Research Explorer

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Researcher

Bruce Poppe

Publications & Research Data

Awards & Distinctions

203 Results

2025

Identifying genetic causes of unexplained rare neurological disorders

Nika SchuermansBart DermautBruce PoppePatrick Santens

2024

Loss of phospholipase PLAAT3 causes a mixed lipodystrophic and neurological syndrome due to impaired PPARγ signaling

Nika SchuermansSalima El ChehadehDimitri HemelsoetJeremie GautheronMarie-Christine VantyghemSonia NouiouaMeriem TazirCorinne VigourouxMartine AuclairElke Bogaert et al.

2023

A Solve-RD ClinVar-based reanalysis of 1522 index cases from ERN-ITHACA reveals common pitfalls and misinterpretations in exome sequencing

Anne-Sophie Denommé-PichonLeslie MatalongaElke de BoerAdam JacksonElisa BenettiSiddharth BankaAnge-Line BruelAndrea CiolfiJill Clayton-SmithBruno Dallapiccola et al.

A1 Journal Article in GENETICS IN MEDICINE

Exome sequencing and multigene panel testing in 1,411 patients with adult-onset neurologic disorders

Nika SchuermansHannah VerdinJody GhijselsMadeleine HellemansElke DebackereElke BogaertSofie SymoensLeslie NaesensElien LecomteDavid Crosiers et al.

A1 Journal Article in NEUROLOGY-GENETICS

From gastrointestinal enigma to genetic clarity : unraveling the MYH11 SM2 connection

Steven CallensBart DermautFilomeen HaerynckDimitri HemelsoetLeslie NaessensBruce PoppeSanne SteyaertWim TerrynArnaud VanlanderPATRICK VERLOO et al.

Loss of phospholipase PLAAT3 causes a mixed lipodystrophic and neurological syndrome due to impaired PPARγ signaling

Nika SchuermansSalima El ChehadehDimitri HemelsoetJérémie GautheronMarie-Christine VantyghemSonia NouiouaMeriem TazirCorinne VigourouxMartine AuclairElke Bogaert et al.

A1 Journal Article in NATURE GENETICS

Twist exome capture allows for lower average sequence coverage in clinical exome sequencing

Burcu YaldizErdi KucukJuliet HampsteadTom HofsteRolph PfundtJordi Corominas GalbanyTuula RinneHelger G. YntemaAlexander HoischenMarcel Nelen et al.

A1 Journal Article in HUMAN GENOMICS

2022

Lipodystrophy due to genetic deficiency of picornavirus host factor and obesity regulator PLAAT3

Nika SchuermansSalima El ChehadehDimitri HemelsoetElke BogaertElke DebackerePascale HilbertNike Van DoninckMarie-Caroline TaquetToon RosseelGriet De Clercq et al.

Shortcutting the diagnostic odyssey : the multidisciplinary program for undiagnosed rare diseases in adults (UD-PrOZA)

Nika SchuermansDimitri HemelsoetWim TerrynSanne SteyaertRudy Van CosterPaul CouckeWouter SteyaertBert CallewaertElke BogaertPATRICK VERLOO et al.

A1 Journal Article in ORPHANET JOURNAL OF RARE DISEASES

2021

A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Juliette CoignardMichael LushJonathan BeesleyTracy A. O'MaraJoe DennisJonathan P. TyrerDaniel R. BarnesLesley McGuffogGoska LeslieManjeet K. Bolla et al.

A1 Journal Article in NATURE COMMUNICATIONS

Prevalence of germline pathogenic variants in cancer predisposing genes in Czech and Belgian pancreatic cancer patients

Greet WiemeJan KralToon RosseelPetra ZemankovaBram PartonMichal VockaMattias Van HeetveldePetra KleiblovaBettina BlaumeiserJana Soukupova et al.

Prevalence of germline pathogenic variants in cancer predisposing genes in Czech and Belgian pancreatic cancer patients

Greet WiemeJan KralToon RosseelPetra ZemankovaBram PartonMichal VockaMattias Van HeetveldePetra KleiblovaBettina BlaumeiserJana Soukupova et al.

A1 Journal Article in CANCERS

Prolonged recombinant pregnancy hormone use in BRCA1 and BRCA2 mutation carriers

Herman DepypereYanrong SuNhi DangBruce PoppeFrank StanczykJaak JanssensJose Russo

A1 Journal Article in EUROPEAN JOURNAL OF CANCER PREVENTION

Tissue is the issue : when a second biopsy reveals the true diagnosis

Anne-Marie BogaertAnne HoorensMarleen PraetJo Van DorpeBruce PoppeMarie-Angélique De Scheerder

Editorial material

2020

Cancer Surveillance Guideline for individuals with PTEN hamartoma tumour syndrome

Marc TischkowitzChrystelle ColasSjaak PouwelsNicoline Hoogerbruggeon behalf of European Reference Network GENTURIon behalf of PHTS Guideline Dev GrpKathleen ClaesBruce PoppeRobin de Putter

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

Guidelines for the Li-Fraumeni and heritable TP53-related cancer syndromes

Thierry FrebourgSvetlana Bajalica LagercrantzCarla OliveiraRita MagenheimD. Gareth Evanson behalf of European Reference Network GENTURIKathleen ClaesBruce PoppeRobin de Putter

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

2019

Analysis of patients with a personal and/or family history of pancreatic cancer with a custom designed broad cancer predisposition gene panel

Greet WiemeToon RosseelBram PartonBettina BlaumeiserSabine TejparBruce PoppeKim De LeeneerKathleen Claes

Analysis of patients with a personal and/or family history of pancreatic cancer with a custom designed broad cancer predisposition gene panel

Greet WiemeToon RosseelBram PartonBettina BlaumeiserJenneke van den EndeSabine TejparBruce PoppeKim De LeeneerKathleen Claes

Application of a custom designed broad cancer predisposition gene panel for the analysis of patients with a personal and/or family history of pancreatic cancer

Greet WiemeToon RosseelBram PartonBettina BlaumeiserJenneke van den EndeSabine TejparBruce PoppeKim De LeeneerKathleen Claes

Boosting care and knowledge about hereditary cancer : European Reference Network on Genetic Tumour Risk Syndromes

Janet R VosLisette GiepmansClaas RöhlNicoline GeverinkNicoline Hoogerbruggeon behalf of ERN GenturisBruce PoppeKathleen Claes

A1 Journal Article in FAMILIAL CANCER

Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

Manuel A FerreiraEric R GamazonFares Al-EjehKristiina AittomakiIrene L AndrulisHoda Anton-CulverAdalgeir ArasonVolker ArndtKristan J AronsonBanu K Arun et al.

A1 Journal Article in NATURE COMMUNICATIONS

Non-invasive prenatal testing (NIPT) : how to handle secondary findings of maternal chromosomal abnormalities

Machteld BaetensTom SanteSarah VergultM. De SmetS. JanssensOlivier VanakkerBert CallewaertBruce PoppeAnnelies DheedeneBjörn Menten

2018

Accurate detection and quantification of epigenetic and genetic second hits in BRCA1 and BRCA2-associated hereditary breast and ovarian cancer reveals multiple co-acting second hits

Mattias Van HeetveldeMieke Van BockstalBruce PoppeKathleen LambeinToon RosseelLilit AtanesyanDieter DeforceIvo Van Den BergheKim De LeeneerJo Van Dorpe et al.

