Research Explorer

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Researcher

Charlotte Grootaert

Awards & Distinctions

124 Results

2024

Acidic hydrothermal processing of wheat using citrate buffer largely enhances iron and zinc bioaccessibility and bioavailability to Caco-2 cells

Marie HuyskensElien LemmensCharlotte GrootaertJohn Van CampKristin VerbekePeter GoosErik SmoldersJan A. Delcour

U Journal Article in Food Chemistry

Bioenergetic effects of pristine and ultraviolet-weathered polydisperse polyethylene terephthalate and polystyrene nanoplastics on human intestinal Caco-2 cells

Miao PengMaaike VercauterenCharlotte GrootaertAna Isabel CatarinoGert EveraertAndreja RajkovicColin JanssenJana Asselman

A1 Journal Article in SCIENCE OF THE TOTAL ENVIRONMENT

Can microplastics modulate the virulence of Listeria monocytogenes?

Irene Ortega SanzCharlotte GrootaertBram JacobsAndreja Rajkovic

Curcumin as a source of inspiration for the development of novel benzothiazepane-based cancer cell cytotoxic agents

Katarina MagdalenicFelien MorlionUlrike RonseSteven De JongheLeentje PersoonsDominique ScholsJulie De MunckCharlotte GrootaertJohn Van CampMatthias D'hooghe

Mitochondrial activity of semen cells as marker for cereulide toxin

Bram JacobsJaniek De BackerSoyeon KimFalke EngelbeenJulien MasquelierTom Van NieuwenhuysenJacques MahillonKoenraad Van HoordeCharlotte GrootaertAndreja Rajkovic

Probing long-term impacts : low-dose polystyrene nanoplastics exacerbate mitochondrial health and evoke secondary glycolysis via repeated and single dosing

Miao PengCharlotte GrootaertMaaike VercauterenNico BoonColin JanssenAndreja RajkovicJana Asselman

A1 Journal Article in ENVIRONMENTAL SCIENCE & TECHNOLOGY

Role of microplastics in the contamination and virulence of Listeria monocytogenes

Irene Ortega SanzCharlotte GrootaertBram JacobsAndreja Rajkovic

Synthesis and anticancer activity assessment of curcumin-inspired benzothiazepane derivatives

Katarina MagdalenicFelien MorlionUlrike RonseSteven De JongheLeentje PersoonsDominique ScholsJulie De MunckCharlotte GrootaertJohn Van CampMatthias D'hooghe

Synthesis and cancer cell cytotoxicity of 2-heteroaryl-4-(4-heteroaryl-2-oxobut-3-en-1-ylidene)-substituted benzothiazepanes

Katarina MagdalenicFelien MorlionSteven De JongheLeentje PersoonsDominique ScholsCharlotte GrootaertJohn Van CampMatthias D'hooghe

A1 Journal Article in TETRAHEDRON

The boar semen assay 2.0: changes in mitochondrial activity of semen cells as marker for cereulide toxin

Bram JacobsJaniek De BackerSoyeon KimFalke EngelbeenJulien MasquelierTom Van NieuwenhuysenJacques Mahillonkoenraad Van HoordeCharlotte GrootaertAndreja Rajkovic

To Swim Or Not To Swim: Probing The Influence Of Nanoparticles On Male Cell Viability And How Plastics React With Bacillus Cereus Cereulide

Bram JacobsJaniek De BackerGuilherme RizzotoJuri GnagnarelliKristel DemeyereEvelyne MeyerAnn Van SoomCharlotte GrootaertAndreja Rajkovic

2023

Cellular and bioenergetic effects of polystyrene microplastic in function of cell type, differentiation status and post-exposure time

Miao PengMaaike VercauterenCharlotte GrootaertAndreja RajkovicNico BoonColin JanssenJana Asselman

A1 Journal Article in ENVIRONMENTAL POLLUTION

Chronic exposure to dietary compounds shifts bioenergetics in colorectal cancer

Elien AlderweireldtCharlotte GrootaertAndreja RajkovicFilip Van NieuwerburghJohn Van CampOlivier De Wever

Curcumin as a source of inspiration for the development of novel benzothiazepane-based cancer cell cytotoxic agents

Katarina MagdalenicUlrike RonseFelien MorlionSteven De JongheLeentje PersoonsDominique ScholsJulie De MunckCharlotte GrootaertJohn Van CampMatthias D'hooghe

Curcumin as a source of inspiration for the development of novel benzothiazepane-based cancer cell cytotoxic agents

Katarina MagdalenicUlrike RonseFelien MorlionSteven De JongheLeentje PersoonsDominique ScholsJulie De MunckCharlotte GrootaertJohn Van CampMatthias D'hooghe

