Research Explorer

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Researcher

Chris Verhofstede

Publications & Research Data

Awards & Distinctions

120 Results

2025

Aberrant strand transfer events across multiple stages of reverse transcription shape the heterogeneous landscape of the HIV-1 reservoir

Jarryt HardyVirginie MortierYiannis De MeersmanDelfien StaelensEls DemecheleerMarlies SchauvliegeCiel VermeerschElizaveta PadalkoChris Verhofstede

U Journal Article in COMMUNICATIONS BIOLOGY

2024

Longitudinal patterns of inflammatory mediators after acute HIV infection correlate to intact and total reservoir

Jozefien De ClercqMarie-Angélique De ScheerderVirginie MortierChris VerhofstedeStefaan J. VandecasteeleSabine D. AllardCoca NecsoiStephane De WitSarah GerloLinos Vandekerckhove

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Profile of persons recently infected with HIV-1 in Belgium : new insights to tailor prevention efforts

Charlotte Vanden BulckeJ. DeblondeC. NecsoiJens Van PraetE. Van CutsemL. MertensF. VanroyeK. StoffelsL. DebaisieuxVirginie Mortier et al.

A1 Journal Article in AIDS AND BEHAVIOR

Reverse transcription of plasma-derived HIV-1 RNA generates multiple artifacts through tRNA(Lys-3)-priming

Jarryt HardyEls DemecheleerMarlies SchauvliegeDelfien StaelensVirginie MortierChris Verhofstede

A1 Journal Article in MICROBIOLOGY SPECTRUM

2023

Towards novel HIV-1 serodiagnostic tests without vaccine-induced seroreactivity

Ole LagatieDax LauwersHarvinder SinghFien VanroyeDaniel J. StiehJohan VingerhoetsLudo LavreysValérie Oriol-MathieuWill ColónChris Verhofstede et al.

A1 Journal Article in MICROBIOLOGY SPECTRUM

2022

Benefits of antiretroviral therapy initiation during acute HIV infection

Jozefien De ClercqSofie RutsaertMarie-Angélique De ScheerderChris VerhofstedeSteven CallensLinos Vandekerckhove

A1 Journal Article in ACTA CLINICA BELGICA

Impact of COVID-19 on the Belgian HIV epidemic : slowdown of HIV transmission and testing and adaptation of care

D Van BeckhovenB SerrienM MontourcyChris VerhofstedeD Van den BosscheA LiboisD De GeyterT MartinS Van den EyndeB Vuylsteke et al.

A1 Journal Article in BMC INFECTIOUS DISEASES

Prevalence and evolution of transmitted human immunodeficiency virus drug resistance in Belgium between 2013 and 2019

Virginie MortierLaurent DebaisieuxGeraldine DessillyKarolien StoffelsDolores VairaEllen VancutsemKristel Van LaethemFien VanroyeChris Verhofstede

A1 Journal Article in OPEN FORUM INFECTIOUS DISEASES

Screening algorithms for HBV, HCV, HIV and syphilis in an anatomical donation program

Brecht ValckeKoen VercauterenElizaveta PadalkoChris VerhofstedeKatharina D'HerdeWouter Willaert

A1 Journal Article in ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

2020

Chronic and early antiretroviral therapy impact Human Immunodeficiency Virus (HIV) serological assay sensitivity, leading to more false-negative test results in HIV diagnosis

Karolien StoffelsFien VanroyeVirginie MortierLaurent DebaisieuxMarie-Luce DelforgeMelissa DepypereGéraldine DessillyDolores VairaEllen VancutsemSigi Van den Wijngaert et al.

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

High frequency of new recombinant forms in HIV-1 transmission networks demonstrated by full genome sequencing

Laura HebberechtVirginie MortierKenny DauweMarlies SchauvliegeDelfien StaelensEls DemecheleerKarolien StoffelsFien VanroyeMarie-Luce DelforgeEllen Vancutsem et al.

A1 Journal Article in INFECTION GENETICS AND EVOLUTION

2019

Comparison of Sanger sequencing for hepatitis C virus genotyping with a commercial line probe assay in a tertiary hospital

Sylvie GolettiSiméon ZuytenLéonie GoeminneChris VerhofstedeHector Rodriguez-VillalobosMonique BodeusPeter StärkelYves HorsmansBenoît Kabamba-Mukadi

A1 Journal Article in BMC INFECTIOUS DISEASES

Earlier initiation of antiretroviral treatment coincides with an initial control of the HIV-1 sub-subtype F1 outbreak among men-having-sex-with-men in Flanders, Belgium

Lore VinkenKatrien FransenLize CuypersIvailo AlexievClaudia BalottaLaurent DebaisieuxCarole Seguin-DevauxSergio García RibasPerpétua GomesFrancesca Incardona et al.

