Research Explorer

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Researcher

Daan Van Hauwermeiren

Publications & Research Data

Awards & Distinctions

52 Results

2025

A knowledge-guided neural network approach to model tablet properties in direct compression

Manuel Borja Lopez PelaezJens DhondtJohny BertelsDaan Van HauwermeirenJan Verwaeren

A multitask modelling framework for tablet manufacturability and quality attributes in direct compression using knowledge-guided neural networks

Manuel Borja Lopez PelaezJens DhondtJohny BertelsDaan Van HauwermeirenJan Verwaeren

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Modelling the effect of base component properties and processing conditions on mixture products using probabilistic, knowledge-guided neural networks

Manuel Borja Lopez PelaezJens DhondtJohny BertelsDaan Van HauwermeirenJan Verwaeren

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Neural network approach to direct compression : integrating expert knowledge and data

Manuel Borja Lopez PelaezJens DhondtJohny BertelsDaan Van HauwermeirenJan Verwaeren

Quality‐diversity methods for the modern data scientist

Michiel StockDaan Van HauwermeirenBernard De BaetsSteff TaelmanDries MarzouguiMaxime Van Haeverbeke

A1 Journal Article in WILEY INTERDISCIPLINARY REVIEWS-COMPUTATIONAL STATISTICS

2024

A framework for the in silico assessment of the robustness of an MPC in a CDC line in function of process variability

Ruben WaeytensDaan Van HauwermeirenWouter GrymonpréIngmar NopensThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Modeling and control of pharmaceutical feeding and blending processes

Ruben WaeytensIngmar NopensThomas De BeerDaan Van Hauwermeiren

Modelling tablet quality attributes using probabilistic, knowledge-guided neural networks

Manuel Borja Lopez PelaezJens DhondtJohny BertelsDaan Van HauwermeirenJan Verwaeren

2023

An extended 3-compartmental model for describing step-change experiments in pharmaceutical twin-screw feeders at different refill regimes

Ruben WaeytensLisa De SouterWouter GrymonpréDaan Van HauwermeirenIngmar NopensThomas De Beer

An in silico framework for the robust tuning of an MPC for a continuous blender in a production line for pharmaceutical oral solid dosages.

Ruben WaeytensDaan Van HauwermeirenWouter GrymonpréIngmar NopensThomas De Beer

Analysis of the influence of process and formulation properties on the drying behavior of pharmaceutical granules in a semi-continuous fluid bed drying system

Tuur VandeputteMichael GhijsMichiel PeetersAlexander De ManDaan Van HauwermeirenEduardo Dos Santos SchultzTamas VighFanny StaufferIngmar NopensThomas De Beer

A2 Journal Article in POWDERS

Exploring the effect of raw material properties on continuous twin-screw wet granulation manufacturability

Michiel PeetersAna Alejandra Barrera JiménezKensaku MatsunamiDaan Van HauwermeirenFanny StaufferLærke ArnfastTamas VighIngmar NopensThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Linking material properties to 1D-PBM parameters towards a generic model for twin-screw wet granulation

Ana Alejandra Barrera JiménezKensaku MatsunamiDaan Van HauwermeirenMichiel PeetersFanny StaufferEduardo dos Santos SchultzAshish KumarThomas De BeerIngmar Nopens

A1 Journal Article in CHEMICAL ENGINEERING RESEARCH & DESIGN

Mechanistic modeling of semicontinuous fluidized bed drying of pharmaceutical granules by incorporating single particle and bulk drying kinetics

Tuur VandeputteMichael GhijsDaan Van HauwermeirenEduardo Dos Santos SchultzElisabeth SchäferFanny StaufferThomas De BeerIngmar Nopens

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Model development and calibration of two-dimensional population balance model for twin-screw wet granulation based on particle size distribution and porosity

Ana Alejandra Barrera JiménezKensaku MatsunamiMichael GhijsDaan Van HauwermeirenMichiel PeetersFanny StaufferThomas De BeerIngmar Nopens

A1 Journal Article in POWDER TECHNOLOGY

Partial least squares regression to calculate population balance model parameters from material properties in continuous twin-screw wet granulation

Ana Alejandra Barrera JiménezKensaku MatsunamiDaan Van HauwermeirenMichiel PeetersFanny StaufferEduardo dos Santos SchultzAshish KumarThomas De BeerIngmar Nopens

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

T-shaped partial least squares for high-dosed new active pharmaceutical ingredients in continuous twin-screw wet granulation : granule size prediction with limited material information