A1 Journal Article in CANCER LETTERS

Future perspectives of genome-scale sequencing

Wouter SteyaertSteven CallensPaul CouckeBart DermautDimitri HemelsoetWim TerrynBruce Poppe

A1 Journal Article in ACTA CLINICA BELGICA

Identification of germline mutations in cancer predisposition genes in patients with a personal and/or family history of pancreatic cancer

Greet WiemeToon RosseelBettina BlaumeiserJenneke van den EndeSabine TejparBruce PoppeKim De LeeneerKathleen Claes

Identification of germline mutations in cancer predisposition genes in patients with a personal and/or family history of pancreatic cancer

Greet WiemeBruce PoppeToon RosseelKim De LeeneerKathleen Claes

Identification of germline mutations in cancer predisposition genes in patients with a personal and/or family history of pancreatic cancer

Greet WiemeToon RosseelBettina BlaumeiserJenneke van den EndeSabine TejparBruce PoppeKim De LeeneerKathleen Claes

Identification of germline mutations in cancer predisposition genes in patients with a personal and/or family history of pancreatic cancer

Greet WiemeToon RosseelBettina BlaumeiserJenneke van den EndeSabine TejparBruce PoppeKim De LeeneerKathleen Claes

IRF2BPL is associated with neurological phenotypes

Paul C MarcoglieseVandana ShashiRebecca C SpillmannNicholas StongJill A RosenfeldMary Kay KoenigJulian A Martínez-AgostoMatthew HerzogAgnes H ChenPatricia I Dickson et al.

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

Thorough in silico and in vitro cDNA analysis of 21 putative BRCA1 and BRCA2 splice variants and a complex tandem duplication in BRCA2 allowing the identification of activated cryptic splice donor sites in BRCA2 exon 11

Annelot BaertEva MachackovaIlse CoeneCarol CreminKristin TurnerCheryl Portigal-ToddMarie Jill AsratJennifer NukAllison MindlinSean Young et al.

A1 Journal Article in HUMAN MUTATION

Tissue is the issue : when a second biopsy reveals the true diagnosis

Anne-Marie BogaertAnne HoorensMarleen PraetJo Van DorpeBruce PoppeMarie-Angélique De Scheerder

2017

Analysis of chromosomal radiosensitivity of healthy BRCA2 mutation carriers and non-carriers in BRCA families with the G2 micronucleus assay

Annelot BaertJulie DepuydtTom Van MaerkenBruce PoppeFransiska MalfaitTim Van DammeSylvia De NobeleGianpaolo PerlettiKim De LeeneerKathleen Claes et al.

A1 Journal Article in ONCOLOGY REPORTS

Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in BRCA1 and BRCA2 mutation carriers

Karoline B KuchenbaeckerLesley McGuffogDaniel BarrowdaleAndrew LeePenny SoucySue HealeyJoe DennisMichael LushMark RobsonAmanda B Spurdle et al.

A1 Journal Article in JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Catherine M PhelanKaroline B KuchenbaeckerJonathan P TyrerSiddhartha P KarKate LawrensonStacey J WinhamJoe DennisAilith PirieMarjorie J RigganGanna Chornokur et al.

A1 Journal Article in NATURE GENETICS

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Roger L MilneKaroline B KuchenbaeckerKyriaki MichailidouJonathan BeesleySiddhartha KarSara LindströmShirley HuiAudrey LemaçonPenny SoucyJoe Dennis et al.

A1 Journal Article in NATURE GENETICS

In-house developed 15-gene sequencing panel for acute myeloid leukemia and myelodysplasia allows robust detection of genetic defects including FLT3-ITD and CEBPA mutations

Joni Van der MeulenBarbara DenysElien De LatterSteve LefeverToon RosseelWouter SteyaertGRETA VAN DER CRUYSSENIsabelle RottiersDavid CreytensJo Van Dorpe et al.

In-house developed 15-gene sequencing panel for acute myeloid leukemia and myelodysplasia allows robust detection of genetic defects including FLT3-ITD and CEBPA mutations

Joni Van der MeulenBarbara DenysElien De LatterSteve LefeverToon RosseelWouter SteyaertGRETA VAN DER CRUYSSENIsabelle RottiersDavid CreytensJo Van Dorpe et al.

Novel molecular insights and targeted therapies in T-cell acute lymphoblastic leukemia

Sofie PeirsBruce PoppePieter Van Vlierberghe

Prediction of breast and prostate cancer risks in male BRCA1 and BRCA2 mutation carriers using polygenic risk scores

Julie LecarpentierValentina SilvestriKaroline B KuchenbaeckerDaniel BarrowdaleJoe DennisLesley McGuffogPenny SoucyGoska LesliePiera RizzoloAnna Sara Navazio et al.

A1 Journal Article in JOURNAL OF CLINICAL ONCOLOGY

Second hit landscape in BRCA-associated breast cancer

Mattias Van HeetveldeMieke Van BockstalTrees LepezSteve LefeverLeen PietersKathleen LambeinMarleen PraetIvo Van Den BergheFrauke CoppietersNadine Van Roy et al.

Second hit landscape in BRCA1/2-associated breast cancer

Mattias Van HeetveldeMieke Van BockstalTrees LepezKathleen LambeinDieter DeforceAnne VralBruce PoppeKim De LeeneerJo Van DorpeKathleen Claes

Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia

Sofie PeirsV FrismantasFilip MatthijssensW Van LoockeTim PietersNiels VandammeBéatrice LintermansMP DobayGeert BerxBruce Poppe et al.

A1 Journal Article in LEUKEMIA

2016

BRD4 inhibition improves the efficacy of ABT-199 in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensTim PietersNiels VandammeGeert BerxBruce PoppePieter Van Vlierberghe

BRD4 inhibition improves the efficacy of ABT-199 in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensTim PietersNiels VandammeGeert BerxBruce PoppePieter Van Vlierberghe

Evaluation of the role of germline RECQL variants in Belgian patients referred for genetic testing in the context of familial breast/ovarian cancer

Greet WiemeIlse CoeneLiselotte VergoteBruce PoppeFransiska MalfaitTom Van MaerkenKim De LeeneerKathleen Claes

Expanding the TLX1 regulome in T-cell acute lymphoblastic leukemia towards long noncoding RNAs

Kaat DurinckWouter Van LoockeInge Van de WalleJoni Van der MeulenPieter-Jan VoldersNadine Van RoyYves BenoitBruce PoppePieter MestdaghJo Vandesompele et al.

Fine-scale mapping at 9p22.2 identifies candidate causal variants that modify ovarian cancer risk in BRCA1 and BRCA2 mutation carriers

E VigoritoKB KuchenbaeckerJ BeesleyJ AdlardBA AgnarssonIL AndrulisBK ArunL BarjhouxM BelottiJ Benitez et al.

A1 Journal Article in PLOS ONE

Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer

FJ CouchKB KuchenbaeckerK MichailidouGA Mendoza-FandinoS NordJ LilyquistC OlswoldE HallbergS AgataH Ahsan et al.

A1 Journal Article in NATURE COMMUNICATIONS

Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation

Annelot BaertJulie DepuydtTom Van MaerkenBruce PoppeFransiska MalfaitKatrien StormJenneke van den EndeTim Van DammeSylvia De NobeleGianpaolo Perletti et al.

A1 Journal Article in BREAST CANCER RESEARCH

Long noncoding RNA signatures define oncogenic subtypes in T-cell acute lymphoblastic leukemia

Annelynn WallaertKaat DurinckWouter Van LoockeInge Van de WalleFilip MatthijssensPieter-Jan VoldersFrancisco Avila CobosDries RombautPieter RondouPieter Mestdagh et al.