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

Exploring HIV-1 transmission dynamics by combining phylogenetic analysis and infection timing

Chris VerhofstedeVirginie MortierKenny DauweSteven CallensJessika DeblondeGéraldine DessillyMarie-Luce DelforgeKatrien FransenAndré SasseKarolien Stoffels et al.

A1 Journal Article in VIRUSES-BASEL

HIV rebound is predominantly fueled by genetically identical viral expansions from diverse reservoirs

Marie-Angélique De ScheerderBram VranckenSimon DellicourTimothy SchlubEunok LeeWei ShaoSofie RutsaertChris VerhofstedeTessa KerreThomas Malfait et al.

A1 Journal Article in CELL HOST & MICROBE

Piloting a surveillance system for HIV drug resistance in the European Union

Marita JW van de LaarArnold BosmanAnastasia PharrisEmmi AnderssonLambert AssoumouEva AyNorbert BannertBarbara BartmeyerMelissa BradyMarie-Laure Chaix et al.

A1 Journal Article in EUROSURVEILLANCE

Predominance of the heterozygous CCR5 delta‐24 deletion in African individuals resistant to HIV infection might be related to a defect in CCR5 addressing at the cell surface

Vic ArendtMathieu AmandGilles IserentantMorgane LemaireCécile MasquelierGilles F NdayisabaChris VerhofstedeEtienne KaribaSusan AllenAndy Chevigné et al.

A1 Journal Article in JOURNAL OF THE INTERNATIONAL AIDS SOCIETY

Single genome sequencing of near full-length HIV-1 RNA using a limiting dilution approach

Laura HebberechtLeen VancoillieMarlies SchauvliegeDelfien StaelensEls DemecheleerJarryt HardyVirginie MortierChris Verhofstede

A1 Journal Article in JOURNAL OF VIROLOGICAL METHODS

2018

Causes and clinical implications of persistent low-level viremia in HIV-1 patients on antiretroviral therapy

Leen VancoillieChris VerhofstedeVirginie Mortier

Frequency of occurrence of HIV-1 dual infection in a Belgian MSM population

Laura HebberechtLeen VancoillieMarlies SchauvliegeDelfien StaelensKenny DauweVirginie MortierChris Verhofstede

A1 Journal Article in PLOS ONE

Meticulous plasma isolation is essential to avoid false low-level viraemia in Roche Cobas HIV-1 viral load assays

Virginie MortierLeen VancoillieKenny DauweDelfien StaelensEls DemecheleerMarlies SchauvliegeSylvie DinakisTom Van MaerkenGéraldine DessillyJean Ruelle et al.

A1 Journal Article in ANTIVIRAL THERAPY

Phylogenetic analysis of the Belgian HIV-1 epidemic reveals that local transmission is almost exclusively driven by men having sex with men despite presence of large African migrant communities

Chris VerhofstedeKenny DauweKatrien FransenKristel Van LaethemSigi Van den WijngaertJean RuelleMarie-Luce DelforgeEllen VancutsemDolores VairaKarolien Stoffels et al.

A1 Journal Article in INFECTION GENETICS AND EVOLUTION

Quantification of total HIV-1 DNA in buffy coat cells, feasibility and potential added value for clinical follow-up of HIV-1 infected patients on ART

Virginie MortierEls DemecheleerDelfien StaelensMarlies SchauvliegeKenny DauweSylvie DinakisLaura HebberechtLeen VancoillieChris Verhofstede

A1 Journal Article in JOURNAL OF CLINICAL VIROLOGY

2017

Decision tree for accurate infection timing in individuals newly diagnosed with HIV-1 infection

Chris VerhofstedeKatrien FransenAnnelies Van Den HeuvelKristel Van LaethemJean RuelleEllen VancutsemKarolien StoffelsSigi Van den WijngaertMarie-Luce DelforgeDolores Vaira et al.

A1 Journal Article in BMC INFECTIOUS DISEASES

Influence of chronic azithromycin treatment on the composition of the oropharyngeal microbial community in patients with severe asthma

Guido Lopes dos Santos SantiagoGuy BrusselleKenny DauwePieter DeschaghtChris VerhofstedeDries VaneechoutteEllen DeschepperPaul JordensGuy JoosMario Vaneechoutte

A1 Journal Article in BMC MICROBIOLOGY

Longitudinal sequencing of HIV-1 infected patients with low-level viremia for years while on ART shows no indications for genetic evolution of the virus

Leen VancoillieLaura HebberechtKenny DauweEls DemecheleerSylvie DinakisDries VaneechoutteVirginie MortierChris Verhofstede

A1 Journal Article in VIROLOGY

2016

Deep sequencing of HIV-1 RNA and DNA in newly diagnosed patients with baseline drug resistance showed no indications for hidden resistance and is biased by strong interference of hypermutation

Kenny DauweDelfien StaelensLeen VancoillieVirginie MortierChris Verhofstede

A1 Journal Article in JOURNAL OF CLINICAL MICROBIOLOGY

Late presentation to HIV testing is overestimated when based on the consensus definition

A SasseE FlorenceA PharrisS De WitP LacorD Van BeckhovenJ DeblondeM-L DelforgeK FransenJ-C Goffard et al.

