Research Explorer

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Researcher

Béatrice Lintermans

Publications & Research Data

Awards & Distinctions

45 Results

2025

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Nele VandenbusscheRenske ImschootBéatrice LintermansLode DenolfJoachim TaminauCharlotte FieuwsGeert BerxKris GevaertKathleen Claes

A1 Journal Article in MOLECULAR ONCOLOGY

Profiling histone post-translational modifications to identify signatures of epigenetic drug response in T-cell acute lymphoblastic leukemia

Laura CorveleynLien ProvezOsman SatilmisNina RefhagenMattias LandforsWouter SleeckxBéatrice LintermansAmélie De MaesschalckRishi S. KotechaBarbara De Moerloose et al.

2024

A dual role for PSIP1/LEDGF in T cell acute lymphoblastic leukemia

Lisa DemoenFilip MatthijssensLindy ReunesBruno PalhaisBéatrice LintermansSara T'SasIgor FijalkowskiJoachim TaminauMuluembet Z. AkeleSiska Van Belle et al.

A1 Journal Article in SCIENCE ADVANCES

Advances in CRISPR-mediated knock-in of disease- and cancer-related variants in zebrafish

Elyne De NeefMichiel VanhooydonckHanna De SaffelBéatrice LintermansAndy WillaertBert CallewaertAnne VralKathleen Claes

Advances in CRISPR-mediated knock-in of disease-related variants in zebrafish

Elyne De NeefMichiel VanhooydonckHanna De SaffelBéatrice LintermansAndy WillaertBert CallewaertAnne VralKathleen Claes

Myb overexpression synergizes with the loss of Pten and is a dependency factor and therapeutic target in T-cell lymphoblastic leukemia

André Pedro Pinto De AlmeidaSara T'SasLuca PagliaroIgor FijalkowskiWouter SleeckxHannah Van SteenbergeRaffaella ZamponiBéatrice LintermansWouter Van LoockeBruno Palhais et al.

A1 Journal Article in HEMASPHERE

Prime editing outperforms optimized homology-directed repair as a tool for knock-in generation in zebrafish

Elyne De NeefMichiel VanhooydonckKathleen ClaesBert CallewaertHanna De SaffelBéatrice LintermansAndy WillaertAnne Vral

Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma

Stien De ConinckRenate De SmedtBéatrice LintermansLindy ReunesHansen J. KosasihAlexandra ReekmansLauren M. BrownNadine Van RoyBruno PalhaisJuliette Roels et al.

A1 Journal Article in HAEMATOLOGICA

Tet2 is a tumor suppressor in the pre-leukemic phase of T-cell acute lymphoblastic leukemia

Stien De ConinckJuliette RoelsBéatrice LintermansSara T'SasTom TaghonDavid CurtisTim PietersSteven GoossensPieter Van Vlierberghe

A1 Journal Article in BLOOD ADVANCES

Towards improved Parsortix® efficiency for circulating tumor cell enrichment in pancreatic cancer

Nele VandenbusscheBéatrice LintermansTijs MerckaertCharlotte FieuwsKris GevaertKathleen Claes

2023

Pre-clinical evaluation of the hypomethylating agent decitabine for the treatment of T-cell lymphoblastic lymphoma

Lien ProvezTom PuttemanMattias LandforsJuliette RoelsLindy ReunesSara T'SasWouter Van LoockeBéatrice LintermansStien De ConinckMorgan Thenoz et al.

A1 Journal Article in CANCERS

2022

PDGFR-β as a new therapeutic target in T-cell acute lymphoblastic leukemia

Stien De ConinckRenate De SmedtBéatrice LintermansSteven GoossensPieter Van Vlierberghe

The role of TET2 in (pre-) leukemic T-ALL : TET2 to the rescue?

Stien De ConinckJuliette RoelsMorgan ThénozBéatrice LintermansSteven GoossensPieter Van Vlierberghe

2021

Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice

Tim PietersSara T'SasStijn VanheeAndré Pedro Pinto De AlmeidaYasmine DriegeJuliette RoelsWouter Van LoockeWillem DaneelsMathijs BaensArnaud Marchand et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia

Filip MatthijssensNitesh D. SharmaMonique NysusChristian K. NicklHuining KangDominique R. PerezBéatrice LintermansWouter Van LoockeJuliette RoelsSofie Peirs et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

The spleen as a sanctuary site for residual leukemic cells following ABT-199 monotherapy in ETP-ALL

Alessandra Di GrandeSofie PeirsPaul D. DonovanMaaike Van TrimpontJulie MorscioBéatrice LintermansLindy ReunesNiels VandammeSteven GoossensHien Anh Nguyen et al.