Effect on colorectal cancer bioenergetics by chronic exposure to red meat metabolites

Elien AlderweireldtCharlotte GrootaertSophie Van WeldenDebby LaukensAndreja RajkovicJohn Van CampOlivier De Wever

Effect on colorectal cancer bioenergetics by chronic exposure to red meat metabolites

Elien AlderweireldtCharlotte GrootaertAndreja RajkovicFilip Van NieuwerburghStijn LucaJohn Van CampOlivier De Wever

Elucidating the combined toxicity of aflatoxin B1 and fumonisin B1 on HepG2 cells based on respirometry and transcriptome analyses

Xiangrong ChenMohamed Fathi AbdallahCharlotte GrootaertFilip Van NieuwerburghAndreja Rajkovic

Exposure of curcumin (analogues) to 2D and 3D intestinal in vitro models

Julie De MunckCharlotte GrootaertElien AlderweireldtKatarina MagdalenicMatthias D'hoogheJohn Van Camp

In vitro bioaccessibility and uptake of β-carotene from encapsulated carotenoids from mango by-products in a coupled gastrointestinal digestion/Caco-2 cell model

Katty Elizabeth Cabezas TeránCharlotte GrootaertJohana OrtizSilvana DonosoJenny RualesFilip Van BockstaeleJohn Van CampTom Van de Wiele

A1 Journal Article in FOOD RESEARCH INTERNATIONAL

In vitro bioavailability and impact of food-derived amyloid-like protein fibrils on health-related markers

Trui LuyckxJohn Van CampCharlotte Grootaert

Investigating the combined toxicity of aflatoxin B1 and fumonisin B1 on HepG2 using respirometry and transcriptomic analyses

Xiangrong ChenMohamed Fathi AbdallahCharlotte GrootaertAndreja Rajkovic

New insights into the combined toxicity of aflatoxin B1 and fumonisin B1 in HepG2 cells using Seahorse respirometry analysis and RNA transcriptome sequencing

Xiangrong ChenMohamed Fathi AbdallahCharlotte GrootaertFilip Van NieuwerburghAndreja Rajkovic

A1 Journal Article in ENVIRONMENT INTERNATIONAL

Rare sugar metabolism and impact on insulin sensitivity along the gut-liver-muscle axis in vitro

Amar Daniël Emanuel Van LaarCharlotte GrootaertAndreja RajkovicTom DesmetKoen BeerensJohn Van Camp

A1 Journal Article in NUTRIENTS

Synthesis and cancer cell cytotoxicity of 2-aryl-4-(4-aryl-2-oxobut-3-en-1-ylidene)-substituted benzothiazepanes

Katarina MagdalenicUlrike RonseSteven De JongheLeentje PersoonsDominique ScholsJulie De MunckCharlotte GrootaertJohn Van CampMatthias D'hooghe

A1 Journal Article in PHYTOCHEMISTRY LETTERS

2022

A two-front nutritional environment fuels colorectal cancer : perspectives for dietary intervention

Elien AlderweireldtCharlotte GrootaertOlivier De WeverJohn Van Camp

A1 Journal Article in TRENDS IN ENDOCRINOLOGY AND METABOLISM

Bioavailability and health impact of ingested amyloid-like protein fibrils and their link with inflammatory status : a need for more research?

Trui LuyckxCharlotte GrootaertMargarita Monge‐MoreraJan A. DelcourFrederic RousseauJoost SchymkowitzJohn Van Camp

A1 Journal Article in MOLECULAR NUTRITION & FOOD RESEARCH

Bioenergetic status of the intestinal and hepatic cells after short term exposure to fumonisin B1 and aflatoxin B1

Xiangrong ChenMohamed Fathi AbdallahCharlotte GrootaertAndreja Rajkovic

Bioenergetic status of the intestinal and hepatic cells after short term exposure to fumonisin B1 and aflatoxin B1

Xiangrong ChenMohamed Fathi AbdallahCharlotte GrootaertAndreja Rajkovic

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Curcumin-derived functionalized thiazepanes to selectively target colon cancer cells

Julie De MunckCharlotte GrootaertNathan VanwinsenMatthias D'hoogheJohn Van Camp

Curcumin-derived functionalized thiazepanes to selectively target colon cancer cells

Julie De MunckCharlotte GrootaertNathan VanwinsenMatthias D'hoogheJohn Van Camp

Effect of chronic exposure of dietary compounds on colorectal cancer bioenergetics

Elien AlderweireldtCharlotte GrootaertAndreja RajkovicJohn Van CampOlivier De Wever

Exposure of microplastics at levels relevant for human health : acute and long-term cytotoxicity and cellular localization of polystyrene microparticles in four human cell lines

Miao PengMaaike VercauterenCharlotte GrootaertAndreja RajkovicNico BoonColin JanssenJana Asselman

Flavonoids and cellular stress : a complex interplay affecting human health

Hanne VissenaekensHanne CrielCharlotte GrootaertKatleen RaesGuy SmaggheJohn Van Camp

A1 Journal Article in CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Foodborne pathogens in the plastisphere : can microplastics in the food chain threaten microbial food safety?