A1 Journal Article in HIV MEDICINE

2015

Characteristics and spread to the native population of HIV-1 non-B subtypes in two European countries with high migration rate

Kenny DauweVirginie MortierMarlies SchauvliegeAnnelies Van den HeuvelKatrien FransenJean-Yves ServaisDanielle Perez BercoffCarole Seguin-DevauxChris Verhofstede

A1 Journal Article in BMC INFECTIOUS DISEASES

Comparison of methods for in-house screening of HLA*B57:01 to prevent abacavir hypersensitivity in HIV-1 care

Ward De SpiegelaereJan PhilippéKAREN VERVISCHChris VerhofstedeEva MalatinkováMaja KiselinovaWim TrypsteenPawel BonczkowskiDirk VogelaersSteven Callens et al.

A1 Journal Article in PLOS ONE

Drug resistance is rarely the cause or consequence of long-term persistent low-level viraemia in HIV-1-infected patients on ART

Leen VancoillieVirginie MortierEls DemecheleerMarlies SchauvliegeLinos VandekerckhoveDirk VogelaersChris Verhofstede

A1 Journal Article in ANTIVIRAL THERAPY

Good continuum of HIV care in Belgium despite weaknesses in retention and linkage to care among migrants

D Van BeckhovenE FlorenceJ RuelleJ DeblondeChris VerhofstedeSteven CallensE VancutsemP LacorR DemeesterJ-C Goffard et al.

A1 Journal Article in BMC INFECTIOUS DISEASES

HIV-1 RNA and HIV-1 DNA persistence during suppressive ART with PI-based or nevirapine-based regimens

Maja KiselinovaAnna Maria GerettiEva MalatinkováKAREN VERVISCHApostolos BeloukasPeter MessiaenPawel BonczkowskiWim TrypsteenSteven CallensChris Verhofstede et al.

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and mucosal reservoirs

Eva MalatinkováWard De SpiegelaerePawel BonczkowskiMaja KiselinovaWim TrypsteenMargaret JohnsonChris VerhofstedeDanny De LoozeCharles MurraySabine Kinloch-de Loes et al.

A1 Journal Article in ELIFE

Long-term early antiretroviral therapy limits the HIV-1 reservoir size as compared to later treatment initiation but not to levels found in long-term non-progressors

Eva MalatinkováWard De SpiegelaerePawel BonczkowskiMaja KiselinovaKAREN VERVISCHWim TrypsteenMargaret JohnsonChris VerhofstedeDanny De LoozeCharles Murray et al.

Primary resistance to integrase strand-transfer inhibitors in Europe

M CasadellàPM van HamM Noguera-JulianA van KesselC PouLM HofstraJR SantosF GarciaD StruckI Alexiev et al.

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

2014

Antiretrovirals for HIV prevention: when should they be recommended?

Maja KiselinovaWard De SpiegelaereChris VerhofstedeSteven CallensLinos Vandekerckhove

A1 Journal Article in EXPERT REVIEW OF ANTI-INFECTIVE THERAPY

Comparative performances of HIV-1 RNA load assays at low viral load levels: results of an international collaboration

Luke C SwensonBryan CobbAnna Maria GerettiP Richard HarriganMario PoljakCarole Seguin-DevauxChris VerhofstedeMarc WirdenAlessandra AmendolaJurg Boni et al.

A1 Journal Article in JOURNAL OF CLINICAL MICROBIOLOGY

Determinants of adherence in a cohort of Belgian HIV patients: a pilot study

Sophie DegrooteDirk VogelaersPeter VermeirAn MarimanAnn De RickBeatrijs Van Der GuchtJolanda PelgromFilip Van WanzeeleChris VerhofstedeJAN VANCAUWENBERGHE et al.

A1 Journal Article in ACTA CLINICA BELGICA

Factors associated with the continuum of care of HIV infected patients in Belgium

Dominique Van BeckhovenPatrick LacorMichel MoutschenDenis PiérardAndré SasseDolorès VairaSigi Van den WijngaertBernard VandercamMarc Van RanstEric Van Wijngaerden et al.

Markers associated with persisting low-level viraemia under antiretroviral therapy in HIV-1 infection

Leen VancoillieEls DemecheleerSteven CallensDirk VogelaersLinos VandekerckhoveVirginie MortierChris Verhofstede

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The impact of nevirapine- versus protease inhibitor-based regimens on virological markers of HIV-1 persistence during seemingly suppressive ART

Maja KiselinovaMaria AnnaEva MalatinkováKAREN VERVISCHApostolos BeloukasPeter MessiaenPawel BonczkowskiWim TrypsteenSteven CallensChris Verhofstede et al.

