SpainA Hillary SteinhartJoanne M StempakLaura StronatiJurgita SventoraityteStephan R TarganKirstin M TaylorAnje ter VeldeLeif TorkvistMark TremellingSuzanne van SommerenEric VasiliauskasHein W VerspagetThomas WaltersKai WangMing-Hsi WangZhi WeiDavid WhitemanCisca WijmengaDavid C WilsonJuliane WinkelmannRamnik J XavierBin ZhangClarence K ZhangHu ZhangWei ZhangHongyu ZhaoZhen Z Zhao

A1 Journal Article in NATURE COMMUNICATIONS

Inflammation-independent mechanisms of intestinal fibrosis : the role of the extracellular matrix

Bookchapter in Fibrostenotic inflammatory bowel disease

New insights into the treatment and pathophysiology of fibrostenotic Crohn’s Disease

Tom HolvoetMartine De VosDebby Laukens

The combination of N-acetylcysteine and anti-MT antibodies as novel therapy for acetaminophen-induced liver injury

Lindsey DevisscherDebby LaukensHannelore Van EeckhoutteSarah RaevensSander LefereAnne HoorensXavier VerhelstM LynesAnja GeertsHans Van Vlierberghe

Unmet needs in IBD : the case of fatigue

Pieter HindryckxDebby LaukensFerdinando D’AmicoSilvio Danese

A1 Journal Article in CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

2017

Assessment of faecal microbial transfer in irritable bowel syndrome with severe bloating

Tom HolvoetMarie JoossensJun WangJerina BoelensBruno VerhasseltDebby LaukensHans Van VlierberghePieter HindryckxMartine De VosDanny De LoozeJeroen Raes

A1 Journal Article in GUT

Bile acids as novel therapeutic agents for inflammatory bowel disease

Lien Van den BosscheDebby LaukensMartine De Vos

Butyrate-producing bacteria supplemented in vitro to Crohn's disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier integrity

Annelies GeirnaertMarta Calatayud ArroyoCharlotte GrootaertDebby LaukensSarah DevrieseGuy SmaggheMartine De VosNico BoonTom Van de Wiele

A1 Journal Article in SCIENTIFIC REPORTS

Detection and manipulation of the stress response protein metallothionein

Sadikshya BhandariClare MelchiorreKristen DostieDebby LaukensLindsey DevisscherAriel LouwrierAmy TheesMichael A Lynes

A2 Journal Article in CURRENT PROTOCOLS IN TOXICOLOGY

Early fibrostenosis in Crohn's disease is associated with multiple susceptibility loci on Immunochip analysis

Tom HolvoetPeter BossuytIsabelle CleynenIsabelle De KockPieter HindryckxSeverine VermeireDebby LaukensMartine De Vos

Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis

Sophie Van WeldenMartine De VosBen WielockxSimon TavernierMelissa DullaersSara NeytBenedicte DescampsLindsey DevisscherSarah DevrieseLien Van den BosscheTom HolvoetAnn BaeyensCarmen CorrealeSilvia D'AlessioChristian VanhoveFilip De VosBruno VerhasseltGeorg BreierBart LambrechtSophie JanssensPeter CarmelietSilvio DaneseDirk ElewautDebby LaukensPieter Hindryckx

A1 Journal Article in JOURNAL OF PATHOLOGY

Incidence, prevention and management of anti-drug antibodies against therapeutic antibodies in inflammatory bowel disease : a practical overview

Pieter HindryckxGregor NovakNiels Vande CasteeleReena KhannaDebby LaukensJairath VipulBrian G Feagan

A1 Journal Article in DRUGS

Prolyl hydroxylase domain-containing protein 1 as potential therapeutic target for inflammatory bowel disease

Sophie Van WeldenDebby LaukensPieter Hindryckx

Reduced mucosa-associated Butyricicoccus activity in patients with ulcerative colitis correlates with aberrant claudin-1 expression

Sarah DevrieseVenessa EeckhautAnnelies GeirnaertLien Van den BosschePieter HindryckxTom Van de WieleFilip Van ImmerseelRichard DucatelleMartine De VosDebby Laukens

A1 Journal Article in JOURNAL OF CROHNS & COLITIS

Review article: dose optimisation of infliximab for acute severe ulcerative colitis

Pieter HindryckxG NovakN Vande CasteeleDebby LaukensC ParkerLM ShackeltonN NarulaR KhannaP DulaiBG LevesqueWJ SandbornG D'HaensBG FeaganV Jairath

A1 Journal Article in ALIMENTARY PHARMACOLOGY & THERAPEUTICS

T84 monolayers are superior to Caco-2 as a model system of colonocytes

Sarah DevrieseLien Van den BosscheSophie Van WeldenTom HolvoetIris PinheiroPieter HindryckxMartine De VosDebby Laukens

A1 Journal Article in HISTOCHEMISTRY AND CELL BIOLOGY

Tauroursodeoxycholic acid protects bile acid homeostasis under inflammatory conditions and dampens Crohn’s disease-like ileitis

Lien Van den BosscheDaniel BorsboomSarah DevrieseSophie Van WeldenTom HolvoetLindsey DevisscherPieter HindryckxMartine De VosDebby Laukens

A1 Journal Article in LABORATORY INVESTIGATION

Treatment of intestinal fibrosis in experimental inflammatory bowel disease by the pleiotropic actions of a local Rho kinase inhibitor

Tom HolvoetSarah DevrieseKarolien CastermansSandro BolandDirk LeysenYves-Paul VandewynckelLindsey DevisscherLien Van den BosscheSophie Van WeldenMelissa DullaersRoosmarijn VandenbrouckeRiet De RyckeKarel GeboesArnaud BourinOlivier DefertPieter HindryckxMartine De VosDebby Laukens

A1 Journal Article in GASTROENTEROLOGY

Treatment strategies for intestinal epithelial barrier dysfunction in inflammatory bowel disease

Sarah DevrieseDebby LaukensMartine De Vos

Tumor PD-L1 status and CD8+ tumor-infiltrating T cells : markers of improved prognosis in oropharyngeal cancer

Astrid De MeulenaereTijl VermassenSANDRINE ASPESLAGHPhilippe DeronFréderic DuprezDebby LaukensJo Van DorpeLiesbeth FerdinandeSylvie Rottey

A1 Journal Article in ONCOTARGET

Ursodeoxycholic acid and its taurine/glycine conjugated species reduce colitogenic dysbiosis and equally suppress experimantal colitis in mice

Lien Van den BosschePieter HindryckxLindsey DevisscherSarah DevrieseSophie Van WeldenTom HolvoetRamiro Vilchez VargasMarius VitalDietmar PieperJulie Vanden BusscheLynn VanhaeckeTom Van de WieleMartine De VosDebby Laukens

