Research Explorer

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Researcher

Danielle Clancy

Publications & Research Data

Awards & Distinctions

17 Results

2026

Structural and mechanistic insights into the constitutive Themis-Grb2 complex in T cell signalling

Danielle ClancyAlba Sanz SanjuanElisabeth GilisPeter TougaardImke VelgheYana Van DroogenbroeckJan FélixYehudi BlochÁlvaro Furones CuadradoRomain Merceron et al.

A1 Journal Article in NATURE COMMUNICATIONS

2024

The pros and confs of IL-18 activation

Danielle ClancyJulie AndriesSavvas Savvides

Editorial material

2022

Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity

Sammy DetryJulie AndriesYehudi BlochCem GabayDanielle ClancySavvas Savvides

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2020

TRAIL receptors serve as stress-associated molecular patterns to promote ER-stress-induced inflammation

Graeme P. SullivanHazel O'ConnorConor M. HenryPavel DavidovichDanielle ClancyMatthew L. AlbertSean P. CullenSeamus J. Martin

A1 Journal Article in DEVELOPMENTAL CELL

2019

To NET or not to NET : current opinions and state of the science regarding the formation of neutrophil extracellular traps

Sebastian BoeltzPoorya AminiHans-Joachim AndersFelipe AndradeRostyslav BilyySimon ChatfieldIwona CichonDanielle ClancyJyaysi DesaiTetiana Dumych et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2018

Extracellular neutrophil proteases are efficient regulators of IL-1, IL-33, and IL-36 cytokine activity but poor effectors of microbial killing

Danielle ClancyGraeme P. SullivanHannah B. T. MoranConor M. HenryEmer P. ReevesNoel G. McElvaneyEd C. LavelleSeamus J. Martin

A1 Journal Article in CELL REPORTS

Identification of small-molecule elastase inhibitors as antagonists of IL-36 cytokine activation

Graeme P. SullivanPavel B. DavidovichSylvia Sura-TruebaEkaterina BelotcerkovskayaConor M. HenryDanielle ClancyAnna ZinovevaTazhir MametnabievAlexander V. GarabadzhiuSeamus J. Martin

A1 Journal Article in FEBS OPEN BIO

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

Ioanna OikonomidiEmma BurbridgeMiguel CavadasGraeme SullivanBlanka CollisHeike NaegeleDanielle ClancyJana BrezinovaTianyi HuAndrea Bileck et al.

A1 Journal Article in ELIFE

Mind bomb regulates cell death during TNF signaling by suppressing RIPK1's cytotoxic potential

Rebecca FelthamKunzah JamalTencho TenevGianmaria LiccardiIsabel JacoCelia Monteiro DominguesOtto MorrisSidonie Wicky JohnAlessandro AnnibaldiMarcella Widya et al.

A1 Journal Article in CELL REPORTS

Suppressing IL-36-driven inflammation using peptide pseudosubstrates for neutrophil proteases

Graeme P. SullivanConor M. HenryDanielle ClancyTazhir MametnabievEkaterina BelotcerkovskayaPavel DavidovichSylvia Sura-TruebaAlexander V. GarabadzhiuSeamus J. Martin

A1 Journal Article in CELL DEATH & DISEASE

2017

Neutrophil extracellular traps can serve as platforms for processing and activation of IL-1 family cytokines

Danielle ClancyConor M. HenryGraeme P. SullivanSeamus J. Martin

A1 Journal Article in FEBS JOURNAL

2016

Getting a gRIP on flu by casting the DAI

Danielle ClancySeamus J. Martin

Editorial material

Neutrophil-derived proteases escalate inflammation through activation of IL-36 family cytokines

Conor HenryGraeme SullivanDanielle ClancyInna AfoninaDagmar KulmsSeamus Martin

A1 Journal Article in CELL REPORTS

Production of biologically active IL-36 family cytokines through insertion of N-terminal caspase cleavage motifs

Danielle ClancyConor M. HenryPavel B. DavidovichGraeme P. SullivanEkaterina BelotcerkovskayaSeamus J. Martin

A1 Journal Article in FEBS OPEN BIO

2015

Diverse activators of the NLRP3 inflammasome promote IL-1 beta secretion by triggering necrosis

Sean P. CullenConor J. KearneyDanielle ClancySeamus J. Martin

A1 Journal Article in CELL REPORTS

Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production

C. J. KearneyS. P. CullenG. A. TynanC. M. HenryDanielle ClancyE. C. LavelleS. J. Martin

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2014

RIPK1 can function as an inhibitor rather than an initiator of RIPK3-dependent necroptosis

Conor J. KearneySean P. CullenDanielle ClancySeamus J. Martin

A1 Journal Article in FEBS JOURNAL