Research Explorer

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Researcher

Brecht De Paepe

Awards & Distinctions

52 Results

2025

Biological switches : past and future milestones of transcription factor-based biosensors

Brecht De PaepeMarjan De Mey

A1 Journal Article in ACS SYNTHETIC BIOLOGY

Expanding the toolbox of quorum sensing switches toward the creation of two-stage fermentation processes

Jasmine De BaetsMarjan De MeyBrecht De Paepe

Unravelling the regulatory network behind chitin degradation in Serratia marcescens

Wouter DemeesterBrecht De PaepeChiara GuidiMarjan De Mey

A1 Journal Article in BIOLOGICAL REVIEWS

2024

A cross-bacterial gene expression toolbox : engineering orthogonal transcription to enable predictable genetic engineering in diverse bacterial hosts

Cara DealDaniel Ariza CalvoBrecht De PaepeAntoni PlanasLien De WannemaekerMarjan De Mey

Delaying production with prokaryotic inducible expression systems

Jasmine De BaetsBrecht De PaepeMarjan De Mey

A1 Journal Article in MICROBIAL CELL FACTORIES

Domain swapping of LysR-type transcriptional regulators for the development of orthogonal biosensors

Wouter DemeesterBrecht De PaepeLuna DeclerckAntoni Sauter PlanasMarjan De Mey

Fundamentals and exceptions of the LysR-type transcriptional regulators

Wouter DemeesterBrecht De PaepeMarjan De Mey

A1 Journal Article in ACS SYNTHETIC BIOLOGY

Harnessing quorum sensing systems for complex genetic circuitry

Jasmine De BaetsIréne ParmentierBrecht De PaepeMarjan De Mey

Standardization and expansion of microbial cell sensors : harnessing the power of LysR-type transcriptional regulators

Wouter DemeesterMarjan De MeyBrecht De PaepeAntoni Planas

Standardized and computer-aided design-build-test-learn for custom biosensor development

Brecht De Paepe

Towards a universal, predictable and tuneable gene expression toolbox : strategies for engineering orthogonal transcription in bacteria

Cara DealDaniel Ariza CalvoBrecht De PaepeAntoni PlanasLien De WannemaekerMarjan De Mey

Unlocking the potential of quorum sensing systems for synthetic biology applications

Jasmine De BaetsIréne ParmentierBrecht De PaepeMarjan De Mey

2023

Computational design of new-to-nature biological sensors : unlocking the full potential of transcriptional regulation for custom biosensor development

Brecht De PaepeWouter DemeesterJasmine De BaetsDries DuchiMarjan De Mey

Engineering orthogonal transcription for the development of a cross-bacterial, orthogonal and tuneable gene expression toolbox

Cara DealLien De WannemaekerBrecht De PaepeAntoni PlanasMarjan De Mey

High-throughput in vivo screening of novel prokaryotic, metabolite-responsive transcription factors for biosensor development

Amber BernauwIndra BervoetsAndries PeetersBrecht De PaepeMarjan De MeyEveline Peeters

MoBioS : modular platform technology for high-throughput construction and characterization of tunable transcriptional biological sensors

Wouter DemeesterJasmine De BaetsDries DuchiMarjan De MeyBrecht De Paepe

A1 Journal Article in BIOSENSORS-BASEL

Promoter engineering to create quorum sensing-based genetic circuits

Jasmine De BaetsBrecht De PaepeMarjan De Mey

Unlocking transcription factor-based biosensors for industrial biotechnology

Wouter DemeesterBrecht De PaepeAntoni PlanasMarjan De Mey

2022

A cross-bacterial, orthogonal and tuneable gene expression toolbox for development of microbial cell factories in diverse bacterial hosts

Cara DealLien De WannemaekerBrecht De PaepeAntoni PlanasMarjan De Mey

Biosensor-driven, model-based optimization of the orthogonally expressed naringenin biosynthesis pathway

Maarten Van BremptAndries PeetersDries DuchiLien De WannemaekerJo MaertensBrecht De PaepeMarjan De Mey

A1 Journal Article in MICROBIAL CELL FACTORIES

Dynamic feedback regulation for efficient membrane protein production using a small RNA-based genetic circuit in Escherichia coli

Chiara GuidiLien De WannemaekerJasmine De BaetsWouter DemeesterJo MaertensBrecht De PaepeMarjan De Mey

A1 Journal Article in MICROBIAL CELL FACTORIES

Expanding the synthetic biology toolbox of Sulfolobus acidocaldarius, a thermoacidophilic Crenarchaeon

Andries PeetersPauline PijpstraDavid SybersBrecht De PaepeEveline PeetersMarjan De Mey

Filling the void : high-throughput development and characterization of transcription-factor based biosensors

Wouter DemeesterBrecht De PaepeAntoni PlanasMarjan De Mey

High-throughput development and characterization of transcription-factor based biosensors

Wouter DemeesterBrecht De PaepeAntoni PlanasMarjan De Mey

In vivo screening for the identification and characterization of prokaryotic, metabolite-responsive transcription factors

Amber BernauwIndra BervoetsAndries PeetersBrecht De PaepeMarjan De MeyEveline Peeters

New synthetic biology tools for the thermoacidophilic Archaeon Sulfolobus acidocaldarius

