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Researcher
Bruno Linclau
Profile
Projects
Publications
Activities
Awards & Distinctions
152
Results
2025
In pursuit of larger lipophilicity enhancement: an investigation of sugar deoxychlorination
Jonas Van De Velde
ARIADNA CALDERON
Zhong Wang
David E. Wheatley
Bruno Linclau
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2025
2024
Conformational analysis of 1,3-difluorinated alkanes
William G. Poole
Florent Peron
Stephen J. Fox
Neil Wells
Chris-Kriton Skylaris
Jonathan W. Essex
Ilya Kuprov
Bruno Linclau
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2024
De novo enantioselective synthesis of hexafluorinated D-glucose
Sébastien Depienne
Clément Q. Fontenelle
Mark E. Light
Kristof Van Hecke
Bruno Linclau
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2024
Harnessing glycofluoroforms for impedimetric biosensing
Alice R. Hewson
Henry O. Lloyd-Laney
Tessa Keenan
Sarah-Jane Richards
Matthew I. Gibson
Bruno Linclau
Nathalie Signoret
Martin A. Fascione
Alison Parkin
A1
Journal Article
in
CHEMICAL SCIENCE
2024
Molecular dynamics and NMR reveal the coexistence of H-bond-assisted and through-space JFH coupling in fluorinated amino alcohols
Cassia Chiari
Patrick R. Batista
Renan V. Viesser
Leonardo A. Schenberg
Lucas C. Ducati
Bruno Linclau
Cláudio F. Tormena
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2024
Novel chemotype NLRP3 inhibitors that target the CRID3-binding pocket with high potency
Lieselotte Vande Walle
Madhukar Said
Oonagh Paerewijck
Arinna Bertoni
Marco Gattorno
Bruno Linclau
Mohamed Lamkanfi
A1
Journal Article
in
LIFE SCIENCE ALLIANCE
2024
Quantitative analysis of 2D EXSY NMR spectra of strongly coupled spin systems in transmembrane exchange
Dmitry Shishmarev
Clement Q. Fontenelle
Bruno Linclau
Ilya Kuprov
Philip W. Kuchel
A1
Journal Article
in
CHEMBIOCHEM
2024
Synthesis and screening of a library of Lewisx deoxyfluoro-analogues reveals differential recognition by glycan-binding partners
Kristian Hollingsworth
Antonio Di Maio
Sarah-Jane Richards
Jean-Baptiste Vendeville
David E. Wheatley
Claire E. Council
Tessa Keenan
Hélène Ledru
Harriet Chidwick
Kun Huang
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2024
2023
Glycosylation of vicinal di- and trifluorinated glucose and galactose donors
Kler Huonnic
Bruno Linclau
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2023
Lipophilicity modulations by fluorination correlate with membrane partitioning
Zhong Wang
Hannah R. Felstead
Robert I. Troup
Bruno Linclau
Philip T. F. Williamson
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2023
Obtaining pure 1H NMR spectra of individual pyranose and furanose anomers of reducing deoxyfluorinated sugars
Gabija Poskaite
David E. Wheatley
Neil Wells
Bruno Linclau
Davy Sinnaeve
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2023
Photoinduced formation of cubyl aryl thioethers and synthesis of monocubyl analogue of dapsone
Laly Donnier-Valentin
Seydou Kassamba
Julien Legros
Catherine Fressigne
Daniela Vuluga
Richard C. D. Brown
Bruno Linclau
Michael De Paolis
A1
Journal Article
in
ORGANIC LETTERS
2023
Reverse thiophosphorylase activity of a glycoside phosphorylase in the synthesis of an unnatural Manβ1,4GlcNAc library
Tessa Keenan
Natasha E. Hatton
Jack Porter
Jean-Baptiste Vendeville
David E. Wheatley
Mattia Ghirardello
Alice. J. C. Wahart
Sanaz Ahmadipour
Julia Walton
M. Carmen Galan
et al.
A1
Journal Article
in
CHEMICAL SCIENCE
2023
2022
Relating conformational equilibria to conformer‐specific lipophilicities : new opportunities in drug discovery
Bruno Linclau
Zhong Wang
Benjamin Jeffries
Jérôme Graton
Rodrigo J. Carbajo
Davy Sinnaeve
Jean‐Yves Le Questel
James S. Scott
Elisabetta Chiarparin
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2022
The synthesis and glycoside formation of polyfluorinated carbohydrates
Kler Huonnic
Bruno Linclau
A1
Journal Article
in
CHEMICAL REVIEWS
2022
2021
Decagram synthesis of dimethyl 1,4-cubanedicarboxylate using continuous-flow photochemistry
Diego E. Collin
Edward H. Jackman
Nicolas Jouandon
Wei Sun
Mark E. Light
David C. Harrowven
Bruno Linclau
A1
Journal Article
in
SYNTHESIS-STUTTGART
2021
Fluorine NMR study of proline-rich sequences using fluoroprolines
Davy Sinnaeve
Abir Ben Bouzayene
Emile Ottoy
Gert-Jan Hofman
Eva Erdmann
Bruno Linclau
Ilya Kuprov
José Martins
Vladimir Torbeev
Bruno Kieffer
A2
Journal Article
in
MAGNETIC RESONANCE
2021
Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands
Sarah-Jane Richards
Tessa Keenan
Jean-Baptiste Vendeville
David E. Wheatley
Harriet Chidwick
Darshita Budhadev
Claire E. Council
Claire S. Webster
Helene Ledru
Alexander N. Baker
et al.
