Research Explorer

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Researcher

Bruno Linclau

Awards & Distinctions

148 Results

2024

Harnessing glycofluoroforms for impedimetric biosensing

Alice R. HewsonHenry O. Lloyd-LaneyTessa KeenanSarah-Jane RichardsMatthew I. GibsonBruno LinclauNathalie SignoretMartin A. FascioneAlison Parkin

U Journal Article in CHEMICAL SCIENCE

Molecular dynamics and NMR reveal the coexistence of H-bond-assisted and through-space <i>J</i><sub>FH</sub> coupling in fluorinated amino alcohols

Cassia ChiariPatrick R. BatistaRenan V. ViesserLeonardo A. SchenbergLucas C. DucatiBruno LinclauClaudio F. Tormena

U Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Novel chemotype NLRP3 inhibitors that target the CRID3-binding pocket with high potency

Lieselotte Vande WalleMadhukar SaidOonagh PaerewijckArinna BertoniMarco GattornoBruno LinclauMohamed Lamkanfi

A1 Journal Article in LIFE SCIENCE ALLIANCE

Quantitative analysis of 2D EXSY NMR spectra of strongly coupled spin systems in transmembrane exchange

Dmitry ShishmarevClement Q. FontenelleBruno LinclauIlya KuprovPhilip W. Kuchel

A1 Journal Article in CHEMBIOCHEM

2023

Glycosylation of vicinal di- and trifluorinated glucose and galactose donors

Kler HuonnicBruno Linclau

A1 Journal Article in CHEMICAL COMMUNICATIONS

Lipophilicity modulations by fluorination correlate with membrane partitioning

Zhong WangHannah R. FelsteadRobert I. TroupBruno LinclauPhilip T. F. Williamson

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Obtaining pure 1H NMR spectra of individual pyranose and furanose anomers of reducing deoxyfluorinated sugars

Gabija PoskaiteDavid E. WheatleyNeil WellsBruno LinclauDavy Sinnaeve

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Photoinduced formation of cubyl aryl thioethers and synthesis of monocubyl analogue of dapsone

Laly Donnier-ValentinSeydou KassambaJulien LegrosCatherine FressigneDaniela VulugaRichard C. D. BrownBruno LinclauMichael De Paolis

A1 Journal Article in ORGANIC LETTERS

Reverse thiophosphorylase activity of a glycoside phosphorylase in the synthesis of an unnatural Manβ1,4GlcNAc library

Tessa KeenanNatasha E. HattonJack PorterJean-Baptiste VendevilleDavid E. WheatleyMattia GhirardelloAlice. J. C. WahartSanaz AhmadipourJulia WaltonM. Carmen Galan et al.

A1 Journal Article in CHEMICAL SCIENCE

2022

Relating conformational equilibria to conformer‐specific lipophilicities : new opportunities in drug discovery

Bruno LinclauZhong WangBenjamin JeffriesJérôme GratonRodrigo J. CarbajoDavy SinnaeveJean‐Yves Le QuestelJames S. ScottElisabetta Chiarparin

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The synthesis and glycoside formation of polyfluorinated carbohydrates

Kler HuonnicBruno Linclau

A1 Journal Article in CHEMICAL REVIEWS

2021

Decagram synthesis of dimethyl 1,4-cubanedicarboxylate using continuous-flow photochemistry

Diego E. CollinEdward H. JackmanNicolas JouandonWei SunMark E. LightDavid C. HarrowvenBruno Linclau

A1 Journal Article in SYNTHESIS-STUTTGART

Fluorine NMR study of proline-rich sequences using fluoroprolines

Davy SinnaeveAbir Ben BouzayeneEmile OttoyGert-Jan HofmanEva ErdmannBruno LinclauIlya KuprovJosé MartinsVladimir TorbeevBruno Kieffer

A2 Journal Article in MAGNETIC RESONANCE

Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands

Sarah-Jane RichardsTessa KeenanJean-Baptiste VendevilleDavid E. WheatleyHarriet ChidwickDarshita BudhadevClaire E. CouncilClaire S. WebsterHelene LedruAlexander N. Baker et al.

A1 Journal Article in CHEMICAL SCIENCE

Rapid screening of diverse biotransformations for enzyme evolution

Emily E. KempaJames L. GalmanFabio ParmeggianiJames R. MarshallJulien MalassisClement Q. FontenelleJean-Baptiste VendevilleBruno LinclauSimon J. CharnockSabine L. Flitsch et al.