Raffaella TavelliMartijn CallensCharlotte GrootaertMohamed Fathi AbdallahAndreja Rajkovic

A1 Journal Article in TRENDS IN FOOD SCIENCE & TECHNOLOGY

Impact of heat and enzymatic treatment on ovalbumin amyloid-like fibril formation and enzyme-induced gelation

Arne HuystLomme J. DeleuTrui LuyckxLouis Van der MeerenJoëlle A.J. HousmansCharlotte GrootaertMargarita Monge-MoreraJan A. DelcourAndre SkirtachFrederic Rousseau et al.

A1 Journal Article in FOOD HYDROCOLLOIDS

Metabolic health impact of rare sugars in cell models simulating the gut-liver-muscle axis

Amar Daniël Emanuel Van LaarJohn Van CampCharlotte Grootaert

Metabolism and health effects of rare sugars in a CACO-2/HepG2 coculture model

Amar Daniël Emanuel Van LaarCharlotte GrootaertFilip Van NieuwerburghDieter DeforceTom DesmetKoen BeerensJohn Van Camp

A1 Journal Article in NUTRIENTS

Quercetin mitigates endothelial activation in a novel intestinal-endothelial-monocyte/macrophage coculture setup

Hanne VissenaekensCharlotte GrootaertKatleen RaesJulie De MunckGuy SmaggheNico BoonJohn Van Camp

A1 Journal Article in INFLAMMATION

Subtoxic doses of polystyrene nanoplastics and microcystin-LR affect the bioenergetic status of Caco-2 and HepG2 cells

Mohamed Fathi AbdallahEleonora Valentia Sode MudaCharlotte GrootaertAndreja Rajkovic

Sweet biotechnology : enzymatic production and digestibility screening of novel kojibiose and nigerose analogues

Shari DhaeneAmar Daniël Emanuel Van LaarMarc De DonckerEmma De BeulKoen BeerensCharlotte GrootaertJurgen CaroenJohan Van der EyckenJohn Van CampTom Desmet

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

2021

Intracellular quercetin accumulation and its impact on mitochondrial dysfunction in intestinal Caco-2 cells

Hanne VissenaekensGuy SmaggheHanne CrielCharlotte GrootaertKatleen RaesAndreja RajkovicGeert GoeminneNico BoonKristof De SchutterJohn Van Camp

A1 Journal Article in FOOD RESEARCH INTERNATIONAL

Method for beta-carotene extraction from processed baby foods as a model for plant-based fatty food products

Charlotte GrootaertMargot VansteenlandAngelique VandemoorteleJohn Van CampBruno De Meulenaer

A1 Journal Article in FOOD RESEARCH INTERNATIONAL

Microplastics in the human digestive environment : a focus on the potential and challenges facing in vitro gut model development

Elora FournierLucie Etienne-MesminCharlotte GrootaertLotte JelsbakKristian SybergStéphanie Blanquet-DiotMuriel Mercier-Bonin

A1 Journal Article in JOURNAL OF HAZARDOUS MATERIALS

Rare mono- and disaccharides as healthy alternative for traditional sugars and sweeteners?

Amar Daniël Emanuel Van LaarCharlotte GrootaertJohn Van Camp

A1 Journal Article in CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Toxic effect of nanoplastics on cellular bioenergetics

Mohamed Fathi AbdallahCharlotte GrootaertAndreja Rajkovic

Lecture / Speech

2020

Chemical composition, antioxidant, antimicrobial and antiproliferative activities of the extracts isolated from the pomace of rowanberry (Sorbus aucuparia L.)