A1
Journal Article
in
CHEMICAL SCIENCE
2021
Rapid screening of diverse biotransformations for enzyme evolution
Emily E. Kempa
James L. Galman
Fabio Parmeggiani
James R. Marshall
Julien Malassis
Clement Q. Fontenelle
Jean-Baptiste Vendeville
Bruno Linclau
Simon J. Charnock
Sabine L. Flitsch
et al.
A2
Journal Article
in
JACS AU
2021
Skipped fluorination motifs : synthesis of building blocks and comparison of lipophilicity trends with vicinal and isolated fluorination motifs
Robert Troup
Benjamin Jeffries
Raphael El-Bekri Saudain
Eleni Georgiou
Johanna Fish
James S. Scott
Elisabetta Chiarparin
Charlene Fallan
Bruno Linclau
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2021
Synthesis and structural characteristics of all mono- and difluorinated 4,6-dideoxy-D-xylo-hexopyranoses
David E. Wheatley
Clement Q. Fontenelle
Ramakrishna Kuppala
Robert Szpera
Edward L. Briggs
Jean-Baptiste Vendeville
Neil J. Wells
Mark E. Light
Bruno Linclau
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2021
Synthesis of ortho-functionalized 1,4-cubanedicarboxylate derivatives through photochemical chlorocarbonylation
Diego E. Collin
Kristina Kovacic
Mark E. Light
Bruno Linclau
A1
Journal Article
in
ORGANIC LETTERS
2021
2020
Anomerisation of fluorinated sugars by mutarotase studied using F-19 NMR two-dimensional exchange spectroscopy
Dmitry Shishmarev
Lucas Quiquempoix
Clement Q. Fontenelle
Bruno Linclau
Philip W. Kuchel
A1
Journal Article
in
AUSTRALIAN JOURNAL OF CHEMISTRY
2020
Chemoenzymatic synthesis of 3-deoxy-3-fluoro-l-fucose and its enzymatic incorporation into glycoconjugates
Pablo Valverde
Jean-Baptiste Vendeville
Kristian Hollingsworth
Ashley P. Mattey
Tessa Keenan
Harriet Chidwick
Helene Ledru
Kler Huonnic
Kun Huang
Mark E. Light
et al.
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2020
Cubane electrochemistry : direct conversion of cubane carboxylic acids to alkoxy cubanes using the Hofer-Moest reaction under flow conditions
Diego E. Collin
Ana A. Folgueiras-Amador
Derek Pletcher
Mark E. Light
Bruno Linclau
Richard C. D. Brown
A1
Journal Article
in
CHEMISTRY-A EUROPEAN JOURNAL
2020
Enzymatic glycosylation involving fluorinated carbohydrates
Claire E. Council
Kelly J. Kilpin
Jessica S. Gusthart
Sarah A. Allman
Bruno Linclau
Seung Seo Lee
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2020
Exploring anomeric glycosylation of phosphoric acid : optimisation and scope for non-native substrates
Laura Beswick
Sanaz Ahmadipour
Gert-Jan Hofman
Hannah Wootton
Eleni Dimitriou
Johannes Reynisson
Robert A. Field
Bruno Linclau
Gavin J. Miller
A1
Journal Article
in
CARBOHYDRATE RESEARCH
2020
Fluorinated carbohydrates as chemical probes for molecular recognition studies : current status and perspectives
Bruno Linclau
Ana Arda
Niels-Christian Reichardt
Matthieu Sollogoub
Luca Unione
Stephane P. Vincent
Jesus Jimenez-Barbero
A1
Journal Article
in
CHEMICAL SOCIETY REVIEWS
2020
Lipophilicity trends upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl groups
Benjamin Jeffries
Zhong Wang
Robert Troup
Anais Goupille
Jean-Yves Le Questel
Charlene Fallan
James S. Scott
Elisabetta Chiarparin
Jerome Graton
Bruno Linclau
A1
Journal Article
in
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
2020
Profiling substrate promiscuity of wild-type sugar kinases for multi-fluorinated monosaccharides
Tessa Keenan
Fabio Parmeggiani
Julien Malassis
Clement Q. Fontenelle
Jean-Baptiste Vendeville
Wendy Offen
Peter Both
Kun Huang
Andrea Marchesi
Alex Heyam
et al.
A1
Journal Article
in
CELL CHEMICAL BIOLOGY
2020
Review of mutarotase in 'metabolic subculture' and analytical biochemistry : prelude to F-19 NMR studies of its substrate specificity and mechanism
Dmitry Shishmarev
Lucas Quiquempoix
Clement Q. Fontenelle
Bruno Linclau
Philip W. Kuchel
A1
Journal Article
in
AUSTRALIAN JOURNAL OF CHEMISTRY
2020
Systematic investigation of lipophilicity modulation by aliphatic fluorination motifs
Benjamin Jeffries
Zhong Wang
Hannah R. Felstead
Jean-Yves Le Questel
James S. Scott
Elisabetta Chiarparin
Jerome Graton
Bruno Linclau
A1
Journal Article
in
JOURNAL OF MEDICINAL CHEMISTRY
2020
2019
3,4-Dideoxy-3,3,4,4-tetrafluoro- and 4-OH epimeric 3-deoxy-3,3-difluoro-alpha-GalCer analogues : synthesis and biological evaluation on human iNKT cells stimulation
Samuel Golten
Allan Patinec
Katy Akoumany
Jezabel Rocher
Jerome Graton
Denis Jacquemin
Jean-Yves Le Questel
Arnaud Tessier
Jacques Lebreton
Virginie Blot
et al.
