Research Explorer

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Researcher

Daisy Flamez

Awards & Distinctions

46 Results

2018

Immuno-T, a motion comic educating patients and caregivers on how immunotherapy works

Chiel Gharakhani NiaStijn CalisYves BertrandLieve AchtenJASMIEN SOETENSBarbara CasteelsDaisy FlamezBruno BollaertTessa Kerre

2012

Molecular diagnostics for congenital hearing loss including 15 deafness genes using a next generation sequencing platform

Sarah De KeulenaerJan HellemansSteve LefeverJean-Pierre RenardJoachim De SchrijverHendrik Van de VoordeMohammad Amin TabatabaiefarFilip Van NieuwerburghDaisy FlamezFilip Pattyn et al.

A1 Journal Article in BMC MEDICAL GENOMICS

2010

A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)γa as a pancreatic beta cell-specific biomarker

Daisy FlamezI RolandA BertonB KutluD DufraneMC BeckersE De WaeleI RoomanL BouwensA Clark et al.

A1 Journal Article in DIABETOLOGIA

Cytokines interleukin-1β and tumor necrosis factor-α regulate different transcriptional and alternative splicing networks in primary β-cells

Fernanda OrtisNajib NaamaneDaisy FlamezLaurence LadrièreFabrice MooreDaniel A CunhaMaikel L ColliThomas ThykjaerKasper ThorsenTorben F Ørntoft et al.

A1 Journal Article in DIABETES

Identification of new pancreatic beta cell targets for in vivo imaging by a systems biology approach

Thomas BouckenoogheDaisy FlamezFernanda OrtisSerge GoldmanDecio L Eizirik

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

2009

Cytokines regulate both transcriptional and alternative splicing networks in primary beta cells

Fernanda OrtisN NaamaneDaisy FlamezLaurence LadrièreF MooreDA CunhaML ColliT ThykjaerK ThorsenTF Orntoft et al.

Detailed transcriptome atlas of the pancreatic beta cell

Burak KutluDavid BurdickDavid BaxterJoanne RasschaertDaisy FlamezDécio L EizirikNils WelshNathan GoodmanLeroy Hood

A1 Journal Article in BMC MEDICAL GENOMICS

2008

A platform for the identification and validation of beta cell specific membrane biomarkers

Daisy FlamezA BertonI RolandBurak KutluN GoodmanM-C BeckersD MarechalS GoldmanC Van HuffelI Salmon et al.

Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways

Zeynep DogusanMonica GarcíaDaisy FlamezLena AlexopouiouMichel GoldmanConny GysemansChantal MathieuClaude LibertDécio L EizirikJoanne Rasschaert

A1 Journal Article in DIABETES

Identification of gene networks regulated by the cytokines IL-1 beta and TNF alpha in primary rat beta cells

F OrtisN NaamaneDaisy FlamezF MooreDecio L Elzirik

Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate

Els LouagieNeil A TaylorDaisy FlamezAnton JM RoebroekNicholas A BrightSandra MeulemansRoel QuintensPedro L HerreraFrans SchuitWim JM van de Ven et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes

Décio L EizirikFabrice MooreDaisy FlamezFernanda Ortis

A1 Journal Article in BIOCHEMICAL SOCIETY TRANSACTIONS

2007

Early mediators and downstream effectors of dsRNA-induced beta cell apoptosis: the role of IRF-3 and ER stress

Joanne RasschaertZeynep DogusanMonica GarcíaDaisy FlamezLena AlexopoulouMichele GoldmanConny GysemansChantal MathieuClaude LibertDécio L Eizirik

Proteomics analysis of cytokine-induced dysfunction and death in insulin-producing INS-1E cells

Wannes D'HertogLut OverberghKasper LageGabriela Bonfim FerreiraMichael MarisConny GysemansDaisy FlamezAlessandra Kupper CardozoGert Van den BerghLiliane Schoofs et al.