Ramunė BobinaitėCharlotte GrootaertJohn Van CampAntanas ŠarkinasMindaugas LiaudanskasVaidotas ŽvikasPranas ViškelisPetras Rimantas Venskutonis

A1 Journal Article in FOOD RESEARCH INTERNATIONAL

Co-ingestion of black carrot and strawberry : effects on anthocyanin stability, bioaccessibility and uptake

Celia CarrilloSenem KamilogluCharlotte GrootaertJohn Van CampMarc Hendrickx

A1 Journal Article in FOODS

Effect of (processed) meat related compounds on intestinal organoids

Elien AlderweireldtCharlotte GrootaertOlivier De WeverJohn Van Camp

Exposure of microplastic at levels relevant for human health : cytotoxicity and cellular localization of polystyrene microparticles in four human cell lines

Miao PengCharlotte GrootaertAndreja RajkovicColin JanssenJana Asselman

Microbiome metabolic potency towards plant bioactives and consequences for health effects

Charlotte GrootaertTom Van de Wiele

Bookchapter in Health consequences of microbial interactions with hydrocarbons, oils, and lipids

Mitochondrial toxicity of chemical mixtures : a tool for whole effluent testing

João Alves BarbosaCelien CaerelsCharlotte GrootaertJana AsselmanColin JanssenAndreja RajkovicKarel De Schamphelaere

2019

Cell line-dependent increase in cellular quercetin accumulation upon stress induced by valinomycin and lipopolysaccharide, but not by TNF-alpha

Hanne VissenaekensCharlotte GrootaertAndreja RajkovicKristof De SchutterKatleen RaesGuy SmaggheTom Van de WieleJohn Van Camp

A1 Journal Article in FOOD RESEARCH INTERNATIONAL

Clinical aspects of egg bioactive peptide research : a review

Charlotte GrootaertStefan VoorspoelsGriet JacobsBea MatthijsSam PossemiersHans Van der SaagJohn Van CampAlice Lucey

A1 Journal Article in INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY

Effect of processed meat related compounds on colon cells

Elien AlderweireldtCharlotte GrootaertStefaan De SmetAndreja RajkovicOlivier De WeverJohn Van Camp

Effect of processed meat related compounds on colon cells

Elien AlderweireldtCharlotte GrootaertStefaan De SmetAndreja RajkovicOlivier De WeverJohn Van Camp

Rational design of amyloid-like fibrillary structures for tailoring food protein techno-functionality and their potential health implications

Koen JA JansensIne RomboutsCharlotte GrootaertKristof BrijsJohn Van CampPaul Van der MeerenFrederic RousseauJoost SchymkowitzJan A Delcour

A1 Journal Article in COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Self-assembly, functionality, and in-vitro properties of quercetin loaded nanoparticles based on shellac-almond gum biological macromolecules

Ali Sedaghat DoostVincent KassoziCharlotte GrootaertMyriam ClaeysKoen DewettinckJohn Van CampPaul Van der Meeren

A1 Journal Article in INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Synthesis and cytotoxic evaluation of monocarbonyl curcuminoids and their pyrazoline derivatives

Tim Van de WalleAtiruj TheppawongCharlotte GrootaertSteven De JongheLeentje PersoonsDirk DaelemansKristof Van HeckeJohn Van CampMatthias D'hooghe

A1 Journal Article in MONATSHEFTE FUR CHEMIE

Synthesis of 1,4‐thiazepane‐based curcuminoids with promising anticancer activity

Atiruj TheppawongTim Van de WalleKristof Van HeckeCharlotte GrootaertJohn Van CampMatthias D'hooghe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of non‐symmetrical nitrogen‐containing curcuminoids in the pursuit of new anticancer candidates

Atiruj TheppawongTim Van de WalleCharlotte GrootaertKristof Van HeckeNathalie CatryTom DesmetJohn Van CampMatthias D'hooghe

A1 Journal Article in CHEMISTRYOPEN

The effect of processed meat related compounds on colon cells : relevance of long term approach

Elien AlderweireldtCharlotte GrootaertStefaan De SmetOlivier De WeverJohn Van Camp

The intestinal fate of citrus flavanones and their effects on gastrointestinal health

Yala StevensEvelien Van RymenantCharlotte GrootaertJohn Van CampSam PossemiersAdrian MascleeDaisy Jonkers

A1 Journal Article in NUTRIENTS

The response of five intestinal cell lines to anoxic conditions in vitro

Hanne VissenaekensCharlotte GrootaertAndreja RajkovicTom Van de WieleMarta Calatayud Arroyo

A1 Journal Article in BIOLOGY OF THE CELL

2018

A critical evaluation of in vitro hesperidin 2S bioavailability in a model combining luminal (microbial) digestion and Caco-2 cell absorption in comparison to a randomized controlled human trial

Evelien Van RymenantBouke SaldenStefan VoorspoelsGriet JacobsBart NotenJudit PitartSam PossemiersGuy SmaggheCharlotte GrootaertJohn Van Camp

A1 Journal Article in MOLECULAR NUTRITION & FOOD RESEARCH

Aronia (Aronia melanocarpa) polyphenols modulate the microbial community in a simulator of the human intestinal microbial ecosystem (SHIME) and decrease secretion of proinflammatory markers in a Caco-2/endothelial cell coculture model

Ting WuCharlotte GrootaertJudit PitartNevena Kardum VidovicSenem KamilogluSam PossemiersMaria GlibeticGuy SmaggheKatleen RaesTom Van de Wiele et al.

