Research Explorer

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Researcher

Christophe Van Neste

Publications & Research Data

Awards & Distinctions

54 Results

2025

Synergistic inhibition of CHK1 and MUS81 to combat replication stress resistance in high-risk neuroblastoma

Elien HilgertChristophe Van NesteSarah-Lee BekaertFien MartensSuzanne VanhauwaertEllen SandersPeter VerstraelenMartijn RisseeuwEllen M. WesterhoutMark A. Grannetia et al.

A1 Journal Article in SCIENTIFIC REPORTS

2023

SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry

Bieke DecaestekerAmber LouwagieSiebe LoontiensFanny De VloedSarah-Lee BekaertJuliette RoelsSuzanne VanhauwaertSara De BrouwerEllen SandersA Berezovskaya et al.

A1 Journal Article in NATURE COMMUNICATIONS

2022

RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition

Carolina de Carvalho NunesLisa DepestelLiselot MusKaylee M. KellerLouis DelhayeAmber LouwagieMuhammad RishfiAlex WhaleNeesha KaraSimon R. Andrews et al.

A1 Journal Article in SCIENCE ADVANCES

2021

From DNA copy number gains and tumor dependencies to novel therapeutic targets for high-risk neuroblastoma

Bieke DecaestekerKaat DurinckNadine Van RoyBram De WildeChristophe Van NesteStéphane Van HaverStephen RobertsKatleen De PreterVanessa VermeirssenFranki Speleman

A1 Journal Article in JOURNAL OF PERSONALIZED MEDICINE

MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells

Sofia ZanottiSuzanne VanhauwaertChristophe Van NesteVolodimir OlexioukJolien Van LaereMarlies VerschuurenJoni Van der MeulenLiselot MusKaat DurinckLaurentijn Tilleman et al.

A1 Journal Article in SCIENTIFIC REPORTS

Recurrent chromosomal imbalances provide selective advantage to human embryonic stem cells under enhanced replicative stress conditions

Liselot MusStéphane Van HaverMina PopovicWim TrypsteenSteve LefeverNadja ZeltnerYudelca OgandoEva JacobsGeertrui DeneckerEllen Sanders et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

SOX11 as guardian of epigenetic plasticity in neuroblastoma

Bieke DecaestekerAmber LouwagieSiebe LoontiensSara De BrouwerCarolina de Carvalho NunesGeertrui DeneckerFanny De VloedLisa DepestelJuliette RoelsKaren Verboom et al.

2020

Long noncoding RNA SILC1 is an upstream regulator of SOX11 in neuroblastoma

Amber LouwagieBieke DecaestekerEva D'haeneLouis DelhayeEric de Bony de LavergneChristophe Van NesteRogier VersteegSara EkBjörn MentenJan Koster et al.

SOX11 as guardian of epigenetic plasticity in neuroblastoma

Bieke DecaestekerAmber LouwagieSiebe LoontiensCarolina de Carvalho NunesKaren VerboomJuliette RoelsEva D'haeneRogier VersteegKaat DurinckAnton Henssen et al.

The ETS transcription factor ETV5 is a target of activated ALK in neuroblastoma contributing to increased tumour aggressiveness

Liselot MusIrina LambertzShana ClaeysCandy KumpsWouter Van LoockeChristophe Van NesteGanesh UmapathyMarica VaapilChristoph BartenhagenGenevieve Laureys et al.

A1 Journal Article in SCIENTIFIC REPORTS

2019

17q gain provides proliferative advantage to human embryonic stem cells under conditions of replicative stress

Liselot MusGeertrui DeneckerStéphane Van HaverNadja ZeltnerYudelca OgandoEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne Vanhauwaert et al.

17q gain provides proliferative advantage to human embryonic stem cells under replicative stress

Liselot MusStéphane Van HaverGeertrui DeneckerNadja ZeltnerYudelca OgandoEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne Vanhauwaert et al.