A1 Journal Article in LEUKEMIA

Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2

Valentina SilvestriDaniel BarrowdaleAnna Marie MulliganSusan L NeuhausenStephen FoxBeth Y KarlanGillian MitchellPaul JamesDarcy L ThullKristin K Zorn et al.

A1 Journal Article in BREAST CANCER RESEARCH

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

Antoinette HollestelleFrederieke H van der BaanAndrew BerchuckSharon E JohnattyKatja K AbenBjarni A AgnarssonKristiina AittomäkiElisa AlducciIrene L AndrulisHoda Anton-Culver et al.

A1 Journal Article in GYNECOLOGIC ONCOLOGY

Targeting BET family proteins improves the efficacy of ABT-199 in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensBéatrice LintermansTim PietersNiels VandammeGeert BerxBruce PoppePieter Van Vlierberghe

Targeting BET family proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia

Sofie PeirsViktoras FrismantasFilip MatthijssensBéatrice LintermansTim PietersNiels VandammeWouter Van LoockeGeert BerxBruce PoppeJean-Pierre Bourquin et al.

The combination of ABT-199 and JQ1 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensTim PietersNiels VandammeBéatrice LintermansLindy ReunesGeert BerxBruce PoppePieter Van Vlierberghe

The T-ALL oncogene TLX1 controls enhancer lncRNA expression

Karen VerboomKaat DurinckWouter Van LoockeFilip MatthijssensInge Van de WalleAnnelynn WallaertPieter-Jan VoldersNadine Van RoyYves BenoitBruce Poppe et al.

2015

Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer

Timothy R RebbeckNandita MitraFei WanOlga M SinilnikovaSue HealeyLesley McGuffogSylvie MazoyerGeorgia Chenevix-TrenchDouglas F EastonAntonis C Antoniou et al.

A1 Journal Article in JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

BRCA1, BRCA2 and PALB2 mutations and CHEK2 c. 1100delC in different South African ethnic groups diagnosed with premenopausal and/or triple negative breast cancer

FZ FranciesT WainsteinKim De LeeneerA CairnsM MurdochS NietzH CubaschBruce PoppeTom Van MaerkenBrecht Crombez et al.

A1 Journal Article in BMC CANCER

Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia

Kaat DurinckWouter Van LoockeJoni Van der MeulenInge Van de WalleMaté OngenaertPieter RondouAnnelynn WallaertCE de BockNadine Van RoyBruce Poppe et al.

A1 Journal Article in LEUKEMIA

Epigenetics in T-cell acute lymphoblastic leukemia

Sofie PeirsJoni Van der MeulenInge Van de WalleTom TaghonFranki SpelemanBruce PoppePieter Van Vlierberghe

A1 Journal Article in IMMUNOLOGICAL REVIEWS

MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia

Evelien MetsJoni Van der MeulenGert Van PeerMichael BoicePieter MestdaghInge Van de WalleTim LammensSteven GoossensBarbara De MoerlooseYves Benoit et al.

A1 Journal Article in LEUKEMIA

Molecular basis and clinical significance of genetic aberrations in B-cell precursor acute lymphoblastic leukemia

Farzaneh GhazaviTim LammensNadine Van RoyBruce PoppeFranki SpelemanYves BenoitPieter Van VlierbergheBarbara De Moerloose

A1 Journal Article in EXPERIMENTAL HEMATOLOGY

Nevoid basal cell carcinoma syndrome and dysgerminoma : an incidental association?

Isabelle HoorensMaya Van de KerckhoveBruce PoppeKatrien Vossaert

A1 Journal Article in JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Novel biological insights in T-cell acute lymphoblastic leukemia

Kaat DurinckSteven GoossensSofie PeirsAnnelynn WallaertWouter Van LoockeFilip MatthijssensTim PietersGloria MilaniTim LammensPieter Rondou et al.

A1 Journal Article in EXPERIMENTAL HEMATOLOGY

Oncogenetic testing and follow-up for women with familial breast/ovarian cancer, Li-Fraumeni syndrome and Cowden syndrome

Jo RobaysSabine StordeurFrank HulstaertTom Van MaerkenKathleen ClaesNicolas JaninGert MatthijsDaphné 't Kint de RoodenbekeMartine BerlièreHans Wildiers et al.

Oncogenetic testing for persons with hereditary endocrine cancer syndromes

Joan VlayenMarie BexBert BravenboerKathleen ClaesBruno LapauwAlexandre PersuKris PoppeUrielle UllmanTom Van MaerkenLaurent Vroonen et al.

Oncogenetic testing, diagnosis and follow-up in Birt-Hogg-Dubé syndrome, familial atypical multiple mole melanoma syndrome and neurofibromatosis 1 and 2

Jo RobaysSabine StordeurFrank HulstaertJean-François BaurainLieve BrochezTeofila CaplanusiKathleen ClaesEric LegiusSylvie RotteyDirk Schrijvers et al.

The G2 micronucleus-assay for the analysis of in vitro chromosomal radiosensitivity in individuals carrying a BRCA1 mutation

Annelot BaertJulie DepuydtBruce PoppeTom Van MaerkenFransiska MalfaitTim Van DammeSylvia De NobeleKim De LeeneerKathleen ClaesAnne Vral

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

Joni Van der MeulenViraj SanghviKonstantinos MavrakisKaat DurinckFang FangFilip MatthijssensPieter RondouMonica RosenTim PietersPeter Vandenberghe et al.

A1 Journal Article in BLOOD

Transcriptional antagonism between the cooperative oncogenes TLX1 and NOTCH1 in T-cell acute lymphoblastic leukemia.

Kaat DurinckWouter Van LoockeJoni Van der MeulenInge Van de WallePieter RondouCharles E De BockBruce PoppeJan CoolsJean SoulierTom Taghon et al.

2014

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in early immature T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensKirsten Canté-BarrettTim LammensBarbara De MoerlooseYves BenoitJean SoulierBruce PoppeTom Taghon et al.

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensInge Van de WalleKatia RuggeroCharles E de BockSandrine DegryseKirsten Canté-BarrettDelphine BriotEmmanuelle Clappier et al.

A1 Journal Article in BLOOD

ABT-199 mediated inhibition of BCL2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensCharles De BockKirsten Canté-BarrettTim LammensInge Van de WalleBarbara De MoerlooseYves BenoitBruce Poppe et al.

Breast-cancer risk in families with mutations in PALB2

AC AntoniouS CasadeiT HeikkinenD BarrowdaleK PylkäsJ RobertsA LeeD SubramanianKim De LeeneerF Fostira et al.

A1 Journal Article in NEW ENGLAND JOURNAL OF MEDICINE

DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers

Ana OsorioRoger L MilneKaroline KuchenbaeckerTereza VaclováGuillermo PitaRosario AlonsoPaolo PeterlongoIgnacio BlancoMiguel de la HoyaMercedes Duran et al.

A1 Journal Article in PLOS GENETICS

Integrative analysis of the NOTCH1 regulatory network identifies key downstream lncRNAs in acute T-cell lymphoblastic leukemia and normal T-cell development

Annelynn WallaertKaat DurinckPieter RondouInge Van de WalleWouter Van LoockePieter-Jan VoldersMaté OngenaertNadine Van RoyBruce PoppeYves Benoit et al.

LncRNA profiling in T-cell acute lymphoblastic leukemia predicts a functional connection between lncRNAs and the major T-ALL genetic subgroups

Annelynn WallaertKaat DurinckWouter Van LoockePieter-Jan VoldersYves BenoitBruce PoppePieter MestdaghJo VandesompeleJean SoulierJan Cools et al.