A1 Journal Article in MOLECULAR NUTRITION & FOOD RESEARCH

Cu isotope fractionation response to oxidative stress in a hepatic cell line studied using multi-collector ICP-mass spectrometry

Maria del Rosario Florez GarciaMarta Costas RodriguezCharlotte GrootaertJohn Van CampFrank Vanhaecke

A1 Journal Article in ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Protein hydrolysate from canned sardine and brewing by-products improves TNF-α-induced inflammation in an intestinal-endothelial co-culture cell model

Elsa F. VieiraJohn Van CampIsabel MPLVO FerreiraCharlotte Grootaert

A1 Journal Article in EUROPEAN JOURNAL OF NUTRITION

Synthesis of Novel Aza‐aromatic Curcuminoids with Improved Biological Activities towards Various Cancer Cell Lines

Atiruj TheppawongTim Van de WalleCharlotte GrootaertMargot BultinckTom DesmetJohn Van CampMatthias D'hooghe

A1 Journal Article in CHEMISTRYOPEN

Synthesis of nitrogen-containing curcumin analogues in the pursuit of new anticancer candidates

Atiruj TheppawongCharlotte GrootaertJohn Van CampMatthias D'hooghe

Synthesis, biology and structure-activity relationships of novel β-enaminone-, aza-aromatic- and thiazepanebased curcuminoids

Atiruj TheppawongCharlotte GrootaertJohn Van CampMatthias D'hooghe

Vasorelaxant activity of twenty-one physiologically relevant (poly)phenolic metabolites on isolated mouse arteries

Evelien Van RymenantCharlotte GrootaertKatrijn BeerensPW NeedsPA KroonA KerimiG WilliamsonR García-VillalbaA González-SarríasF Tomas-Barberan et al.

A1 Journal Article in FOOD & FUNCTION

2017

Anti-inflammatory potential of black carrot (Daucus carota L.) polyphenols in a co-culture model of intestinal Caco-2 and endothelial EA.hy926 cells

Senem KamilogluCharlotte GrootaertEsra CapanogluCeren OzkanGuy SmaggheKatleen RaesJohn Van Camp

A1 Journal Article in MOLECULAR NUTRITION & FOOD RESEARCH

Aronia (Aronia melanocarpa) phenolics bioavailability in a combined in vitro digestion/Caco-2 cell model is structure and colon region dependent

Ting WuCharlotte GrootaertStefan VoorspoelsGriet JacobsJudit PitartSenem KamilogluSam PossemiersMarina HeinonenNevena KardumMaria Glibetic et al.

A1 Journal Article in JOURNAL OF FUNCTIONAL FOODS

Biocatalytic synthesis of the rare sugar kojibiose : process scale-up and application testing

Koen BeerensKarel De WinterDavy Van de WalleCharlotte GrootaertSenem KamilogluLisa MiclotteTom Van de WieleJohn Van CampKoen DewettinckTom Desmet

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Butyrate-producing bacteria supplemented in vitro to Crohn's disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier integrity

Annelies GeirnaertMarta Calatayud ArroyoCharlotte GrootaertDebby LaukensSarah DevrieseGuy SmaggheMartine De VosNico BoonTom Van de Wiele

A1 Journal Article in SCIENTIFIC REPORTS

Chronic exposure to short-chain fatty acids modulates transport and metabolism of microbiome-derived phenolics in human intestinal cells

Evelien Van RymenantLászló AbrankóSarka TumovaCharlotte GrootaertJohn Van CampGary WilliamsonAsimina Kerimi

A1 Journal Article in JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Development of an in vitro screening assay to study the bioavailability and vasorelaxant activity of polyphenols

Evelien Van RymenantJohn Van CampCharlotte GrootaertJohan Van de Voorde

Egg-derived bioactive peptides with ACE-inhibitory properties : a literature update

Charlotte GrootaertBea MatthijsStefan VoorspoelsSam PossemiersGuy SmaggheJohn Van Camp

A1 Journal Article in FOOD & FUNCTION

Ferulic acid-4-O-sulfate rather than ferulic acid relaxes arteries and lowers blood pressure in mice

Evelien Van RymenantJohn Van CampBart PauwelsCharlotte BoydensLaura Vanden DaeleKatrijn BeerensPeter BrouckaertGuy SmaggheAsimina KerimiGary Williamson et al.