ALK positively regulates MYCN activity through repression of HBP1 expression

Shana ClaeysGeertrui DeneckerKaat DurinckBieke DecaestekerLiselot MusSiebe LoontiensSuzanne VanhauwaertKristina AlthoffCaroline WigerupDaniel Bexell et al.

A1 Journal Article in ONCOGENE

Exploring the contribution of gene dosage effects of 17q gain genes on hESC and neuroblastoma proliferation

Liselot MusGeertrui DeneckerStéphane Van HaverNadja ZeltnerYudelca OgandoEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne Vanhauwaert et al.

SOX11 as mediator of the adrenergic cell state in NB

Bieke DecaestekerAmber LouwagieSara De BrouwerVolodimir OlexioukGeertrui DeneckerCarolina de Carvalho NunesKaren VerboomMoritz GartlgruberWouter Van LoockeElena Afanasyeva et al.

SOX11 is a key epigenetic regulator in the adrenergic MYCN amplified neuroblastoma

Amber LouwagieBieke DecaestekerCarolina de Carvalho NunesGeertrui DeneckerVolodimir OlexioukKaren VerboomMoritz GartlgruberWouter Van LoockeElena AfanasyevaPauline Depuydt et al.

2018

DES-mutation : system for exploring links of mutations and diseases

Vasiliki KordopatiAdil SalhiRozaimi RazaliAleksandar RadovanovicFaroug TifrateneMahmut UludagYu LiAmeerah BokhariAhdab AlSaieediArwa Bin Raies et al.

A1 Journal Article in SCIENTIFIC REPORTS

Exploring the contribution of gene dosage effects of 17q gain genes on hESC and neuroblastoma proliferation

Liselot MusGeertrui DeneckerStéphane Van HaverNadja ZeltnerYudelca OgandoEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne Vanhauwaert et al.

Exploring the contribution of gene dosage effects of 17q gain on ESC and neuroblastoma proliferation

Liselot MusGeertrui DeneckerNadja ZeltnerYudelca OgandoStéphane Van HaverEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne Vanhauwaert et al.

Exploring the contribution of gene dosage effects of 17Q gain on ESC and neuroblastoma proliferation

Liselot MusGeertrui DeneckerNadja ZeltnerYudelca OgandoStéphane Van HaverEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne Vanhauwaert et al.

Exploring the contribution of gene dosage effects of 17q gain on ESC and neuroblastoma proliferation

Liselot MusGeertrui DeneckerNadja ZeltnerYudelca OgandoStéphane Van HaverEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne Vanhauwaert et al.

In silico discovery of a FOXM1 driven embryonal signaling pathway in therapy resistant neuroblastoma tumors

Suzanne VanhauwaertBieke DecaestekerSara De BrouwerCarina LeonelliKaat DurinckPieter MestdaghJo VandesompeleKaren SermonGeertrui DeneckerChristophe Van Neste et al.

A1 Journal Article in SCIENTIFIC REPORTS

Scrutinizing PHF6 regulatory networks in T-ALL and normal hematopoiesis using zebrafish

Siebe LoontiensKaat DurinckInge Van de WalleFinola MooreSuzanne VanhauwaertEls JanssensGivani DewynLisa DepestelChristophe Van NesteDavid Langenau et al.

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets

Bieke DecaestekerGeertrui DeneckerChristophe Van NesteEmmy M DolmanWouter Van LoockeMoritz GartlgruberCarolina de Carvalho NunesFanny De VloedPauline DepuydtKaren Verboom et al.

A1 Journal Article in NATURE COMMUNICATIONS

TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerChristophe Van NesteFanny De VloedMoritz GartlgruberPauline DepuydtWouter Van LoockeShana ClaeysDries RombautSiebe Loontiens et al.

The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerWouter Van LoockeMoritz GartlgruberPauline DepuydtFanny De VloedShana ClaeysDries RombautSiebe LoontiensAnton Henssen et al.

The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerChristophe Van NesteFanny De VloedMoritz GartlgruberPauline DepuydtWouter Van LoockeShana ClaeysDries RombautSiebe Loontiens et al.