Mate pair sequencing for the detection of chromosomal aberrations in patients with intellectual disability and congenital malformations

Sarah VergultEllen Van BinsbergenTom SanteSilke NowakOlivier VanakkerKathleen ClaesBruce PoppeNathalie Van der AaMarkus J van RoosmalenKaren Duran et al.

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia

Evelien MetsGert Van PeerJoni Van der MeulenMichael BoiceTom TaghonSteven GoossensPieter MestdaghYves BenoitBarbara De MoerlooseNadine Van Roy et al.

A1 Journal Article in HAEMATOLOGICA

The first lncRNA landscape of major genetic T-ALL subsets and guilt-by-association analysis for ETP-ALL specific lncRNAs

Annelynn WallaertKaat DurinckWouter Van LoockePieter-Jan VoldersInge Van de WalleYves BenoitBruce PoppeJo VandesompeleTom TaghonJean Soulier et al.

The G2 micronucleus assay for the analysis of in vitro chromosomal radiosensitivity in individuals carrying a BRCA1 or BRCA2 mutation

Annelot BaertJulie DepuydtBruce PoppeTom Van MaerkenFransiska MalfaitTim Van DammeSylvia De NobeleKim De LeeneerKathleen ClaesAnne Vral

The G2-micronucleus assay for the detection of in vitro chromosomal radiosensitivity in BRCA1 and BRCA2 mutation carriers

Annelot BaertJulie DepuydtBruce PoppeTom Van MaerkenFransiska MalfaitTim Van DammeKim De LeeneerKathleen ClaesAnne Vral

The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

Kaat DurinckAnnelynn WallaertInge Van de WalleWouter Van LoockePieter-Jan VoldersSuzanne VanhauwaertEllen GeerdensYves BenoitNadine Van RoyBruce Poppe et al.

A1 Journal Article in HAEMATOLOGICA

The NOTCH1 driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

Annelynn WallaertKaat DurinckPieter RondouInge Van de WalleWouter VanloockePieter-Jan VoldersSuzanne VanhauwaertEllen GeerdensMaté OngenaertNadine Van Roy et al.

Uncovering the microRNA landscape in T-cell acute lymphoblastic leukemia

Evelien MetsFranki SpelemanBruce Poppe

Unique lncRNA signatures mark the major T-ALL genetic subgroups

Annelynn WallaertKaat DurinckWouter Van LoockePieter-Jan VoldersYves BenoitBruce PoppePieter MestdaghJo VandesompeleJean SoulierJan Cools et al.

2013

Analysis of the novel Fanconi anemia gene SLX4/FANCP in familial breast cancer cases

Janine L BakkerSaskia van MilGerry CrossanNelly SabbaghianKim De LeeneerBruce PoppeMuriel AdankHans GilleHenk VergeulHanne Meijers-Heijboer et al.

A1 Journal Article in HUMAN MUTATION

Development of an S-G2 micronucleus assay for the detection of in vitro chromosomal radiosensitivity in high-risk women subjected to early mammography screening for breast cancer

Anne VralJulie DepuydtAnnelot BaertBruce PoppeTom Van MaerkenFransiska MalfaitKim De LeeneerMarc D'HoogheKathleen Claes

Expanding the TLX1 regulate in T-cell acute lymphoblastic leukemia towards long non-coding RNAs

Kaat DurinckJoni Van der MeulenMaté OngenaertPieter-Jan VoldersAnnelynn WallaertNadine Van RoyYves BenoitBruce PoppePieter MestdaghJo Vandesompele et al.

Expanding the TLX1-regulome in T cell acute lymphoblastic leukemia towards long non-coding RNAs

Kaat DurinckJoni Van der MeulenMaté OngenaertPieter-Jan VoldersAnnelynn WallaertNadine Van RoyYves BenoitBruce PoppePieter MestdaghJo Vandesompele et al.

Fabry nephropathy: indications for screening and guidance for diagnosis and treatment by the European Renal Best Practice

Wim TerrynPierre CochatRoseline FroissartAlberto OrtizYves PirsonBruce PoppeAndreas SerraWim Van BiesenRaymond VanholderChristoph Wanner

A1 Journal Article in NEPHROLOGY DIALYSIS TRANSPLANTATION

Matepair sequencing for the detection of chromosomal aberrations in patients with intellectual disability and congenital malformations

Sarah VergultEllen Van BinsbergenTom SanteSilke NowakOlivier VanakkerKathleen ClaesBruce PoppeNathalie Van der AaMJ Van RoosmalenK Duran et al.

MiR-128 is a novel PHF6 targeting regulatory non-coding RNA acting as a T-ALL oncogene

Evelien MetsJoni Van der MeulenGert Van PeerMichael BoicePieter MestdaghTom TaghonDavid AvranBarbara De MoerlooseYves BenoitBruce Poppe et al.

Prevalence of Fabry disease in a predominantly hypertensive population with left ventricular hypertrophy

Wim TerrynGert DeschoenmakereJan De KeyserWouter MeerssemanWim Van BiesenBrigitte WuytsDimitri HemelsoetHilbert PascaleJulie De BackerAnne De Paepe et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CARDIOLOGY

Questioning the pathogenic role of the GLA p.Ala143Thr 'mutation' in Fabry disease: implications for screening studies and ERT

Wim TerrynRaymond VanholderDimitri HemelsoetBart LeroyWim Van BiesenG De SchoenmakereBrigitte WuytsKathleen ClaesJulie De BackerAnne De Paepe et al.

Bookchapter in JIMD reports : case and research reports 2012/5

Screening for Fabry disease: indications, methods and implications

Wim TerrynRaymond VanholderBruce Poppe

Variant ataxia telangiectasia: clinical and molecular findings and evaluation of radiosensitive phenotypes in a patient and relatives

Kathleen ClaesJulie DepuydtA Malcolm R TaylorJames I LastAnnelot BaertPeter SchietecatteVeerle VandersickelBruce PoppeKim De LeeneerMarc D'Hooghe et al.

A1 Journal Article in NEUROMOLECULAR MEDICINE

2012

Adults with Down syndrome: health/care considerations for health professionals

BARBARA DELLE CHIAIES Van den BraembusscheC ElsingS van den EntRoos LeroyBert CallewaertM WojciechowskiBruce PoppeG Van BuggenhoutG Van Goethem

A2 Journal Article in TIJDSCHRIFT VAN DE BELGISCHE KINDERARTS = JOURNAL DU PEDIATRE BELGE

Association of PHB 1630 C > T and MTHFR 677 C > T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study

A JakubowskaD RozkrutA AntoniouU HamannRJ ScottL McGuffogS HealyOM SinilnikovaG RennertF Lejbkowicz et al.

A1 Journal Article in BRITISH JOURNAL OF CANCER

Characterization of LEDGF/p75 genetic variants and association with HIV-1 disease progression

Peter MessiaenWard De SpiegelaereJose AlcamiKaren VervischPetra Van AckerBruno VerhasseltPieter MeuwissenEsther CalongeNuria GonzalezFelix Gutierrez-Rodero et al.

A1 Journal Article in PLOS ONE

Comprehensive characterization of LEDGF/p75 in a HIV-1 infected patient cohort

Peter MessiaenWard De SpiegelaereJose AlcamiPaul CouckePetra Van AckerKaren VervischBruno VerhasseltPieter MeeuwissenBruce PoppeDirk Vogelaers et al.