A1 Journal Article in JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Gastrointestinal simulation model TWIN-SHIME shows differences between human urolithin-metabotypes in gut microbiota composition, pomegranate polyphenol metabolism, and transport along the intestinal tract

Rocio Garcia-VillalbaHanne VissenaekensJudit PitartMaria Romo-VaqueroJuan Carlos EspínCharlotte GrootaertMaría V SelmaKatleen RaesGuy SmaggheSam Possemiers et al.

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Natural Fe isotope fractionation in an intestinal Caco-2 cell line model

Maria del Rosario Florez GarciaYulia AnoshkinaMarta Costas RodriguezCharlotte GrootaertJohn Van CampJoris DelangheFrank Vanhaecke

A1 Journal Article in JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Quantification of egg ovalbumin hydrolysate-derived anti-hypertensive peptides in an in vitro model combining luminal digestion with intestinal Caco-2 cell transport

Charlotte GrootaertGriet JacobsBea MatthijsJudit PitartGeert BaggermanSam PossemiersHans Van der SaagGuy SmaggheJohn Van CampStefan Voorspoels

A1 Journal Article in FOOD RESEARCH INTERNATIONAL

Synthesis, biology and structure-activity relationships of novel β-enaminone-, aza-aromatic- and thiazepane-based curcuminoids

Atiruj TheppawongTim Van de WalleCharlotte GrootaertJohn Van CampMatthias D'hooghe

2016

Bioaccessibility of polyphenols from plant-processing byproducts of black carrot (Daucus carota L.)

Senem KamilogluEsra CapanogluFatma Damla BilenGerard GonzalesCharlotte GrootaertTom Van de WieleJohn Van Camp

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Flow cytometric method for the detection of flavonoids in cell lines

Charlotte GrootaertGerard GonzalesHanne VissenaekensTom Van de WieleKatleen RaesGuy SmaggheJohn Van Camp

A1 Journal Article in JOURNAL OF BIOMOLECULAR SCREENING

Intestinal arsenic absorption is increased by colon suspension from IBD patients

Marta Calatayud ArroyoAnnelies GeirnaertCharlotte GrootaertGijs Du LaingTom Van de Wiele

Quercetin mitigates valinomycin-induced cellular stress via stress-induced metabolism and cell uptake

Gerard GonzalesGuy SmaggheHanne VissenaekensCharlotte GrootaertAndreja RajkovicTom Van de WieleKatleen RaesJohn Van Camp

A1 Journal Article in MOLECULAR NUTRITION & FOOD RESEARCH

Resveratrol improves TNF-α-induced endothelial dysfunction in a coculture model of a Caco-2 with an endothelial cell line

Isabela Maia ToaldoJohn Van CampGerard GonzalesSenem KamilogluMarilde T Bordignon-LuizGuy SmaggheKatleen RaesEsra CapanogluCharlotte Grootaert

A1 Journal Article in JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Synthesis and biological assessment of novel N-(hydroxy/methoxy)alkyl β-enaminone curcuminoids

Atiruj TheppawongRob De VreeseLore VanneckeCharlotte GrootaertJohn Van CampMatthias D'hooghe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of novel curcuminoids accommodating a central β-enaminone motif and their impact on cell growth and oxidative stress

Rob De VreeseCharlotte GrootaertSander D'hooreAtiruj TheppawongSam Van DammeMaarten Van BogaertJohn Van CampMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Transepithelial transport of dry-cured ham peptides with ACE inhibitory activity through a Caco-2 cell monolayer

Marta GallegoCharlotte GrootaertLeticia MoraM Concepción AristoyJohn Van CampFidel Toldrá

A1 Journal Article in JOURNAL OF FUNCTIONAL FOODS

2015

Anthocyanin absorption and metabolism by human intestinal Caco-2 cells: a review

Senem KamilogluEsra CapanogluCharlotte GrootaertJohn Van Camp

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bioavailability and metabolism of grape trans-resveratrol on Caco-2 cells

Isabela Maia ToaldoCharlotte GrootaertMarilde T Bordignon-LuizJohn Van Camp

A4 Journal Article in COMMUNICATIONS IN AGRICULTURAL AND APPLIED BIOLOGICAL SCIENCES

Cell systems to investigate the impact of polyphenols on cardiovascular health

Charlotte GrootaertSenem KamilogluEsra CapanogluJohn Van Camp

A1 Journal Article in NUTRIENTS

Flavonoid interactions during digestion, absorption, distribution and metabolism: a sequential structure–activity/property relationship-based approach in the study of bioavailability and bioactivity

Gerard GonzalesGuy SmaggheCharlotte GrootaertMoises João ZottiKatleen RaesJohn Van Camp

A1 Journal Article in DRUG METABOLISM REVIEWS

Microbial inhibition of oral epithelial wound recovery: potential role for quorum sensing molecules?