A1
Journal Article
in
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2019
A new straightforward method for lipophilicity (logP) measurement using F-19 NMR spectroscopy
Zhong Wang
Benjamin F. Jeffries
Hannah R. Felstead
Neil J. Wells
Elisabetta Chiarparin
Bruno Linclau
A1
Journal Article
in
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
2019
Conformational influence of fluorinated building blocks on the physical properties of polyesters
Sophie Lingier
Robert Szpera
Bart Goderis
Bruno Linclau
Filip Du Prez
A1
Journal Article
in
POLYMER
2019
Five-membered ring pucker conformational analysis of novel fluorinated prolines
Emile Ottoy
Steven Worswick
Chris Brett
Gert-Jan Hofman
Bruno Kieffer
José Martins
Bruno Linclau
Ilya Kuprov
Davy Sinnaeve
C3
Conference
2019
Kinetic analysis of the cis/trans isomerism of mono- and difluorinated proline analogues
Emile Ottoy
Gert-Jan Hofman
Bruno Linclau
José Martins
Davy Sinnaeve
C3
Conference
2019
Molecular insights into DC-SIGN binding to self-antigens : the interaction with the blood group A/B antigens
Pablo Valverde
Sandra Delgado
J. Daniel Martinez
Jean-Baptiste Vendeville
Julien Malassis
Bruno Linclau
Niels-Christian Reichardt
Francisco Javier Canada
Jesus Jimenez-Barbero
Ana Arda
A1
Journal Article
in
ACS CHEMICAL BIOLOGY
2019
Synthesis and conformational properties of 3,4-difluoro-L-prolines
Gert-Jan Hofman
Emile Ottoy
Mark E. Light
Bruno Kieffer
José Martins
Ilya Kuprov
Davy Sinnaeve
Bruno Linclau
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2019
Synthesis of 2,3,4-trideoxy-2,3,4-trifluoroglucose
Lucas Quiquempoix
Zhong Wang
Jerome Graton
Peter G. Latchem
Mark Light
Jean-Yves Le Questel
Bruno Linclau
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2019
Synthesis of vicinal dideoxy-difluorinated galactoses
Julien Malassis
Jean-Baptiste Vendeville
[missing] Qui-Hien Nguyen
Marie Boujon
Quentin Gaignard-Gaillard
Mark Light
Bruno Linclau
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2019
The synthesis of fluorinated proline analogues
Gert-Jan Hofman
Bruno Linclau
Davy Sinnaeve
José Martins
Dissertation
2019
Unraveling sugar binding modes to DC-SIGN by employing fluorinated carbohydrates
J. Daniel Martinez
Pablo Valverde
Sandra Delgado
Cecilia Romano
Bruno Linclau
Niels C. Reichardt
Stefan Oscarson
Ana Arda
Jesus Jimenez-Barbero
F. Javier Canada
A1
Journal Article
in
MOLECULES
2019
2018
An accurate method for J-coupling based conformational analysis of five-membered rings : study of β- and γ-fluorinated prolines
Emile Ottoy
Steven Worswick
Chris Brett
Gert-Jan Hofman
Bruno Kieffer
José Martins
Bruno Linclau
Ilya Kuprov
Davy Sinnaeve
C3
Conference
2018
Full conformational characterization of novel fluorinated prolines
Emile Ottoy
Steven Worswick
Chris Brett
Gert-Jan Hofman
Bruno Kieffer
José Martins
Bruno Linclau
Ilya Kuprov
Davy Sinnaeve
C3
Conference
2018
Full conformational characterization of novel fluorinated prolines
Emile Ottoy
Steven Worswick
Chris Brett
Gert-Jan Hofman
Bruno Kieffer
José Martins
Bruno Linclau
Ilya Kuprov
Davy Sinnaeve
C3
Conference
2018
Isolation and characterisation of an unexpected byproduct in the regioselective butane diacetal protection of α-methyl galactopyranoside
Clement Q. Fontenelle
Ramakrishna Kuppala
Mark Light
Bruno Linclau
A1
Journal Article
in
CARBOHYDRATE RESEARCH
2018
Minimising conformational bias in fluoroprolines through vicinal difluorination
Gert-Jan Hofman
Emile Ottoy
Mark E Light
Bruno Kieffer
Ilya Kuprov
José Martins
Davy Sinnaeve
Bruno Linclau
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2018
Reducing the lipophilicity of perfluoroalkyl groups by CF2-F/CF2-Me or CF3/CH3 exchange