Ursodeoxycholic acid and its taurine/glycine conjugated species reduce colitogenic dysbiosis and equally suppress experimental colitis in mice

Lien Van den BosschePieter HindryckxLindsey DevisscherSarah DevrieseSophie Van WeldenTom HolvoetRamiro Vilchez VargasMarius VitalDietmar H PieperJulie VandenbusscheLynn VanhaeckeTom Van de WieleMartine De VosDebby Laukens

A1 Journal Article in APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Ursodeoxycholic acid and its taurine/glycine conjugated species reduce colitogenic dysbiosis and equally suppress experimental colitis in mice

Lien Van den BosschePieter HindryckxLindsey DevisscherSarah DevrieseSophie Van WeldenTom HolvoetRamiro Vilchez VargasMarius VitalDietmar H PieperJulie VandenbusscheLynn VanhaeckeTom Van de WieleMartine De VosDebby Laukens

2016

Chronic cigarette smoke exposure induces microbial and inflammatory shifts and mucin changes in the murine gut

Liesbeth AllaisFrederiek-Maarten KerckhofStephanie VerscheureKen BrackeRebecca De SmetDebby LaukensPieter Van den AbbeeleMartine De VosNico BoonGuy BrusselleClaude CuvelierTom Van de Wiele

A1 Journal Article in ENVIRONMENTAL MICROBIOLOGY

Genome-wide copy number variation scan identifies complement component C4 as novel susceptibility gene for Crohn's disease

Isabelle CleynenPeter KoningsCaroline RobberechtDebby LaukensLeila AmininejadEmilie ThéâtreKathleen MachielsIngrid ArijsPaul RutgeertsEdouard LouisDenis FranchimontMartine De VosKristel Van SteenMichel GeorgesYves MoreauJoris VermeeschSéverine Vermeire

A1 Journal Article in INFLAMMATORY BOWEL DISEASES

Heterogeneity of the gut microbiome in mice : guidelines for optimizing experimental design

Debby LaukensBrigitta BrinkmanJeroen RaesMartine De VosPeter Vandenabeele

A1 Journal Article in FEMS MICROBIOLOGY REVIEWS

Inherited determinants of Crohn's disease and ulcerative colitis phenotypes : a genetic association study

Isabelle CleynenGabrielle BoucherLuke JostinsL. Philip SchummSebastian ZeissigTariq AhmadVibeke AndersenJane M. AndrewsVito AnneseStephan BrandSteven R. BrantJudy H. ChoMark J. DalyMarla DubinskyRichard H. DuerrLynnette R. FergusonAndre FrankeRichard B. GearryPhilippe GoyetteHakon HakonarsonJonas HalfvarsonJohannes R. HovHailang HuangNicholas A. KennedyLimas KupcinskasIan C. LawranceJames C. LeeJack SatsangiStephan SchreiberEmilie TheatreAndrea E. van der Meulen-de JongRinse K. WeersmaDavid C. WilsonMiles ParkesSeverine VermeireJohn D. RiouxJohn MansfieldMark S. SilverbergGraham Radford-SmithDermot P. B. McGovernJeffrey C. BarrettCharlie W. LeesMartine De VosDebby Laukens[missing] International IBD Genetics Consortium

A1 Journal Article in LANCET

Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma

Yves-Paul VandewynckelCéline CouckeDebby LaukensLindsey DevisscherAnnelies ParidaensEliene BogaertsAstrid VandierendonckSarah RaevensXavier VerhelstChristophe Van SteenkisteLouis LibbrechtAnja GeertsHans Van Vlierberghe

Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma

Yves-Paul VandewynckelCéline CouckeDebby LaukensLindsey DevisscherAnnelies ParidaensEliene BogaertsAster VandierendonckSarah RaevensXavier VerhelstChristophe Van SteenkisteLouis LibbrechtAnja GeertsHans Van Vlierberghe

A1 Journal Article in ONCOTARGET

Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma

Yves-Paul VandewynckelDebby LaukensLindsey DevisscherEliene BogaertsAnnelies ParidaensAnja Van den BusscheSarah RaevensXavier VerhelstChristophe Van SteenkisteBart JonckxLouis LibbrechtAnja GeertsPeter CarmelietHans Van Vlierberghe

A1 Journal Article in BMC CANCER

The unfolded protein response underlies microenvironmental stress-induced phenotype switching leading to stemness and chemoresistance in human hepatocellular carcinoma

Yves-Paul VandewynckelO GovaereAstrid VandierendonckDebby LaukensLindsey DevisscherAnnelies ParidaensEliene BogaertsSarah RaevensXavier VerhelstChristophe Van SteenkisteLouis LibbrechtChristophe AmpeMarleen Van TroysAnja GeertsT RoskamsHans Van Vlierberghe

2015

Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer : diagnostic and therapeutic potential

B FloodK OficjalskaDebby LaukensJ FayA O'GradyF CaiazzaZ HeetunKHG MillsK SheahanEJ RyanGA DohertyE KayEM Creagh

A1 Journal Article in CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

Jimmy Z LiuSuzanne van SommerenHailiang HuangSiew C NgRudi AlbertsAtsushi TakahashiStephan RipkeJames C LeeLuke JostinsTejas ShahShifteh AbedianJae Hee CheonJudy ChoNaser E DaryaniLude FrankeYuta FuyunoAilsa HartRamesh C JuyalGarima JuyalWon Ho KimAndrew P MorrisHossein PoustchiWilliam G NewmanVandana MidhaTimothy R OrchardHomayon VahediAjit SoodJoseph J Y SungReza MalekzadehHarm-Jan WestraKeiko YamazakiSuk-Kyun YangJeffrey C BarrettAndre FrankeBehrooz Z AlizadehMiles ParkesThelma B KMark J DalyMichiaki KuboCarl A AndersonRinse K WeersmaDebby Laukens[missing] International Multiple Sclerosis Genetics Consortium[missing] International IBD Genetics Consortium

A1 Journal Article in NATURE GENETICS

GPR84 inhibition as a novel therapeutic approach in IBD: mechanistic and translational studies

S DupontI ArijsR BlanqueDebby LaukensK NysMC CeccottiD MercirisS De VosO MateI ParentV De VriendtF LabeguereR GalienMartine De VosP RutgeertsN VandeghinsteS VermeireR Brys

Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1

Sophie SteelandLeen PuimègeRoosmarijn VandenbrouckeFilip Van HauwermeirenJurgen HaustraeteNick DevoogdtPaco HulpiauGeert Leroux-RoelsDebby LaukensPhilip MeulemanMartine De VosClaude Libert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