The RRM2-PHF6 complex protects neuroblastoma cells from DNA damage accumulation to install a replication stress resistance phenotype

Carolina de Carvalho NunesKaat DurinckLisa DepestelSiebe LoontiensLouis DelhayeSofia ZanottiEmmy DolmanAline EggermontBieke DecaestekerPauline Depuydt et al.

2017

Epigenetic sampling effects : nephrectomy modifies the clear cell renal cell cancer methylome

Christophe Van NesteAlexander LairdFiach O’MahonyWim Van CriekingeDieter DeforceFilip Van NieuwerburghThomas PowlesDavid J HarrisonGrant D StewartTim De Meyer

A1 Journal Article in CELLULAR ONCOLOGY

Flagging false positives following untargeted LCMS characterization of histone PTM combinations

Sander WillemsMaarten DhaenensElisabeth GovaertLaura De ClerckPaulien MeertChristophe Van NesteFilip Van NieuwerburghDieter Deforce

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

RMNE calculation in forensic profiles with a high number of loci and allelic drop-outs using polynomial expansion

Sander WillemsSenne CornelisYannick GansemansBart BroeckxDieter De ConinckChristophe Van NesteMaarten DhaenensDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in FORENSIC SCIENCE INTERNATIONAL-GENETICS

RRM2 is an essential and druggable component of the FOXM1 driven replicative stress DNA damage response in neuroblastoma

Carolina de Carvalho NunesSiebe LoontiensPauline DepuydtSuzanne VanhauwaertBieke DecaestekerBram De WildeKatleen De PreterGeertrui DeneckerChristophe Van NesteKaat Durinck et al.

RRM2 is an essential and druggable component of the FOXM1 driven replicative stress DNA damage response in neuroblastoma

Carolina de Carvalho NunesSiebe LoontiensPauline DepuydtSuzanne VanhauwaertBieke DecaestekerBram De WildeKatleen De PreterGeertrui DeneckerChristophe Van NesteKaat Durinck et al.

The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerWouter Van LoockeMoritz GartlgruberPauline DepuydtFanny De VloedShana ClaeysDries RombautSiebe LoontiensAnton Henssen et al.

The ETV5 oncogene is a target of activated ALK signaling in neuroblastoma

Liselot MusIrina LambertzCandy KumpsShana ClaeysGeertrui DeneckerWouter Van LoockeChristophe Van NesteJan KosterRogier VersteegNadine Van Roy et al.

The ETV5 oncogene is a target of activated ALK signaling in neuroblastoma

Liselot MusIrina LambertzCandy KumpsShana ClaeysGeertrui DeneckerWouter Van LoockeChristophe Van NesteJan KosterRogier VersteegNadine Van Roy et al.

The ETV5 oncogene is a target of activated ALK signaling in neuroblastoma

Liselot MusIrina LambertzCandy KumpsShana ClaeysGeertrui DeneckerWouter Van LoockeChristophe Van NesteJan KosterRogier VersteegNadine Van Roy et al.

The HBP1 tumour suppressor is a negative epigenetic regulator of MYCN-driven neuroblastoma through interaction with the PRC2 complex

Shana ClaeysGeertrui DeneckerBieke DecaestekerEls JanssensCandy KumpsSara De BrouwerIrina LambertzAnnelies FieuwSuzanne VanhauwaertKristina Althoff et al.

2016

Dynamic epigenetic changes to VHL occur with sunitinib in metastatic clear cell renal cancer

Grant D StewartThomas PowlesChristophe Van NesteAlison MeynertFiach O'MahonyAlexander LairdDieter DeforceFilip Van NieuwerburghGeert TrooskensWim Van Criekinge et al.