Benjamin Jeffries
Zhong Wang
Jerome Graton
Simon D. Holland
Thomasin Brind
Ryan D. R. Greenwood
Jean-Yves Le Questel
James S. Scott
Elisabetta Chiarparin
Bruno Linclau
A1
Journal Article
in
JOURNAL OF MEDICINAL CHEMISTRY
2018
Ring pucker and cis/trans isomerism of 3,4-difluoroprolines
Emile Ottoy
Gert-Jan Hofman
Bruno Linclau
José Martins
Ilya Kuprov
Davy Sinnaeve
C3
Conference
2018
Transmembrane exchange of fluorosugars : characterization of red cell GLUT1 kinetics using( 19)F NMR
Dmitry Shishmarev
Clement Q. Fontenelle
Ilya Kuprov
Bruno Linclau
Philip W. Kuchel
A1
Journal Article
in
BIOPHYSICAL JOURNAL
2018
2017
1,1,1-trifluoropropan-2-ammonium triflate enantiomers : stereoselective synthesis and direct use in reaction with epoxides
Gemma Packer
Julien Malassis
Neil Wells
Mark Light
Bruno Linclau
A1
Journal Article
in
TETRAHEDRON-ASYMMETRY
2017
A study of intramolecular hydrogen bonding in levoglucosan derivatives
Lucas Quiquempoix
Elena Bogdan
Neil J. Wells
Jean-Yves Le Questel
Jerome Graton
Bruno Linclau
A1
Journal Article
in
MOLECULES
2017
Ab initio and NMR conformational analysis of β- and γ-fluorinated prolines
Emile Ottoy
Steven Worswick
Chris Brett
Gert-Jan Hofman
Bruno Kieffer
José Martins
Bruno Linclau
Ilya Kuprov
Davy Sinnaeve
C3
Conference
2017
Development of a solid phase array assay for the screening of galactose oxidase activity and for fast identification of inhibitors
Martin J. Weissenborn
Damien P. Debecker
Samuel Golten
Bruno Linclau
Nicholas J. Turner
Sabine L. Flitsch
A1
Journal Article
in
PROTEIN AND PEPTIDE LETTERS
2017
Influence of alcohol beta-fluorination on hydrogen-bond acidity of conformationally flexible substrates
Jerome Graton
Guillaume Compain
Francois Besseau
Elena Bogdan
Joseph M. Watts
Lewis Mtashobya
Zhong Wang
Alex Weymouth-Wilson
Nicolas Galland
Jean-Yves Le Questel
et al.
A1
Journal Article
in
CHEMISTRY-A EUROPEAN JOURNAL
2017
Synthesis of fluoroprolines
Gert-Jan Hofman
Davy Sinnaeve
José Martins
Bruno Linclau
C3
Conference
2017
The synthesis of 3,4-dideoxy-3,4-difluoro-D-glucose
Clement Q. Fontenelle
Dmitry Shishmarev
Philip W. Kuchel
Bruno Linclau
A2
Journal Article
in
TRENDS IN CARBOHYDRATE RESEARCH
2017
The synthesis of the 2,3-difluorobutan-1,4-diol diastereomers
Robert Szpera
Nadia Kovalenko
Kalaiselvi Natarajan
Nina Paillard
Bruno Linclau
A1
Journal Article
in
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
2017
2016
Analysis of the five-membered ring pucker of β- and γ-fluorinated prolines by means of NMR spectroscopy and pseudorotation theory
Emile Ottoy
Gert-Jan Hofman
José Martins
Bruno Linclau
Davy Sinnaeve
C3
Conference
2016
Effects of fluorination on the conformation of proline : an NMR study
Emile Ottoy
Gert-Jan Hofman
Bruno Linclau
José Martins
Davy Sinnaeve
C3
Conference
2016
Enantioselective synthesis of dideoxy-tetrafluorinated hexoses
Samuel Golten
Clement Q. Fontenelle
Roxana S. Timofte
Laura Bailac
Mark Light
Muriel Sebban
Hassan Oulyadi
Bruno Linclau
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2016
Investigating the influence of (deoxy) fluorination on the lipophilicity of non-UV-active fluorinated alkanols and carbohydrates by a new log P determination method
Bruno Linclau
Zhong Wang
Guillaume Compain
Vincent Paumelle
Clement Q. Fontenelle
Neil Wells
Alex Weymouth-Wilson
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2016
Plant cell wall imaging by metabolic click-mediated labelling of rhamnogalacturonan II using azido 3-deoxy-D-manno-oct-2-ulosonic acid
Marie Dumont
Arnaud Lehner
Boris Vauzeilles
Julien Malassis
Alan Marchant
Kevin Smyth
Bruno Linclau
Aurelie Baron
Jordi Mas Pons
Charles T. Anderson
et al.