A2 Journal Article in JACS AU

Skipped fluorination motifs : synthesis of building blocks and comparison of lipophilicity trends with vicinal and isolated fluorination motifs

Robert TroupBenjamin JeffriesRaphael El-Bekri SaudainEleni GeorgiouJohanna FishJames S. ScottElisabetta ChiarparinCharlene FallanBruno Linclau

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Synthesis and structural characteristics of all mono- and difluorinated 4,6-dideoxy-D-xylo-hexopyranoses

David E. WheatleyClement Q. FontenelleRamakrishna KuppalaRobert SzperaEdward L. BriggsJean-Baptiste VendevilleNeil J. WellsMark E. LightBruno Linclau

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Synthesis of ortho-functionalized 1,4-cubanedicarboxylate derivatives through photochemical chlorocarbonylation

Diego E. CollinKristina KovacicMark E. LightBruno Linclau

A1 Journal Article in ORGANIC LETTERS

2020

Anomerisation of fluorinated sugars by mutarotase studied using F-19 NMR two-dimensional exchange spectroscopy

Dmitry ShishmarevLucas QuiquempoixClement Q. FontenelleBruno LinclauPhilip W. Kuchel

A1 Journal Article in AUSTRALIAN JOURNAL OF CHEMISTRY

Chemoenzymatic synthesis of 3-deoxy-3-fluoro-l-fucose and its enzymatic incorporation into glycoconjugates

Pablo ValverdeJean-Baptiste VendevilleKristian HollingsworthAshley P. MatteyTessa KeenanHarriet ChidwickHelene LedruKler HuonnicKun HuangMark E. Light et al.

A1 Journal Article in CHEMICAL COMMUNICATIONS

Cubane electrochemistry : direct conversion of cubane carboxylic acids to alkoxy cubanes using the Hofer-Moest reaction under flow conditions

Diego E. CollinAna A. Folgueiras-AmadorDerek PletcherMark E. LightBruno LinclauRichard C. D. Brown

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Enzymatic glycosylation involving fluorinated carbohydrates

Claire E. CouncilKelly J. KilpinJessica S. GusthartSarah A. AllmanBruno LinclauSeung Seo Lee

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Exploring anomeric glycosylation of phosphoric acid : optimisation and scope for non-native substrates

Laura BeswickSanaz AhmadipourGert-Jan HofmanHannah WoottonEleni DimitriouJohannes ReynissonRobert A. FieldBruno LinclauGavin J. Miller

A1 Journal Article in CARBOHYDRATE RESEARCH

Fluorinated carbohydrates as chemical probes for molecular recognition studies : current status and perspectives

Bruno LinclauAna ArdaNiels-Christian ReichardtMatthieu SollogoubLuca UnioneStephane P. VincentJesus Jimenez-Barbero

A1 Journal Article in CHEMICAL SOCIETY REVIEWS

Lipophilicity trends upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl groups

Benjamin JeffriesZhong WangRobert TroupAnais GoupilleJean-Yves Le QuestelCharlene FallanJames S. ScottElisabetta ChiarparinJerome GratonBruno Linclau

A1 Journal Article in BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

Profiling substrate promiscuity of wild-type sugar kinases for multi-fluorinated monosaccharides

Tessa KeenanFabio ParmeggianiJulien MalassisClement Q. FontenelleJean-Baptiste VendevilleWendy OffenPeter BothKun HuangAndrea MarchesiAlex Heyam et al.

A1 Journal Article in CELL CHEMICAL BIOLOGY

Review of mutarotase in 'metabolic subculture' and analytical biochemistry : prelude to F-19 NMR studies of its substrate specificity and mechanism

Dmitry ShishmarevLucas QuiquempoixClement Q. FontenelleBruno LinclauPhilip W. Kuchel

A1 Journal Article in AUSTRALIAN JOURNAL OF CHEMISTRY

Systematic investigation of lipophilicity modulation by aliphatic fluorination motifs

Benjamin JeffriesZhong WangHannah R. FelsteadJean-Yves Le QuestelJames S. ScottElisabetta ChiarparinJerome GratonBruno Linclau

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

2019

3,4-Dideoxy-3,3,4,4-tetrafluoro- and 4-OH epimeric 3-deoxy-3,3-difluoro-alpha-GalCer analogues : synthesis and biological evaluation on human iNKT cells stimulation

Samuel GoltenAllan PatinecKaty AkoumanyJezabel RocherJerome GratonDenis JacqueminJean-Yves Le QuestelArnaud TessierJacques LebretonVirginie Blot et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A new straightforward method for lipophilicity (logP) measurement using F-19 NMR spectroscopy