A1 Journal Article in ONCOTARGET

Forensic Loci Allele Database (FLAD) : automatically generated, permanent identifiers for sequenced forensic alleles

Christophe Van NesteWim Van CriekingeDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in FORENSIC SCIENCE INTERNATIONAL-GENETICS

Sensing mutant ALK: Capicua and ETV5 as executors of aberrant ALK-driven MAPK signaling

Irina LambertzLiselot MusCandy KumpsShana ClaeysWouter Van LoockeChristophe Van NesteJan KosterRogier VersteegNadine Van RoyBram De Wilde et al.

2015

Differential transcriptome analysis of the common shrimp Crangon crangon: special focus on the nuclear receptors and RNAi-related genes

Olivier ChristiaensDaan DelbareChristophe Van NesteNa YuRuben De WildeFilip Van NieuwerburghDieter DeforceKris CooremanGuy Smagghe

A1 Journal Article in GENERAL AND COMPARATIVE ENDOCRINOLOGY

Effect of multiple allelic drop-outs in forensic RMNE calculations

Christophe Van NesteDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in FORENSIC SCIENCE INTERNATIONAL-GENETICS

Effect of sunitinib treatment on mutations and methylation in metastatic renal cancer

Grant StewartChristophe Van NesteAlison MeynertColin SempleFinch O'MahonyAlexander LairdAlan MackayGeert TrooskensWim Van CriekingeTim De Meyer et al.

Forensic massively parallel sequencing data analysis tool: implementation of MyFLq as a standalone web- and Illumina BaseSpace®-application

Christophe Van NesteYannick GansemansDieter De ConinckDavid Van HoofstatWim Van CriekingeDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in FORENSIC SCIENCE INTERNATIONAL-GENETICS

Porting forensic DNA analysis to deep sequencing

Christophe Van NesteDieter DeforceWim Van CriekingeFilip Van Nieuwerburgh

2014

My-Forensic-Loci-queries (MyFLq) framework for analysis of forensic STR data generated by massive parallel sequencing

Christophe Van NesteMado VandewoestyneWim Van CriekingeDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in FORENSIC SCIENCE INTERNATIONAL-GENETICS

Retrospective study of the impact of miniSTRs on forensic DNA profiling of touch DNA samples

Filip Van NieuwerburghDavid Van HoofstatChristophe Van NesteDieter Deforce

A1 Journal Article in SCIENCE & JUSTICE

2013

Differential transcriptome analysis of glandular and filamentous trichomes in Artemisia annua

Sandra SoetaertChristophe Van NesteMado VandewoestyneSteven R HeadAlain GoossensFilip Van NieuwerburghDieter Deforce

A1 Journal Article in BMC PLANT BIOLOGY

Reference loci for RT-qPCR analysis of differentiating human embryonic stem cells

Liesbeth VossaertThomas O'LearyChristophe Van NesteBjörn HeindryckxJo VandesompelePetra De SutterDieter Deforce

A1 Journal Article in BMC MOLECULAR BIOLOGY

The effect of VEGF-targeted therapy on biomarker expression in sequential tissue from patients with metastatic clear cell renal cancer

Kevin SharpeGrant D StewartAlan MackayChristophe Van NesteCharlotte RofeDan BerneyIrfan KayaniAxel BexElaine WanFiach C O'Mahony et al.

A1 Journal Article in CLINICAL CANCER RESEARCH

The prevalence of nine genetic disorders in a dog population from Belgium, the Netherlands and Germany

Bart BroeckxFrank CoopmanGeert VerhoevenWim Van HaeringenLeanne van de GoorTim BosmansIngrid GielenJimmy SaundersSandra SoetaertHenri van Bree et al.

A1 Journal Article in PLOS ONE

TRAPID : an efficient online tool for the functional and comparative analysis of de novo RNA-Seq transcriptomes

Michiel Van BelSebastian ProostChristophe Van NesteDieter DeforceYves Van de PeerKlaas Vandepoele

A1 Journal Article in GENOME BIOLOGY

2012

Forensic STR analysis using massive parallel sequencing

Christophe Van NesteFilip Van NieuwerburghDavid Van HoofstatDieter Deforce

A1 Journal Article in FORENSIC SCIENCE INTERNATIONAL-GENETICS