A1
Journal Article
in
PLANT JOURNAL
2016
Total synthesis of (-)-luminacin D
Julien Malassis
Nathan Bartlett
Kane Hands
Matthew D. Selby
Bruno Linclau
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2016
alpha-fluoro-o-cresols : the key role of intramolecular hydrogen bonding in conformational preference and hydrogen-bond acidity
Elena Bogdan
Alexis Quarre de Verneuil
Francois Besseau
Guillaume Compain
Bruno Linclau
Jean-Yves Le Questel
Jerome Graton
A1
Journal Article
in
CHEMPHYSCHEM
2016
2015
A computational study of vicinal fluorination in 2,3-difluorobutane : implications for conformational control in alkane chains
Stephen J. Fox
Stephanie Gourdain
Anton Coulthurst
Clare Fox
Ilya Kuprov
Jonathan W. Essex
Chris-Kriton Skylaris
Bruno Linclau
A1
Journal Article
in
CHEMISTRY-A EUROPEAN JOURNAL
2015
A linear synthesis of gemcitabine
Kylie Brown
Alex Weymouth-Wilson
Bruno Linclau
A1
Journal Article
in
CARBOHYDRATE RESEARCH
2015
Disubstituted bis-THF moieties as new P2 ligands in nonpeptidal HIV-1 protease inhibitors (II)
Konrad Hohlfeld
Joerg Kurt Wegner
Bart Kesteleyn
Bruno Linclau
Johan Unge
A1
Journal Article
in
JOURNAL OF MEDICINAL CHEMISTRY
2015
Influence of fluorination on alcohol hydrogen bonding and lipophilicity properties
Bruno Linclau
C3
Conference
2015
Influence of fluorination on the conformational properties and hydrogen-bond acidity of benzyl alcohol derivatives
Elena Bogdan
Guillaume Compain
Lewis Mtashobya
Jean-Yves Le Questel
Francois Besseau
Nicolas Galland
Bruno Linclau
Jerome Graton
A1
Journal Article
in
CHEMISTRY-A EUROPEAN JOURNAL
2015
Intramolecular OH⋅⋅⋅fluorine hydrogen bonding in saturated, acyclic fluorohydrins : the γ-fluoropropanol motif
Bruno Linclau
Florent Peron
Elena Bogdan
Neil Wells
Zhong Wang
Guillaume Compain
Clement Q. Fontenelle
Nicolas Galland
Jean-Yves Le Questel
Jerome Graton
A1
Journal Article
in
CHEMISTRY-A EUROPEAN JOURNAL
2015
Structural basis of ligand binding to UDP-galactopyranose mutase from Mycobacterium tuberculosis using substrate and tetrafluorinated substrate analogues
Karin E. van Straaten
Jijin R. A. Kuttiyatveeti
Charlotte M. Sevrain
Sydney A. Villaume
Jesus Jimenez-Barbero
Bruno Linclau
Stephane P. Vincent
David A. R. Sanders
A1
Journal Article
in
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2015
Synthesis and properties of polyfluorinated carbohydrates
Bruno Linclau
C3
Conference
2015
The development of a short route to the API ropinirole hydrochloride
Zeshan Yousuf
Andrew K. Richards
Andrew N. Dwyer
Bruno Linclau
David C. Harrowven
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2015
The synthesis of mono- and difluorinated 2,3-dideoxy-D-glucopyranoses
Lewis Mtashobya
Lucas Quiquempoix
Bruno Linclau
A1
Journal Article
in
JOURNAL OF FLUORINE CHEMISTRY
2015
The synthesis of tetrafluorinated aminosugars
Clement Q. Fontenelle
Graham J. Tizzard
Bruno Linclau
A1
Journal Article
in
JOURNAL OF FLUORINE CHEMISTRY
2015
2014
Effect of fluorine introduction on hydrogen bond donating capacity of alcohols
Guillaume Compain
Zhong Wang
Lewis A. Mtashobya
Jerome Graton
Jean-Yves Le Questel
Bruno Linclau
C3
Conference
2014
Effects of sugar functional groups, hydrophobicity, and fluorination on carbohydrate-DNA stacking interactions in water
Ricardo Lucas
Pablo Penalver
Irene Gomez-Pinto
Empar Vengut-Climent
Lewis Mtashobya
Jonathan Cousin
Olivia S. Maldonado
Violaine Perez
Virginie Reynes
Anna Avino
et al.
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2014
How much conformational control can fluorine really give you?
Stephen J. Fox
Clare Fox
Ilya Kuprov
Bruno Linclau
Jonathan W. Essex
Chris-Kriton Skylaris
C3
Conference
2014
Observation on how intramolecular hydrogen bonding of alcohol with fluorine affects its intermolecular hydrogen bonding with acceptors
Guillaume Compain
Zhong Wang
Lewis Atugonza Mtashobya
Jerome Graton
Jean-Yves Le Questel
Bruno Linclau
C3
Conference
2014
Stereocontrol by quaternary centres : a stereoselective synthesis of (-)-luminacin D
Nathan Bartlett
Leona Gross
Florent Peron
Daniel J. Asby
Matthew D. Selby
Ali Tavassoli
Bruno Linclau
A1
Journal Article
in
CHEMISTRY-A EUROPEAN JOURNAL
2014
Stereoselective conformational control via difluorination of hydrocarbon chains
Stephen J. Fox
Clare Fox
Ilya Kuprov
Bruno Linclau
Jonathan W. Essex