Evaluation of RAD51C as cancer susceptibility gene in a large breast-ovarian cancer patient population referred for genetic testing

Kim De LeeneerMieke Van BockstalSara De BrouwerNATALIA SWIETEKPeter SchietecatteN SabbaghianJ Van den EndeS WillocxK StormB Blaumeiser et al.

A1 Journal Article in BREAST CANCER RESEARCH AND TREATMENT

High-risk clonal evolution in chronic B-lymphocytic leukemia: single-center interphase fluorescence in situ hybridization study and review of the literature

Ann JanssensNadine Van RoyBruce PoppeLucien NoensJan PhilippéFranki SpelemanFritz Offner

A1 Journal Article in EUROPEAN JOURNAL OF HAEMATOLOGY

Matepair sequencing for the detection of chromosomal aberrations in patients with intellectual disability and congenital malformations

Sarah VergultEllen Van BinsbergenTom SanteSilke NowakOlivier VanakkerKathleen ClaesBruce PoppeNathalie Van der AaMJ Van RoosmalenK Duran et al.

Mutation analysis of RAD51D in non-BRCA1/2 ovarian and breast cancer families

DJ OsherKim De LeeneerG MichilsN HamelE TomiakBruce PoppeK LeunenE LegiusA ShuenE Smith et al.

A1 Journal Article in BRITISH JOURNAL OF CANCER

Prevalence of BRCA1/2 mutations in sporadic breast/ovarian cancer patients and identification of a novel de novo BRCA1 mutation in a patient diagnosed with late onset breast and ovarian cancer: implications for genetic testing

Kim De LeeneerIlse CoeneBrecht CrombezJustine SimkensRudy Van den BroeckeAlain BolsBarbara StragierIlse VanhoutteAnne De PaepeBruce Poppe et al.

A1 Journal Article in BREAST CANCER RESEARCH AND TREATMENT

2011

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)

Evelien MetsJoni Van der MeulenKonstantinos J MavrakisAndrew L WolfeTom TaghonAly A KhanManu SettyXiaoping LiuPieter RondouPeter Vandenberghe et al.

Combined effect of polymorphisms in Rad51 and XRCC3 on breast cancer risk and chromosomal radiosensitivity

Anne VralPetra WillemsKathleen ClaesBruce PoppeAns BaeyensGianpaolo PerlettiHubert Thierens

A1 Journal Article in MOLECULAR MEDICINE REPORTS

Comprehensive characterization of LEDGF/p75 in a HIV-1-infected patient cohort

Peter MessiaenWard De SpiegelaereChris VerhofstedePaul CouckePetra Van AckerPhilip VlummensKAREN VERVISCHDirk VogelaersBruce PoppeJose Alcami et al.

Evaluation of RAD51C as a new breast cancer suceptibility gene in Belgian/Dutch population

Kim De LeeneerM Van BockstaelNATALIA SWIETEKJ Van den EndeK StormB BlaumeiserK LeunensCJ van AsperenJT WijnenE Legius et al.

EVI1-mediated down regulation of MIR449A is essential for the survival of EVI1 positive leukaemic cells

An De WeerJoni Van der MeulenPieter RondouTom TaghonTorsten A KonradKatleen De PreterPieter MestdaghTom Van MaerkenNadine Van RoyMarta Jeison et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Familial adenomatous polyposis: clinical presentation, detection and surveillance

Stéphanie LaurentD FranchimontJP CoppensK LeunenL MackenMarc PeetersO PlomteuxM PolusBruce PoppeC Sempoux et al.

A1 Journal Article in ACTA GASTRO-ENTEROLOGICA BELGICA

Massive parallel amplicon sequencing of the breast cancer genes BRCA1 and BRCA2: opportunities, challenges, and limitations

Kim De LeeneerJan HellemansJoachim De SchrijverMachteld BaetensBruce PoppeWim Van CriekingeAnne De PaepePaul CouckeKathleen Claes

A1 Journal Article in HUMAN MUTATION

Regulatory networks governed by microRNAs in T-ALL oncogenesis and normal T-cell development

Joni Van der MeulenEvelien MetsPieter MestdaghPeter PipelersTom TaghonDavid Camacho TrujilloDavid AvranGert Van PeerNadine Van RoyOlivier Thas et al.

The relationship between genetic testing, psychological well-being and surveillance behavior: a questionnaire study in presymptomatic female and male BRCA carriers and non-carriers

Katrien VerhoevenPhilippe De WildeBruce PoppeAnne De PaepeGeert Crombez

A1 Journal Article in PSYCHOLOGIE & GEZONDHEID

2010

Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction

Antonio C AntoniouJonathan BeesleyLesley McGuffogOlga M SinilnikovaSue HealeySusan L NeuhausenYuan Chung DingTimothy R RebbeckJeffrey N WeitzelHenry T Lynch et al.

A1 Journal Article in CANCER RESEARCH

Identification of two critically deleted regions within chromosome segment 7q35-q36 in EVI1 deregulated myeloid leukemia cell lines

An De WeerBruce PoppeSarah VergultPieter Van VlierbergheMarjan PetrickRobrecht De BockYves BenoitLucien NoensAnne De PaepeNadine Van Roy et al.

A1 Journal Article in PLOS ONE

Kanker en erfelijkheid : van moleculaire diagnostiek tot psychologische begeleiding

Philippe De WildeKathleen ClaesKim De LeeneerBruce PoppeAnne De Paepe

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

PHF6 mutations in T-cell acute lymphoblastic leukemia

Pieter Van VlierbergheTeresa PalomeroHossein KhiabanianJoni Van der MeulenMireia CastilloNadine Van RoyBarbara De MoerlooseJan PhilippéSara Gonzalez-GarciaMaria L Toribio et al.

A1 Journal Article in NATURE GENETICS

Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogénétique Hématologique study

Etienne CoyaudStephanie StruskiNais PradeJulien FamiliadesRuth EichnerCathy QuelenMarina BousquetFrancine MugneretPascaline TalmantMarie-Pierre Pages et al.

A1 Journal Article in BLOOD

2009

Comparison of miRNA profiles of microdissected Hodgkin/Reed-Sternberg cells and Hodgkin cell lines versus CD77+ B-cells reveals a distinct subset of differentially expressed miRNAs

Pieter Van VlierbergheAn De WeerPieter MestdaghTom FeysKatleen De PreterAnne De PaepeKathleen LambeinJo VandesompeleNadine Van RoyBruno Verhasselt et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Downregulation of miR-449a is essential for the survival of EVI1 positive leukemic cells through modulation of NOTCH1 and BCL2

An De WeerPieter MestdaghKatleen De PreterJoni Van der MeulenPieter Van VlierbergheTom Van MaerkenNadine Van RoyMarta JeisonIsaac YanivBarbara Cauwelier et al.

Genome profiling of acute myelomonocytic leukemia: alteration of the MYB locus in MYST3-linked cases

A MuratiC GervaisN CarbucciaP FinettiN CerveraJ AdelaideS StruskiE LippertF MugneretI Tigaud et al.

A1 Journal Article in LEUKEMIA

Genotyping of Frequent BRCA1/2 SNPs with Unlabeled Probes A Supplement to HRMCA Mutation Scanning, Allowing the Strong Reduction of Sequencing Burden

Kim De LeeneerIlse CoeneBruce PoppeAnne De PaepeKathleen Claes

A1 Journal Article in JOURNAL OF MOLECULAR DIAGNOSTICS

MICRORNA SIGNATURES IN GENETIC SUBTYPES OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Joni Van der MeulenPieter Van VlierberghePieter MestdaghJo VandesompeleBruce PoppeNadine Van RoyTom TaghonJean PlumB. CauwelierDLD Selleslag et al.

