Research Explorer

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Researcher

Bjorn Vergauwen

Awards & Distinctions

32 Results

2016

Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF

Jan FélixEaazhisai KandiahSteven De MunckYehudi BlochGydo CP van ZundertKris PauwelsAnn DansercoerKatka NovanskaRandy J ReadAlexandre MJJ Bonvin et al.

A1 Journal Article in NATURE COMMUNICATIONS

2014

The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence

Yurong WenEster BehielsJan FélixJonathan ElegheertBjorn VergauwenBart DevreeseSavvas Savvides

A1 Journal Article in NUCLEIC ACIDS RESEARCH

2013

Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor

Jan FélixJonathan ElegheertIrina GutscheAlexander ShkumatovYurong WenNathalie BrackeErwin PannecouckeIsabel VandenbergheBart DevreeseDmitri Svergun et al.

A1 Journal Article in STRUCTURE

Molecular and structural basis of glutathione import in Gram-positive bacteria via GshT and the cystine ABC importer TcyBC of Streptococcus mutans

Bjorn VergauwenKenneth VerstraeteDilani B. SenadheeraAnn DansercoerDennis G. CvitkovitchEric GuedonSavvas Savvides

A1 Journal Article in MOLECULAR MICROBIOLOGY

Structural and biochemical characterization of an atypical short-chain dehydrogenase/reductase reveals an unusual cofactor preference

Géraldine BuysschaertKenneth VerstraeteSavvas SavvidesBjorn Vergauwen

A1 Journal Article in FEBS JOURNAL

2012

Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1

Jonathan ElegheertNathalie BrackePhilippe PouliotIrina GutscheAlexander V ShkumatovNicolas TarbouriechKenneth VerstraeteAnaïs BekaertWim P BurmeisterDmitri I Svergun et al.

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystallization of an atypical short-chain dehydrogenase from Vibrio vulnificus lacking the conserved catalytic tetrad

Géraldine BuysschaertKenneth VerstraeteSavvas SavvidesBjorn Vergauwen

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS

Glutathione biosynthesis in bacteria by bifunctional GshF is driven by a modular structure featuring a novel hybrid ATP-grasp fold

Jan StoutDirk De VosBjorn VergauwenSavvas Savvides

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

2011

Delineation of the Pasteurellaceae-specific GbpA-family of glutathione-binding proteins

Bjorn VergauwenRuben Van der MeerenAnn DansercoerSavvas Savvides

A1 Journal Article in BMC BIOCHEMISTRY

Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principles

Jonathan ElegheertAmbroise DesfossesAlexander V ShkumatovXiongwu WuNathalie BrackeKenneth VerstraeteKathleen Van CraenenbroeckBernard R BrooksDmitri I SvergunBjorn Vergauwen et al.

A1 Journal Article in STRUCTURE

Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex

Kenneth VerstraeteGonzalez VandriesscheMariska JanuarJonathan ElegheertAlexander V ShkumatovAmbroise DesfossesKathleen Van CraenenbroeckDmitri I SvergunIrina GutscheBjorn Vergauwen et al.

A1 Journal Article in BLOOD

2010

Glutathione import in Haemophilus influenzae Rd is primed by the periplasmic heme-binding protein HbpA

Bjorn VergauwenJonathan ElegheertAnn DansercoerBart DevreeseSavvas Savvides

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The 285 kDa Bap/RTX hybrid cell surface protein (SO4317) of Shewanella oneidensis MR-1 is a key mediator of biofilm formation

Sofie TheunissenLina De SmetAnn DansercoerBart MotteTom CoenyeJozef Van BeeumenBart DevreeseSavvas SavvidesBjorn Vergauwen

A1 Journal Article in RESEARCH IN MICROBIOLOGY

2009

A direct spectrophotometric gamma-glutamyltransferase inhibitor screening assay targeting the hydrolysis-only mode

Bjorn VergauwenLW DudyczAnn DansercoerBart Devreese

A1 Journal Article in Biochemical and Biophysical research communications

The agglutination protein AggA from Shewanella oneidensis MR-1 is a TolC-like protein and forms active channels in vitro

Sofie TheunissenBjorn VergauwenLina De SmetJozef Van BeeumenPatrick Van GelderSavvas Savvides