2013

Frequency and predictors of HIV-1 co-receptor switch in treatment naive patients

Virginie MortierKenny DauweLeen VancoillieDelfien StaelensFilip Van WanzeeleDirk VogelaersLinos VandekerckhoveKristen ChalmetChris Verhofstede

A1 Journal Article in PLOS ONE

HIV-1 tropism determination using a phenotypic Env recombinant viral assay highlights overestimation of CXCR4-usage by genotypic prediction algorithms for CRRF01_AE and CRF02_AG

Martin MulingeMorgane LemaireJean-Yves ServaisArkadiusz RybickiDaniel StruckEveline Santos da SilvaChris VerhofstedeYolanda LieCarole Seguin-DevauxJean-Claude Schmit et al.

A1 Journal Article in PLOS ONE

Polyfunctional CD4⁺ T cell responses in HIV-1 infected viral controllers compared with those in healthy recipients of an adjuvanted polyprotein HIV-1 vaccine

Eva Van BraeckelIsabelle DesombereFrédéric ClementLinos VandekerckhoveChris VerhofstedeDirk VogelaersGeert Leroux-Roels

A1 Journal Article in VACCINE

Socio-economic, behavioural, (neuro)psychological and clinical determinants of HRQoL in people living with HIV: a pilot study

Sophie DegrooteDirk VogelaersPeter VermeirAn MarimanAnn De RickBeatrijs Van Der GuchtJolanda PelgromFilip Van WanzeeleChris VerhofstedeDominique Vandijck

A1 Journal Article in JOURNAL OF THE INTERNATIONAL AIDS SOCIETY

Touchdown digital PCR for quantification of difficult amplicons in the HIV genome

Ward De SpiegelaereEva MalatinkováMaja KiselinovaPawel BonczkowskiChris VerhofstedeDirk VogelaersLinos Vandekerckhove

Touchdown digital polymerase chain reaction for quantification of highly conserved sequences in the HIV-1 genome

Ward De SpiegelaereEva MalatinkováMaja KiselinovaPawel BonczkowskiChris VerhofstedeDirk VogelaersLinos Vandekerckhove

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

Transmission network of an HIV type 1 strain with K103N in young Belgian patients from different risk groups

Jean RuelleMarie-Gabrielle IngelsKarima JnaouiNathalie AusseletAnne VincentAndré SasseChris VerhofstedePatrick Goubau

A1 Journal Article in AIDS RESEARCH AND HUMAN RETROVIRUSES

2012

Characterization of LEDGF/p75 genetic variants and association with HIV-1 disease progression

Peter MessiaenWard De SpiegelaereJose AlcamiKaren VervischPetra Van AckerBruno VerhasseltPieter MeuwissenEsther CalongeNuria GonzalezFelix Gutierrez-Rodero et al.

A1 Journal Article in PLOS ONE

Comprehensive characterization of LEDGF/p75 in a HIV-1 infected patient cohort

Peter MessiaenWard De SpiegelaereJose AlcamiPaul CouckePetra Van AckerKaren VervischBruno VerhasseltPieter MeeuwissenBruce PoppeDirk Vogelaers et al.

Correlation of coreceptor usage and disease progression

Chris VerhofstedeMonique NijhuisLinos Vandekerckhove

A1 Journal Article in CURRENT OPINION IN HIV AND AIDS

Impact of triplicate testing on HIV genotypic tropism prediction in routine clinical practice

J SymonsLinos VandekerckhoveR ParedesChris VerhofstedeR BellidoEls DemecheleerPM van HamSFL van LelyveldAJ StamD van Versendaal et al.

A1 Journal Article in CLINICAL MICROBIOLOGY AND INFECTION

Presence of CXCR4-using HIV-1 in patients with recently diagnosed infection: correlates and evidence for transmission

Kristen ChalmetKenny DauweLander FoquetFranky BaatzCarole Seguin-DevauxBeatrijs Van Der GuchtDirk VogelaersLinos VandekerckhoveJean PlumChris Verhofstede

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Transmission of primary resistance mutation K103N in a cluster of Belgian young patients from different risk groups

J RuelleM IngelsK JnaouiN AusseletA SasseChris VerhofstedeP Goubau

Ultra-deep sequencing of HIV-1 reverse transcriptase before start of an NNRTI-based regimen in treatment-naive patients

Peter MessiaenChris VerhofstedeIna VandenbrouckeSylvie DinakisVeerle Van EygenKim ThysBart WintersJeroen AerssensDirk VogelaersLieven J Stuyver et al.

A1 Journal Article in VIROLOGY

2011

Association of haptoglobin phenotypes with the development of Kaposi's sarcoma in HIV patients

Reinhart SpeeckaertBob ColebundersJohan R BoelaertLieve BrochezJos Van AckerFilip Van WanzeeleRobert HemmerMarijn SpeeckaertChris VerhofstedeMarc De Buyzere et al.