MODULATION OF MIR-449A EXPRESSION DECREASES CELL VIABILITY, INCREASES APOPTOSIS AND INDUCES DIFFERENTIATION IN EVI1 DEREGULATED LEUKEMIA CELLS

An De WeerBruce PoppePieter MestdaghKatleen De PreterPieter Van VlierbergheNadine Van RoyM JeisonB CauwelierBruno VerhasseltJan Philippé et al.

2008

Acute myeloid leukaemia with 8p11 (MYST3) rearrangement: an integrated cytologic, cytogenetic and molecular study by the groupe francophone de cytogenetique de hematologique

C GERVAISA MURATIC HELIASS STRUSKIA EISCHENE LIPPERTI TIGAUDD PENTHERC BASTARDF MUGNERET et al.

A1 Journal Article in LEUKEMIA

Copy number alterations and copy number variation in cancer: close encounters of the bad kind

Franki SpelemanCandy KumpsKaren BuysseBruce PoppeBjörn MentenKatleen De Preter

A1 Journal Article in CYTOGENETIC AND GENOME RESEARCH

EVI1 overexpression in t(3;17) positive myeloid malignancies results from juxtaposition of EVI1 to the MSI2 locus at 17q22

An De WeerFranki SpelemanBarbara CauwelierNadine Van RoyNurten YigitBruno VerhasseltBarbara De MoerlooseYves BenoitLucien NoensDominik Selleslag et al.

A1 Journal Article in HAEMATOLOGICA-THE HEMATOLOGY JOURNAL

EVII activation in blast crisis CML due to juxtaposition to the rare 17q22 partner region as part of a 4-way variant translocation t(9;22)

An De WeerBruce PoppeBarbara CauwelierA CARLIERJ DIERICKBruno VerhasseltJan PhilippéNadine Van RoyFranki Speleman

A1 Journal Article in BMC CANCER

MICRORNA PROFILING OF EVI1 DEREGULATED MYELOID LEUKEMIA

An De WeerBruce PoppePieter MestdaghPieter Van VlierbergheNadine Van RoyAnne De PaepeBruno VerhasseltJo VandesompeleFranki Speleman

MicroRNA signatures in genetic subtypes of T-cell acute lymphoblastic leukemia.

Pieter Van VlierbergheBruce PoppeNadine Van RoyTom TaghonJean PlumB CauwelierD SelleslagP HeimannP VandenbergheN Dastugue et al.

Polymorphisms in nonhomologous end-joining genes associated with breast cancer risk and chromosomal radiosensitivity

Petra WillemsKathleen ClaesAns BaeyensVeerle VandersickelJoke WerbrouckKim De RuyckBruce PoppeRudy Van den BroeckeAmin MakarEmanuela Marras et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Rapid and sensitive detection of BRCA1/2 mutations in a diagnostic setting: Comparison of two high-resolution melting platforms

Kim De LeeneerIlse CoeneBruce PoppeAnne De PaepeKathleen Claes

A1 Journal Article in CLINICAL CHEMISTRY

Two-tier approach for the detection of alpha-galactosidase A deficiency in a predominantly female haemodialysis population

W TERRYNBruce PoppeB WUYTSKathleen ClaesB MAESD VERBEELENRaymond VanholderK DE BOECKNorbert LameireAnne De Paepe et al.

A1 Journal Article in NEPHROLOGY DIALYSIS TRANSPLANTATION

Two-tier approach for the detection of alpha-galactosidase A deficiency in kidney transplant recipients

Gert De SchoenmakereBruce PoppeBirgitte WuytsKathleen ClaesDavid CassimanBart MaesDierik VerbeelenRaymond VanholderDirk R. KuypersNorbert Lameire et al.

A1 Journal Article in NEPHROLOGY DIALYSIS TRANSPLANTATION

2007

A detailed inventory of DNA copy number alterations in four commonly used Hodgkin lymphoma cell lines

Tom FeysBruce PoppeKatleen De PreterNadine Van RoyBruno VerhasseltPascale De PaepeAnne De PaepeFranki Speleman

A detailed inventory of DNA copy number alterations in four commonly used Hodgkin's lymphoma cell lines

Tom FeysBruce PoppeKatleen De PreterNadine Van RoyBruno VerhasseltPascale De PaepeAnne De PaepeFranki Speleman

A1 Journal Article in HAEMATOLOGICA

Acquired chromosomal rearrangements targeting selected transcription factors: contribution of molecular cytogenetic and expression analyses to the identification of clinically and biologically relevant subgroups in hematological malignancies

Bruce PoppeAnne De PaepeFranki Speleman

A4 Journal Article in VERHANDELINGEN VAN DE KONINKLIJKE ACADEMIE VOOR GENEESKUNDE VAN BELGIË

Borstkanker en erfelijkheid

Bruce PoppePhilippe De WildeAnne De Paepe

Bookchapter in Mijn borst : alles over borstchirurgie

Clinical, cytogenetic and molecular characteristics of 14 T-ALL patients carrying the TCR β-HOXA rearrangement : a study of the Groupe Francophone de Cytogénétique Hématologique

Barbara CauwelierH CavéC GervaisM LessardC BarinC PerotJ Van den AkkerF MugneretC CharrinMP Pagès et al.

A1 Journal Article in LEUKEMIA

De bijdrage van M-FISH aan de moleculaire diagnostiek in de hemato-oncologie

Bruce PoppeNadine Van RoyNurten YigitAnne De PaepeFranki Speleman

A2 Journal Article in Ned Tijdschr Hematol

Identification of EVI1 transcriptional target genes using RNAI

An De WeerBruce PoppeB CAUWEUERNadine Van RoyBruno VerhasseltFranki Speleman

MicroRNA profiling of EVI1 deregulated myeloid leukemia

An De WeerBruce PoppePieter MestdaghNadine Van RoyAnne De PaepeBruno VerhasseltJo VandesompeleFranki Speleman

Preliminary screening results for fabry disease in young stroke patients reveals a new mutation

Dimitri HemelsoetBruce PoppeAnne SiebenFREDERIK VANHEEPASCAL PROOTM De ClerckBart LeroyJulie De BackerBirgit WuytsLJ De Meirleir et al.

Report of an unusual translocation t(3;14)(q26;q32) involving both EVI1 and IGH in an unclassified acute myeloid leukaemia (AML)

V HAVELANGEG AMEYEA DEWEERK BAHLOULAC MULLIERJM LIBOUTONM DETRAITP SAUSSOYSBruce PoppeFranki Speleman et al.

2006

EVII is consistently expressed as principal transcript in common and rare recurrent 3q26 rearrangements

Bruce PoppeN DASTUGUEJo VandesompeleBarbara CauwelierB DE SMETNurten YigitAnne De PaepeJ CERVERAC RECHERV DE MAS et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

GAB2 is a novel target of 11q amplification in AML/MDS

A ZATKOVAC SCHOCHFranki SpelemanBruce PoppeC MANNHALTERC FONATSCHK WIMMER

A1 Journal Article in GENES CHROMOSOMES & CANCER

Molecular cytogenetic study of 126 unselected T-ALL cases reveals high incidence of TCR beta locus rearrangements and putative new T-cell oncogenes

Barbara CauwelierN DASTUGUEJ COOLSBruce PoppeC HERENSAnne De PaepeA HAGEMEIJERFranki Speleman

A1 Journal Article in LEUKEMIA

Recurrent t(3;17) translocations in AML with EVII rearrangement.

