Research Explorer

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Researcher

Bart Braeckman

Awards & Distinctions

133 Results

2025

The Proprotein Convertase <scp>BLI</scp>‐4 Is Required for Axenic Dietary Restriction Mediated Longevity in <scp><i>Caenorhabditis elegans</i></scp>

Ping WuLieselot VandemeulebrouckeHuaihan CaiBart Braeckman

U Journal Article in Aging Cell

2024

Multi-omics analysis of longevity and age-associated changes in axenically cultured Caenorhabditis elegans

Ping WuBart Braeckman

The effect of axenic dietary restriction on the age-related changes in Caenorhabditis elegans

Ping WuLieselot VandemeulebrouckeMyriam ClaeysWim BertBart Braeckman

A1 Journal Article in JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

2023

Adult-restricted gene knock-down reveals candidates that affect locomotive healthspan in C. elegans

Areta JushajMatthew ChurginMiguel De La TorreAmanda KieswetterBrecht DriesschaertIneke DhondtBart BraeckmanChristopher Fang-YenLiesbet Temmerman

A1 Journal Article in BIOGERONTOLOGY

Functional analysis of globin 3 in Caenorhabditis elegans

Tim LoierBart BraeckmanIneke Dhondt

GLB-3 : a resilient, cysteine-rich, membrane-tethered globin expressed in the reproductive and nervous system of Caenorhabditis elegans

Zainab HafideddineTim LoierNiels Van BremptSasha De HenauH.Y. Vincent ChingSander NeukermansSaskia DefosséHerald BerghmansRoberta SgammatoRoy Aerts et al.

A1 Journal Article in JOURNAL OF INORGANIC BIOCHEMISTRY

Reverse genetic screening during L1 arrest reveals a role of the diacylglycerol kinase 1 gene dgk-1 and sphingolipid metabolism genes in sleep regulation

Anastasios KoutsoumparisInka BusackChung-Kuan ChenYu HayashiBart BraeckmanDavid MeierhoferHenrik Bringmann

A1 Journal Article in GENETICS

2022

Accumulation of glycogen and upregulation of LEA-1 in C. elegans daf-2(e1370) support stress resistance, not longevity

Aleksandra ZečićIneke DhondtBart Braeckman

A1 Journal Article in CELLS

Amplicon_sorter : a tool for reference‐free amplicon sorting based on sequence similarity and for building consensus sequences

Andy VierstraeteBart Braeckman

A1 Journal Article in ECOLOGY AND EVOLUTION

Axenic culture of Caenorhabditis elegans alters lysosomal/proteasomal balance and increases neuropeptide expression

Huaihan CaiPing WuLieselot VandemeulebrouckeIneke DhondtMadina RasulovaAndy VierstraeteBart Braeckman

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study

Nadine SaulIneke DhondtMikko KuokkanenMarkus PerolaClara VerschuurenBrecht WoutersHenrik von ChrzanowskiWinnok H. De VosLiesbet TemmermanWalter Luyten et al.

A1 Journal Article in BIOGERONTOLOGY

Regulation of lifespan and healthspan in axenically cultured Caenorhabditis elegans

Lieselot VandemeulebrouckeBart Braeckman

The bacterial quorum sensing peptide iAM373 is a novel inducer of sarcopenia

Anton De SpiegeleerEvelien WynendaeleAmélie DescampsNathan DebunneBart BraeckmanMarjan De MeyJulie CoudenysLiesbeth CrombezFrederick VerbekeYorick Janssens et al.

A1 Journal Article in CLINICAL AND TRANSLATIONAL MEDICINE

2021

Elevated trehalose levels in C. elegans daf-2 mutants increase stress resistance, not lifespan

Madina RasulovaAleksandra ZečićJose Manuel Monje MorenoLieselot VandemeulebrouckeIneke DhondtBart Braeckman

A1 Journal Article in METABOLITES

Prediction of biological age by morphological staging of sarcopenia in Caenorhabditis elegans

Ineke DhondtClara VerschuurenAleksandra ZečićTim LoierBart BraeckmanWinnok H. De Vos