High-density mapping of the MHC identifies a shared role for HLA-DRB1⋆01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

Philippe GoyetteGabrielle BoucherDermot MallonEva EllinghaustLuke JostinsHaiLiang HuangStephan RipkeElena S GusarevaVito AnneseStephen L HauserJorge R OksenbergIngo ThomsentStephen LeslieMark J DalyKristel Van SteenRichard H DuerrJeffrey C BarrettDermot PB McGovernL Philip SchummJames A TraherneMary N CarringtonVasilis KosmoliaptsisTom H KarsenAndre FrankeJohn D Rioux[missing] International Inflammatory Bowel Disease Genetics ConsortiumDebby Laukens

A1 Journal Article in NATURE GENETICS

Interindividual differences in response to treatment with butyrate-producing Butyricicoccus pullicaecorum 25–3T studied in an in vitro gut model

Annelies GeirnaertJun WangMagali TinckAlix SteyaertPieter Van den AbbeeleVenessa EeckhautRamiro Vilchez VargasGwen FalonyDebby LaukensMartine De VosFilip Van ImmerseelJeroen RaesNico BoonTom Van de Wiele

A1 Journal Article in FEMS MICROBIOLOGY ECOLOGY

Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy

Yves-Paul VandewynckelDebby LaukensEliene BogaertsAnnelies ParidaensAnja Van den BusscheXavier VerhelstChristophe Van SteenkisteBenedicte DescampsChristian VanhoveLouis LibbrechtRiet De RyckeBart LambrechtAnja GeertsSophie JanssensHans Van Vlierberghe

A1 Journal Article in HEPATOLOGY INTERNATIONAL

Placental growth factor inhibition modulates the interplay between hypoxia and the unfolded protein response in hepatocellular carcinoma

Yves-Paul VandewynckelDebby LaukensLindsey DevisscherAnnelies ParidaensEliene BogaertsXavier VerhelstAnja Van den BusscheSarah RaevensChristophe Van SteenkisteB JonckxLouis LibbrechtAnja GeertsP CarmelietHans Van Vlierberghe

Soft ROCK inhibition prevents intestinal fibrosis in a murine colitis model

Tom HolvoetSarah DevrieseKarolien CastermansSandro BolandPieter HindryckxA BorinMartine De VosOlivier DefertDebby Laukens

Soft ROCK inhibition prevents intestinal fibrosis in a murine colitis model

Tom HolvoetSarah DevrieseKarolien CastermansSandro BolandPieter HindryckxArnaud BourinMartine De VosOlivier DefertDebby Laukens

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure

Yves-Paul VandewynckelDebby LaukensLindsey DevisscherAnnelies ParidaensEliene BogaertsXavier VerhelstAnja Van den BusscheSarah RaevensChristophe Van SteenkisteMarleen Van TroysChristophe AmpeBenedicte DescampsChristian VanhoveOlivier GovaereAnja GeertsHans Van Vlierberghe

A1 Journal Article in ONCOTARGET

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure

Yves-Paul VandewynckelDebby LaukensLindsey DevisscherAnnelies ParidaensEliene BogaertsXavier VerhelstA Van den BusscheSarah RaevensChristophe Van SteenkisteMarleen Van TroysChristophe AmpeBenedicte DescampsChristian VanhoveO GovaereLouis LibbrechtAnja GeertsHans Van Vlierberghe

The effect of cigarette smoke exposure on the development of inflammation in lungs, gut and joints of TNFΔARE mice

Liesbeth AllaisSmitha KumarKarlijn DebusschereStephanie VERSCHUERETania MaesRebecca De SmetGriet ConickxMartine De VosDebby LaukensGuy JoosGuy BrusselleDirk ElewautClaude CuvelierKen Bracke

A1 Journal Article in PLOS ONE

Validated high resolution mass spectrometry-based approach for metabolomic fingerprinting of the human gut phenotype

Julie Vanden BusscheMassimo MarzoratiDebby LaukensLynn Vanhaecke

A1 Journal Article in ANALYTICAL CHEMISTRY

2014

Cigarette smoke exposure alters the development of inflammation in experimental Crohn-like colitis

Liesbeth AllaisStephanie VerscheureKen BrackeRebecca De SmetDebby LaukensClaus BachertMartine De VosGuy BrusselleClaude Cuvelier

Endoplasmic reticulum stress and angiogenesis: is there an interaction between them?

Annelies ParidaensDebby LaukensYves-Paul VandewynckelStephanie CoulonHans Van VlierbergheAnja GeertsIsabelle Colle

A1 Journal Article in LIVER INTERNATIONAL

Hepatitis mouse models : from acute-to-chronic autoimmune hepatitis

Muhammed YükselDebby LaukensFemke HeindrickxHans Van VlierbergheAnja GeertsF Susan WongLi WenIsabelle Colle

A1 Journal Article in INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Metallothionein and stress combine to affect multiple organ systems

Michael A LynesJuan HidalgoYasmina MansoLindsey DevisscherDebby LaukensDavid A Lawrence

A1 Journal Article in CELL STRESS & CHAPERONES

Metallothioneins as modulators of intestinal inflammation and potential therapeutic targets for inflammatory bowel diseases

Lindsey DevisscherMARTINE DE VOSDebby Laukens

Reduced B. pullicaecorum levels in mucosa of UC patients correlate with aberrant CLDN1 expression

Sarah DevrieseVenessa EeckhautFilip Van ImmerseelRichard DucatelleMartine De VosDebby Laukens

Reduced Butyricicoccus pullicaecorum levels in mucosa of UC patients correlate with aberrant CLDN1 expression

Sarah DevrieseVenessa EeckhautFilip Van ImmerseelRichard DucatelleMartine De VosDebby Laukens

Role of metallothioneins as danger signals in the pathogenesis of colitis

Lindsey DevisscherPieter HindryckxMichael A LynesAnouk WaeytensClaude CuvelierFilip De VosChristian VanhoveMartine De VosDebby Laukens

A1 Journal Article in JOURNAL OF PATHOLOGY

Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death

Debby LaukensLindsey DevisscherLien Van den BosschePieter HindryckxRoosmarijn VandenbrouckeYves-Paul VandewynckelClaude CuvelierBrigitta BrinkmanClaude LibertPeter VandenabeeleMartine De Vos

A1 Journal Article in LABORATORY INVESTIGATION

Temporal dynamics and therapeutic potential of the unfolded protein espouse in hepatocellular carcinoma

Yves-Paul VandewynckelDebby LaukensAnja GeertsEliene BogaertsAnnelies ParidaensXavier VerhelstChristophe Van SteenkisteBenedicte DescampsChristian VanhoveLouis LibbrechtRiet De RyckeBart LambrechtSophie Janssens