A De WeerBruce PoppeB CauwelierNadine Van RoyN DastugueBarbara De MoerlooseYves BenoitLucien NoensAnne De PaepeFranki Speleman

Recurrent T(3;17)translocations in AML with EVI1 rearrangement

An De WeerBruce PoppeB CauwelierNadine Van RoyN DASTUGUEBarbara De MoerlooseYves BenoitLucien NoensAnne De PaepeFranki Speleman

Screening for EVII: ectopic expression absent in T-cell acute lymphoblastic leukemia patients and cell lines

An De WeerBruce PoppeB CauwelierNadine Van RoyN DASTUGUEA HAGEMEIJERAnne De PaepeFranki Speleman

A1 Journal Article in CANCER GENETICS AND CYTOGENETICS

2005

A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias

Franki SpelemanBarbara CauwelierN DASTUGUEJ COOLSBruno VerhasseltBruce PoppeNadine Van RoyJo VandesompeleC GRAUXA UYTTEBROECK et al.

A1 Journal Article in LEUKEMIA

Acquired chromosomal rearrangements targeting selected transcription factors: contribution of molecular cytogenetic and expression analyses to the identification of clinically and biologically relevant subgroups in hematological malignancies

Bruce PoppeFranki SpelemanAnne De Paepe

HOYA gene cluster rearrangement in a t(7;9)(p15;q34) in a child with MDS

Bruce PoppeNurten YigitBarbara De MoerlooseAnne De PaepeYves BenoitFranki Speleman

A1 Journal Article in CANCER GENETICS AND CYTOGENETICS

Novel cryptic chromosomal rearrangements in childhood acute lymphoblastic leukemia detected by multiple color fluorescent in situ hybridization

Bruce PoppeBarbara CauwelierH VAN LIMBERGENNurten YigitJan PhilippéBruno VerhasseltAnne De PaepeYves BenoitFranki Speleman

A1 Journal Article in HAEMATOLOGICA-THE HEMATOLOGY JOURNAL

PAX5/IGH rearrangement is a recurrent finding in a subset of aggressive B-NHL with complex chromosomal rearrangements

Bruce PoppeP DE PAEPEL MICHAUXN DASTUGUEC BASTARDC HERENSELS MOREAUF CAVAZZININurten YigitH VAN LIMBERGEN et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Rapid detection of VHL exon deletions using real-time quantitative PCR

Jasmien HoebeeckR VAN DER LUIJTBruce PoppeEls De SmetNurten YigitKathleen ClaesR ZEWALDGJ DE JONGAnne De PaepeFranki Speleman et al.

A1 Journal Article in LABORATORY INVESTIGATION

Recente moleculaire inzichten in erfelijke borst- en ovariumkanker in België

Kathleen ClaesBruce PoppeIlse CoeneL MESSIAENAnne De Paepe

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

2004

BRCA1 and BRCA2 germline mutation spectrum and frequencies in Belgian breast/ovarian cancer families

Kathleen ClaesBruce PoppeIlse CoeneAnne De PaepeLudwine Messiaen

A1 Journal Article in BRITISH JOURNAL OF CANCER

Chromosomal radiosensitivity in BRCA1 and BRCA2 mutation carriers

Ans BaeyensHubert ThierensKathleen ClaesBruce PoppeLeo De RidderAnne Vral

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951

H CAVÉS SUCIUC PREUDHOMMEBruce PoppeA ROBERTA UYTTEBROECKM MALETP BOUTARDYves BenoitL MAUVIEUX et al.

A1 Journal Article in BLOOD

Expression analyses identify MLL as a prominent target of 11q23 amplification and support an etiologic role for MLL gain of function in myeloid malignancies

Bruce PoppeJo VandesompeleC SCHOCHC LINDVALLK MROZEKCD BLOOMFIELDHB BEVERLOOL MICHAUXN DASTUGUEC HERENS et al.

A1 Journal Article in BLOOD

Recommendations for the cytogenetic management of acute myeloblastic leukemia (AML) proposed by the Groupe Francais de Cytogenetique Hematologique (GFCH)

C BASTARDL BARANGERC BILHOU-NABERAC CHARRINN DASTUGUEV ECLACHEM LAFAGE-POCHITALOFFJL LAID LEROUXM LESSARD et al.

A1 Journal Article in PATHOLOGIE BIOLOGIE

Recommendations for the cytogenetic management of adult and chidhoodacute lymphoblastic leukemia (ALL) proposed by the Groupe Francais de Cytogenetique Hematologique (GFCH)

L BARANGERC BARIC CHARRINP CORNILLET-LEFEBVREN DASTUGUEM LAFAGE-POCHITALOFFC PEROTBruce PoppeS ROMANAFranki Speleman et al.

A1 Journal Article in PATHOLOGIE BIOLOGIE

Recommendations for the cytogenetic management of myelodysplastic syndromes proposed by the Groupe Francais de Cytogenetique Hematologique (GFCH)

C BASTARDI LUCQUETMJ MOZZICONACCIBruce PoppeS RAYNAUDFranki Speleman

A1 Journal Article in PATHOLOGIE BIOLOGIE

Routine microsatellite instability testing in sporadic colorectal tumours

Nancy Van DammePieter DemetterKathleen ClaesBruce PoppeF BAERTJ ROELENSAnne De PaepeClaude CuvelierMarc Peeters

The impact of proband mediated information dissemination in families with a BRCA1/2 gene mutation

E SERMIJNG GOELENE TEUGELSL KAUFMANM BONDUELLEB NEYNSBruce PoppeAnne De PaepeJ DE GREVE

A1 Journal Article in JOURNAL OF MEDICAL GENETICS

Translocation t(2;3)(p15-23;q26-27) in myeloid malignancies: report of 21 new cases, clinical, cytogenetic and molecular genetic features

M STEVENS-KROEFBruce PoppeS VAN ZELDEREN-BHOLAE VAN DEN BERGM VAN DER BLIJ-PHILIPSENAG VAN KESSELR SLATERG HAMERSL MICHAUXFranki Speleman et al.

A1 Journal Article in LEUKEMIA

2003

3q rearrangements in myeloid malignancies

Bruce PoppeNicole DastugueFranki Speleman

A2 Journal Article in ATLAS OF GENETICS AND CYTOGENETICS IN ONCOLOGY AND HAEMATOLOGY

ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma

P DE PAEPEM BAENSH VAN KRIEKENBruno VerhasseltM STULANN SIMONSBruce PoppeGenevieve LaureysP BRONSPieter Vandenberghe et al.

A1 Journal Article in BLOOD

BRCA-genmutaties bij borstkanker

Bruce PoppeRudy Van den BroeckeAnne De Paepe

A2 Journal Article in PATIENT CARE (BELGIE NEDERLANDSE ED.)

BRCA1/2 mutation spectrum and frequencies in Belgian breast/ovarian cancer families

Kathleen ClaesBruce PoppeIlse CoeneAnne De PaepeLudwine Messiaen

Differentiating pathogenic mutations from polymorphic alterations in the splice sites of BRCA1 and BRCA2

Kathleen ClaesBruce PoppeE MACHACKOVAIlse CoeneL FORETOVAAnne De PaepeLudwine Messiaen

A1 Journal Article in GENES CHROMOSOMES & CANCER

Soft tissue tumors : clear cell sarcoma

Bruce PoppeRamses ForsythKarl DhaeneFranki Speleman

A2 Journal Article in ATLAS OF GENETICS AND CYTOGENETICS IN ONCOLOGY AND HAEMATOLOGY

t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Francais de Cytogenetique Hematologique (GFCH)

R BERGERN DASTUGUEM BUSSONJ VAN DEN AKKERC PEROTP BALLERINIA HAGEMEIJERL MICHAUXC CHARRINMP PAGES et al.