A1 Journal Article in DISEASE MODELS & MECHANISMS

Protein pile-up plays havoc in ageing nematode worms

Editorial material

Role of coelomocytes and immunity in axenic dietary restriction

Lucas MerganBrecht DriesschaertElisabeth DensElke VandewyerLouis CoussementGerben MenschaertBart BraeckmanLiesbet Temmerman

The role of the C. elegans daf-2(e1370) metabolic shift in longevity and stress resistance

Aleksandra ZečićBart BraeckmanGeert Depuydt

2020

DAF-16/FoxO in Caenorhabditis elegans and its role in metabolic remodeling

Aleksandra ZečićBart Braeckman

A1 Journal Article in CELLS

Phenotypic screening in C. elegansas as a tool for the discovery of new geroprotective drugs

Sven BulterijsBart Braeckman

A1 Journal Article in PHARMACEUTICALS

2019

A multi-parent recombinant inbred line population of C. elegans allows identification of novel QTLs for complex life history traits

Basten L SnoekRita JM VolkersHarm NijveenCarola PetersenPhilipp DirksenMark G SterkenRania NakadJoost AG RiksenPhilip RosenstielJana J Stastna et al.

A1 Journal Article in BMC BIOLOGY

CBP-1 acts in GABAergic neurons to double life span in axenically cultured Caenorhabditis elegans

Huaihan CaiIneke DhondtLieselot VandemeulebrouckeCaroline VlaeminckMadina RasulovaBart Braeckman

A1 Journal Article in JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Near-infrared fluorescence guided esophageal reconstructive surgery : a systematic review

Elke Van DaeleYves Van NieuwenhoveWim CeelenChristian VanhoveBart BraeckmanAnne HoorensJurgen van LimmenOswald VarinDirk Van de PutteWouter Willaert et al.

A1 Journal Article in WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY

The nutritional requirements of Caenorhabditis elegans

Aleksandra ZečićIneke DhondtBart Braeckman

A1 Journal Article in GENES AND NUTRITION

2018

Ancient origin of the CARD-coiled coil/Bcl10/MALT1-like paracaspase signaling complex indicates unknown critical functions

Jens StaalYasmine DriegeMira HaegmanAlice BorghiPaco HulpiauLaurens LievensIsmail Sahin GülSrividhya Sundararaman IyerAmanda GonçalvesIneke Dhondt et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Assessment of graft perfusion and oxygenation for improved outcome in esophageal cancer surgery : protocol for a single-center prospective observational study

Elke Van DaeleYves Van NieuwenhoveWim CeelenChristian VanhoveBart BraeckmanAnne HoorensJurgen van LimmenOswald VarinDirk Van de PutteWouter Willaert et al.

A1 Journal Article in MEDICINE

Bioassay-guided isolation of three anthelmintic compounds from Warburgia ugandensis Sprague subspecies ugandensis, and the mechanism of action of polygodial

Maoxuan LiuPurity KipangaAnh Hung MaiIneke DhondtBart BraeckmanWim De BorggraeveWalter Luyten

A1 Journal Article in INTERNATIONAL JOURNAL FOR PARASITOLOGY

Laser-induced remote release in vivo in C. elegans from novel silver nanoparticles-alginate hydrogel shells

Ekaterina LengertBogdan ParakhonskiyDmitry KhalenkowAleksandra ZečićMatthew VangheelJose Manuel Monje MorenoBart BraeckmanAndre Skirtach

A1 Journal Article in NANOSCALE

Multiple molecular mechanisms rescue mtDNA disease in C. elegans

Suraiya HaroonAnnie LiJaye L WeinertClark FritschNolan G EricsonJasmine Alexander-FloydBart BraeckmanCole M HaynesJason H BielasTali Gidalevitz et al.