Temporal dynamics and therapeutic potential of the unfolded protein response in hepatocellular carcinoma

Yves-Paul VandewynckelDebby LaukensAnja GeertsEliene BogaertsAnnelies ParidaensXavier VerhelstChristophe Van SteenkisteBenedicte DescampsChristian VanhoveLouis LibbrechtRiet De RyckeBart LambrechtS JanssensHans Van Vlierberghe

The effect of chronic cigarette smoke exposure on gut microbial diversity in healthy mice

Liesbeth AllaisFrederiek-Maarten KerckhofStephanie VerscheureKen BrackeRebecca De SmetDebby LaukensPieter Van den AbbeeleMartine De VosNico BoonGuy BrusselleTom Van de WieleClaude Cuvelier

The effect of chronic cigarette smoke exposure on the gut microbiome in healthy mice

Liesbeth AllaisFrederiek-Maarten KerckhofStephanie VerscheureKen BrackeRebecca De SmetDebby LaukensPieter Van den AbbeeleMartine De VosNico BoonGuy BrusselleTom Van de WieleClaude Cuvelier

Therapeutic effects of artesunate in hepatocellular carcinoma : repurposing an ancient antimalarial agent

Yves-Paul VandewynckelDebby LaukensAnja GeertsChristian VanhoveBenedicte DescampsLindsey DevisscherEliene BogaertsAnnelies ParidaensXavier VerhelstChristophe Van SteenkisteLouis LibbrechtBart LambrechtS JanssensHans Van Vlierberghe

Therapeutic effects of artesunate in hepatocellular carcinoma: repurposing an ancient antimalarial agent

Yves-Paul VandewynckelDebby LaukensAnja GeertsChristian VanhoveBenedicte DescampsIsabelle ColleLindsey DevisscherEliene BogaertsAnnelies ParidaensXavier VerhelstChristophe Van SteenkisteLouis LibbrechtBart LambrechtSophie JanssensHans Van Vlierberghe

A1 Journal Article in EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

2013

A dried yeast fermentate selectively modulates both the luminal and mucosal gut microbiota and protects against inflammation, as studied in an integrated in vitro approach

Sam PossemiersIris PinheiroAn VerhelstPieter Van den AbbeeleLoïs MaignienDebby LaukensStuart G ReevesLarry E RobinsonThomas RaasYves-Jacques SchneiderTom Van de WieleMassimo Marzorati

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Chronic cigarette smoke exposure alters the murine gut microbiome

Liesbeth AllaisFrederiek-Maarten KerckhofStephanie VerschuereKen BrackeRebecca De SmetDebby LaukensMartine De VosNico BoonGuy BrusselleTom Van de WieleClaude Cuvelier

Chronic cigarette smoke exposure alters the murine gut microbiome

Liesbeth AllaisFrederiek-Maarten KerckhofStephanie VerschuereKen BrackeRebecca De SmetDebby LaukensMartine De VosNico BoonGuy BrusselleTom Van de WieleClaude Cuvelier

Chronic cigarette smoke exposure alters the murine gut microbiome

Liesbeth AllaisFrederiek-Maarten KerckhofStephanie VerscheureKen BrackeRebecca De SmetDebby LaukensMartine De VosNico BoonGuy BrusselleTom Van de WieleClaude Cuvelier

Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis

Mélissa BeaudoinPhilippe GoyetteGabrielle BoucherKen Sin LoManuel A. RivasChristine StevensAzadeh AlikashaniMartin LadouceurDavid EllinghausLeif TörkvistGautam GoelCaroline LagacéVito AnneseAlain BittonJakob BegunSteve R. BrantFrancesca BressoJudy H. ChoRichard H. DuerrJonas HalfvarsonDermot P. B. McGovernGraham Radford-SmithStefan SchreiberPhilip L. SchummYashoda SharmaMark S. SilverbergRinse K. WeersmaMauro D'AmatoSeverine VermeireAndre FrankeGuillaume LettreRamnik J. XavierMark J. DalyJohn D. RiouxDebby Laukens[missing] Quebec IBD Genetics Consortium[missing] NIDDK IBD Genetics Consortium[missing] International IBD Genetics Consortium

A1 Journal Article in PLOS GENETICS

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

Jimmy Z LiuJohannes Roksund HovTrine FolseraasEva EllinghausSimon M RushbrookNadezhda T DonchevaOle A AndreassenRinse K WeersmaTobias J WeismüllerBertus EksteenPietro InvernizziGideon M HirschfieldDaniel Nils GotthardtAlbert ParesDavid EllinghausTejas ShahBrian D JuranPiotr MilkiewiczChristian RustChristoph SchrammTobias MüllerBrijesh SrivastavaGeorgios DalekosMarkus M NöthenStefan HermsJuliane WinkelmannMitja MitrovicFelix BraunCyriel Y PonsioenPeter J P CroucherMartina SterneckAndreas TeufelAndrew L MasonJanna SaarelaVirpi LeppaRuslan DorfmanDomenico AlvaroAnnarosa FloreaniSuna Onengut-GumuscuStephen S RichWesley K ThompsonAndrew J SchorkSigrid NæssIngo ThomsenGabriele MayrInke R KönigKristian HveemIsabelle CleynenJavier Gutierrez-AchuryIsis Ricaño-PonceDavid van HeelEinar BjörnssonRichard N SandfordPeter R DurieEspen MelumMorten H VatnMark S SilverbergRichard H DuerrLeonid PadyukovStephan BrandMiquel SansVito AnneseJean-Paul AchkarKirsten Muri BobergHanns-Ulrich MarschallOlivier ChazouillèresChristopher L BowlusCisca WijmengaErik SchrumpfSeverine VermeireMario AlbrechtJohn D RiouxGraeme AlexanderAnnika BergquistJudy ChoStefan SchreiberMichael P MannsMartti FärkkiläAnders M DaleRoger W ChapmanKonstantinos N LazaridisAndre FrankeCarl A AndersonTom H Karlsen[missing] UK-PSCSC Consortium[missing] International IBD Genetics Consortium[missing] International PSC Study GroupDebby Laukens

A1 Journal Article in NATURE GENETICS

Differential expression of prolyl hydroxylase 1 in patients with ulcerative colitis versus patients with Crohn's disease/infectious colitis and healthy controls

Sophie Van WeldenDebby LaukensLiesbeth FerdinandeMartine De VosPieter Hindryckx

A1 Journal Article in JOURNAL OF INFLAMMATION-LONDON

Endoplasmic reticulum aminopeptidase 1 is a promising candidate gene for inflammatory bowel disease

Debby LaukensHarald PeetersPieter HindryckxMartine De Vos

Metallothionein, an emerging danger signal during experimental colitis

Lindsey DevisscherPieter HindryckxKim OlievierHarald PeetersMichael LynesClaude CuvelierMartine De VosDebby Laukens

Pharmacologic activation of tumor hypoxia: a means to increase tumor 2-deoxy-2-[18F]fluoro-D-glucose uptake?