Zhong WangBenjamin F. JeffriesHannah R. FelsteadNeil J. WellsElisabetta ChiarparinBruno Linclau

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Conformational influence of fluorinated building blocks on the physical properties of polyesters

Sophie LingierRobert SzperaBart GoderisBruno LinclauFilip Du Prez

A1 Journal Article in POLYMER

Five-membered ring pucker conformational analysis of novel fluorinated prolines

Emile OttoySteven WorswickChris BrettGert-Jan HofmanBruno KiefferJosé MartinsBruno LinclauIlya KuprovDavy Sinnaeve

Kinetic analysis of the cis/trans isomerism of mono- and difluorinated proline analogues

Emile OttoyGert-Jan HofmanBruno LinclauJosé MartinsDavy Sinnaeve

Molecular insights into DC-SIGN binding to self-antigens : the interaction with the blood group A/B antigens

Pablo ValverdeSandra DelgadoJ. Daniel MartinezJean-Baptiste VendevilleJulien MalassisBruno LinclauNiels-Christian ReichardtFrancisco Javier CanadaJesus Jimenez-BarberoAna Arda

A1 Journal Article in ACS CHEMICAL BIOLOGY

Synthesis and conformational properties of 3,4-difluoro-L-prolines

Gert-Jan HofmanEmile OttoyMark E. LightBruno KiefferJosé MartinsIlya KuprovDavy SinnaeveBruno Linclau

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 2,3,4-trideoxy-2,3,4-trifluoroglucose

Lucas QuiquempoixZhong WangJerome GratonPeter G. LatchemMark LightJean-Yves Le QuestelBruno Linclau

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Synthesis of vicinal dideoxy-difluorinated galactoses

Julien MalassisJean-Baptiste Vendeville[missing] Qui-Hien NguyenMarie BoujonQuentin Gaignard-GaillardMark LightBruno Linclau

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

The synthesis of fluorinated proline analogues

Gert-Jan HofmanBruno LinclauDavy SinnaeveJosé Martins

Unraveling sugar binding modes to DC-SIGN by employing fluorinated carbohydrates

J. Daniel MartinezPablo ValverdeSandra DelgadoCecilia RomanoBruno LinclauNiels C. ReichardtStefan OscarsonAna ArdaJesus Jimenez-BarberoF. Javier Canada

A1 Journal Article in MOLECULES

2018

An accurate method for J-coupling based conformational analysis of five-membered rings : study of β- and γ-fluorinated prolines

Emile OttoySteven WorswickChris BrettGert-Jan HofmanBruno KiefferJosé MartinsBruno LinclauIlya KuprovDavy Sinnaeve

Full conformational characterization of novel fluorinated prolines

Emile OttoySteven WorswickChris BrettGert-Jan HofmanBruno KiefferJosé MartinsBruno LinclauIlya KuprovDavy Sinnaeve

Full conformational characterization of novel fluorinated prolines

Emile OttoySteven WorswickChris BrettGert-Jan HofmanBruno KiefferJosé MartinsBruno LinclauIlya KuprovDavy Sinnaeve

Isolation and characterisation of an unexpected byproduct in the regioselective butane diacetal protection of α-methyl galactopyranoside

Clement Q. FontenelleRamakrishna KuppalaMark LightBruno Linclau

A1 Journal Article in CARBOHYDRATE RESEARCH

Minimising conformational bias in fluoroprolines through vicinal difluorination

Gert-Jan HofmanEmile OttoyMark E LightBruno KiefferIlya KuprovJosé MartinsDavy SinnaeveBruno Linclau

A1 Journal Article in CHEMICAL COMMUNICATIONS

Reducing the lipophilicity of perfluoroalkyl groups by CF2-F/CF2-Me or CF3/CH3 exchange

Benjamin JeffriesZhong WangJerome GratonSimon D. HollandThomasin BrindRyan D. R. GreenwoodJean-Yves Le QuestelJames S. ScottElisabetta ChiarparinBruno Linclau

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Ring pucker and cis/trans isomerism of 3,4-difluoroprolines

Emile OttoyGert-Jan HofmanBruno LinclauJosé MartinsIlya KuprovDavy Sinnaeve

Transmembrane exchange of fluorosugars : characterization of red cell GLUT1 kinetics using( 19)F NMR

Dmitry ShishmarevClement Q. FontenelleIlya KuprovBruno LinclauPhilip W. Kuchel

A1 Journal Article in BIOPHYSICAL JOURNAL

2017

1,1,1-trifluoropropan-2-ammonium triflate enantiomers : stereoselective synthesis and direct use in reaction with epoxides