A1 Journal Article in ARCHIVES OF DERMATOLOGICAL RESEARCH

Comparison of phenotypic and genotypic tropism determination in triple-class-experienced HIV patients eligible for maraviroc treatment

Linos VandekerckhoveChris VerhofstedeEls DemecheleerStephane De WitEric FlorenceKatrien FransenMichel MoutschenWendy MostmansKabamba KabeyaNicola Mackie et al.

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Comprehensive characterization of LEDGF/p75 in a HIV-1-infected patient cohort

Peter MessiaenWard De SpiegelaereChris VerhofstedePaul CouckePetra Van AckerPhilip VlummensKAREN VERVISCHDirk VogelaersBruce PoppeJose Alcami et al.

Concordance between HIV-1 genotypic coreceptor tropism predictions based on plasma RNA and proviral DNA

Chris VerhofstedeD BrudneyJacqueline ReynaertsD VairaK FransenA De BelC Seguin-DevauxS De WitLinos VandekerckhoveA-M Geretti

A1 Journal Article in HIV MEDICINE

European guidelines on the clinical management of HIV-1 tropism testing

Linos VandekerckhoveAMJ WensingR KaiserF Brun-VézinetB ClotetA De LucaS DresslerF GarciaAM GerettiT Klimkait et al.

A1 Journal Article in LANCET INFECTIOUS DISEASES

2010

Comparison of the Generic HIV Viral Load® assay with the Amplicor™ HIV-1 Monitor v1.5 and Nuclisens HIV-1 EasyQ® v1.2 techniques for plasma HIV-1 RNA quantitation of non-B subtypes: the Kesho Bora preparatory study

François RouetVincent FoulongneJohannes ViljoenKim SteegenPierre BecquartDiane ValeaSivapragashini DanaviahMichel SegondyChris VerhofstedePhilippe Van de Perre

A1 Journal Article in JOURNAL OF VIROLOGICAL METHODS

Effect of triplicate testing on genotypic tropism prediction in routine clinical practice

J SymonsLinos VandekerckhoveR ParedesChris VerhofstedeR BellidoEls DemecheleerPaulyn Van HammeSFL van LelyveldAL StamD van Versendaal et al.

Epidemiological study of phylogenetic transmission clusters in a local HIV-1 epidemic reveals distinct differences between subtype B and non-B infections

Kristen ChalmetDelfien StaelensStijn BlotSylvie DinakisJolanda PelgromJean PlumDirk VogelaersLinos VandekerckhoveChris Verhofstede

A1 Journal Article in BMC INFECTIOUS DISEASES

High prevalence of bevirimat resistance mutations in protease inhibitor-resistant HIV isolates

Jens VerheyenChris VerhofstedeElena KnopsLinos VandekerckhoveAxel FunDiede BrunenKenny DauweAnnemarie MJ WensingHerbert PfisterRolf Kaiser et al.

A1 Journal Article in AIDS

HIV-1 V3 envelope deep sequencing for clinical plasma specimens failing in phenotypic tropism assays

Ina VandenbrouckeHerwig Van MarckWendy MostmansVeerle Van EygenEvelien RondelezKim ThysKurt Van BaelenKatrien FransenDolores VairaKabamba Kabeya et al.

A1 Journal Article in AIDS RESEARCH AND THERAPY

O121. Consensus statement of the European guidelines on clinical management of HIV-1 tropism testing

Linos VandekerckhoveAMJ WensingR KaiserF Brun-VezinetB ClotetA De LucaS DresslerF GarciaAM GerettiT Klimkait et al.

Treatment intensification has no effect on the HIV-1 central nervous system infection in patients on suppressive antiretroviral therapy

Aylin YilmazChris VerhofstedeAntonio D'AvolioVictoria WatsonLars HagbergDietmar FuchsBo SvennerholmMagnus Gisslen

A1 Journal Article in JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Viral load assay sensitivity and low level viremia in HAART treated HIV patients

Chris VerhofstedeFilip Van WanzeeleJacqueline ReynaertsMarianne MangelschotsJean PlumKatrien Fransen

A1 Journal Article in JOURNAL OF CLINICAL VIROLOGY

2009

Comparison of population and 454 genotyping and Trofile phenotyping for tropism determination in patients selected for maraviroc initiation

Linos VandekerckhoveChris VerhofstedeI VandenbrouckeC BoothH Van MarckAM GerettiL Stuyver

CXCR4-using HIV type 1 variants are more commonly found in peripheral blood mononuclear cell DNA than in plasma RNA

Chris VerhofstedeLinos VandekerckhoveVeerle Van EygenEls DemecheleerIna VandenbrouckeBart WintersJean PlumDirk VogelaersLieven Stuyver

A1 Journal Article in JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Effectiveness of antiretroviral therapy and development of drug resistance in HIV-1 infected patients in Mombasa, Kenya

Kim SteegenStanley LüchtersKenny DauweJacqueline ReynaertsKishor MandaliyaWalter JaokoJean PlumMarleen TemmermanChris Verhofstede

A2 Journal Article in AIDS RESEARCH AND THERAPY

High prevalence of bevirimat resistance mutations in non-B subtypes and in PI-resistant HIV isolates

J VerheyenChris VerhofstedeE KnopsLinos VandekerckhoveA FunD BrunenKenny DauweA WensingH PfisterR Kaiser et al.