A1 Journal Article in CELL REPORTS

2017

Changes of protein turnover in aging Caenorhabditis elegans

Ineke DhondtVladislav A PetyukSophie BauerHeather M BrewerRichard D SmithGeert DepuydtBart Braeckman

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Exploring superlongevity in the nematode Caenorhabditis elegans and the role of trehalose in its lifespan determination

Madina RasulovaBart Braeckman

Life-span extension by axenic dietary restriction is independent of the mitochondrial unfolded protein response and mitohormesis in Caenorhabditis elegans

Huaihan CaiMadina RasulovaLieselot VandemeulebrouckeLea Marie MeagherCaroline VlaeminckIneke DhondtBart Braeckman

A1 Journal Article in JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Lifespan extension in Caenorhabditis elegans insulin/IGF-1 signalling mutants is supported by non-vertebrate physiological traits

Bart BraeckmanIneke Dhondt

A1 Journal Article in NEMATOLOGY

Oxidative stress

Bart BraeckmanPatricia BackFilip Matthijssens

Bookchapter in Ageing : lessons from C. elegans

Physiological analysis of two members in the Caenorhabditis elegans globin family

Matthew VangheelBart Braeckman

Single swim sessions in C. elegans induce key features of mammalian exercise

Ricardo LaranjeiroGirish HarinathDaniel BurkeBart BraeckmanMonica Driscoll

A1 Journal Article in BMC BIOLOGY

THADA regulates the organismal balance between energy storage and heat production

Alexandra MoraruGulcin Cakan-AkdoganKatrin StrassburgerMatilda MalesSandra MuellerMarkus JabsMichael MuellederMartin FrejnoBart BraeckmanMarkus Ralser et al.

A1 Journal Article in DEVELOPMENTAL CELL

2016

Ageing with elegans: a research proposal to map healthspan pathways

Walter LuytenPeter AntalBart BraeckmanJake BundyFrancesca CirulliChristopher Fang-YenGeorg FuellenArmand LeroiQingfei LiuPatricia Martorell et al.

A1 Journal Article in BIOGERONTOLOGY

FOXO/DAF-16 activation slows down turnover of the majority of proteins in C. elegans

Ineke DhondtVladislav A PetyukHuaihan CaiLieselot VandemeulebrouckeAndy VierstraeteRichard D SmithGeert DepuydtBart Braeckman

A1 Journal Article in CELL REPORTS

Genetic and transcriptomic analysis of axenic longevity in Caenorhabditis elegans

Huaihan CaiBart Braeckman

Globin-based redox signaling

Sasha De HenauBart Braeckman

A2 Journal Article in WORM

In vivo detection of reactive oxygen species and redox status in Caenorhabditis elegans

Bart BraeckmanArne SmoldersPatricia BackSasha De Henau

A1 Journal Article in ANTIOXIDANTS & REDOX SIGNALING

Increased protein stability and decreased protein turnover in the Caenorhabditis elegans Ins/IGF-1 daf-2 mutant

Geert DepuydtNilesh ShanmugamMadina RasulovaIneke DhondtBart Braeckman

A1 Journal Article in JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Life history trade-offs imposed by dragline use in two money spiders

Dries BonteLieselot VerduynBart Braeckman

A1 Journal Article in JOURNAL OF EXPERIMENTAL BIOLOGY

Proteome-wide changes in protein turnover rates in C. elegans models of longevity and age-related disease

Marieke VisscherSasha De HenauMattheus HE WildschutRobert M van EsIneke DhondtHelen MichelsPatrick KemmerenEllen A NollenBart BraeckmanBoudewijn MT Burgering et al.

A1 Journal Article in CELL REPORTS

Unbiased RNA shotgun metagenomics in social and solitary wild bees detects associations with eukaryote parasites and new viruses

Karel SchoonvaereLina De SmetGuy SmaggheAndy VierstraeteBart BraeckmanDirk de Graaf

A1 Journal Article in PLOS ONE

2015

A globin domain in a neuronal transmembrane receptor of Caenorhabditis elegans and Ascaris suum: molecular modeling and functional properties

Lesley TillemanFrancesca GermaniSasha De HenauSigne HelboFilip DesmetHerald BerghmansSabine Van DoorslaerDavid HoogewijsLiliane SchoofsBart Braeckman et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

A redox signalling globin is essential for reproduction in Caenorhabditis elegans

Sasha De HenauLesley TillemanMatthew VangheelEvi LuyckxStanislav TrashinMartje PauwelsFrancesca GermaniCaroline VlaeminckJacques VanfleterenWim Bert et al.