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

Miriam CnopLaurence LadrièrePaul HekermanFernanda OrtisAlessandra K CardozoZeynep DogusanDaisy FlamezMichael BoyceJun-Ying YuanDécio L Eizirik

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

T1DBase: integration and presentation of complex data for type 1 diabetes research

Erin M HulbertLuc J SminkEllen C AdlemJames E AllenDavid B BurdickOliver S BurrenVictor M CassenChristopher C CavnorGeoffrey E DolmanDaisy Flamez et al.

A1 Journal Article in NUCLEIC ACIDS RESEARCH

T1DBase: integration and presentation of complex data for type 1 diabetes research (vol 35, pg D742, 2007)

Erin M HulbertLuc J SminkEllen C AdlemJames E AllenDavid B BurdickOliver S BurrenVictor M CassenChristopher C CavnorGeoffrey E DolmanDaisy Flamez et al.

2006

Cytokines and dsRNA induce expression and activation of HIF-1 alpha in rat pancreatic beta cells

Laurence LadrièreDaisy FlamezFernanda OrtisJoanne RasschaertDécio L Eizirik

Molecular pathways underlying Toll-like receptor 3 (TLR3)-induced beta cell apoptosis

Joanne RasschaertZeynep DogusanDaisy FlamezLena AlexopoulouChantal MathieuDécio L Eizirik

2005

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

D ScheunerDV MierdeB SongDaisy FlamezJWM CreemersK TsukamotoM RibickFC SchuitRJ Kaufman

A1 Journal Article in NATURE MEDICINE

Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells

Conny A GysemansLaurence LadrièreHanne CallewaertJoanne RasschaertDaisy FlamezDavid E LevyPatrick MatthysDécio L EizirikChantal Mathieu

A1 Journal Article in DIABETES

Essential role of chicken ovalbumin upstream promoter-transcription factor II in insulin secretion and insulin sensitivity revealed by conditional gene knockout

Pascale BardouxPi-Li ZhangDaisy FlamezAnaïs PerilhouTiphaine Aguirre LavinJean-François TantiKarine HellemansEmmanuel GomasCécile GodardFabrizio Andreelli et al.

A1 Journal Article in DIABETES

T1DBase, a community web-based resource for type 1 diabetes research

Luc J SminkErin M HeltonBarry C HealyChristopher C CavnorAlex C LamDaisy FlamezOliver S BurrenYang WangGeoffrey E DolmanDavid B Burdick et al.

A1 Journal Article in NUCLEIC ACIDS RESEARCH

2004

Prior in vitro exposure to GLP-1 with or without GIP can influence the subsequent beta cell responsiveness

Dominique DelmeireDaisy FlamezKaren MoensSimon A HinkeChris Van SchravendijkDaniel PipeleersFrans Schuit

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2003

A globin in the nucleus!

Eva GeuensInge BrounsDaisy FlamezSylvia DewildeJean-Pierre TimmermansLuc Moens

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoglycemia, defective islet glucagon secretion, but normal islet mass in mice with a disruption of the gastrin gene

Robin P BousheyAmir AbadirDaisy FlamezLaurie L BaggioYa-Zhou LiVeerle BergerBess A MarshallDiane FinegoodTimothy C WangFrans Schuit et al.

A1 Journal Article in GASTROENTEROLOGY

Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models

Benoit ViolletFabrizio AndreelliSebastian B JorgensenChristophe PerrinDaisy FlamezJames MuJorgen FP WojtaszewskiFrans C SchuitMorris J BirnbaumErik A Richter et al.