Gemma PackerJulien MalassisNeil WellsMark LightBruno Linclau

A1 Journal Article in TETRAHEDRON-ASYMMETRY

A study of intramolecular hydrogen bonding in levoglucosan derivatives

Lucas QuiquempoixElena BogdanNeil J. WellsJean-Yves Le QuestelJerome GratonBruno Linclau

A1 Journal Article in MOLECULES

Ab initio and NMR conformational analysis of β- and γ-fluorinated prolines

Emile OttoySteven WorswickChris BrettGert-Jan HofmanBruno KiefferJosé MartinsBruno LinclauIlya KuprovDavy Sinnaeve

Development of a solid phase array assay for the screening of galactose oxidase activity and for fast identification of inhibitors

Martin J. WeissenbornDamien P. DebeckerSamuel GoltenBruno LinclauNicholas J. TurnerSabine L. Flitsch

A1 Journal Article in PROTEIN AND PEPTIDE LETTERS

Influence of alcohol beta-fluorination on hydrogen-bond acidity of conformationally flexible substrates

Jerome GratonGuillaume CompainFrancois BesseauElena BogdanJoseph M. WattsLewis MtashobyaZhong WangAlex Weymouth-WilsonNicolas GallandJean-Yves Le Questel et al.

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of fluoroprolines

Gert-Jan HofmanDavy SinnaeveJosé MartinsBruno Linclau

The synthesis of 3,4-dideoxy-3,4-difluoro-D-glucose

Clement Q. FontenelleDmitry ShishmarevPhilip W. KuchelBruno Linclau

A2 Journal Article in TRENDS IN CARBOHYDRATE RESEARCH

The synthesis of the 2,3-difluorobutan-1,4-diol diastereomers

Robert SzperaNadia KovalenkoKalaiselvi NatarajanNina PaillardBruno Linclau

A1 Journal Article in BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

2016

Analysis of the five-membered ring pucker of β- and γ-fluorinated prolines by means of NMR spectroscopy and pseudorotation theory

Emile OttoyGert-Jan HofmanJosé MartinsBruno LinclauDavy Sinnaeve

Effects of fluorination on the conformation of proline : an NMR study

Emile OttoyGert-Jan HofmanBruno LinclauJosé MartinsDavy Sinnaeve

Enantioselective synthesis of dideoxy-tetrafluorinated hexoses

Samuel GoltenClement Q. FontenelleRoxana S. TimofteLaura BailacMark LightMuriel SebbanHassan OulyadiBruno Linclau

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Investigating the influence of (deoxy) fluorination on the lipophilicity of non-UV-active fluorinated alkanols and carbohydrates by a new log P determination method

Bruno LinclauZhong WangGuillaume CompainVincent PaumelleClement Q. FontenelleNeil WellsAlex Weymouth-Wilson

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Plant cell wall imaging by metabolic click-mediated labelling of rhamnogalacturonan II using azido 3-deoxy-D-manno-oct-2-ulosonic acid

Marie DumontArnaud LehnerBoris VauzeillesJulien MalassisAlan MarchantKevin SmythBruno LinclauAurelie BaronJordi Mas PonsCharles T. Anderson et al.

A1 Journal Article in PLANT JOURNAL

Total synthesis of (-)-luminacin D

Julien MalassisNathan BartlettKane HandsMatthew D. SelbyBruno Linclau

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

alpha-fluoro-o-cresols : the key role of intramolecular hydrogen bonding in conformational preference and hydrogen-bond acidity

Elena BogdanAlexis Quarre de VerneuilFrancois BesseauGuillaume CompainBruno LinclauJean-Yves Le QuestelJerome Graton

A1 Journal Article in CHEMPHYSCHEM

2015

A computational study of vicinal fluorination in 2,3-difluorobutane : implications for conformational control in alkane chains

Stephen J. FoxStephanie GourdainAnton CoulthurstClare FoxIlya KuprovJonathan W. EssexChris-Kriton SkylarisBruno Linclau

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

A linear synthesis of gemcitabine

Kylie BrownAlex Weymouth-WilsonBruno Linclau

A1 Journal Article in CARBOHYDRATE RESEARCH

Disubstituted bis-THF moieties as new P2 ligands in nonpeptidal HIV-1 protease inhibitors (II)

Konrad HohlfeldJoerg Kurt WegnerBart KesteleynBruno LinclauJohan Unge

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Influence of fluorination on alcohol hydrogen bonding and lipophilicity properties

Influence of fluorination on the conformational properties and hydrogen-bond acidity of benzyl alcohol derivatives