Maraviroc: perspectives for use in antiretroviral-naive HIV-1-infected patients

Linos VandekerckhoveChris VerhofstedeDirk Vogelaers

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Population and clonal tropism phenotyping of clinical isolates and comparison with next generation sequencing and prediction tools

K Van BaelenE RondelezL Van WesenbeeckW MostmansH Van MarckV Van EygenChris VerhofstedeLinos VandekerckhoveI VandenbrouckeL Stuyver

2008

Impact of Delta 32-CCR5 heterozygosity on HIV-1 genetic evolution and variability - A study of 4 individuals infected with closely related HIV-1 strains

Kristen ChalmetFilip Van WanzeeleEls DemecheleerKenny DauweJolanda PelgromBeatrijs Van Der GuchtDirk VogelaersJean PlumLieven StuyverLinos Vandekerckhove et al.

A1 Journal Article in Virology

Maraviroc: integration of a new antiretroviral drug class into clinical practice

Linos VandekerckhoveChris VerhofstedeDirk Vogelaers

A1 Journal Article in Journal of Antimicrobial Chemotherapy

Prevalence and epidemiology of HIV type 1 drug resistance among newly diagnosed therapy-naive patients in Belgium from 2003 to 2006

Jurgen VercauterenInge DerdelinckxAndre SasseMarleen BogaertHelga CeunenAnn De RooStephane De WitKoen DeforcheFedoua EchahidiKatrien Fransen et al.

A1 Journal Article in AIDS RESEARCH AND HUMAN RETROVIRUSES

Transmitted drug resistance, selection of resistance mutations and moderate antiretroviral efficacy in HIV-2: Analysis of the HIV-2 Belgium and Luxembourg database

Jean RuelleFrancois RomanAnne-Therese VandenbrouckeChristine LambertKatrien FransenFedoua EchahidiDenis PierardChris VerhofstedeKristel Van LaethemMarie-Luce Delforge et al.

A1 Journal Article in BMC INFECTIOUS DISEASES

2007

Detection of drug resistance mutations as a predictor of subsequent virological failure in patients with HIV-1 viral rebounds of less than 1,000 RNA copies/ml

Chris VerhofstedeFilip Van WanzeeleBeatrijs Van Der GuchtJolanda PelgromLinos VandekerckhoveJean PlumDirk Vogelaers

A1 Journal Article in JOURNAL OF MEDICAL VIROLOGY

Evaluation of two commercially available alternatives for HIV-1 viral load testing in resource-limited settings

K SteegenS LUCHTERSNancy De CabooterJacqueline ReynaertsK MANDALIYAJean PlumW JAOKOChris VerhofstedeMarleen Temmerman

A1 Journal Article in JOURNAL OF VIROLOGICAL METHODS

Feasibility of detecting human immunodeficiency virus type 1 drug resistance in DNA extracted from whole blood or dried blood spots

K SteegenStanley LüchtersEls DemecheleerKenny DauweK MandaliyaW JaokoJean PlumMarleen TemmermanChris Verhofstede

A1 Journal Article in JOURNAL OF CLINICAL MICROBIOLOGY

2006

A sensitive in-house RT-PCR genotyping system for combined detection of plasma HIV-1 and assessment of drug resistance

Kim SteegenEls DemecheleerNancy De CabooterD NGESMarleen TemmermanP NDUMBEK MANDALIYAJean PlumChris Verhofstede

A1 Journal Article in JOURNAL OF VIROLOGICAL METHODS

2005

Mortality among HIV-1-infected women according to children's feeding modality - An individual patient data meta-analysis

ML NEWELLJS READW FAWZIG HAVERKAMPRD HARRISS KEASTS LIR MITCHELLL MUENZD OWEN et al.