A1 Journal Article in NATURE COMMUNICATIONS

Comparative metabolomic profiling reveals that dysregulated glycolysis stemming from lack of salvage NAD⁺ biosynthesis impairs reproductive development in Caenorhabditis elegans

Wenqing WangMelanie R McReynoldsJimmy F GoncalvesMuya ShuIneke DhondtBart BraeckmanStephanie E LangeKelvin KhoAriana C DetwilerMarisa J Pacella et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Intraspecific functional trait variability does not result in higher fitness under thermal stress in a free-living marine nematode

Lara MacheriotouBart BraeckmanAnnelien RigauxNele De MeesterTom MoensSofie Derycke

A1 Journal Article in JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY

Iron-starvation-induced mitophagy mediates lifespan extension upon mitochondrial stress in C. elegans

Alfonso SchiaviSilvia MaglioniKonstantinos PalikarasAnjumara ShaikFlavie StrappazzonVanessa BrinkmannAlessandro TorgovnickNatascha CasteleinSasha De HenauBart Braeckman et al.

A1 Journal Article in CURRENT BIOLOGY

Metabolic profiling of a transgenic Caenorhabditis elegans Alzheimer model

Roel Van AsscheLiesbet TemmermanDaniel A DiasBerin BoughtonKurt BoonenBart BraeckmanLiliane SchoofsUte Roessner

A1 Journal Article in METABOLOMICS

Patterns of protein turnover in aging Caenorhabditis elegans

Ineke DhondtBart BraeckmanGeert Depuydt

2014

Functional analysis of the Caenorhabditis elegans globin family

Sasha De HenauBart Braeckman

Germline quality control: eEF2K stands guard to eliminate defective oocytes

Hsueh-Ping ChuYi LiaoJames S NovakZhixian HuJason J MerkinYuriy ShymkivBart BraeckmanMaxim V DorovkovAlexandra NguyenPeter M Clifford et al.

A1 Journal Article in DEVELOPMENTAL CELL

LC-MS proteomics analysis of the iInsulin/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism

Geert DepuydtFang XieVladislav A PetyukArne SmoldersHeather M BrewerDavid G, II CampRichard D SmithBart Braeckman

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

Lifespan regulation under axenic dietary restriction: a close look at the usual suspects

Natascha CasteleinHuaihan CaiMadina RasulovaBart Braeckman

A1 Journal Article in EXPERIMENTAL GERONTOLOGY

Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2

Wouter De HaesLotte FrooninckxRoel Van AsscheArne SmoldersGeert DepuydtJohan BillenBart BraeckmanLiliane SchoofsLiesbet Temmerman

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial efficiency is increased in axenically cultured Caenorhabditis elegans

Natascha CasteleinMichael MuscholIneke DhondtHuaihan CaiWinnok De VosNorbert A DencherBart Braeckman

A1 Journal Article in EXPERIMENTAL GERONTOLOGY

Proteostasis in the long-lived daf-2 mutant of Caenorhabditis elegans: the influence of protein turnover and stability

Nilesh ShanmugamBart BraeckmanGeert Depuydt

2013

Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans

Cassandra CoburnErik AllmanParag MahantiAlexandre BenedettoFilipe CabreiroZachary PincusFilip MatthijssensCaroline AraizAbraham MandelManolis Vlachos et al.

A1 Journal Article in PLOS BIOLOGY

Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans

Alfonso SchiaviAlessandro TorgovnickAlison KellEvgenia MegalouNatascha CasteleinIlaria GucciniLaura MarzocchellaSara GelinoMalene HansenFlorence Malisan et al.

A1 Journal Article in EXPERIMENTAL GERONTOLOGY

GLB-13 is associated with oxidative stress resistance in Caenorhabditis elegans

Changhong RenYuan LiRongrong HanDawen GaoWeiguang LiJinping ShiDavid HoogewijsBart BraeckmanSasha De HenauYiming Lu et al.