Gilles MeesRudi DierckxCHRISTEL VANGESTELDebby LaukensNancy Van DammeChristophe Van De Wiele

A1 Journal Article in MOLECULAR IMAGING

Temporal dynamics of the unfolded protein response and chemoresistance in hepatocellular carcinoma

Yves-Paul VandewynckelIsabelle ColleDebby LaukensBart LambrechtBenedicte DescampsChristian VanhoveHans Van Vlierberghe

The paradox of the unfolded protein response in cancer

Yves-Paul VandewynckelDebby LaukensAnja GeertsEliene BogaertsAnnelies ParidaensXavier VerhelstSophie JanssensFemke HeindryckxHans Van Vlierberghe

A1 Journal Article in ANTICANCER RESEARCH

The therapeutic potential of artesunate in hepatocellular carcinoma

Yves-Paul VandewynckelDebby LaukensAnja GeertsIsabelle ColleLouis LibbrechtEliene BogaertsLindsey DevisscherAnnelies ParidaensXavier VerhelstChristian VanhoveBenedicte DescampsSophie JanssensBart LambrechtChristophe Van SteenkisteHans Van Vlierberghe

2012

Decreased colonization of fecal Clostridium coccoides/Eubacterium rectale species from ulcerative colitis patients in an in vitro dynamic gut model with mucin environment

Joan VermeirenPieter Van den AbbeeleDebby LaukensLouise Kristine VigsnæsMartine De VosNico BoonTom Van de Wiele

A1 Journal Article in FEMS MICROBIOLOGY ECOLOGY

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

Luke JostinsStephan RipkeRinse K WeersmaRichard H DuerrDermot P McGovernKen Y HuiJames C LeeL Philip SchummYashoda SharmaCarl A AndersonJonah EssersMitja MitrovicKaida NingIsabelle CleynenEmilie TheatreSarah L SpainSoumya RaychaudhuriPhilippe GoyetteZhi WeiClara AbrahamJean-Paul AchkarTariq AhmadLeila AmininejadAshwin N AnanthakrishnanVibeke AndersenJane M AndrewsLeonard BaidooTobias BalschunPeter A BamptonAlain BittonGabrielle BoucherStephan BrandCarsten BüningAriella CohainSven CichonMauro D'AmatoDirk De JongKathy L DevaneyMarla DubinskyCathryn EdwardsDavid EllinghausLynnette R FergusonDenis FranchimontKarin FransenRichard GearryMichel GeorgesChristian GiegerJürgen GlasTalin HarituniansAilsa HartChris HawkeyMatija HedlXinli HuTom H KarlsenLimas KupcinskasSubra KugathasanAnna LatianoDebby LaukensIan C LawranceCharlie W LeesEdouard LouisGillian MahyJohn MansfieldAngharad R MorganCraig MowatWilliam NewmanOrazio PalmieriCyriel Y PonsioenUros PotocnikNatalie J PrescottMiguel RegueiroJerome I RotterRichard K RussellJeremy D SandersonMiquel SansJack SatsangiStefan SchreiberLisa A SimmsJurgita SventoraityteStephan R TarganKent D TaylorMark TremellingHein W VerspagetMartine De VosCisca WijmengaDavid C WilsonJuliane WinkelmannRamnik J XavierSebastian ZeissigBin ZhangClarence K ZhangHongyu ZhaoMark S SilverbergVito AnneseHakon HakonarsonSteven R BrantGraham Radford-SmithChristopher G MathewJohn D RiouxEric E SchadtMark J DalyAndre FrankeMiles ParkesSeverine VermeireJeffrey C BarrettJudy H Cho

A1 Journal Article in NATURE

How accurate is endoscopic ultrasound in the differentiation of cystic lesions of the pancreas?

Ercan CesmeliBrecht PauwelsDebby LaukensMartine De Vos

Intestinal barrier dysfunction: the primary driver of IBD?

Pieter HindryckxDebby Laukens

Bookchapter in Inflammatory bowel disease : advances in pathogenesis and management

Intrarectal nitric oxide administration prevents cellular infiltration but not colonic injury during dextran sodium sulfate colitis

Joan VermeirenPieter HindryckxGlynn Van NieuwenhuyseDebby LaukensMartine De VosNico BoonTom Van de Wiele

A1 Journal Article in DIGESTIVE DISEASES AND SCIENCES

Oral supplementation with sulodexide inhibits neo-angiogenesis in a rat model of peritoneal perfusion

Anneleen PletinckMaria Van LandschootSonja SteppanDebby LaukensJutta Passlick-DeetjenRaymond VanholderWim Van Biesen

A1 Journal Article in NEPHROLOGY DIALYSIS TRANSPLANTATION

TUDCA alleviates DSS-induced colitis by forcing IRE1 activity and reducing colonocyte apoptosis

Debby LaukensLindsey DevisscherPieter HindryckxHarald PeetersMartine De Vos

Targeting metallothionein in dextran sulfate sodium-induced colitis points to new therapeutic strategies for patients suffering from inflammatory bowel diseases

Lindsey DevisscherPieter HindryckxKim OlievierHarald PeetersMichael LynesClaude CuvelierMartine De VosDebby Laukens

Tauroursodeoxycholic acid forces epithelial IRE1 activation and alleviates DSS-induced colitis

Debby LaukensLindsey DevisscherPieter HindryckxHarald PeetersMartine De Vos

2011

Boosting the hypoxia-induced adaptive response in inflammatory bowel disease: a novel concept of treatment

Pieter HindryckxDebby LaukensMartine De Vos

A1 Journal Article in INFLAMMATORY BOWEL DISEASES

Detrimental shifts in microbial communities from inflammatory bowel disease patients upon selective pressures

Joan VermeirenTom Van de WieleVenessa EeckhautMartine De VosDebby LaukensNico Boon

A4 Journal Article in COMMUNICATIONS IN AGRICULTURAL AND APPLIED BIOLOGICAL SCIENCES

Intrarectal administration of oxygenated perfluorodecalin promotes healing of murine colitis by targeting inflammatory hypoxia

Pieter HindryckxLindsey DevisscherDebby LaukensKoen VenkenHarald PeetersMartine De Vos

A1 Journal Article in LABORATORY INVESTIGATION

Intrarectal administration of oxygenated perfluorodecalin promotes healing of murine colitis by targeting inflammatory hypoxia

Pieter HindryckxLindsey DevisscherDebby LaukensHarald PeetersMartine De Vos

Inverse correlation between metallothioneins and hypoxia-inducible factor 1 alpha in colonocytes and experimental colitis

Lindsey DevisscherPieter HindryckxHarald PeetersMartine De VosDebby Laukens

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Involvement of endoplasmic reticulum stress in inflammatory bowel disease : a different implication for colonic and ileal disease?