Kensaku MatsunamiJonathan MeyerMartin RowlandNeil DawsonThomas De BeerDaan Van Hauwermeiren

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Validation of model-based design of experiments for continuous wet granulation and drying

Kensaku MatsunamiTuur VandeputteAna Alejandra Barrera JiménezMichiel PeetersMichael GhijsDaan Van HauwermeirenFanny StaufferEduardo dos Santos SchultzIngmar NopensThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2022

An extended 3-compartment model for describing step change experiments in pharmaceutical twin-screw feeders at different refill regimes

Ruben WaeytensLisa De SouterWouter GrymonpréDaan Van HauwermeirenIngmar NopensThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

An extended 3-compartmental model for describing step-change experiments in pharmaceutical twin-screw feeders at different refill regimes

Ruben WaeytensLisa De SouterWouter GrymonpréDaan Van HauwermeirenIngmar NopensThomas De Beer

An extended 3-D compartment model for describing step-change experiments in pharmaceutical feeders for different refill regimes

Ruben WaeytensLisa De SouterWouter GrymonpréDaan Van HauwermeirenIngmar NopensThomas De Beer

In-depth analysis of the impacts of material properties on size distributions in continuous twin-screw wet granulation to construct a generic 1D population balance model

Kensaku MatsunamiAna Alejandra Barrera JiménezMichiel PeetersDaan Van HauwermeirenThomas De BeerIngmar Nopens

Increasing the applicability of population balance models in continuous pharmaceutical twin-screw wet granulation

Ana Alejandra Barrera JiménezIngmar NopensThomas De BeerDaan Van Hauwermeiren

Model-based design of experiments in drug product development in continuous manufacturing

Tuur VandeputteAna Alejandra Barrera JiménezKensaku MatsunamiMichiel PeetersMichael GhijsDaan Van HauwermeirenIngmar NopensThomas De Beer

Towards a generic population balance model for twin-screw wet granulation : from material properties to particle size distribution

Ana Alejandra Barrera JiménezDaan Van HauwermeirenKensaku MatsunamiMichiel PeetersThomas De BeerIngmar Nopens

Two-dimensional population balance model for twin-screw wet granulation : model development and calibration based on particle size distribution and porosity

Kensaku MatsunamiAna Alejandra Barrera JiménezMichiel PeetersMichael GhijsDaan Van HauwermeirenThomas De BeerIngmar Nopens

2021

Improvement of a 1D population balance model for twin-screw wet granulation by using identifiability analysis

Ana Alejandra Barrera JiménezDaan Van HauwermeirenMichiel PeetersThomas De BeerIngmar Nopens

A1 Journal Article in PHARMACEUTICS

TPLS as predictive platform for twin-screw wet granulation process and formulation development

Alexander RyckaertDaan Van HauwermeirenJens DhondtAlexander De ManAdrian FunkeDejan DjuricChris VervaetIngmar NopensThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2020

In-line temperature measurement to improve the understanding of the wetting phase in twin-screw wet granulation and its use in process development

Fanny StaufferAlexander RyckaertValérie VanhoorneDaan Van HauwermeirenAdrian FunkeDejan DjuricChris VervaetIngmar NopensThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

On the simulation of particle size distributions in continuous pharmaceutical wet granulation

Daan Van HauwermeirenIngmar NopensThomas De Beer

Predicting pharmaceutical particle size distributions using kernel mean embedding

Daan Van HauwermeirenMichiel StockThomas De BeerIngmar Nopens

A1 Journal Article in PHARMACEUTICS

2019

Heat transfer evaluation during twin-screw wet granulation in view of detailed process understanding

Fanny StaufferAlexander RyckaertDaan Van HauwermeirenAdrian FunkeDejan DjuricIngmar NopensThomas De Beer

A1 Journal Article in AAPS PHARMSCITECH

Kernel mean embedding of distributions : a new data-driven model approach for modelling a continuous pharmaceutical twin-screw granulation process

Daan Van HauwermeirenMichiel StockThomas De BeerIngmar Nopens

On the modelling of granule size distributions in twin-screw wet granulation : calibration of a novel compartmental population balance model

Daan Van HauwermeirenMaxim VerstraetenPankaj DoshiMary T am EndeNeil TurnbullKai LeeThomas De BeerIngmar Nopens

A1 Journal Article in POWDER TECHNOLOGY

Population balance modelling for twin-screw wet granulation : insight in the notion of distance between distributions and the need for identifiable models for good model predictive power