Andries PeetersPauline PijpstraDavid SybersBrecht De PaepeEveline PeetersMarjan De Mey

New-to-nature biological sensors : unlocking the full potential of biological sensors beyond nature

Brecht De Paepe

Quorum sensing-based genetic circuits for the automated delay of microbial production

Jasmine De BaetsBrecht De PaepeMarjan De Mey

Quorum sensing-based switches to bypass the growth-production trade-off in microbial cell factories

Jasmine De BaetsBrecht De PaepeMarjan De Mey

Scaffolding for product yield maximization of fine chemicals in microbial cell factories

Marte EliasBabette LamoteJulie VanderstraetenBrecht De PaepeMarjan De MeyYves Briers

Scaffolding for product yield maximization of fine chemicals in microbial cell factories

Marte EliasBabette LamoteJulie VanderstraetenBrecht De PaepeMarjan De MeyYves Briers

SynBio extreme : expanding the synthetic biology toolbox of Sulfolobus acidocaldarius, a thermoacidophilic Crenarchaeon

Andries PeetersPauline PijpstraDavid SybersBrecht De PaepeEveline PeetersMarjan De Mey

Unlocking the potential of non-model bacteria : a cross-bacterial gene expression toolbox

Cara DealLien De WannemaekerBrecht De PaepeAntoni PlanasMarjan De Mey

2021

Expanding the transcriptional toolbox of the Crenarchaeon Sulfolobus acidocaldarius

Andries PeetersPauline PijpstraDavid SybersBrecht De PaepeEveline PeetersMarjan De Mey

Tuning automated switches to uncouple growth and production in Escherichia coli

Jasmine De BaetsBrecht De PaepeMarjan De Mey

2020

Expanding the biosensor horizon

Wouter DemeesterBrecht De PaepeAntoni PlanasMarjan De Mey

2019

Chimeric LysR-type transcriptional biosensors for customizing ligand specificity profiles toward flavonoids

Brecht De PaepeJo MaertensBartel VanholmeMarjan De Mey

A1 Journal Article in ACS SYNTHETIC BIOLOGY

Development of microbial cell factories for the production of chito-oligosaccharides

David BauwensSofie SnoeckChiara GuidiDries DuchiBrecht De PaepeJo MaertensMarjan De Mey

2018

Development of N-acetylneuraminic acid responsive biosensors based on the transcriptional regulator NanR

Gert PetersBrecht De PaepeLien De WannemaekerDries DuchiJo MaertensJeroen LammertynMarjan De Mey

A1 Journal Article in BIOTECHNOLOGY AND BIOENGINEERING

Modularization and response curve engineering of a naringenin-responsive transcriptional biosensor

Brecht De PaepeJo MaertensBartel VanholmeMarjan De Mey

A1 Journal Article in ACS SYNTHETIC BIOLOGY

Standardization in synthetic biology : an engineering discipline coming of age

Thomas DecoeneBrecht De PaepeJo MaertensPieter CoussementGert PetersSofie De MaeseneireMarjan De Mey

A1 Journal Article in CRITICAL REVIEWS IN BIOTECHNOLOGY

Tailor-made transcriptional biosensors for optimising microbial production of specialised plant metabolites in Escherichia coli

Brecht De PaepeMarjan De MeyBartel Vanholme

Tailor-made transcriptional biosensors for optimizing microbial cell factories

Brecht De Paepe

2017

Microbial cell factories for the production of specialised plant metabolites

Frederik De BruynMaarten Van BremptBrecht De PaepeJo MaertensDavid BauwensPieter CoussementChin Giaw LimBradley Walter BiggsRyan PhilippeParayil Kumaran Ajikumar et al.

Tailor-made transcriptional biosensors for optimizing microbial cell factories

Brecht De PaepeJo MaertensBartel VanholmeMarjan De Mey

Tailor-made transcriptional biosensors for optimizing microbial cell factories

Brecht De PaepeGert PetersPieter CoussementJo MaertensMarjan De Mey

A1 Journal Article in JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

2016

Tailor-made transcriptional biosensors

Brecht De PaepeJo MaertensBartel VanholmeMarjan De Mey

2015

Development of an in vivo glucosylation platform by coupling production to growth: production of phenolic glucosides by a glycosyltransferase of Vitis vinifera

Frederik De BruynBrecht De PaepeJo MaertensJoeri BeauprezPieter De CockerStein MinckeChristian StevensMarjan De Mey

A1 Journal Article in BIOTECHNOLOGY AND BIOENGINEERING

2014

Biosensors and high throughput metabolic engineering for the production of specialized plant metabolites in E. coli

Brecht De PaepeBartel VanholmeMarjan De Mey

Creating a novel and versatile glycosylation platform in E. coli

Frederik De BruynBrecht De PaepeMaarten Van BremptPieter De CockerJo MaertensJoeri BeauprezWim SoetaertMarjan De Mey

Multivariate modular metabolic engineering for pathway and strain optimization

Bradley Walters BiggsBrecht De PaepeChristine Nicole S SantosMarjan De MeyParayil Kumaran Ajikumar

A1 Journal Article in CURRENT OPINION IN BIOTECHNOLOGY

2013

Building a glucosylation platform in E. coli through Metabolic Engineering

Frederik De BruynBrecht De PaepeJoeri BeauprezJo MaertensWim SoetaertMarjan De Mey