Elena BogdanGuillaume CompainLewis MtashobyaJean-Yves Le QuestelFrancois BesseauNicolas GallandBruno LinclauJerome Graton

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Intramolecular OH⋅⋅⋅fluorine hydrogen bonding in saturated, acyclic fluorohydrins : the γ-fluoropropanol motif

Bruno LinclauFlorent PeronElena BogdanNeil WellsZhong WangGuillaume CompainClement Q. FontenelleNicolas GallandJean-Yves Le QuestelJerome Graton

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Structural basis of ligand binding to UDP-galactopyranose mutase from Mycobacterium tuberculosis using substrate and tetrafluorinated substrate analogues

Karin E. van StraatenJijin R. A. KuttiyatveetiCharlotte M. SevrainSydney A. VillaumeJesus Jimenez-BarberoBruno LinclauStephane P. VincentDavid A. R. Sanders

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and properties of polyfluorinated carbohydrates

The development of a short route to the API ropinirole hydrochloride

Zeshan YousufAndrew K. RichardsAndrew N. DwyerBruno LinclauDavid C. Harrowven

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

The synthesis of mono- and difluorinated 2,3-dideoxy-D-glucopyranoses

Lewis MtashobyaLucas QuiquempoixBruno Linclau

A1 Journal Article in JOURNAL OF FLUORINE CHEMISTRY

The synthesis of tetrafluorinated aminosugars

Clement Q. FontenelleGraham J. TizzardBruno Linclau

A1 Journal Article in JOURNAL OF FLUORINE CHEMISTRY

2014

Effect of fluorine introduction on hydrogen bond donating capacity of alcohols

Guillaume CompainZhong WangLewis A. MtashobyaJerome GratonJean-Yves Le QuestelBruno Linclau

Effects of sugar functional groups, hydrophobicity, and fluorination on carbohydrate-DNA stacking interactions in water

Ricardo LucasPablo PenalverIrene Gomez-PintoEmpar Vengut-ClimentLewis MtashobyaJonathan CousinOlivia S. MaldonadoViolaine PerezVirginie ReynesAnna Avino et al.

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

How much conformational control can fluorine really give you?

Stephen J. FoxClare FoxIlya KuprovBruno LinclauJonathan W. EssexChris-Kriton Skylaris

Observation on how intramolecular hydrogen bonding of alcohol with fluorine affects its intermolecular hydrogen bonding with acceptors

Guillaume CompainZhong WangLewis Atugonza MtashobyaJerome GratonJean-Yves Le QuestelBruno Linclau

Stereocontrol by quaternary centres : a stereoselective synthesis of (-)-luminacin D

Nathan BartlettLeona GrossFlorent PeronDaniel J. AsbyMatthew D. SelbyAli TavassoliBruno Linclau

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Stereoselective conformational control via difluorination of hydrocarbon chains

Stephen J. FoxClare FoxIlya KuprovBruno LinclauJonathan W. EssexChris-Kriton Skylaris

Stereoselective formation of (Z)-2-fluoroalkenoates via Julia-Kocienski reaction of aldehydes with pyrimidinyl-fluorosulfones

Florent LarnaudEmmanuel PfundBruno LinclauThierry Lequeux

A1 Journal Article in TETRAHEDRON

Stereoselectivity of the Honda-Reformatsky reaction in reactions with ethyl bromodifluoroacetate with alpha-oxygenated sulfinylimines

Clement Q. FontenelleMatthew ConroyMark LightThomas PoissonXavier PannecouckeBruno Linclau

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Synthesis and conformational analysis of both 2,3-difluorobutane and 3,5-difluoroheptane diastereomers

Stephanie GourdainStephen FoxChris-Kriton SkylarisJonathan W. EssexIlya KuprovBruno Linclau

Tetrafluorination of sugars as strategy for enhancing protein-carbohydrate affinity : application to UDP-Galp mutase inhibition

Ines N'GoSamuel GoltenAna ArdaJavier CanadaJesus Jimenez-BarberoBruno LinclauStephane P. Vincent

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

The synthesis of gemcitabine

Kylie BrownMichael DixeyAlex Weymouth-WilsonBruno Linclau

A1 Journal Article in CARBOHYDRATE RESEARCH

Total synthesis of (+/-)-paroxetine by diastereoconvergent cobalt-catalysed arylation

Carole F. DespiauAndrew P. DomineyDavid C. HarrowvenBruno Linclau

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Using fluorine to optimise affinity : direct interactions and pre-organisation in lipid binding to CD1d

