Research Explorer

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Researcher

Conor Mc Guire

Awards & Distinctions

21 Results

2018

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

Sofie VoetConor Mc GuireNora HagemeyerArne MartensAnna SchroederPeter WieghoferCarmen DaemsOri StaszewskiLieselotte Vande WalleMarta Joana Costa Jordao et al.

A1 Journal Article in NATURE COMMUNICATIONS

2017

Elevated ΔNp63α levels facilitate epidermal and biliary oncogenic transformation

Michael DevosBarbara GilbertGeertrui DeneckerKirsten LeursConor Mc GuireKelly LemeireTino HochepiedMarnik VuylstekeJo LambertCaroline Van den Broecke et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

2016

A20 deficiency in lung epithelial cells protects against influenza A virus infection

Jonathan MaelfaitKenny RooseLars VereeckeConor Mc GuireMozes SzeMartijn SchuijsMonique WillartLorena IbanezHamida HammadBart Lambrecht et al.

A1 Journal Article in PLOS PATHOGENS

A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death

Leen CatrysseMorvarid Farhang GhahremaniLars VereeckeSA YoussefConor Mc GuireMozes SzeA WeberM HeikenwalderA de BruinRudi Beyaert et al.

A1 Journal Article in CELL DEATH & DISEASE

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNF AIP3/A20

Michael DrennanSrinath GovindarajanEveline VerheugenJonathan CoquetJens StaalConor Mc GuireTom TaghonGeorges LeclercqRudi BeyaertGeert van Loo et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling

Karolina SlowickaLars VereeckeConor Mc GuireMozes SzeJonathan MaelfaitAnnasaheb KolpeXavier SaelensRudi BeyaertGeert van Loo

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

2015

Developing 3D SEM in a broad biological context

Anna KremerSaskia LippensSona BartunkovaBob AsselberghC BlanpainMatyas FendrychAlain GoossensM HoltSophie JanssensMichiel Krols et al.

A1 Journal Article in JOURNAL OF MICROSCOPY

2014

A20 controls intestinal homeostasis through cell-specific activities

Lars VereeckeSara Vieira-SilvaThomas BillietJohan H van EsConor Mc GuireKarolina SlowickaMozes SzeMaaike van den BornGert De HertoghHans Clevers et al.

A1 Journal Article in NATURE COMMUNICATIONS

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis

Conor Mc GuireLynn EltonPeter WieghoferJens StaalSofie VoetAnnelies DemeyerDaniel NagelDaniel KrappmannMarco PrinzRudi Beyaert et al.

A1 Journal Article in JOURNAL OF NEUROINFLAMMATION

2013

Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology

Conor Mc GuireMarco PrinzRudi BeyaertGeert van Loo

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination

Conor Mc GuirePeter WieghoferLynn EltonDavid MuylaertMarco PrinzRudi BeyaertGeert van Loo

A1 Journal Article in JOURNAL OF IMMUNOLOGY

The study of signaling pathways controlling central nervous system inflammation and pathology

Conor Mc GuireGeert van LooRudi Beyaert

The ubiquitin editing enzyme A20 (TNFAIP3) is upregulated during permanent middle cerebral artery occlusion but does not influence disease outcome

Conor Mc GuireM RahmanM SchwaningerRudi BeyaertGeert van Loo

A1 Journal Article in CELL DEATH & DISEASE

2012

Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases

Roosmarijn VandenbrouckeEline DejonckheerePhilippe Van LintDelphine DemeestereElien Van WonterghemIneke VanlaereLeen PuimègeFilip Van HauwermeirenRiet De RyckeConor Mc Guire et al.

A1 Journal Article in JOURNAL OF NEUROSCIENCE

2011

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

Mourad MatmatiPeggy JacquesJonathan MaelfaitEveline VerheugenMirjam KoolMozes SzeLies GeboesEls LouagieConor Mc GuireLars Vereecke et al.

A1 Journal Article in NATURE GENETICS

A20 (TNFAIP3) deficiency in myeloid cells triggers rheumatoid arthritis

Dirk ElewautMourad MatmatiPeggy JacquesJonathan MaelfaitEveline VerheugenMirjam KoolMozes SzeLies GeboesEls LouagieConor Mc Guire et al.

Death receptor signalling in central nervous system inflammation and demyelination

Conor Mc GuireRudi BeyaertGeert van Loo

A1 Journal Article in TRENDS IN NEUROSCIENCES

Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

Saskia LippensS LefebvreBarbara GilbertMozes SzeMichael DevosKelly VerhelstLars VereeckeConor Mc GuireChris GuerinPeter Vandenabeele et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2010

Antiinflammatory Properties of a Plant-Derived Nonsteroidal, Dissociated Glucocorticoid Receptor Modulator in Experimental Autoimmune Encephalomyelitis

Geert van LooMozes SzeNadia BougarneJelle PraetConor Mc GuireAndrea UllrichGuy HaegemanMarco PrinzRudi BeyaertKarolien De Bosscher

A1 Journal Article in MOLECULAR ENDOCRINOLOGY

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis

Lars VereeckeMozes SzeConor Mc GuireBrecht RogiersYuanyuan ChuMarc Schmidt-SupprianManolis PasparakisRudi BeyaertGeert van Loo

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Oligodendrocyte-specific FADD deletion protects mice from autoimmune-mediated demyelination

Conor Mc GuireThomas VolckaertUta WolkeMozes SzeRiet De RyckeAri WaismanMarco PrinzRudi BeyaertManolis PasparakisGeert van Loo

A1 Journal Article in JOURNAL OF IMMUNOLOGY