A1 Journal Article in JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

The latent HIV-1 reservoir in patients undergoing HAART: an archive of pre-HAART drug resistance

A NOEJean PlumChris Verhofstede

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

2004

Drug-resistant variants that evolve during nonsuppressive therapy persist in HIV-1-infected peripheral blood mononuclear cells after long-term highly active antiretroviral therapy

Chris VerhofstedeAnne NoëEls DemecheleerNancy De CabooterFilip Van WanzeeleBeatrijs Van Der GuchtDirk VogelaersJean Plum

A1 Journal Article in JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Low efficacy of nevirapine (HIVNET012) in preventing perinatal HIVA transmission in a real-life situation

An QuaghebeurL MUTUNGAF MWANYUMBAK MANDALIYAChris VerhofstedeMarleen Temmerman

A1 Journal Article in AIDS

The AIDS epidemic: the spread of a deadly disease in the biotech era

Ann NoëChris VerhofstedeJean Plum

A1 Journal Article in JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS

2003

Diversity of the human immunodeficiency virus type 1 (HIV-1) env sequence after vertical transmission in mother-child pairs infected with HIV-1 subtype A

Chris VerhofstedeEls DemecheleerNancy De CabooterP GAILLARDF MWANYUMBAPatricia ClaeysV. CHOHANK MANDALIYAMarleen TemmermanJean Plum

A1 Journal Article in JOURNAL OF VIROLOGY

Placental malaria and perinatal transmission of human immunodeficiency virus type 1

I INIONF MWANYUMBAP GAILLARDV CHOHANChris VerhofstedePatricia ClaeysK MANDALIYAE VAN MARCKMarleen Temmerman

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

2002

Placental inflammation and perinatal transmission of HIV-1

Fabian MwanyumbaPhilippe GaillardIngrid InionChris VerhofstedePatricia ClaeysVarsha ChohanStijn VansteelandtKishorchandra MandaliyaMarleen PraetMarleen Temmerman

A1 Journal Article in JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

2001

Correlation between maternal and infant HIV infection and low birth weight: a study in Mombasa, Kenya

F. MwanyumbaPatricia ClaeysP. GaillardChris VerhofstedeV. ChohanKishor MandaliyaJ. Ndinya-AcholaJ. BwayoMarleen Temmerman

A2 Journal Article in JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Prevalence of genotypic resistance among antiretroviral drug-naive HTV-1-infected patients in Belgium

K VAN VAERENBERGHL DEBAISIEUXNancy De CabooterC DECLERCQK DESMETK FRANSENB MAESD MARISSENSK MILLERG MUYLDERMANS et al.

A1 Journal Article in ANTIVIRAL THERAPY

Vaginal lavage with chlorhexidine during labour to reduce mother-to-child HIV transmission: clinical trial in Mombasa, Kenya.

P GAILLARDF MWANYUMBAChris VerhofstedePatricia ClaeysV CHOHANEls GoetghebeurK MANDALIYAJ NDINYA-ACHOLAMarleen Temmerman

A1 Journal Article in AIDS

2000

Baseline HIV type 1 genotypic resistance to a newly added nucleoside analog is predictive of virologic failure of the new therapy.

K VAN VAERENBERGHK VAN LAETHEME VAN WIJNGAERDENJC SCHMITF SCHNEIDERL RUIZB CLOTETChris VerhofstedeFilip Van WanzeeleG. MUYLDERMANS et al.

A1 Journal Article in AIDS RESEARCH AND HUMAN RETROVIRUSES

Blinded, multicenter quality control study for the quantification of human immunodeficiency virus type 1 RNA in plasma by the Belgian AIDS reference laboratories.

G MUYLDERMANSL DEBAISIEUXK FRANSEND MARISSENSK MILLERD VAIRAAM VANDAMMEAT VANDENBROUCKEChris VerhofstedeR SCHUURMAN et al.

A1 Journal Article in CLINICAL MICROBIOLOGY AND INFECTION

Exposure to HIV-1 during delivery and mother-to-child transmission.

P GAILLARDChris VerhofstedeF MWANYUMBAPatricia ClaeysV CHOHANK MANDALIYAJ BWAYOJean PlumMarleen Temmerman

A1 Journal Article in AIDS

1999

Human immunodeficiency virus nef gene expression affects generation and function of human T cells, but not dendritic cells

Bruno VerhasseltEvelien NaessensChris VerhofstedeMagda De SmedtSigrid SchollenTessa KerreDominique VanheckeJean Plum

A1 Journal Article in BLOOD

Interruption of reverse transcriptase inhibitors or a switch from reverse transcriptase to protease inhibitors resulted in a fast reappearance of virus strains with a reverse transcriptase inhibitor-sensitive genotype.

Chris VerhofstedeFilip Van WanzeeleBeatrijs Van Der GuchtNancy De CabooterJean Plum

A1 Journal Article in AIDS

1997

Line probe assay for rapid detection of drug-selected mutations in the human immunodeficiency virus type 1 reverse transcriptase gene.

L STUYVERA WYSEURA ROMBOUTJ LOUWAGIET SCARCEZChris VerhofstedeD RIMLANDRF SCHINAZIR ROSSAU

A1 Journal Article in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Prevention of congenital toxoplasmosis in Szeged, Hungary.

Z SZENASIZ OZSVARE NAGYM JESZENSZKYJ SZABOJ GELLENM VEGHChris Verhofstede

A1 Journal Article in INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

1996

Isolation of HIV-1 RNA from plasma: Evaluation of eight different extraction methods.