Daan Van HauwermeirenIngmar NopensThomas De Beer

Towards a generic model for twin-screw wet granulation

Daan Van HauwermeirenMaxim VerstraetenMichael GhijsKai LeeNeil TurnbullMary T am EndePankaj DoshiDavid WilsonThomas De BeerIngmar Nopens

Bookchapter in Chemical engineering in the pharmaceutical industry : drug product design, development, and modeling

2018

Model-based NIR spectroscopy implementation for in-line assay monitoring during a pharmaceutical suspension manufacturing process

Maxim VerstraetenDaan Van HauwermeirenMario HellingsEline HermansJeroen GeensChris VervaetIngmar NopensThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

On the identifiability of kernels for Population Balance Modelling

Daan Van HauwermeirenThomas De BeerIngmar Nopens

2017

Application of iterative robust model-based optimal experimental design for the calibration of biocatalytic models

Timothy Van DaeleKrist V GernaeyRolf H RingborgTim BornerSoren HeintzDaan Van HauwermeirenCarl GreyUlrich KruhnePatrick AdlercreutzIngmar Nopens

A1 Journal Article in BIOTECHNOLOGY PROGRESS

In-depth experimental analysis of pharmaceutical twin-screw wet granulation in view of detailed process understanding

Maxim VerstraetenDaan Van HauwermeirenKai LeeNeil TurnbullDavid WilsdonMary Am EndePankaj DoshiChris VervaetDavinia BrouckaertSéverine Mortier et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Methodology and pitfalls when calibrating a PBM : the case of twin-screw wet granulation

Daan Van HauwermeirenMaxim VerstraetenThomas De BeerIngmar Nopens

Methodology and pitfalls when calibrating a PBM : the case of twin-screw wet granulation

Daan Van HauwermeirenMaxim VerstraetenThomas De BeerIngmar Nopens

Towards a general model for twin-screw wet granulation : application of a novel validated PBM model to a hydrophilic compound and linking model parameters to blend properties

Daan Van HauwermeirenMaxim VerstraetenKai LeeNeil TurnbullMary T am EndePankaj DoshiThomas De BeerIngmar Nopens

Towards a general model for twin-screw wet granulation : development and calibration of a novel three compartmental PBM model

Daan Van HauwermeirenMaxim VerstraetenKai LeeNeil TurnbullMary T am EndePankaj DoshiThomas De BeerIngmar Nopens

Towards a general model for twin-screw wet granulation : validation of a PBM model through linking calibrated model parameters to process conditions

Daan Van HauwermeirenMaxim VerstraetenKai LeeNeil TurnbullMary T am EndePankaj DoshiThomas De BeerIngmar Nopens

2016

A generic model-based methodology for quantification of mass transfer limitations in microreactors

Timothy Van DaeleDavid Fernandes del PozoDaan Van HauwermeirenKrist V GernaeyRoland WohlgemuthIngmar Nopens

A1 Journal Article in CHEMICAL ENGINEERING JOURNAL

Methodology and pitfalls when calibrating a PBM : the case of twin-screw wet granulation

Daan Van HauwermeirenThomas De BeerMichael GhijsMaxim VerstraetenAshish KumarKrist V GernaeyKai LeeMary T am EndePankaj DoshiIngmar Nopens

Model-based process analysis in continuous manufacturing of pharmaceuticals : calibration of a fluid bed dryer model

Michael GhijsFien De LeersnyderDaan Van HauwermeirenValérie VanhoorneJurgen VercruyssePhilippe CappuynsSéverine MortierThomas De BeerKrist GernaeyIngmar Nopens

Quantifying the importance of flow maldistribution in numbered-up microreactors

David Fernandes del PozoTimothy Van DaeleDaan Van HauwermeirenKrist V GernaeyIngmar Nopens

The potential of using microreactors for the enzymatic production of unstable intermediates

Timothy Van DaeleDaan Van HauwermeirenRoland WohlgemuthIngmar Nopens

2015

A case study on robust optimal experimental design for model calibration of ω-transaminase

Timothy Van DaeleDaan Van HauwermeirenRolf RingborgSøren HeintzStijn Van HoeyKrist V GernaeyIngmar Nopens

Model-based analysis of mass transfer limitations in microreactors

Timothy Van DaeleDavid Fernandes del PozoDaan Van HauwermeirenKrist V GernaeyIngmar Nopens