A1 Journal Article in IUBMB LIFE

Gene-environment and protein-degradation signatures characterize genomic and phenotypic diversity in wild Caenorhabditis elegans populations

Rita JM VolkersL Basten SnoekCaspara J van Hellenberg HubarRenata CoopmanWei ChenWentao YangMark G SterkenHinrich SchulenburgBart BraeckmanJan E Kammenga

A1 Journal Article in BMC BIOLOGY

Reduced insulin/insulin-like growth factor-1 signaling and dietary restriction inhibit translation but preserve muscle mass in Caenorhabditis elegans

Geert DepuydtFang XieVladislav A PetyukNilesh ShanmugamArne SmoldersIneke DhondtHeather M BrewerDavid G CampRichard D SmithBart Braeckman

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

The genetics and biochemistry of longevity in axenically cultured Caenorhabditis elegans

Natascha CasteleinBart Braeckman

2012

A simplified hydroethidine method for fast and accurate detection of superoxide production in isolated mitochondria

Patricia BackFilip MatthijssensJacques VanfleterenBart Braeckman

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans

Lesley TillemanSasha De HenauMartje PauwelsNora NagyIsabel PintelonBart BraeckmanKarolien De WaelSabine Van DoorslaerDirk AdriaensenJean-Pierre Timmermans et al.

A1 Journal Article in PLOS ONE

Exploring ROS and redox biology in aging Caenorhabditis elegans

Patricia BackBart BraeckmanFilip Matthijssens

Exploring real-time in vivo redox biology of developing and aging Caenorhabditis elegans

Patricia BackWinnok De VosGeert DepuydtFilip MatthijssensJacques VanfleterenBart Braeckman

A1 Journal Article in FREE RADICAL BIOLOGY AND MEDICINE

Protein dynamics and diversity in long-lived Caenorhabditis elegans

Geert DepuydtBart Braeckman

RNA interference links oxidative stress to the inhibition of heat stress adaptation

Zoltán SpiróMehmet Alper ArslanMilán SomogyváriMinh Tu NguyenArne SmoldersBalázs DancsóNóra NémethZsuzsanna ElekBart BraeckmanPéter Csermely et al.

A1 Journal Article in ANTIOXIDANTS & REDOX SIGNALING

ROS in aging Caenorhabditis elegans: damage or signaling?

Patricia BackBart BraeckmanFilip Matthijssens

A1 Journal Article in OXIDATIVE MEDICINE AND CELLULAR LONGEVITY

2011

Globins in Caenorhabditis elegans

Lesley TillemanFrancesca GermaniSasha De HenauEva GeuensDavid HoogewijsBart BraeckmanJacques VanfleterenLuc MoensSylvia Dewilde

A1 Journal Article in IUBMB LIFE

Heavy metal toxicity in an insect cell line (methyl-HgCl, HgCl2, CdCl2 and CuSO4)

Bookchapter in Cellular effects of heavy metals

Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage

Filipe CabreiroDaniel AckermanRyan DoonanCaroline AraizPatricia BackDiana PappBart BraeckmanDavid Gems

A1 Journal Article in FREE RADICAL BIOLOGY AND MEDICINE

Lack of metabolic ageing in the long-lived flatworm Schmidtea polychroa

Stijn MoutonMaxime WillemsWouter HouthoofdWim BertBart Braeckman

A1 Journal Article in EXPERIMENTAL GERONTOLOGY

Metabolism and bioenergetics in long-lived mutants of Caenorhabditis elegans

Kristel BrysBart BraeckmanJacques Vanfleteren

The importance of feeding status and desiccation rate in successful anhydrobiosis of Panagrolaimus detritophagus

Shakiba SalehianBart BraeckmanLynda BeladjalWim BertJames S CleggJohan Mertens

A1 Journal Article in NEMATOLOGY

The quest for the fountain of youth : developing flatworm models for ageing and rejuvenation research

Stijn MoutonBart BraeckmanWouter HouthoofdMaxime Willems

2010

Constraints on home range behaviour affect nutritional condition in urban house sparrows (Passer domesticus)

Carl VangestelBart BraeckmanHans MatheveLuc Lens

A1 Journal Article in BIOLOGICAL JOURNAL OF THE LINNEAN SOCIETY

Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans

Kristel BrysNatascha CasteleinFilip MatthijssensJacques VanfleterenBart Braeckman