Sara BogaertMartine De VosKim OlievierHarald PeetersDirk ElewautBart LambrechtPhilippe PouliotDebby Laukens

A1 Journal Article in PLOS ONE

Longitudinal quantification of inflammation in the murine DSS-induced colitis model using μPET/CT

Pieter HindryckxSteven StaelensLindsey DevisscherSteven DeleyeFilip De VosLouke DelrueHarald PeetersDebby LaukensMartine De Vos

A1 Journal Article in INFLAMMATORY BOWEL DISEASES

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

Carl A AndersonGabrielle GoucherCharlie W LeesAndre FrankeMauro D'AmatoKent D TaylorJames C LeePhilippe GoyetteMarcin ImielinskiAnna LatianoCaroline LagacéRegan ScottLeila AmininejadSuzannah BumpsteadLeonard BaidooRobert N BaldassanoMurray BarclayTheodore M BaylessStephan BrandCarsten BüningJean-Frederic ColombelLee A DensonMartine De VosMaria DubinskiCathryn EdwardsDavid EllinghausRudolf S FehrmannJames A FloydTimothy FlorinDenis FranchimontLude FrankeMichel GeorgesJuergen GlasNicole L GlazerStephen L GutheryTalin HarituniansNicholas K HaywardJean-Pierre HugotGilles JobinDebby LaukensIan LawranceMarc LémannArie LevineCecile LibioulleEdouard LouisDermot P McGovernMonica MillaGrant W MontgomeryKatherine I MorleyCraig MowatAylwin NgWilliam NewmanRoel A OphoffLaura PapiOrazio PalmieriLaurant Peyrin-BirouletJulian PanésAnne PhillipsNatalie J PrescottDeborah D ProctorRebecca RobertsRichard RussellPaul RutgeertsJeremy SandersonMiquel SansPhilip SchummFrank SeiboldYashoda SharmaLisa A SimmsMark SeielstadA Hillary SteinhartStephan R TarganLeonard H Van den BergMorten VatnHein VerspagetThomas WaltersCisca WijmengaDavid C WilsonHarm-Jan WestraRamnik J XavierZhen Z ZhaoCyriel Y PonsioenVibeke AndersenLeif TorkvistMaria GazouliNicholas P AnagouTom H KarlsenLimas KupcinskasJurgita SventoraityteJohn C MansfieldSubra KugathasanMark S SilverbergJonas HalfvarsonJerom I RotterChristopher G MathewAnne M GriffithsRichard GearryTariq AhmadSteven R BrantMathias ChamaillardJack SatsangiJudy H ChoStefan SchreiberMark J DalyJeffrey C BarrettMiles ParkesVito AnneseHakon HakonarsonGraham Radford-SmithRichard H DuerrSeverine VermeireRinse K WeersmaJohn D Rioux

A1 Journal Article in NATURE GENETICS

Novel development in extraintestinal manifestations and spondyloarthropathy

Martine De VosPieter HindryckxDebby Laukens

A1 Journal Article in BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology

Elizabeth J RossinKasper LageSoumya RaychaudhuriRamnik J XavierDiana TatarYair BenitaChris CotsapasMark J Dalythe International Inflammatory Bowel Disease Genetics ConstortiumMartine De VosDebby Laukens

A1 Journal Article in PLOS GENETICS

Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease

Yukihide MomozawaMyriam MniKayo NakamuraWouter CoppietersSven AlmerLeila AmininejadIsabelle CleynenJean-Frederic ColombelPeter de RijkOlivier DewitYigael FinkelMiquel A GassullDirk GoossensDebby LaukensMarc LemannCecile LibioulleColm O'MorainCatherine ReenaersPaul RutgeertsCurt TyskDiana ZelenikaMark LathropJurgen Del-FaveroJean-Pierre HugotMartine De VosDenis FranchimontSeverine VermeireEdouard LouisMichel Georges

A1 Journal Article in NATURE GENETICS

Subclinical gut inflammation in spondyloarthritis is associated with a pro-angiogenic intestinal mucosal phenotype

Pieter HindryckxDebby LaukensGerlinde SerryLiesbet Van PraetClaude CuvelierHerman MielantsHarald PeetersDirk ElewautMartine De Vos

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

The hypoxia adaptive response regulates metallothionein expression in intestinal epithelial cells

Lindsey DevisscherPieter HindryckxHarald PeetersMartine De VosDebby Laukens

2010

Absence of placental growth factor blocks dextran sodium sulfate-induced colonic mucosal angiogenesis, increases mucosal hypoxia and aggravates acute colonic injury

Pieter HindryckxAnouk WaeytensDebby LaukensHarald PeetersJacques VanhuysseLiesbeth FerdinandePeter CarmelietMartine De Vos

A1 Journal Article in LABORATORY INVESTIGATION

Different mucosal expression of Th17 related genes in the small and large bowel of IBD patients

Sarah BogaertDebby LaukensHarald PeetersLode MelisKim OlievierNico BoonJo VandesompeleDirk ElewautMartine De Vos

Differential mucosal expression of Th17-related genes between the inflamed colon and ileum of patients with inflammatory bowel disease

Sara BogaertDebby LaukensHarald PeetersLode MelisKim OlievierNico BoonAugust VerbruggenJo VandesompeleDirk ElewautMartine De Vos

A1 Journal Article in BMC IMMUNOLOGY

Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis

Debby LaukensMichel GeorgesCécile LibioulleCynthia SandorMyriam MniBert Vander CruyssenHarald PeetersDirk ElewautMartine De Vos

A1 Journal Article in PLOS ONE

Fatigue in active and quiescent IBD is not related to serum levels of zinc, carnitine or pro-inflammatory cytokines