A1 Journal Article in BLOOD ADVANCES

2020

Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma

Renate De SmedtJulie MorscioLindy ReunesJuliette RoelsValentina BardelliBéatrice LintermansWouter Van LoockeAfonso AlmeidaLaurence C. CheungRishi S. Kotecha et al.

A1 Journal Article in BLOOD

The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1

Catherine L. CarmichaelJueqiong WangThao NguyenOluseyi KolawoleAissa BenyoucefCharlotte De MazièreAnna MilneSona SamuelKevin Robert GillinderSoroor Hediyeh-zadeh et al.

A1 Journal Article in BLOOD

2019

Genetic characterization and therapeutic targeting of MYC-rearranged T cell acute lymphoblastic leukaemia

Gloria MilaniFilip MatthijssensWouter Van LoockeKaat DurinckJuliette RoelsSofie PeirsMorgan ThénozTim PietersLindy ReunesBéatrice Lintermans et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies

Tim PietersSara T'SasLisa DemoenAndré Pedro Pinto De AlmeidaLieven HaenebalckeFilip MatthijssensKelly LemeireJinke D'HontFrédérique VanrockeghemTino Hochepied et al.

A1 Journal Article in SCIENTIFIC REPORTS

2018

Pre-clinical evaluation of second generation PIM inhibitors for the treatment of T-cell acute lymphoblastic leukemia and lymphoma

Renate De SmedtSofie PeirsJulie MorscioFilip MatthijssensJuliette RoelsLindy ReunesBéatrice LintermansSteven GoossensTim LammensNadine Van Roy et al.

A1 Journal Article in HAEMATOLOGICA

2017

Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia

Sofie PeirsV FrismantasFilip MatthijssensW Van LoockeTim PietersNiels VandammeBéatrice LintermansMP DobayGeert BerxBruce Poppe et al.

A1 Journal Article in LEUKEMIA

2016

Characterization of the interaction between the dopamine D4 receptor, KLHL12 and β-arrestins

Kamila SkieterskaAo ShenDorien ClarissePieter RondouDasiel Oscar Borroto-EscuelaBéatrice LintermansKjell FuxeYang Kevin XiangKathleen Van Craenenbroeck

A1 Journal Article in CELLULAR SIGNALLING

Fast generation of conditional ROSA26-based mouse models that recapitulate genomic events in human T-ALL

Tim PietersSteven GoossensSara T'SasLieven HaenebalckeTino HochepiedBéatrice LintermansSofie PeirsFilip MatthijssensJ HaighGeert Berx et al.

Genetic characterization and therapeutic targeting of MYC translocated pediatric T-cell acute lymphoblastic leukemia

Gloria MilaniKaat DurinckFilip MatthijssensSofie PeirsTim PietersLindy ReunesBéatrice LintermansNiels VandammeTim LammensYunlei Li et al.

Targeting BET family proteins improves the efficacy of ABT-199 in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensBéatrice LintermansTim PietersNiels VandammeGeert BerxBruce PoppePieter Van Vlierberghe

Targeting BET family proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia

Sofie PeirsViktoras FrismantasFilip MatthijssensBéatrice LintermansTim PietersNiels VandammeWouter Van LoockeGeert BerxBruce PoppeJean-Pierre Bourquin et al.

The combination of ABT-199 and JQ1 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensTim PietersNiels VandammeBéatrice LintermansLindy ReunesGeert BerxBruce PoppePieter Van Vlierberghe

2015

KLHL12 promotes non-lysine ubiquitination of the dopamine receptors D-4.2 and D-4.4, but not of the ADHD-associated D-4.7 variant

Kamila SkieterskaPieter RondouBéatrice LintermansKathleen Van Craenenbroeck

A1 Journal Article in PLOS ONE

2014

Non-degradative and non-lysine mediated ubiquitination of the dopamine D4 receptor

Kamila SkieterskaPieter RondouBéatrice LintermansKathleen Van Craenenbroeck

2013

Role of non-degradative ubiquitination of the dopamine D4 receptor

Kamila SkieterskaPieter RondouDasiel O Borroto-EscuelaBéatrice LintermansKjell FuxeKathleen Van Craenenbroeck