A1 Journal Article in BMC BIOLOGY

Effects of sod gene overexpression and deletion mutation on the expression profiles of reporter genes of major detoxification pathways in Caenorhabditis elegans

Patricia BackFilip MatthijssensCaroline VlaeminckBart BraeckmanJacques Vanfleteren

A1 Journal Article in EXPERIMENTAL GERONTOLOGY

Establishing a flatworm ageing model

Stijn MoutonFreija VerdoodtMaxime WillemsIneke DhondtJeroen CruckeBart BraeckmanWouter Houthoofd

Editorial material

Protein metabolism and lifespan in Caenorhabditis elegans

Geert DepuydtJacques VanfleterenBart Braeckman

A1 Journal Article in Advances in Experimental Medicine and Biology

2009

Demographic analysis reveals gradual senescence in the flatworm Macrostomum lignano

Stijn MoutonMaxime WillemsPatricia BackBart BraeckmanGaetan Borgonie

A1 Journal Article in FRONTIERS IN ZOOLOGY

Establishing a flatworm ageing model

Stijn MoutonMaxime WillemsBart BraeckmanGaetan BorgonieWouter Houthoofd

Establishing a flatworm ageing model

Stijn MoutonMaxime WillemsFreija VerdoodtBart BraeckmanGaetan BorgonieWouter Houthoofd

Intermediary metabolism

Bart BraeckmanKoen HouthoofdJacques Vanfleteren

Bookchapter in WormBook

The free-living flatworm Macrostomum lignano: a new model organism for ageing research

Stijn MoutonMaxime WillemsBart BraeckmanBernhard EggerPeter LadurnerLukas SchärerGaetan Borgonie

A1 Journal Article in EXPERIMENTAL GERONTOLOGY

2008

Dietary restriction by growth in axenic medium induces discrete changes in the transcriptional output of genes involved in energy metabolism in Caenorhabditis elegans

Natascha CasteleinDavid HoogewijsAnna De VreeseBart BraeckmanJacques Vanfleteren

A2 Journal Article in BIOTECHNOLOGY JOURNAL

Lifespan, survival curve and age-related mortality rate of the flatworm M. lignano

Stijn MoutonMaxime WillemsPatricia BackBart BraeckmanGaetan Borgonie

Prooxidant activity of the superoxide dismutase (SOD)-mimetic EUK-8 in proliferating and growth-arrested Escherichia coli cells

Filip MatthijssensPatricia BackBart BraeckmanJacques Vanfleteren

A1 Journal Article in Free Radical Biology and Medicine

2007

Evaluation of different methods for assaying protein carbonylation

Filip MatthijssensBart BraeckmanJacques Vanfleteren

A1 Journal Article in CURRENT ANALYTICAL CHEMISTRY

Genetic control of longevity in C-elegans

Bart BraeckmanJacques Vanfleteren

A1 Journal Article in EXPERIMENTAL GERONTOLOGY

Testing the rate-of-living/oxidative damage theory of aging in the nematode model Caenorhabditis elegans

Kristel BrysJacques VanfleterenBart Braeckman

A1 Journal Article in EXPERIMENTAL GERONTOLOGY

2006

The dietary restriction effect in C-elegans and humans: is the worm a one-millimeter human?

Bart BraeckmanL DEMETRIUSJacques Vanfleteren

A1 Journal Article in BIOGERONTOLOGY

2005

DAF-2 pathway mutations and food restriction in aging Caenorhabditis elegans differentially affect metabolism

Koen HouthoofdBart BraeckmanIsabelle LenaertsKristel BrysFilip MatthijssensAnna De VreeseSylvie Van EygenJacques Vanfleteren

A1 Journal Article in NEUROBIOLOGY OF AGING

Metabolism, physiology and stress defense in three aging Ins/IGF-1 mutants of the nematode Caenorhabditis elegans

Koen HouthoofdMA FIDALGODavid HoogewijsBart BraeckmanIsabelle LenaertsKristel BrysFilip MatthijssensAnna De VreeseSylvie Van EygenMJ MUNOZ et al.