Harald PeetersChloë De RooAna MalfaitDebby LaukensMartine De Vos

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

Andre FrankeDermot PB McGovernJeffrey C BarrettKai WangGraham L Radford-SmithTariq AhmadCharlie W LeesTobias BalschunJames LeeRebecca RobertsCarl A AndersonJoshua C BisSuzanne BumpsteadDavid EllinghausEleonora M FestenMichel GeorgesTodd GreenTalin HarituniansLuke JostinsAnna LatianoChristopher G MathewGrant W MontgomeryNatalie J PrescottSoumya RaychaudhuriJerome I RotterPhilip SchummYashoda SharmaLisa A SimmsKent D TaylorDavid WhitemanCisca WijmengaRobert N BaldassanoMurray BarclayTheodore M BaylessStephan BrandCarsten BüningAlbert CohenJean-Frederick ColombelMario CottoneLaura StronatiTed DensonMartine De VosRenata D'IncaMarla DubinskyCathryn EdwardsTim FlorinDenis FranchimontRichard GearryJürgen GlasAndre Van GossumStephen L GutheryJonas HalfvarsonHein W VerspagetJean-Pierre HugotAmir KarbanDebby LaukensIan LawranceMarc LemannArie LevineCecile LibioulleEdouard LouisCraig MowatWilliam NewmanJulián PanésAnne PhillipsDeborah D ProctorMiguel RegueiroRichard RussellPaul RutgeertsJeremy SandersonMiquel SansFrank SeiboldA Hillary SteinhartPieter CF StokkersLeif TorkvistGerd Kullak-UblickDavid WilsonThomas WaltersStephan R TarganSteven R BrantJohn D RiouxMauro D'AmatoRinse K WeersmaSubra KugathasanAnne M GriffithsJohn C MansfieldSeverine VermeireRichard H DuerrMark S SilverbergJack SatsangiStefan SchreiberJudy H ChoVito AnneseHakon HakonarsonMark J DalyMiles Parkes

A1 Journal Article in NATURE GENETICS

Hydroxylase inhibition abrogates TNF-α-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD

Pieter HindryckxMartine De VosPeggy JacquesLiesbeth FerdinandeHarald PeetersKim OlievierSara BogaertBrigitta BrinkmanPeter VandenabeeleDirk ElewautDebby Laukens

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Oxygen sensor inhibition attenuates TNF-α induced intestinal epithelial damage by hypoxia inducible factor (HIF) 1-dependent repression of fas-associated death domain protein (Fadd)

Pieter HindryckxMartine De VosPeggy JacquesLiesbeth FerdinandeHarald PeetersBrigitta BrinkmanPeter VandenabeeleDirk ElewautDebby Laukens

Small animal PET-CT as a non-invasive method to evaluate terminal ileal inflammation in a murine model of Crohn's disease

Pieter HindryckxSteven StaelensSteven DeleyeHarald PeetersDebby LaukensMartine De Vos

2009

Absence of placental growth factor aggravates DSS-induced acute colonic injury

Pieter HindryckxAnouk WaeytensDebby LaukensHarald PeetersJacques Van HuyssePeter CarmelietMartine De Vos

Absence of placental growth factor aggravates DSS-induced acute colonic injury

Pieter HindryckxAnouk WaeytensDebby LaukensHarald PeetersJacques Van HuysseMartine De Vos

Common variants at five new loci associated with early-onset inflammatory bowel disease

M ImielinskiRN BaldassanoA GriffithsRK RussellV AnneseM DubinskyS KugathasanJP BradfieldTD WaltersP SleimanCE KimA MuiseK WangJT GlessnerS SaeedHT ZhangEC FrackeltonCP HouJH FloryG OtienoRM ChiavacciR GrundmeierM CastroA LatianoB DallapiccolaJ StempakDJ AbramsK TaylorD McGovernMB HeymanGD FerryB KirschnerJ LeeJ EssersR GrandM StephensA LevineD PiccoliJ Van LimbergenS CucchiaraDS MonosSL GutheryL DensonDC WilsonSFA GrantM DalyMS SilverbergJ SatsangiH HakonarsonDebby LaukensMartine De Vos

A1 Journal Article in NATURE GENETICS

Evidence for a potential role of metallothioneins in inflammatory bowel diseases

Anouk WaeytensMartine De VosDebby Laukens

A1 Journal Article in MEDIATORS OF INFLAMMATION

Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis

M GeorgesDebby LaukensC LibioulleC SandorM MniBert Vander CruyssenHarald PeetersDirk ElewautMartine De Vos

Human metallothionein expression under normal and pathological conditions : mechanisms of gene regulation based on in silico promoter analysis

Debby LaukensAnouk WaeytensPieter De BleserClaude CuvelierMartine De Vos

A1 Journal Article in CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Increased intestinal VEGF expression and mucosal vascularization in patients with spondylarthropathy

Pieter HindryckxGerlinde SerryDebby LaukensHarald PeetersMartine De Vos

Role of Placental Growth Factor in Mesenteric Neoangiogenesis in a Mouse Model of Portal Hypertension

Christophe Van SteenkisteAnja GeertsEline VanheuleHans Van VlierbergheFilip De VosKim OlievierChristophe CasteleynDebby LaukensMartine De VosJean-Marie StassenPeter CarmelietIsabelle Colle

A1 Journal Article in GASTROENTEROLOGY

2008

Development of cirrhosis is associated with increased levels of placental growth factor

Christophe Van SteenkisteBen SchroyenAnja GeertsEline VanheuleHans Van VlierbergheDebby LaukensKim OlievierHendrik ReynaertMartine De VosIsabelle Colle

Development of cirrhosis is associated with increased levels of placental growth factor: a descriptive study

Christophe Van SteenkisteBen SchroyenAnja GeertsEline VanheuleHans Van VlierbergheDebby LaukensKim OlievierHendrik ReynaertAlbert GeertsPeter CarmelietMartine De VosIsabelle Colle

Development of cirrhosis is associated with increased levels of placental growth factor: a descriptive study

Christophe Van SteenkisteBen SchroyenAnja GeertsEline VanheuleHans Van VlierbergheDebby LaukensKim OlievierHendrik ReynaertAlbert GeertsPeter CarmelietMartine De VosIsabelle Colle

Genetics of spondyloarthropathies and inflammatory bowel disease: searching for common susceptibility factors

Debby LaukensMartine De Vos

A2 Journal Article in CURRENT RHEUMATOLOGY REVIEWS

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

JC BARRETTS HANSOULDL NICOLAEJH CHORH DUERRJD RIOUXSR BRANTMS SILVERBERGKD TAYLORMM BARMADAA BITTONT DASSOPOULOSLW DATTAT GREENAM GRIFFITHSEO KISTNERMT MURTHAMD REGUEIROJI ROTTERLP SCHUMMAH STEINHARTSR TARGANRJ XAVIERC LIBIOULLEC SANDORM LATHROPJ BELAICHEO DEWITI GUTS HEATHDebby LaukensM MNIP RUTGEERTSA VAN GOSSUMD ZELENIKAD FRANCHIMONTJP HUGOTMartine De VosS VERMEIREE LOUISLR CARDONCA ANDERSONH DRUMMONDE NIMMOT AHMADNJ PRESCOTTCM ONNIESA FISHERJ MARCHINIJ GHORIS BUMPSTEADR GWILLIAMM TREMELLINGP DELOUKASJ MANSFIELDD JEWELLJ SATSANGICG MATHEWM PARKESM GEORGESMJ DALY