Tine De RyckEline VanlanckerCharlotte GrootaertBart RomanLaurens De CoenIsabel VandenbergheChristian StevensMarc BrackeTom Van de WieleBarbara Vanhoecke

A1 Journal Article in AMB EXPRESS

Review on the use of cell cultures to study metabolism, transport, and accumulation of flavonoids: from mono-cultures to co-culture systems

Gerard GonzalesJohn Van CampHanne VissenaekensKatleen RaesGuy SmaggheCharlotte Grootaert

A1 Journal Article in COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates

Tom SieprathTobias CorneMarco NooteboomCharlotte GrootaertAndreja RajkovicBenjamin BuysschaertJoke RobijnsJos LV BroersFrans CS RamaekersWerner JH Koopman et al.

A1 Journal Article in NUCLEUS

Two- and three-dimensional quantitative structure–permeability relationship of flavonoids in Caco-2 cells using stepwise multiple linear regression (SMLR), partial least squares regression (PLSR), and pharmacophore (GALAHAD)-based comparative molecular similarity index analysis (COMSIA)

Gerard GonzalesJohn Van CampMoises João ZottiVladimer KobayashiCharlotte GrootaertKatleen RaesGuy Smagghe

A1 Journal Article in MEDICINAL CHEMISTRY RESEARCH

Use of metabolomics and fluorescence recovery after photobleaching to study the bioavailability and intestinal mucus diffusion of polyphenols from cauliflower waste

Gerard GonzalesGuy SmaggheAlan MackieCharlotte GrootaertBalazs BajkaNeil RigbyKatleen RaesJohn Van Camp

A1 Journal Article in JOURNAL OF FUNCTIONAL FOODS

2014

Development of an oral mucosa model to study host-microbiome interactions during wound healing

Tine De RyckCharlotte GrootaertLaura JaspaertFrederiek-Maarten KerckhofMireille Van GeleJoachim De SchrijverPieter Van den AbbeeleSimon SwiftMarc BrackeTom Van de Wiele et al.

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Models of the human microbiota and microbiome in vitro

Massimo MarzoratiPieter Van den AbbeeleCharlotte GrootaertRosemarie De WeirdtAne Marcos CarcavillaJoan VermeirenTom Van de Wiele

Bookchapter in The human microbiota and microbiome

Sub-emetic toxicity of Bacillus cereus toxin cereulide on cultured human enterocyte-like Caco-2 cells

Andreja RajkovicCharlotte GrootaertAna ButoracTatiana CucuBruno De MeulenaerJohn Van CampMarc BrackeMieke UyttendaeleVišnja Bačun-DružinaMario Cindrćc

A1 Journal Article in TOXINS

2013

Anthocyanin determination in blueberry extracts from various cultivars and their antiproliferative and apoptotic properties in B16-F10 metastatic murine melanoma cells

Andrea BuneaDumitriţa RuginăZoriţa SconţaRaluca M PopAdela PinteaCarmen SocaciuFlaviu TăbăranCharlotte GrootaertKarin StruijsJohn Van Camp

A1 Journal Article in PHYTOCHEMISTRY

2012

Angiopoietin-like protein 4 : health effects, modulating agents and structure-function relationships

Charlotte GrootaertTom Van de WieleWilly Verstraetemarc brackeBarbara Vanhoecke

A1 Journal Article in EXPERT REVIEW OF PROTEOMICS

2011

Adherence and viability of intestinal bacteria to differentiated Caco-2 cells quantified by flow cytometry

Charlotte GrootaertNico BoonFjoralba ZekaBarbara Vanhoeckemarc brackeWilly VerstraeteTom Van de Wiele

A1 Journal Article in JOURNAL OF MICROBIOLOGICAL METHODS

Bacterial modulation of the fasting-induced adipose factor (FIAF): an example of host-microbe crosstalk related to obesity

Charlotte GrootaertTom Van de WieleIlse Van RoosbroeckSam PossemiersAnne-Sophie Vercoutter-EdouartWilly Verstraetemarc brackeBarbara Vanhoecke

