Research Explorer

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Researcher

Bieke Bekaert

Publications & Research Data

Awards & Distinctions

15 Results

2023

CRISPR/Cas9-based correction of infertility-related mutations in the germline : ready or not?

Bieke BekaertBjörn HeindryckxAnnekatrien BoelBjörn Menten

Retained chromosomal integrity following CRISPR-Cas9-based mutational correction in human embryos

Bieke BekaertAnnekatrien BoelLisa De WitteWinter VandenbergheMina PopovicPanagiotis StamatiadisGwenny CosemansLise TordeursAthina-Maria De LooreSusana Marina Chuva de Sousa Lopes et al.

A1 Journal Article in MOLECULAR THERAPY

2022

CRISPR/Cas gene editing in the human germline

Bieke BekaertAnnekatrien BoelGwenny CosemansLisa De WitteBjörn MentenBjörn Heindryckx

A1 Journal Article in SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Distinct genetic impact of CRISPR/Cas9 gene correction in human embryos compared to induced pluripotent stem cells

Bieke BekaertAnnekatrien BoelLisa De WitteGwenny CosemansLise TordeursAthina-Maria De LooreSusana Marina Chuva de Sousa LopesPetra De SutterDominic StoopPaul Coucke et al.

Evaluation of CRISPR/Cas9-induced DNA break repair outcomes in mouse and human embryos

Bieke BekaertAnnekatrien BoelLisa De WitteGwenny CosemansSusana Marina Chuva de Sousa LopesBjörn MentenBjörn Heindryckx

Human germline nuclear transfer to overcome mitochondrial disease and failed fertilization after ICSI

Maoxing TangAnnekatrien BoelNoemi CastelluccioArantxa Cardona BarberánAntonia ChristodoulakiBieke BekaertMina PopovicFrauke Vanden MeerschautPetra De SutterBjörn Menten et al.

A1 Journal Article in JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

2021

Comparative analysis of mouse and human preimplantation development following POU5F1 CRISPR/Cas9 targeting reveals interspecies differences

Panagiotis StamatiadisAnnekatrien BoelGwenny CosemansMina PopovicBieke BekaertRamesh Reddy GuggillaMaoxing TangPetra De SutterFilip Van NieuwerburghBjörn Menten et al.

A1 Journal Article in HUMAN REPRODUCTION

Correcting a PLCζ mutation in the human germ line to overcome hereditary infertility

Bieke BekaertAnnekatrien BoelMina PopovicPanagiotis StamatiadisS M Chuva de Sousa LopesPetra De SutterBjörn MentenDominic StoopPaul CouckeBjörn Heindryckx

Engineering microvasculature by 3D bioprinting of prevascularized spheroids in photo-crosslinkable gelatin

Lise De MoorJasper SmetMagaly PlovytBieke BekaertChris VercruysseMahtab AsadianNathalie De GeyterSandra Van VlierberghePeter DubruelHeidi Declercq

A1 Journal Article in BIOFABRICATION

2020

A proof-of-concept study to investigate DNA repair mechanisms in the human embryo after the application of CRISPR/Cas9 gene editing in the germ line

Bieke BekaertAnnekatrien BoelLisa De WitteMina PopovicRamesh Reddy GuggillaSwati MishraGwenny CosemansLise TordeursSusana Marina Chuva de Sousa LopesPetra De Sutter et al.

Correcting a PLCζ mutation in the human germ line to overcome hereditary infertility

Bieke BekaertAnnekatrien BoelMina PopovicPanagiotis StamatiadisSusana Marina Chuva de Sousa LopesPetra De SutterPaul CouckeBjörn Heindryckx

Correcting PLCζ mutation in the germ line to overcome transmission of hereditary infertility in mice

Bieke BekaertAnnekatrien BoelVanessa ThysPanagiotis StamatiadisSusana Marina Chuva de Sousa LopesPetra De SutterJohn ParringtonBjörn MentenDominic StoopPaul Coucke et al.

Germline nuclear transfer to overcome mitochondrial disease and female infertility

Maoxing TangAnnekatrien BoelRamesh Reddy GuggillaBieke BekaertPetra De SutterBjörn MentenFrauke Vanden MeerschautDominic StoopPaul CouckeBjörn Heindryckx

2019

Genome editing by CRISPR-Cas9 reveals that pre-implantation development in the mouse is compromised in Pou5f1-null embryos

Panagiotis StamatiadisAnnekatrien BoelMargot Van der JeughtBieke BekaertRamesh Reddy GuggillaMaoxing TangPetra De SutterPaul CouckeBjörn Heindryckx

2018

Generation and bioprinting of prevascularized spheroids using a photo-crosslinkable gelatin

Lise De MoorIdriz MerovciSarah BaetensBieke BekaertJulien VerstraetenPaulina KowalskaSandra Van VlierberghePeter DubruelDmitri KryskoWinnok De Vos et al.