Stephen J. FoxAnnie TochevaStephanie GourdainSalah MansourBruno LinclauStephan GadolaTim ElliotChris-Kriton SkylarisJonathan W. Essex

2013

Design of fluorinated 5-HT4R antagonists : influence of the basicity and lipophilicity toward the 5-HT4R binding affinities

Clement Q. FontenelleZhong WangChristine FosseyThomas CaillyBruno LinclauFrederic Fabis

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Ready synthetic access to enantiopure allylic α(F)-branched fluoroalkenes

Florent LarnaudJulien MalassisEmmanuel PfundBruno LinclauThierry Lequeux

A1 Journal Article in ORGANIC LETTERS

2012

An unexpected and significantly lower hydrogen-bond-donating capacity of fluorohydrins compared to nonfluorinated alcohols

Jerome GratonZhong WangAnne-Marie BrossardDaniela Goncalves MonteiroJean-Yves Le QuestelBruno Linclau

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Decarboxylation of fluorosulfones for the preparation fluoroalkylidene precursors

Florent LarnaudEmmanuel PfundBruno LinclauThierry Lequeux

A1 Journal Article in JOURNAL OF FLUORINE CHEMISTRY

Stereoarrays with an all-carbon quaternary center : diastereoselective desymmetrization of prochiral malonaldehydes

Bruno LinclauElena CiniCatherine S. OakesSolen JosseMark LightVictoria Ironmonger

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of polyfluorinated carbohydrates

Tetrafluorinated carbohydrates

2011

Developing an in vitro correlate for the effects of vaccine adjuvants on human CD4 T helper cell differentiation

Y. GaoBruno LinclauS. GadolaT. ElliottA. Williams

Disubstituted bis-THF moieties as new P2 ligands in non peptidal HIV-1 protease inhibitors

Konrad HohlfeldCyrille TomassiJorg Kurt WegnerBart KesteleynBruno Linclau

A1 Journal Article in ACS MEDICINAL CHEMISTRY LETTERS

Divergent synthetic approach to 6''-modified α-GalCer analogues

Nora PauwelsSandrine AspeslaghGerd VanhoenackerKoen SandraEsther D. YuDirk M. ZajoncDirk ElewautBruno LinclauSerge Van Calenbergh

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Heavily fluorinated carbohydrates as enzyme substrates : oxidation of tetrafluorinated galactose by galactose oxidase

Avgousta IoannouElena CiniRoxana S. TimofteSabine L. FlitschNicholas J. TurnerBruno Linclau

A1 Journal Article in CHEMICAL COMMUNICATIONS

The conformation of tetrafluorinated methyl galactoside anomers : crystallographic and NMR studies

Bruno LinclauSamuel GoltenMark LightMuriel SebbanHassan Oulyadi

A1 Journal Article in CARBOHYDRATE RESEARCH

The crystal structure of 4,6-di-O-benzyl-2,3-dideoxy-2,2,3,3-tetrafluorogalactose

Bruno LinclauSamuel GoltenMark Light

A1 Journal Article in JOURNAL OF CARBOHYDRATE CHEMISTRY

2010

A novel, versatile D -> BCD steroid construction strategy, illustrated by the enantioselective total synthesis of estrone

Vincent FoucherBenedetta GuizzardiMarinus B. GroenMark LightBruno Linclau

A1 Journal Article in ORGANIC LETTERS

CD1d glycolipid analogues dissociate cytokine production, proliferation and antigen specific cytotoxicity in human iNKT cells

Y. GaoBruno LinclauS. GadolaT. ElliottA. P. Williams

Synthesis and crystallographic analysis of meso-2,3-difluoro-1,4-butanediol and meso-1,4-dibenzyloxy-2,3-difluorobutane

Bruno LinclauLeo LeungJean NonnenmacherGraham Tizzard

A1 Journal Article in BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

Synthesis and evaluation of amino-modified α-GalCer analogues

Matthias TrappeniersRené ChoforSandrine AspeslaghYali LiBruno LinclauDirk M ZajoncDirk ElewautSerge Van Calenbergh

A1 Journal Article in ORGANIC LETTERS

2009

A linchpin carbacyclization approach for the synthesis of carbasugars and carbanucleosides

Leo M. H. LeungBruno Linclau

A new steroid construction method illustrated by the enantioselective total synthesis of estrone

Vincent FoucherBenedetta GuizzardiBruno Linclau

An enantioselective synthesis of carbafuranose sugars based on a linchpin carbacyclisation approach