Chris VerhofstedeK FRANSEND MARISSENSRita VerhelstG VANDERGROENS LAUWERSG ZISSISJean Plum

A1 Journal Article in JOURNAL OF VIROLOGICAL METHODS

Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

M SamsonF LibertBJ DoranzJ RuckerC LiesnardC-M FarberS SaragostiC LapouméroulieJ CogniauxC Forceille et al.

A1 Journal Article in NATURE

1995

Mogelijkheden en obstakels voor toepassing van DNA en RNA amplificatie en hybridisatietechnieken in de diagnostiek van infecties.

Mario VaneechoutteBruno VerhasseltChris VerhofstedeGeert ClaeysGerda VerschraegenJean Plum

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

1994

Evaluation of Proviral copy number and plasma RNA level as early indicators of progression in HIV-1 infection: correlation with virological and immunological markers of disease.

Chris VerhofstedeS RENIERSFilip Van WanzeeleJean Plum

A1 Journal Article in AIDS

1993

MIXED PHENOTYPE MURINE LEUKEMIAS

M.P. DefresneB. BorremansChris VerhofstedeA. PeledA. ThiryR. GreimersP. RobberechtB. NabarraL. VerschaeveR. Hooghe

A1 Journal Article in LEUKEMIA

Polymerase chain-reaction in the diagnosis of Toxoplasma encephalitis.

Chris VerhofstedeS RENIERSR COLEBUNDERSFilip Van WanzeeleJean Plum

A1 Journal Article in AIDS

1990

CONGENITAL TOXOPLASMOSIS AND TORCH

Chris VerhofstedeL. Van RenterghemJean PlumS. VanderschuerenP. Vanhaesebrouck

A1 Journal Article in LANCET

EVALUATION OF IMMUNOBLOTTING FOR THE DETECTION OF TOXOPLASMA-GONDII IMMUNOGLOBULIN-M ANTIBODIES

Chris VerhofstedeL. Van RenterghemJean Plum

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

S. VanderscheurenJean PlumL. Van RenterghemChris Verhofstede

A2 Journal Article in Tijdschrift voor Geneeskunde

1989

COMPARISON OF 6 COMMERCIAL ENZYME LINKED IMMUNOSORBENT ASSAYS FOR DETECTING IGM ANTIBODIES AGAINST TOXOPLASMA-GONDII

Chris VerhofstedeL. Van RenterghemJean Plum

A1 Journal Article in JOURNAL OF CLINICAL PATHOLOGY

De serodiagnose van een toxoplasma gondii-infectie

Chris VerhofstedeJ. PlumP.H. De Rycke

THE SUBCELLULAR-LOCALIZATION OF THE NEU PROTEIN IN HUMAN NORMAL AND NEOPLASTIC-CELLS

C. De PotterJ. QuatackerG. MaertensS. Van DaeleC. PauwelsChris VerhofstedeW. EechauteH. Roels

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

1988

THE INFECTION-STAGE-RELATED IGG RESPONSE TO TOXOPLASMA-GONDII STUDIED BY IMMUNOBLOTTING

Chris VerhofstedePatrick Van GelderM. Rabaey

A1 Journal Article in PARASITOLOGY RESEARCH

1987

ABILITY OF ENZYME-LINKED IMMUNOSORBENT ASSAYS TO DETECT EARLY IMMUNOGLOBULIN-G ANTIBODIES TO TOXOPLASMA-GONDII

Chris VerhofstedeL. SabbeL. Van Renterghem

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

1986

De prevalentie van HTLVIII infectie bij homofielen in Oost-en West-Vlaanderen

L. SabbeL. Van RenterghemE. Van HeckeJean PlumChris Verhofstede

A2 Journal Article in Tijdschrift voor Geneeskunde

1985

Evolutie van de immuniteit voor Rubella en Toxoplasma bij zwangeren tussen 1976 en 1983

Chris VerhofstedeL. SabbeL. Van RenterghemJean PlumM. Thiery

A2 Journal Article in Tijdschrift voor Geneeskunde

Haptoglobin polymorphism and progression of human immune deficiency syndrome. AIDS 1998;12:1027-1032.

Joris DelangheJ VAN ACKERR HEMMERMichel LangloisG VAN DER GROENChris VerhofstedeFilip Van WanzeeleD DE BACQUERJean Plum

Hepatitis C among risk groups for HIV and hepatitis B. Intern. J. of STD & AIDS, 1991, 2, 185-187.

S VANDERSCHUERENL VAN RENTERGHEMJean PlumChris VerhofstedeRudolf MakJohny Vincke

A2 Journal Article

Line probe assay (LiPA) for the detection of drug-selected variants in the HIV-1 reverse transcriptase gene. International Antiviral News, 1997, 5, 38-40.

L STUYVERA WYSEURA ROMBOUTChris VerhofstedeD RIMLANDRF SCHINAZIR ROSSAU