A1 Journal Article in NATURE GENETICS

Reduced metallothionein expression in colonic Crohn's disease: evidence for a new disease-modifying gene

Debby LaukensHarald PeetersAnouk WaeytensSara BogaertBert Vander CruyssenDirk ElewautFilip De KeyserHerman MielantsClaude CuvelierKenny KnechtPaul Van HummelenJurgen Del-FaveroErik RemautMartine De VosPieter Rottiers

Reduced metallothionein expression in colonic Crohn's disease: evidence for it new disease-modifying gene

Debby LaukensHarald PeetersAnouk WaeytensSara BogaertBert Vander CruyssenDirk ElewautFilip De KeyserHerman MielantsClaude CuvelierP Van HummelenJurgen Del-FaveroErik RemautMartine De VosPieter Rottiers

2007

A functional promoter polymorphism in CARD15 associated with Crohn's disease

Debby LaukensMichaela LoosSara BogaertsHarald PeetersJ DEL-FAVEROMartine De Vos

A functional promotor polymorphism in CARD15 associated with Crohn's disease

Debby LaukensMichaela LoosSara BogaertHarald PeetersJurgen Del-FaveroMartine De Vos

CARD15 variants determine a disturbed early response of monocytes to adherent-invasive Escherichia coli strain LF82 in Crohn's disease

Harald PeetersSara BogaertDebby LaukensPieter RottiersFilip De KeyserA Darfeuille-MichaudAL GlasserDirk ElewautMartine De Vos

A1 Journal Article in INTERNATIONAL JOURNAL OF IMMUNOGENETICS

Disturbed expression of alpha-defensins and tissue inhibitor of matrix Metalloproteinase-1 in neutrophils of Crohn's Disease patients

Sara BogaertHarald PeetersDebby LaukensMartine De Vos

Disturbed expression of alpha-defensins and tissue inhibitor of matrix metalloproteinase-1 in neutrophils of Crohn's disease patients

Sara BogaertHarald PeetersDebby LaukensMartine De Vos

Downregulation of metallothioneins (MTS) in intestinal epithelial cells (IECs) is associated with impaired chemoattractant activity

Anouk WaeytensDebby LaukensSylvie JanssensHarald PeetersPieter RottiersClaude CuvelierMartine De Vos

Metallothionein silencing in intestinal epithelial cells results in impaired chemoattractant activity

Anouk WaeytensDebby LaukensSylvie JanssensHarald PeetersPieter RottiersClaude CuvelierMartine De Vos

Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4

C LIBIOULLEE LOUISS HANSOULC SANDORF FARNIRD FRANCHIMONTS VERMEIREO DEWITMartine De VosA DIXONB DEMARCHEI GUTS HEATHM FOGLIOLM LIANGDebby LaukensM MNID ZELENIKAA VAN GOSSUMP RUTGEERTSJ BELAICHEM LATHROPM GEORGES

A1 Journal Article in PLOS GENETICS

2006

Altered gut transcriptome in spondyloarthropathy

Debby LaukensHarald PeetersBert Vander CruyssenTom BoonefaesDirk ElewautFilip De KeyserHerman MielantsClaude CuvelierEric VeysKenny KnechtP Van HummelenErik RemautLothar SteidlerMartine De VosPieter Rottiers

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Transcriptome Profiling and Genetic Analysis to Identify Susceptibility Genes for Crohn’s Disease

Debby LaukensErik RemautP Rottiers

2005

CARD15 gene polymorphisms in patients with spondyloarthropathies identify a specific phenotype previously related to Crohn's disease

Debby LaukensHarald PeetersDENIS MARICHALBert Vander CruyssenHerman MielantsDirk ElewautPieter DemetterClaude CuvelierM VAN DEN BERGHEPieter RottiersEric VeysErik RemautLothar SteidlerFilip De KeyserMartine De Vos

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

CARD15 polymorphisms are associated with anti-Saccharomyces cerevisiae antibodies in caucasian Crohn's disease patients

Bert Vander CruyssenHarald PeetersIlse HoffmanDebby LaukensPaul CouckeDENIS MARICHALClaude CuvelierErik RemautEric VeysHerman MielantsMartine De VosFilip De Keyser

A1 Journal Article in CLINICAL AND EXPERIMENTAL IMMUNOLOGY

2004

Radiological sacroiliitis is linked with CARD15 gene polymorphisms in patients with Crohn's disease

Bert Vander CruyssenHarald PeetersDebby LaukensP COUCKEHerman MielantsMartine De VosFilip De Keyser

Radiological sacroiliitis, a hallmark of spondylitis, is linked with CARD15 gene polymorphisms in patients with Crohn's disease

Harald PeetersBert Vander CruyssenDebby LaukensPaul CouckeDENIS MARICHALMARTINA VAN DEN BERGHEClaude CuvelierErik RemautHerman MielantsFilip De KeyserMartine De Vos

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

The presence of CARD15 polymorphisms is linked with higher ASCA titers in Crohn's disease

Harald PeetersBert Vander CruyssenDebby LaukensP COUCKEIlse HoffmanFilip De KeyserMartine De Vos

Trefoil factor 3 increases MMP3 expression in intestinal epithelial cells

Jacques Van HuyssePieter DemetterI TRUYENK VANDENBROUCKEDebby LaukensL STEIDLERP ROTTIERSClaude Cuvelier

2003

Association between ASCA-positivity and carrier of a CARD-15 mutation in patients with Crohn's disease

B VAN DER CRUYSSENFilip De KeyserHarald PeetersM VAN DEN BERGHED MARICHALIlse HoffmanT VAN OOSTVELDTDebby LaukensErik RemautL STEIDLERDirk ElewautClaude CuvelierMartine De VosHerman MielantsEric Veys

CARD15 mutations in patients with spondyloarthropathy are linked with disease progression and evolution to Crohn's disease

Martine De VosDebby LaukensDENIS MARICHALM VAN DEN BERGHEHarald PeetersDirk ElewautHerman MielantsFilip De KeyserClaude CuvelierEric VeysErik RemautLothar Steidler

Crohn's disease patients with CARD15 variants have higher risk of developing axial joint involvement

Martine De VosHarald PeetersBert Vander CruyssenDebby LaukensDenis MarichalMarthe VandenbergheT Van OostveldtDirk ElewautFilip De KeyserClaude CuvelierEric VeysErik RemautLothar SteidlerHerman Mielants