Leo M. H. LeungMark E. LightVicky GibsonBruno Linclau

A1 Journal Article in TETRAHEDRON-ASYMMETRY

Enantioselective synthesis of tetrafluorinated carbohydrates

Vincent FoucherBruno Linclau

Enantioselective synthesis of tetrafluorinated ribose and fructose

Bruno LinclauA. James BoydellRoxana S. TimofteKylie J. BrownVictoria VinaderAlexander C. Weymouth-Wilson

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Microwave-assisted ester formation using O-alkylisoureas : a convenient method for the synthesis of esters with inversion of configuration

Alessandra ChighineStefano CrosignaniMarie-Claire ArnalMark BradleyBruno Linclau

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Synthesis and diastereoselective Diels-Alder reactions of homochiral C-2-symmetric butane-1,2-diacetal-based 1,3-dienes

Bruno LinclauPhilip J. ClarkeMark E. Light

A1 Journal Article in TETRAHEDRON LETTERS

The synthesis and in vivo evaluation of 2',2'-difluoro KRN7000

Leo LeungCyrille TomassiKatrien Van BenedenTine DecruyMatthias TrappeniersDirk ElewautYifang GaoTim ElliottAymen Al-ShamkhaniChristian Ottensmeier et al.

A1 Journal Article in CHEMMEDCHEM

The total synthesis of desogestrel

Vincent FoucherRobert ClarksonBruno Linclau

2008

6'-Derivatised α-GalCer analogues capable of inducing strong CD1d-mediated Th1-biased NKT cell responses in mice

Matthias TrappeniersKatrien Van BenedenTine DecruyBruno LinclauDirk ElewautSerge Van Calenbergh

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A convenient AIBN-initiated radical addition of ethyl iododifluoroacetate to alkenes

Leo LeungBruno Linclau

A1 Journal Article in JOURNAL OF FLUORINE CHEMISTRY

A linchpin carbacyclization approach for the synthesis of carbanucleosides

Leo M. H. LeungVicky GibsonBruno Linclau

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Enantioselective synthesis of tetrafluorinated glucose and galactose

Roxana S. TimofteBruno Linclau

A1 Journal Article in ORGANIC LETTERS

Invariant NKT cells promote CD8(+) cytotoxic T cell responses by inducing CD70 expression on dendritic cells

Vadim Y. TarabanSonya MartinKathrine E. AttfieldMartin J. GlennieTim ElliottDirk ElewautSerge Van CalenberghBruno LinclauAymen Al-Shamkhani

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Synthesis and in vitro evaluation of α-GalCer epimers

Matthias TrappeniersStijn GoormansKatrien Van BenedenTine DecruyBruno LinclauAymen Al-ShamkhaniTim ElliottChristian OttensmeierJoern M. WernerDirk Elewaut et al.

A1 Journal Article in CHEMMEDCHEM

Synthesis and in vivo evaluation of 4-Deoxy-4,4-difluoro-KRN7000

L LeungC TomassiKatrien Van BenedenTine DecruyDirk ElewautT ElliottA Al-ShamkhaniC OttensmeierSerge Van CalenberghJ Werner et al.

A1 Journal Article in ORGANIC LETTERS

2007

Enantioselective dihydroxylation of perfluoroalkyl-substituted alkenes

A1 Journal Article in CHIMICA OGGI-CHEMISTRY TODAY

2006

An enantioselective desymmetrization approach to C9-substituted trans-hydrindene rings based on a diastereotopic group-selective intramolecular Diels-Alder reaction

Nadia AzziEd GriffenMark LightBruno Linclau

A1 Journal Article in CHEMICAL COMMUNICATIONS

Enantioselective synthesis and selective monofunctionalization of (4R,6R)-4,6-dihydroxy-2,8-dioxabicyclo[3.3.0]octane

Bruno LinclauMartin J. JefferySolen JosseCyrille Tomassi

A1 Journal Article in ORGANIC LETTERS

2005

A practical synthesis of a high-loading solid-supported IBX amide for the oxidation of alcohols

Patrick LecarpentierStefano CrosignaniBruno Linclau

A1 Journal Article in MOLECULAR DIVERSITY

A stereoselective cyclization to carbafuranose derivatives starting from 1,4-bis-epoxides

LMH LeungAJ BoydellV GibsonME LightBruno Linclau

A1 Journal Article in ORGANIC LETTERS

Improved synthesis of enantiopure pseudo-C-2-symmetric 1,4-bis-epoxide building blocks from arabitol

LMH LeungV GibsonBruno Linclau

A1 Journal Article in TETRAHEDRON-ASYMMETRY

2004

Enantioselective synthesis of tetrafluoroethylene-containing monosaccharides

AJ BoydellV VinaderBruno Linclau

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Full and partial differentiation of tris-1,1,1-(hydroxymethyl)ethane via direct and indirect methodology