A1 Journal Article in AGING CELL

2004

Caloric restriction, Ins/IGF-1 signalling and longevity in the nematode Caenorhabditis elegans

Koen HouthoofdBart BraeckmanAnna De VreeseSylvie Van EygenIsabelle LenaertsKristel BrysFilip MatthijssensJacques Vanfleteren

A1 Journal Article in BELGIAN JOURNAL OF ZOOLOGY

Extending life-span in C-elegans

Koen HouthoofdBart BraeckmanTE JOHNSONJacques Vanfleteren

A1 Journal Article in SCIENCE

Is 120 jaar halen fictie?

Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster

AJ HULBERTDJ CLANCYW MAIRBart BraeckmanD GEMSL PARTRIDGE

A1 Journal Article in EXPERIMENTAL GERONTOLOGY

The hunt for the record life span in Caenorhabditis elegans

Koen HouthoofdBart BraeckmanJacques Vanfleteren

A1 Journal Article in JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

2003

A high-throughput screening system for genes extending life-span

Cuiying ChenSylviane DewaeleBart BraeckmanLiesbeth DesmyterJan VerstraelenGaetan BorgonieJacques VanfleterenRoland Contreras

A1 Journal Article in EXPERIMENTAL GERONTOLOGY

Cultured mosquito cells Aedes albopictus C6/36 (Dip., Culicidae) responsive to 20-hydroxyecdysone and non-steroidal ecdysone agonist

Guy SmaggheBart BraeckmanN HUYSHilda Raes

A1 Journal Article in JOURNAL OF APPLIED ENTOMOLOGY-ZEITSCHRIFT FUR ANGEWANDTE ENTOMOLOGIE

Energy metabolism, anti-oxidant defense and aging in Caenorhabditis elegans

Bart BraeckmanKoen HouthoofdJacques Vanfleteren

Bookchapter in Model systems in aging

Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans

Koen HouthoofdBart BraeckmanTE JOHNSONJacques Vanfleteren

A1 Journal Article in EXPERIMENTAL GERONTOLOGY

Metabolism and life span determination in C. elegans

Koen HouthoofdBart BraeckmanJacques Vanfleteren

Bookchapter in Energy metabolism and lifespan determination

2002

A high-throughput microtiter plate assay for superoxide dismutase based on lucigenin chemiluminescence.

Isabelle LenaertsBart BraeckmanFilip MatthijssensJacques Vanfleteren

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

Ageing is reversed, and metabolism is reset to young levels in recovering dauer larvae of C-elegans.

Koen HouthoofdBart BraeckmanIsabelle LenaertsKristel BrysA DE VREESES VAN EYGENJacques Vanfleteren

A1 Journal Article in EXPERIMENTAL GERONTOLOGY

Assaying metabolic activity in ageing Caenorhabditis elegans.

Bart BraeckmanKoen HouthoofdA DE VREESEJacques Vanfleteren

A1 Journal Article in MECHANISMS OF AGEING AND DEVELOPMENT

Assessing metabolic rate in Caenorhabditis elegans: concepts and controversies.

Bart BraeckmanKoen HouthoofdJacques Vanfleteren

A2 Journal Article in AGING CELL

Axenic growth up-regulates mass-specific metabolic rate, stress resistance, and extends life span in C. elegans.

Koen HouthoofdBart BraeckmanIsabelle LenaertsKristel BrysA DE VREESES VAN EYGENJacques Vanfleteren

A1 Journal Article in EXPERIMENTAL GERONTOLOGY

Keynote: mechanisms of senescence complificationists versus simplificationists - Commentary

Bart BraeckmanJacques Vanfleteren

Editorial material

No reduction of energy metabolism in Clk mutants.

Bart BraeckmanKoen HouthoofdKristel BrysIsabelle LenaertsA DE VREESES VAN EYGENHilda RaesJacques Vanfleteren

A1 Journal Article in MECHANISMS OF AGEING AND DEVELOPMENT

No reduction of metabolic rate in food restricted Caenorhabditis elegans.