A1 Journal Article in BIOCHEMICAL SOCIETY TRANSACTIONS

The AMP-activated protein kinase alpha 2 catalytic subunit controls whole-body insulin sensitivity

Benoit ViolletFabrizio AndreelliSebastian B JorgensenChristophe PerrinAlain GeloenDaisy FlamezJames MuClaudia LenznerOlivier BaudMyriam Bennoun et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1

Dominique DelmeireDaisy FlamezSimon A HinkeJJ CaliDaniel PipeleersFrans Schuit

A1 Journal Article in DIABETOLOGIA

2002

Critical role for cataplerosis via citrate in glucose-regulated insulin release

Daisy FlamezVeerle BergerMogens KruhofferTorben OrntoftDaniel PipeleersFrans C Schuit

A1 Journal Article in DIABETES

Glucose-regulated gene expression maintaining the glucose-responsive state of beta-cells

Frans SchuitDaisy FlamezAnick De VosDaniel Pipeleers

A1 Journal Article in DIABETES

2001

Culture of rat beta-cells with incretin hormones preserves their subsequent secretion responsiveness

Dominique DelmeireDaisy FlamezDaniel PipeleersFrans Schuit

Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice

Z LingD WuY ZambreDaisy FlamezDJ DruckerDaniel G PipeleersFrans C Schuit

A1 Journal Article in VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY

Mitogenic effect of gastrin and expression of gastrin receptors in duct-like cells of rat pancreas

Ilse RoomanJessy LardonDaisy FlamezFrans SchuitLuc Bouwens

A1 Journal Article in GASTROENTEROLOGY

Role of locally released glucagon in the insulin secretory response from the intact pancreas

K MoensDaisy FlamezVeerle BergerP HuypensC Van SchraverndijkJ AhnV HrubyDaniel PipeleersFrans Schuit

1999

Altered cAMP and Ca2+ signaling in mouse pancreatic islets with glucagon-like peptide-1 receptor null phenotype

Daisy FlamezPatrick GilonKaren MoensAn Van BreusegemDominique DelmeireLouise A ScrocchiJean-Claude HenquinDaniel J DruckerFrans Schuit

A1 Journal Article in DIABETES

1998

Alterations of cytoplasmic Ca2+ regulation in mouse islets unresponsive to GLP-1

Patrick GilonDaisy FlamezAn Van BreuseghemLouise SchrocchiDaniel J DruckerJean-Claude HenquinFrans Schuit

Dual glucagon recognition by pancreatic beta-cells via glucagon and glucagon-like peptide 1 receptors

Karen MoensDaisy FlamezC Van SchravendijkZD LingDaniel PipeleersFrans Schuit

A1 Journal Article in DIABETES

Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor (-/-) mice

Raymond A PedersonMalathy SatkunarajahChristopher HS McIntoshLouise A ScrocchiDaisy FlamezFrans SchuitDaniel J DruckerMichael B Wheeler

A1 Journal Article in DIABETES

Mouse pancreatic beta-cells exhibit preserved glucose competence after disruption of the glucagon-like peptide-1 receptor gene

Daisy FlamezAn Van BreusegemLouise A ScrocchiErik QuartierDaniel PipeleersDaniel J DruckerFrans Schuit

A1 Journal Article in DIABETES

1996

Expression and functional activity of glucagon, glucagon-like peptide I, and glucose-dependent insulinotropic peptide receptors in rat pancreatic islet cells

Karen MoensH HeimbergDaisy FlamezP HuypensE QuartierZD LingDaniel PipeleersS GremlichB ThorensFrans Schuit

A1 Journal Article in DIABETES

Glucagon and GLP-1 receptors on beta-cells and hepatocytes

Karen MoensC Van SchravendijkA ForiersDaniel PipeleersV RogiersDaisy FlamezFrans Schuit

1995

Expression of GS-coupled hormone receptors in rat pancreatic beta-cells

K MoensH HeimbergDaisy FlamezZ LingD PipeleersB ThorensF Schuit

Production in Escherichia coli of a functional murine and murine::human chimeric F(ab')2 fragment and mature antibody directed against human placental alkaline phosphatase

Daisy FlamezErik RemautWalter Fiers

A1 Journal Article in JOURNAL OF BIOTECHNOLOGY

1994

Synthese van muis en muis-mens chimere antilichamen, antilichaamfragmenten en immunotoxines in Escherichia coli

Daisy FlamezWalter Fiers

1993

Construction of a mouse and a mouse-human chimeric immunotoxin on the genetic level and production of functional protein in E. coli

Daisy FlamezErik RemautWalter Fiers