A1 Journal Article in LEUKEMIA

t(9;14)(p13;q32)

Bruce PoppePascale De PaepeFranki Speleman

A2 Journal Article in ATLAS OF GENETICS AND CYTOGENETICS IN ONCOLOGY AND HAEMATOLOGY

Therapie van het colorectaal carcinoom : kunnen biologische merkers het beleid beïnvloeden?

B SierensMarc PeetersBruce PoppeAnne De PaepePieter DemetterClaude CuvelierMartine De Vos

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

2002

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

Jo VandesompeleKatleen De PreterFilip PattynBruce PoppeNadine Van RoyAnne De PaepeFranki Speleman

A1 Journal Article in GENOME BIOLOGY

Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition

Ans BaeyensHubert ThierensKathleen ClaesBruce PoppeLudwine MessiaenLeo De RidderAnne Vral

A1 Journal Article in BRITISH JOURNAL OF CANCER

HOX11L2 expression linked to t(5;14)(q35;q32) is not associated with poor prognosis in childhood T-ALL treated in EORTC trials 58 881 and 58 951

H CAVÉS SUCIUC PREUDHOMMEBruce PoppeA ROBERTA UYTTEBROEKM MALETP BOUTARDYves BenoitL MAUVIEUX et al.

Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH.

Heidi Van LimbergenBruce PoppeL MICHAUXC HERENSJ BROWNLucien NoensZ BERNEMANR DE BOCKAnne De PaepeFranki Speleman

A1 Journal Article in GENES CHROMOSOMES & CANCER

Meerkleuren fluorescentie in situ hybridisatie: methodologie en toepassingen in diagnostiek en onderzoek

Heidi Van LimbergenBruce PoppeStefan VermeulenNadine Van RoyAnne De PaepeFranki Speleman

A4 Journal Article in TIJDSCHRIFT VAN DE BELGISCHE VERENIGING VAN LABORATORIUM-TECHNOLOGEN = REVUE DE L'ASSOCIATION BELGE DES TECHNOLOGUES DE LABORATOIRE

Molecular cytogenetic analysis of 10;11 rearrangements in acute myeloid leukemia.

Heidi Van LimbergenBruce PoppeA JANSSENSR DE BOCKAnne De PaepeL NOENSFranki Speleman

A1 Journal Article in LEUKEMIA

Pathological splice mutations outside the invariant AG/GT splice sites of BRCA1 exon 5 increase alternative transcript levels in the 5 ' end of the BRCA1 gene.

Kathleen ClaesJo VandesompeleBruce PoppeK DAHANI COENEAnne De PaepeLudwine Messiaen

A1 Journal Article in ONCOGENE

Wanneer speelt erfelijkheid een rol

Anne De PaepeBruce Poppe

Bookchapter in Omgaan met darmkanker

2001

Chromosomal aberrations in Bloom syndrome patients with myeloid malignancies.

Bruce PoppeHeidi Van LimbergenNadine Van RoyE VANDECRUYSAnne De PaepeYves BenoitFranki Speleman

A1 Journal Article in CANCER GENETICS AND CYTOGENETICS

Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines.

Nadine Van RoyHeidi Van LimbergenJo VandesompeleMireille Van GeleBruce PoppeH SALWENGenevieve LaureysN MANOELAnne De PaepeFranki Speleman

A1 Journal Article in GENES CHROMOSOMES & CANCER

Genetisch advies bij het familiaal voorkomen van borstkanker

Bruce PoppeI MEIREI DELVAUXKathleen ClaesL MESSIAENAnne De Paepe

A4 Journal Article in Guneikeïa

Molecular characterization of a t(2;3)(p23;q26): A recurrent translocation involving the EVI1 gene

Bruce PoppeNurten YigitP MARYNENA HAGEMEIJERH VAN LIMBERGENB DE SMETAnne De PaepeFranki Speleman

Molecular cytogenetic and clinical findings in ETV6/ABL1-positive leukemia.

Heidi Van LimbergenHB BEVERLOOE VAN DRUNENAnn JanssensK HAHLENBruce PoppeNadine Van RoyP MARYNENAnne De PaepeR SLATER et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

2000

Chromosome 2 short arm translocations revealed by M-FISH analysis of neuroblastoma cell lines.

Nadine Van RoyHeidi Van LimbergenJo VandesompeleMireille Van GeleBruce PoppeGenevieve LaureysAnne De PaepeFranki Speleman

A1 Journal Article in MEDICAL AND PEDIATRIC ONCOLOGY

Familiale borst- en/of ovariumkanker: diagnostisch en predictief genetisch onderzoek

Isabelle DelvauxM De VosBruce PoppeGeert MortierAnne De Paepe

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Genetica en kanker: perspectieven voor diagnose en behandeling.

Franki SpelemanBruce Poppe

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Identification and characterisation of a founder mutation in the Belgian breast/ovarian cancer population

Kathleen ClaesBruce PoppePETRA SCHEIRM De VosI DelveauxIlse CoeneAnne De PaepeLudwine Messiaen

Repetitive analyses of P-glycoprotein in chronic myeloid leukaemia

Barbara De MoerlooseA MuylaertF GemmelAnne JanssensBruce PoppeCatharina DhoogeWerner Van HoveJan Philippé

A1 Journal Article in ACTA CLINICA BELGICA

1999

A single step real-time quantitative RT-PCR reaction for detection of the BCR/ABL fusion product

H VAN LIMBERENL VAN DE LOCHTBruce PoppeAnne De PaepeFritz OffnerE MENSINKFranki Speleman

Chromosome 7 short arm deletions and disease progression in CML

Bruce PoppeH VAN LIMBERGENANN JANSSENSNadine Van RoyBarbara De MoerlooseJ PHILLIPEAnne De PaepeFritz OffnerFranki Speleman

Cytogenetic findings in bloom syndrome patients with myeloid malignancies

Bruce PoppeYves BenoitH VAN LIMBERGENNadine Van RoyEls VandecruysA JAUCHAnne De PaepeJ GERMANFranki Speleman

Genetic counselling and testing for hereditary breast and ovarian cancer: the gent(le) approach

M De VosBruce PoppeIsabelle DelvauxGeert MortierKathleen ClaesLudwine MessiaenAnne De Paepe

A1 Journal Article in DISEASE MARKERS

Identification of a novel CBFB/MYH11 fusion in a patient with AML-M1 and a t(16;16)(p13;q22)

H VAN LIMBERGENB VAN DER REIJDENBruce PoppeFritz OffnerNadine Van RoyH DAUWERSEAnne De PaepeFranki Speleman

Mutation analysis of the BRCA1 and BRCA2 genes in the Belgian patient population and identification of a Belgian founder mutation BRCA1 IVS5+3A > G

Kathleen ClaesE MachackovaMartine De VosBruce PoppeAnne De PaepeLudwine Messiaen

A1 Journal Article in DISEASE MARKERS

Unusual chromosome 16 rearrangement with absence of classical CBFB/MYH11 fusion transcripts

H VAN LIMBERGENBA VAN DER REIJDENBruce PoppeNadine Van RoyH DAUWERSEAnne De PaepeFranki Speleman