Koen HouthoofdBart BraeckmanIsabelle LenaertsKristel BrysA DE VREESES VAN EYGENJacques Vanfleteren

A1 Journal Article in EXPERIMENTAL GERONTOLOGY

Rebuttal to Van Voorhies: The influence of metabolic rate on longevity in the nematode Caenorhabditis elegans.

Bart BraeckmanKoen HouthoofdJacques Vanfleteren

Editorial material

2001

Insulin-like signaling, metabolism, stress resistance and aging in Caenorhabditis elegans.

Bart BraeckmanKoen HouthoofdJacques Vanfleteren

A1 Journal Article in MECHANISMS OF AGEING AND DEVELOPMENT

2000

Copper induces apoptosis in Aedes C6/36 cells

Hilda RaesBart BraeckmanGodelieve CrielUrszula RzeznikJacques Vanfleteren

A1 Journal Article in JOURNAL OF EXPERIMENTAL ZOOLOGY

Patterns of metabolic activity during aging of the wild type and longevity mutants of Caenorhabditis elegans.

Bart BraeckmanKoen HouthoofdJacques Vanfleteren

A1 Journal Article in JOURNAL OF THE AMERICAN AGING ASSOCIATION

1999

Apparent uncoupling of energy production and consumption in long-lived Clk mutants of Caenorhabditis elegans.

Bart BraeckmanKoen HouthoofdA DE VREESEJacques Vanfleteren

A1 Journal Article in CURRENT BIOLOGY

Cadmium pathology in an insect cell line: ultrastructural and biochemical effects.

Bart BraeckmanKristel BrysU RZEZNIKHilda Raes

A1 Journal Article in TISSUE & CELL

Cadmium uptake and defense mechanism in insect cells

Bart BraeckmanGuy SmaggheN BRUTSAERTRita CornelisHilda Raes

A1 Journal Article in ENVIRONMENTAL RESEARCH

Mechanisms of life span determination in Caenorhabditis elegans.

Jacques VanfleterenBart Braeckman

A1 Journal Article in NEUROBIOLOGY OF AGING

Stress-inducible mechanisms of life-span extension in yeast, eubacteria and metazoans

Bart BraeckmanJacques Vanfleteren

A1 Journal Article in TRENDS IN MICROBIOLOGY

The ultrastructural effect and subcellular localization of mercuric chloride and methylmercuric chloride in insect cells (Aedes albopictus C6/36)

Bart BraeckmanHilda Raes

A1 Journal Article in TISSUE & CELL

1998

Age-specific modulation of light production potential, and alkaline phosphatase and protein tyrosine kinase activities in various age mutants of Caenorhabditis elegans

Jacques VanfleterenBart BraeckmanI RoelensA De Vreese

A1 Journal Article in JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Author's response to commentaries on 'Two-parameter logistic and Weibull equations provide better fits to survival data from isogenic populations of Caenorhabditis elegens in acenic culture than does the Compertz model'

Bart BraeckmanA De VreeseJacques Vanfleteren

Editorial material

Two-parameter logistic and Weibull equations provide better fits to survival data from isogenic populations of Caenorhabditis elegans in axenic culture than does the Gompertz model

Jacques VanfleterenA De VreeseBart Braeckman

A1 Journal Article in JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Uptake of HgCl2 and MeHgCl in an insect cell line (Aedes albopictus C6/36)

Bart BraeckmanRita CornelisUrszula RzeznikHilda Raes

A1 Journal Article in ENVIRONMENTAL RESEARCH

1997

Effect of sublethal doses of cadmium, inorganic mercury and methylmercury on the cell morphology of an insect cell line (Aedes albopictus, C6/36)

Bart BraeckmanCaroline SimoensUrszula RzeznikHilda Raes

A1 Journal Article in CELL BIOLOGY INTERNATIONAL

Heavy-metal toxicity in an insect cell line : effects of cadmium chloride, mercuric chloride and methylmercuric chloride on cell viability and proliferation in Aedes albopictus cells

Bart BraeckmanHilda RaesD Van Hoye

A1 Journal Article in CELL BIOLOGY AND TOXICOLOGY