Bacterial monocultures, propionate, butyrate and H(2)O(2) modulate the expression, secretion and structure of the fasting-induced adipose factor in gut epithelial cell lines

Charlotte GrootaertTom Van de WieleIlse Van RoosbroeckSam PossemiersAnne-Sophie Vercoutter-EdouartWilly Verstraetemarc brackeBarbara Vanhoecke

A1 Journal Article in ENVIRONMENTAL MICROBIOLOGY

In vitro effects of the intestinal microbiota and their prebiotic modulation on parameters regulating fat metabolism

Charlotte GrootaertWilly VerstraeteMarc Bracke

Prebiotics to manage the microbial control of energy homeostasis

Charlotte GrootaertMassimo MarzoratiPieter Van den AbbeeleTom Van de WieleSam Possemiers

A1 Journal Article in BENEFICIAL MICROBES

Propionate as a health-promoting microbial metabolite in the human gut

Elham HosseiniCharlotte GrootaertWilly VerstraeteTom Van de Wiele

A1 Journal Article in NUTRITION REVIEWS

2010

Arabinoxylans and inulin modulate the luminal and mucosa-associated bacteria in vitro and in vivo

Pieter Van den AbbeeleTom Van de WieleCharlotte GrootaertWilly VerstraeteP. GerardA. BruneauS. RabotSam Possemiers

Microbial community development in a dynamic gut model is reproducible, colon region specific, and selective for Bacteroidetes and Clostridium cluster IX

Pieter Van den AbbeeleCharlotte GrootaertMassimo MarzoratiSam PossemiersWilly VerstraetePhilippe GerardSylvie RabotAurelia BruneauSahar El AidyMuriel Derrien et al.

A1 Journal Article in APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Obesity, bacteria and fat

Charlotte GrootaertTom Van de WieleWilly Verstraete

Bookchapter in Handbook of Hydrocarbon and Lipid Microbiology

2009

Arabinoxylan-oligosaccharides (AXOS) affect the protein/carbohydrate fermentation balance and microbial population dynamics of the Simulator of Human Intestinal Microbial Ecosystem

JI SanchezMassimo MarzoratiCharlotte GrootaertM BaranV Van CraeyveldCM CourtinWF BroekaertJA DelcourWilly VerstraeteTom Van de Wiele

A1 Journal Article in MICROBIAL BIOTECHNOLOGY

Arabinoxylans modulate the luminal and mucosa-associated bacteria in vitro and in vivo

Pieter Van den AbbeeleTom Van de WieleCharlotte GrootaertWilly VerstraetePhilippe GérardAurelia BruneauSylvie RabotSam Possemiers

Bookchapter in Dietary fibre : new frontiers for food and health

Chemopreventive effects from prebiotic inulin towards microbial 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine bioactivation

Lynn VanhaeckeCharlotte GrootaertWilly VerstraeteTom Van de Wiele

A1 Journal Article in JOURNAL OF APPLIED MICROBIOLOGY

Comparison of prebiotic effects of arabinoxylan oligosaccharides and inulin in a simulator of the human intestinal microbial ecosystem

Charlotte GrootaertPieter Van den AbbeeleMassimo MarzoratiWillem F BroeckaertChristophe M CourtinJan A DelcourWilly VerstraeteTom Van de Wiele

A1 Journal Article in FEMS MICROBIOLOGY ECOLOGY

In vitro model to study the modulation of the mucin adhered bacterial community

Pieter Van den AbbeeleCharlotte GrootaertSam PossemiersWilly VerstraeteKim VerbekenTom Van de Wiele

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The intestinal environment in health and disease: recent insights on the potential of intestinal bacteria to influence human health

Sam PossemiersCharlotte GrootaertJoan VermeirenGabriele GrossMassimo MarzoratiWilly VerstraeteTom Van de Wiele

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

2007

Microbial metabolism and prebiotic potency of arabinoxylan oligosaccharides in the human intestine

Charlotte GrootaertJA DELCOURCM COURTINWF BROEKAERTWilly VerstraeteTom Van de Wiele

A1 Journal Article in TRENDS IN FOOD SCIENCE & TECHNOLOGY

2006

Arabinoxylan oligosaccharides with different structures exert a bifidogenic effect in a mixed intestinal community

Charlotte GrootaertWilly VerstraeteTom Van de Wiele

The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine

Sam PossemiersSelin BolcaCharlotte GrootaertArne HeyerickKarel DecroosWillem DhoogeDenis De KeukeleireS RABOTWilly VerstraeteTom Van de Wiele

A1 Journal Article in JOURNAL OF NUTRITION