Chris-Kriton Skylaris
C3
Conference
2014
Stereoselective formation of (Z)-2-fluoroalkenoates via Julia-Kocienski reaction of aldehydes with pyrimidinyl-fluorosulfones
Florent Larnaud
Emmanuel Pfund
Bruno Linclau
Thierry Lequeux
A1
Journal Article
in
TETRAHEDRON
2014
Stereoselectivity of the Honda-Reformatsky reaction in reactions with ethyl bromodifluoroacetate with alpha-oxygenated sulfinylimines
Clement Q. Fontenelle
Matthew Conroy
Mark Light
Thomas Poisson
Xavier Pannecoucke
Bruno Linclau
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2014
Synthesis and conformational analysis of both 2,3-difluorobutane and 3,5-difluoroheptane diastereomers
Stephanie Gourdain
Stephen Fox
Chris-Kriton Skylaris
Jonathan W. Essex
Ilya Kuprov
Bruno Linclau
C3
Conference
2014
Tetrafluorination of sugars as strategy for enhancing protein-carbohydrate affinity : application to UDP-Galp mutase inhibition
Ines N'Go
Samuel Golten
Ana Arda
Javier Canada
Jesus Jimenez-Barbero
Bruno Linclau
Stephane P. Vincent
A1
Journal Article
in
CHEMISTRY-A EUROPEAN JOURNAL
2014
The synthesis of gemcitabine
Kylie Brown
Michael Dixey
Alex Weymouth-Wilson
Bruno Linclau
A1
Journal Article
in
CARBOHYDRATE RESEARCH
2014
Total synthesis of (+/-)-paroxetine by diastereoconvergent cobalt-catalysed arylation
Carole F. Despiau
Andrew P. Dominey
David C. Harrowven
Bruno Linclau
A1
Journal Article
in
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
2014
Using fluorine to optimise affinity : direct interactions and pre-organisation in lipid binding to CD1d
Stephen J. Fox
Annie Tocheva
Stephanie Gourdain
Salah Mansour
Bruno Linclau
Stephan Gadola
Tim Elliot
Chris-Kriton Skylaris
Jonathan W. Essex
C3
Conference
2014
2013
Design of fluorinated 5-HT4R antagonists : influence of the basicity and lipophilicity toward the 5-HT4R binding affinities
Clement Q. Fontenelle
Zhong Wang
Christine Fossey
Thomas Cailly
Bruno Linclau
Frederic Fabis
A1
Journal Article
in
BIOORGANIC & MEDICINAL CHEMISTRY
2013
Ready synthetic access to enantiopure allylic α(F)-branched fluoroalkenes
Florent Larnaud
Julien Malassis
Emmanuel Pfund
Bruno Linclau
Thierry Lequeux
A1
Journal Article
in
ORGANIC LETTERS
2013
2012
An unexpected and significantly lower hydrogen-bond-donating capacity of fluorohydrins compared to nonfluorinated alcohols
Jerome Graton
Zhong Wang
Anne-Marie Brossard
Daniela Goncalves Monteiro
Jean-Yves Le Questel
Bruno Linclau
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2012
Decarboxylation of fluorosulfones for the preparation fluoroalkylidene precursors
Florent Larnaud
Emmanuel Pfund
Bruno Linclau
Thierry Lequeux
A1
Journal Article
in
JOURNAL OF FLUORINE CHEMISTRY
2012
Stereoarrays with an all-carbon quaternary center : diastereoselective desymmetrization of prochiral malonaldehydes
Bruno Linclau
Elena Cini
Catherine S. Oakes
Solen Josse
Mark Light
Victoria Ironmonger
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2012
Synthesis of polyfluorinated carbohydrates
Bruno Linclau
C3
Conference
2012
Tetrafluorinated carbohydrates
Bruno Linclau
C3
Conference
2012
2011
Developing an in vitro correlate for the effects of vaccine adjuvants on human CD4 T helper cell differentiation
Y. Gao
Bruno Linclau
S. Gadola
T. Elliott
A. Williams
C3
Conference
2011
Disubstituted bis-THF moieties as new P2 ligands in non peptidal HIV-1 protease inhibitors
Konrad Hohlfeld
Cyrille Tomassi
Jorg Kurt Wegner
Bart Kesteleyn
Bruno Linclau
A1
Journal Article
in
ACS MEDICINAL CHEMISTRY LETTERS
2011
Divergent synthetic approach to 6''-modified α-GalCer analogues
Nora Pauwels
SANDRINE ASPESLAGH
Gerd Vanhoenacker
Koen Sandra
Esther D. Yu
Dirk M. Zajonc
Dirk Elewaut
Bruno Linclau
Serge Van Calenbergh
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2011
Heavily fluorinated carbohydrates as enzyme substrates : oxidation of tetrafluorinated galactose by galactose oxidase
Avgousta Ioannou
Elena Cini
Roxana S. Timofte
Sabine L. Flitsch
Nicholas J. Turner
Bruno Linclau
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2011
The conformation of tetrafluorinated methyl galactoside anomers : crystallographic and NMR studies
Bruno Linclau
Samuel Golten
Mark Light
Muriel Sebban
Hassan Oulyadi
A1
Journal Article
in
CARBOHYDRATE RESEARCH
2011
The crystal structure of 4,6-di-O-benzyl-2,3-dideoxy-2,2,3,3-tetrafluorogalactose
