Research Explorer

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Researcher

Caro De Haes

Publications & Research Data

Awards & Distinctions

15 Results

2026

G-CSF-overexpression induces an inflammatory tumor microenvironment in mouse TNBC models with targetable upregulation of LCN2 and CHI3L1

Caro De HaesKristel DemeyereEvelyne MeyerJonas Steenbrugge

Grade III canine and feline mammary carcinomas are associated with an immunosuppressed, vascularized and proliferative microenvironment

Caro De HaesHilde De RoosterKristel DemeyereKoen Van de VijverHilde De CockEvelyne MeyerJonas Steenbrugge

A1 Journal Article in BMC VETERINARY RESEARCH

TRIPLE-TARGET BLOCKADE OF CHI3L1, LCN2 AND PD-L1 REDUCES TUMOR GROWTH AND ENHANCES IMMUNOSTIMULATION IN A MOUSE TNBC MODEL

Caro De HaesRobbe SalembierBo WylinKristel DemeyereLaurence BuisseretChristos SotiriouEvelyne MeyerJonas Steenbrugge

2025

Canine mammary carcinomas are associated with an immunosuppressed, vascularized and proliferative microenvironment

Caro De HaesHilde De RoosterKristel DemeyereHilde De CockEvelyne MeyerJonas Steenbrugge

Feline mammary carcinomas are associated with an immunosuppressed vascularized and proliferative microenvironment

Caro De HaesHilde De RoosterKristel DemeyereHilde De CockEvelyne MeyerJonas Steenbrugge

Neutrophil-derived chitinase 3-like 1 drives immunosuppression in triple-negative breast cancer : insights from a CHI3L1 knockout mouse model

Robbe SalembierCaro De HaesBo WylinKristel DemeyereEvelyne MeyerJonas Steenbrugge

Tractable mouse TNBC models capture the heterogeneous tumor immune microenvironment and adaptation to PD-L1 blockade

Robbe SalembierCaro De HaesKristel DemeyereSteven Van LaereLucie CervenkovaNicolaas Van RenneChristos SotiriouEvelyne MeyerJonas Steenbrugge

A1 Journal Article in NPJ BREAST CANCER

Transcriptomic adaptation of the cold versus hot triple-negative breast tumor immune microenvironment to PD-L1 blockade

Robbe SalembierCaro De HaesBo WylinKristel DemeyereSteven Van LaereNicolaas Van RenneChristos SotiriouEvelyne MeyerJonas Steenbrugge

Transcriptomic heterogeneity of nine complementary mouse TNBC models based on their comparative in vitro and in vivo characterization

Robbe SalembierCaro De HaesBo WylinKristel DemeyereSteven Van LaereNiek SandersEvelyne MeyerJonas Steenbrugge

2024

Chitin-mediated blockade of chitinase-like proteins reduces tumor growth and immunosuppression in a mouse model for TNBC

Robbe SalembierCaro De HaesBo WylinKristel DemeyereNiek SandersEvelyne MeyerJonas Steenbrugge

Chitin-mediated blockade of chitinase-like proteins reduces tumor immunosuppression, inhibits lymphatic metastasis and enhances anti-PD-1 efficacy in complementary TNBC models

Robbe SalembierCaro De HaesJulie BellemansKristel DemeyereWim Van Den BroeckNiek SandersSteven Van LaereTraci R. LyonsEvelyne MeyerJonas Steenbrugge

A1 Journal Article in BREAST CANCER RESEARCH

Comparative profiling of mouse TNBC models with differential TME states that mimic clinical heterogeneity

Robbe SalembierCaro De HaesBo WylinKristel DemeyereEvelyne MeyerJonas Steenbrugge

Lipocalin-2 blockade enhances anti-PD-1 efficacy in an immunosuppressed mouse TNBC model

Caro De HaesRobbe SalembierBo WylinKristel DemeyereEvelyne MeyerJonas Steenbrugge

Lipocalin-2 blockade reduces tumor growth and neutrophil infiltration in a mouse model for TNBC

Caro De HaesRobbe SalembierBo WylinKristel DemeyereNiek SandersEvelyne MeyerJonas Steenbrugge

2023

Characterization of the immune landscape of canine and feline mammary tumors as a basis for candidate biomarker, drug and toxicity studies

Jonas SteenbruggeCaro De HaesJulie BellemansKristel DemeyereHilde De RoosterEvelyne Meyer