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

2008

Identification and initial characterization of the glutathione disulfide transporter of Haemophilus influenzae

Bjorn VergauwenAnn DansercoerBart Devreese

Structural insights into component SoxY of the thiosulfate-oxidizing multienzyme system of Chlorobaculum thiosulfatiphilum

Jan StoutLina De SmetBjorn VergauwenSavvas SavvidesJozef Van Beeumen

Towards a better understanding of extracellular cytokine receptor biology: the initial characterization of a lectin/R complex

Bert RemmerieKoenraad VerstraeteJonathan ElegheertBjorn VergauwenSavvas Savvides

2007

A beta-galactosidase-based bacterial two-hybrid system to assess protein-protein interactions in the correct cellular environment

Jimmy BorlooLina De SmetBjorn VergauwenJozef Van BeeumenBart Devreese

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

A kinetic approach to the dependence of dissimilatory metal reduction by Shewanella oneidensis MR-1 on the outer membrane cytochromes c OmcA and OmcB

Jimmy BorlooBjorn VergauwenLina De SmetAnn BrigeBart MotteBart DevreeseJozef Van Beeumen

A1 Journal Article in FEBS JOURNAL

Structural investigation of cold activity and regulation of aspartate carbamoyltransferase from the extreme psychrophilic bacterium Moritella profunda

D DE VOSX XUPaco HulpiauBjorn VergauwenJozef Van Beeumen

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Understanding nicotinamide dinucleotide cofactor and substrate specificity in class I flavoprotein disulfide oxidoreductases: Crystallographic analysis of a glutathione amide reductase

Filip Van PetegemDirk De VosSavvas SavvidesBjorn VergauwenJ VAN BEELUMEN

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

2006

Characterization of the bifunctional gamma-glutamate-cysteine ligase/glutathione synthetase (GshF) of Pasteurella multocida

Bjorn VergauwenD DE VOSJozef Van Beeumen

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrogen peroxide scavenging is not a virulence determinant in the pathogenesis of Haemophilus influenzae type b strain Eagan

Bjorn VergauwenM HERBERTJozef Van Beeumen

A1 Journal Article in BMC MICROBIOLOGY

2005

Expression, purification, crystallization and preliminary X-ray crystallographic studies of a cold-adapted aspartate carbamoyltransferase from Moritella profunda

Dirk De VosPaco HulpiauBjorn VergauwenSavvas SavvidesJozef Van Beeumen

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS

2004

Physiological characterization of Haemophilus influenzae Rd deficient in its glutathione-dependent peroxidase PGdx

Frederik PauwelsBjorn VergauwenJozef Van Beeumen

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2003

Exogenous glutathione completes the defense against oxidative stress in Haemophilus influenzae

Bjorn VergauwenFrederik PauwelsMario VaneechoutteJozef Van Beeumen

A1 Journal Article in JOURNAL OF BACTERIOLOGY

Glutathione and catalase provide overlapping defenses for protection against respiration-generated hydrogen peroxide in Haemophilus influenzae

Bjorn VergauwenFrederik PauwelsJozef Van Beeumen

A1 Journal Article in JOURNAL OF BACTERIOLOGY

Purification and characterization of a chimeric enzyme from Haemophilus influenzae Rd that exhibits glutathione-dependent peroxidase activity

Frederik PauwelsBjorn VergauwenFrank VanrobaeysBart DevreeseJozef Van Beeumen

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2002

Crystallization and preliminary X-ray crystallographic analysis of glutathione amide reductase from Chromatium gracile.

Bjorn VergauwenFilip Van PetegemHan RemautFrederik PauwelsJozef Van Beeumen

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

2001

Characterization of glutathione amide reductase from Chromatium gracile - Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide redox cycling.

Bjorn VergauwenF PAUWELSF JACQUEMOTTETE MEYERMK CUSANOVICHRG BARTSCHJozef Van Beeumen

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1999

Characterization of a glutathione amide reductase from the purple phototrophic bacterium Chromatium gracile, its altered substrate specificity and involvement in detoxification of oxygen.

Bjorn VergauwenYves GuisezRG BARTSCHTE MEYERMA CUSANOVICHJozef Van Beeumen