P ClarkeMJ JefferyAJ BoydellS WhitingBruno Linclau

A1 Journal Article in TETRAHEDRON

Polymer-supported O-alkylisoureas : useful reagents for the O-alkylation of carboxylic acids

S CrosignaniPD WhiteBruno Linclau

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 2-oxazolines mediated by N,N '-diisopropylcarbodiimide

S CrosignaniAC YoungBruno Linclau

A1 Journal Article in TETRAHEDRON LETTERS

2003

A mild, phosphine-free method for the conversion of alcohols into halides (Cl, Br, I) via the corresponding O-alkyl isoureas

ZN LiS CrosignaniBruno Linclau

A1 Journal Article in TETRAHEDRON LETTERS

A novel stereoselective one-pot conversion of alcohols into alkyl halides mediated by N,N '-diisopropylcarbodiimide

S CrosignaniB NadalZN LiBruno Linclau

A1 Journal Article in CHEMICAL COMMUNICATIONS

Efficient desymmetrization of "Pseudo"-C-2-symmetric substrates : illustration in the synthesis of a disubstituted butenolide from arabitol

Bruno LinclauAJ BoydellPJ ClarkeR HoranC Jacquet

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Isoureas : versatile synthetic intermediates

Bruno LinclauS CrosignaniZN LiP Lecarpentier

Microwaves, supported-reagents and parallel synthesis : isocyanide and ester synthesis

Stefano CrosignaniDelphine LaunayBruno LinclauMark Bradley

A1 Journal Article in MOLECULAR DIVERSITY

Polymer-supported O-benzyl and O-allylisoureas : convenient preparation and use in ester synthesis from carboxylic acids

S CrosignaniPD WhiteR SteinauerBruno Linclau

A1 Journal Article in ORGANIC LETTERS

Short synthesis of enantiopure C-2-symmetric 1,2 : 4,5-diepoxypentane and 'pseudo'-C-2-symmetric 3-azido-1,2 : 4,5-diepoxypentane from arabitol

AJ BoydellMJ JefferyE BurkstummerBruno Linclau

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Solid-supported isoureas : convenient reagents for O-alkylation of carboxylic acids

Bruno LinclauS CrosignaniP Lecarpentier

2002

Microwave-accelerated O-alkylation of carboxylic acids with O-alkylisoureas

S CrosignaniPD WhiteBruno Linclau

A1 Journal Article in ORGANIC LETTERS

Polymer-supported O-methylisourea : a new reagent for the O-methylation of carboxylic acids

S CrosignaniPD WhiteBruno Linclau

A1 Journal Article in ORGANIC LETTERS

2001

Fluorous triphasic reactions : transportative deprotection of fluorous silyl ethers with concomitant purification

H NakamuraBruno LinclauDP Curran

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tris (perfluoroalkylethyl)silyl alkyl amines as calibration standards for electron ionization mass spectrometry in the mass range of 100-3000 Da

VN FishmanBruno LinclauDP CurranKV Somayajula

A1 Journal Article in JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

1999

Benzotrifluoride and derivatives : useful solvents for organic synthesis and fluorous synthesis

JJ MaulPJ OstrowskiGA UblackerBruno LinclauDP Curran

A1 Journal Article in MODERN SOLVENTS IN ORGANIC SYNTHESIS

Organic-fluorous phase switches : a fluorous amine scavenger for purification in solution phase parallel synthesis

Bruno LinclauAK SingDP Curran

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Organic-fluorous phase switches : a fluorous amine scavenger for purification in solution phase parallel synthesis (vol 64, pg 2835, 1999)

Bruno LinclauAK SingDP Curran

1997

The synthesis of CD-ring modified 1α,25-dihydroxy vitamin D analogues : six-membered D-ring analogues I

Bruno LinclauPierre De ClercqMaurits Vandewalle

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The synthesis of CD-ring modified 1α,25-dihydroxy vitamin D analogues : six-membered D-ring analogues II

Bruno LinclauPierre De ClercqMaurits VandewalleR. BouillonA. Verstuyf

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

1996

Asymmetrische synthese van A-ring en CD-ring gemodificeerde vitamine Dü3-analogen uitgaande van (ßa)-pineen

Bruno LinclauM. Vandewalle

1995

The synthesis of 10,19-dihydro-10-methyl 1α,25-dihydroxyvitamin D3

Bruno LinclauMaurits Vandewalle

A1 Journal Article in SYNLETT