Bruno Linclau
Samuel Golten
Mark Light
A1
Journal Article
in
JOURNAL OF CARBOHYDRATE CHEMISTRY
2011
2010
A novel, versatile D -> BCD steroid construction strategy, illustrated by the enantioselective total synthesis of estrone
Vincent Foucher
Benedetta Guizzardi
Marinus B. Groen
Mark Light
Bruno Linclau
A1
Journal Article
in
ORGANIC LETTERS
2010
CD1d glycolipid analogues dissociate cytokine production, proliferation and antigen specific cytotoxicity in human iNKT cells
Y. Gao
Bruno Linclau
S. Gadola
T. Elliott
A. P. Williams
C3
Conference
2010
Synthesis and crystallographic analysis of meso-2,3-difluoro-1,4-butanediol and meso-1,4-dibenzyloxy-2,3-difluorobutane
Bruno Linclau
Leo Leung
Jean Nonnenmacher
Graham Tizzard
A1
Journal Article
in
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
2010
Synthesis and evaluation of amino-modified α-GalCer analogues
Matthias Trappeniers
René Chofor
SANDRINE ASPESLAGH
Yali Li
Bruno Linclau
Dirk M Zajonc
Dirk Elewaut
Serge Van Calenbergh
A1
Journal Article
in
ORGANIC LETTERS
2010
2009
A linchpin carbacyclization approach for the synthesis of carbasugars and carbanucleosides
Leo M. H. Leung
Bruno Linclau
C3
Conference
2009
A new steroid construction method illustrated by the enantioselective total synthesis of estrone
Vincent Foucher
Benedetta Guizzardi
Bruno Linclau
C3
Conference
2009
An enantioselective synthesis of carbafuranose sugars based on a linchpin carbacyclisation approach
Leo M. H. Leung
Mark E. Light
Vicky Gibson
Bruno Linclau
A1
Journal Article
in
TETRAHEDRON-ASYMMETRY
2009
Enantioselective synthesis of tetrafluorinated carbohydrates
Vincent Foucher
Bruno Linclau
C3
Conference
2009
Enantioselective synthesis of tetrafluorinated ribose and fructose
Bruno Linclau
A. James Boydell
Roxana S. Timofte
Kylie J. Brown
Victoria Vinader
Alexander C. Weymouth-Wilson
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2009
Microwave-assisted ester formation using O-alkylisoureas : a convenient method for the synthesis of esters with inversion of configuration
Alessandra Chighine
Stefano Crosignani
Marie-Claire Arnal
Mark Bradley
Bruno Linclau
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2009
Synthesis and diastereoselective Diels-Alder reactions of homochiral C-2-symmetric butane-1,2-diacetal-based 1,3-dienes
Bruno Linclau
Philip J. Clarke
Mark E. Light
A1
Journal Article
in
TETRAHEDRON LETTERS
2009
The synthesis and in vivo evaluation of 2',2'-difluoro KRN7000
Leo Leung
Cyrille Tomassi
Katrien Van Beneden
Tine Decruy
Matthias Trappeniers
Dirk Elewaut
Yifang Gao
Tim Elliott
Aymen Al-Shamkhani
Christian Ottensmeier
et al.
A1
Journal Article
in
CHEMMEDCHEM
2009
The total synthesis of desogestrel
Vincent Foucher
Robert Clarkson
Bruno Linclau
C3
Conference
2009
2008
6'-Derivatised α-GalCer analogues capable of inducing strong CD1d-mediated Th1-biased NKT cell responses in mice
Matthias Trappeniers
Katrien Van Beneden
Tine Decruy
Bruno Linclau
Dirk Elewaut
Serge Van Calenbergh
A1
Journal Article
in
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2008
A convenient AIBN-initiated radical addition of ethyl iododifluoroacetate to alkenes
Leo Leung
Bruno Linclau
A1
Journal Article
in
JOURNAL OF FLUORINE CHEMISTRY
2008
A linchpin carbacyclization approach for the synthesis of carbanucleosides
Leo M. H. Leung
Vicky Gibson
Bruno Linclau
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2008
Enantioselective synthesis of tetrafluorinated glucose and galactose
Roxana S. Timofte
Bruno Linclau
A1
Journal Article
in
ORGANIC LETTERS
2008
Invariant NKT cells promote CD8(+) cytotoxic T cell responses by inducing CD70 expression on dendritic cells
Vadim Y. Taraban
Sonya Martin
Kathrine E. Attfield
Martin J. Glennie
Tim Elliott
Dirk Elewaut
Serge Van Calenbergh
Bruno Linclau
Aymen Al-Shamkhani
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2008
Synthesis and in vitro evaluation of α-GalCer epimers
Matthias Trappeniers
Stijn Goormans
Katrien Van Beneden
Tine Decruy
Bruno Linclau
Aymen Al-Shamkhani
Tim Elliott
Christian Ottensmeier
Joern M. Werner
Dirk Elewaut
et al.
A1
Journal Article
in
CHEMMEDCHEM
2008
Synthesis and in vivo evaluation of 4-Deoxy-4,4-difluoro-KRN7000
L Leung
C Tomassi
Katrien Van Beneden
Tine Decruy
Dirk Elewaut
T Elliott
A Al-Shamkhani
C Ottensmeier
Serge Van Calenbergh
J Werner
et al.