2012

Biochemical and pharmacological study of N-linked glycosylation of the human serotonin 5-HT7(a) receptor

Evelien GellynckKjetil W AndressenBéatrice LintermansGuy HaegemanFinn O LevyPeter VanhoenackerKathleen Van Craenenbroeck

A1 Journal Article in FEBS JOURNAL

Functional relevance of the KLHL12-mediated D4 dopamine receptor ubiquitination

Kamila SkieterskaPieter RondouDasiel Oscar Borroto-EscuelaDorien ClarisseBéatrice LintermansGuy HaegemanKjell FuxeKathleen Van Craenenbroeck

On the track of function of KLHL12-mediated dopamine D4 receptor ubiquitination

Kamila SkieterskaPieter RondouDasiel Oscar Borroto-EscuelaDorien ClarisseBéatrice LintermansGuy HaegemanKjell FuxeKathleen Van Craenenbroeck

On the track of function of KLHL12-mediated dopamine D4 receptor ubiquitination

Kamila SkieterskaPieter RondouDasiel Oscar Borroto-EscuelaDorien ClarisseBéatrice LintermansGuy HaegemanKjell FuxeKathleen Van Craenenbroeck

RhoBTB3 interacts with the 5-HT7a receptor and inhibits its proteasomal degradation

Anne MatthysKathleen Van CraenenbroeckBéatrice LintermansGuy HaegemanPeter Van Hoenacker

A1 Journal Article in CELLULAR SIGNALLING

2011

Dopamine D-4 receptor oligomerization: contribution to receptor biogenesis

Kathleen Van CraenenbroeckDasiel O Borroto-EscuelaWilber Romero-FernandezKamila SkieterskaPieter RondouBéatrice LintermansPeter VanhoenackerKjell FuxeFrancisco CiruelaGuy Haegeman

A1 Journal Article in FEBS JOURNAL

Inducible production of recombinant human Flt3 ectodomain variants in mammalian cells and preliminary crystallographic analysis of Flt3 ligand-receptor complexes

Kenneth VerstraeteBert RemmerieJonathan ElegheertBéatrice LintermansGuy HaegemanPeter VanhoenackerKathleen Van CraenenbroeckSavvas Savvides

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS

2010

Cooperation of NF kappa B and CREB to induce synergistic IL-6 expression in astrocytes

Anneleen SpoorenRon KooijmanBéatrice LintermansKathleen Van CraenenbroeckLinda VermeulenGuy HaegemanSarah Gerlo

A1 Journal Article in CELLULAR SIGNALLING

KLHL12-mediated ubiquitination of the dopamine D4 receptor does not target the receptor for degradation

Pieter RondouKamila SkieterskaAnn PackeuBéatrice LintermansPeter VanhoenackerGeorges VauquelinGuy HaegemanKathleen Van Craenenbroeck

A1 Journal Article in CELLULAR SIGNALLING

Resistance of the dopamine D4 receptor to agonist-induced internalization and degradation

Anneleen SpoorenPieter RondouKatarzyna DebowskaBéatrice LintermansLinda VermeulenBart SamynKamila SkieterskaGriet DebyserBart DevreesePeter Vanhoenacker et al.

A1 Journal Article in CELLULAR SIGNALLING

2009

The astrocytic β2-adrenergic receptor : a novel target for treatment of neuro-inflammation?

Sarah GerloAnneleen SpoorenRon KooijmanBéatrice LintermansKathleen Van CraenenbroeckGuy Haegeman

2008

Cloning, genomic organization and functionality of 5-HT7 receptor splice variants from mouse brain

Evelien GellynckKoen LAENENKW ANDRESSENBéatrice LintermansKim De MartelaereAnne MatthysFO LEVYGuy HaegemanPeter VanhoenackerKathleen Van Craenenbroeck

A1 Journal Article in GENE

2007

Novel interaction between the human 5-HT7 receptor isoforms and PLAC-24/eIF3k

Kim De MartelaereBéatrice LintermansGuy HaegemanPeter Vanhoenacker

A1 Journal Article in CELLULAR SIGNALLING

2006

Influence of the antipsychotic drug pipamperone on the expression of the dopamine D4 receptor

Kathleen Van CraenenbroeckEvelien GellynckBéatrice LintermansJE LEYSENHHM VAN TOLGuy HaegemanPeter Vanhoenacker

A1 Journal Article in LIFE SCIENCES