A1
Journal Article
in
ORGANIC LETTERS
2008
2007
Enantioselective dihydroxylation of perfluoroalkyl-substituted alkenes
Bruno Linclau
A1
Journal Article
in
CHIMICA OGGI-CHEMISTRY TODAY
2007
2006
An enantioselective desymmetrization approach to C9-substituted trans-hydrindene rings based on a diastereotopic group-selective intramolecular Diels-Alder reaction
Nadia Azzi
Ed Griffen
Mark Light
Bruno Linclau
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2006
Enantioselective synthesis and selective monofunctionalization of (4R,6R)-4,6-dihydroxy-2,8-dioxabicyclo[3.3.0]octane
Bruno Linclau
Martin J. Jeffery
Solen Josse
Cyrille Tomassi
A1
Journal Article
in
ORGANIC LETTERS
2006
2005
A practical synthesis of a high-loading solid-supported IBX amide for the oxidation of alcohols
Patrick Lecarpentier
Stefano Crosignani
Bruno Linclau
A1
Journal Article
in
MOLECULAR DIVERSITY
2005
A stereoselective cyclization to carbafuranose derivatives starting from 1,4-bis-epoxides
LMH Leung
AJ Boydell
V Gibson
ME Light
Bruno Linclau
A1
Journal Article
in
ORGANIC LETTERS
2005
Improved synthesis of enantiopure pseudo-C-2-symmetric 1,4-bis-epoxide building blocks from arabitol
LMH Leung
V Gibson
Bruno Linclau
A1
Journal Article
in
TETRAHEDRON-ASYMMETRY
2005
2004
Enantioselective synthesis of tetrafluoroethylene-containing monosaccharides
AJ Boydell
V Vinader
Bruno Linclau
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2004
Full and partial differentiation of tris-1,1,1-(hydroxymethyl)ethane via direct and indirect methodology
P Clarke
MJ Jeffery
AJ Boydell
S Whiting
Bruno Linclau
A1
Journal Article
in
TETRAHEDRON
2004
Polymer-supported O-alkylisoureas : useful reagents for the O-alkylation of carboxylic acids
S Crosignani
PD White
Bruno Linclau
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2004
Synthesis of 2-oxazolines mediated by N,N '-diisopropylcarbodiimide
S Crosignani
AC Young
Bruno Linclau
A1
Journal Article
in
TETRAHEDRON LETTERS
2004
2003
A mild, phosphine-free method for the conversion of alcohols into halides (Cl, Br, I) via the corresponding O-alkyl isoureas
ZN Li
S Crosignani
Bruno Linclau
A1
Journal Article
in
TETRAHEDRON LETTERS
2003
A novel stereoselective one-pot conversion of alcohols into alkyl halides mediated by N,N '-diisopropylcarbodiimide
S Crosignani
B Nadal
ZN Li
Bruno Linclau
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2003
Efficient desymmetrization of "Pseudo"-C-2-symmetric substrates : illustration in the synthesis of a disubstituted butenolide from arabitol
Bruno Linclau
AJ Boydell
PJ Clarke
R Horan
C Jacquet
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2003
Isoureas : versatile synthetic intermediates
Bruno Linclau
S Crosignani
ZN Li
P Lecarpentier
C3
Conference
2003
Microwaves, supported-reagents and parallel synthesis : isocyanide and ester synthesis
Stefano Crosignani
Delphine Launay
Bruno Linclau
Mark Bradley
A1
Journal Article
in
MOLECULAR DIVERSITY
2003
Polymer-supported O-benzyl and O-allylisoureas : convenient preparation and use in ester synthesis from carboxylic acids
S Crosignani
PD White
R Steinauer
Bruno Linclau
A1
Journal Article
in
ORGANIC LETTERS
2003
Short synthesis of enantiopure C-2-symmetric 1,2 : 4,5-diepoxypentane and 'pseudo'-C-2-symmetric 3-azido-1,2 : 4,5-diepoxypentane from arabitol
AJ Boydell
MJ Jeffery
E Burkstummer
Bruno Linclau
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2003
Solid-supported isoureas : convenient reagents for O-alkylation of carboxylic acids
Bruno Linclau
S Crosignani
P Lecarpentier
C3
Conference
2003
2002
Microwave-accelerated O-alkylation of carboxylic acids with O-alkylisoureas
S Crosignani
PD White
Bruno Linclau
A1
Journal Article
in
ORGANIC LETTERS
2002
Polymer-supported O-methylisourea : a new reagent for the O-methylation of carboxylic acids
S Crosignani
PD White
Bruno Linclau
A1
Journal Article
in
ORGANIC LETTERS
2002
2001
Fluorous triphasic reactions : transportative deprotection of fluorous silyl ethers with concomitant purification
H Nakamura
Bruno Linclau
DP Curran
A1
Journal Article
in
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2001
Tris (perfluoroalkylethyl)silyl alkyl amines as calibration standards for electron ionization mass spectrometry in the mass range of 100-3000 Da
VN Fishman
Bruno Linclau
DP Curran
KV Somayajula
A1
Journal Article
in
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
2001
1999
Benzotrifluoride and derivatives : useful solvents for organic synthesis and fluorous synthesis
JJ Maul
PJ Ostrowski
GA Ublacker
Bruno Linclau
DP Curran
A1
Journal Article
in
MODERN SOLVENTS IN ORGANIC SYNTHESIS
1999
Organic-fluorous phase switches : a fluorous amine scavenger for purification in solution phase parallel synthesis
Bruno Linclau
AK Sing
DP Curran
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
1999
Organic-fluorous phase switches : a fluorous amine scavenger for purification in solution phase parallel synthesis (vol 64, pg 2835, 1999)
Bruno Linclau
AK Sing
DP Curran
Correction
1999
1997
The synthesis of CD-ring modified 1α,25-dihydroxy vitamin D analogues : six-membered D-ring analogues I
Bruno Linclau
Pierre De Clercq
Maurits Vandewalle
A1
Journal Article
in
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
1997
The synthesis of CD-ring modified 1α,25-dihydroxy vitamin D analogues : six-membered D-ring analogues II
Bruno Linclau
Pierre De Clercq
Maurits Vandewalle
R. Bouillon
A. Verstuyf
A1
Journal Article
in
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
1997
1996
Asymmetrische synthese van A-ring en CD-ring gemodificeerde vitamine Dü3-analogen uitgaande van (ßa)-pineen
Bruno Linclau
M. Vandewalle
Dissertation
1996
1995
The synthesis of 10,19-dihydro-10-methyl 1α,25-dihydroxyvitamin D3
Bruno Linclau
Maurits Vandewalle
A1
Journal Article
in
SYNLETT
1995