Research Explorer

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Researcher

Barbara Vanhoecke

Awards & Distinctions

73 Results

2018

Oral microbiota reduce wound healing capacity of epithelial monolayers, irrespective of the presence of 5-fluorouracil

Eline VanlanckerBarbara VanhoeckeTom SieprathJanie BourgeoisAnnelore BeteramsBarbara De MoerlooseWinnok De VosTom Van de Wiele

A1 Journal Article in EXPERIMENTAL BIOLOGY AND MEDICINE

The impact of chemotherapy on the host microbiota in the context of oral and gastrointestinal mucositis

Eline VanlanckerBarbara VanhoeckeBarbara De MoerlooseTom Van de Wiele

A2 Journal Article in BELGIAN JOURNAL OF HEMATOLOGY

2017

5-Fluorouracil and irinotecan (SN-38) have limited impact on colon microbial functionality and composition &ITin vitro&IT

Eline VanlanckerBarbara VanhoeckeAndrea StringerTom Van de Wiele

A1 Journal Article in PEERJ

The impact of chemotherapy on the host microbiota in the context of oral and gastrointestinal mucositis

Eline VanlanckerTom Van de WieleBarbara Vanhoecke

2016

5-Fluorouracil and irinotecan (SN-38) do not modulate the gut microbiome composition and activity in the absence of a host sytem

Eline VanlanckerBarbara VanhoeckeAndrea StringerTom Van de Wiele

5-Fluorouracil sensitivity varies among oral micro-organisms

Eline VanlanckerTom Van de WieleBarbara VanhoeckeRozel SmetRuben Props

A1 Journal Article in JOURNAL OF MEDICAL MICROBIOLOGY

Host-microbe interactions in chemotherapy-induced oral mucositis

Eline VanlanckerTom Van de WieleBarbara Vanhoecke

Low-dose irradiation affects the functional behavior of oral microbiota in the context of mucositis

Barbara VanhoeckeTine De RyckKevin De boelSiouxsie WilesTom BoterbergTom Van de WieleSimon Swift

A1 Journal Article in EXPERIMENTAL BIOLOGY AND MEDICINE

2015

8-prenylnaringenin and tamoxifen inhibit the shedding of irradiated epithelial cells and increase the latency period of radiation-induced oral mucositis

Tine De RyckAnnouchka Van ImpeBarbara VanhoeckeArne HeyerickLuc VakaetWilfried De NeveDoreen MüllerMargret SchmidtWolfgang DörrMarc Bracke

A1 Journal Article in STRAHLENTHERAPIE UND ONKOLOGIE

Dark Agouti rat model of chemotherapy-induced mucositis: establishment and current state of the art

Barbara VanhoeckeEmma BatemanBronwen MayoEline VanlanckerAndrea StringerDaniel ThorpeDorothy Keefe

A1 Journal Article in EXPERIMENTAL BIOLOGY AND MEDICINE

Dynamic shifts in the oral microbiome during radiotherapy

Tine De RyckFréderic DuprezMarc BrackeTom Van de WieleBarbara Vanhoecke

A2 Journal Article in CLINICAL RESEARCH IN INFECTIOUS DISEASES

Effects of irradiation on epithelial wound healing and microbial diversity in an in-vitro oral mucosa model

Tine De RyckTom BoterbergFrederiek-Maarten KerckhofJoachim De SchrijverMarc BrackeTom Van De WieleBarbara Vanhoecke

A2 Journal Article in JOURNAL OF NUCLEAR MEDICINE AND RADIATION THERAPY

Host-microbe cross talk in cancer therapy

Barbara VanhoeckeAndrea Stringer

A1 Journal Article in CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE

Microbial inhibition of oral epithelial wound recovery: potential role for quorum sensing molecules?

Tine De RyckEline VanlanckerCharlotte GrootaertBart RomanLaurens De CoenIsabel VandenbergheChristian StevensMarc BrackeTom Van de WieleBarbara Vanhoecke

A1 Journal Article in AMB EXPRESS

Microbiota and their role in the pathogenesis of oral mucositis

Barbara VanhoeckeTine De RyckA StringerTom Van de WieleD Keefe

A1 Journal Article in ORAL DISEASES

Radiotherapy-induced oral mucositis : the host-microbe interactions come into play

Tine De RyckMarc BrackeTom Van de WieleBarbara Vanhoecke

2014

Chick heart invasion assay

Marc BrackeVirinder S ParmarAnthony L DePassChristian StevensBarbara VanhoeckeMarcus Mareel

Bookchapter in Metastasis research protocols

Development of an oral mucosa model to study host-microbiome interactions during wound healing

Tine De RyckCharlotte GrootaertLaura JaspaertFrederiek-Maarten KerckhofMireille Van GeleJoachim De SchrijverPieter Van den AbbeeleSimon SwiftMarc BrackeTom Van de Wiele et al.

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The HMI™ module: a new tool to study the host-microbiota interaction in the human gastrointestinal tract in vitro

Massimo MarzoratiBarbara VanhoeckeTine De RyckMehdi Sadaghian SadabadIris PinheiroSam PossemiersPieter Van den AbbeeleLara DeryckeMarc BrackeJan Pieters et al.

A1 Journal Article in BMC MICROBIOLOGY

The effect of oral microbes on the proliferation, healing, and immune response of intestinal epithelial cells (IEC6) treated with SN-38 (metabolite of irinotecan)

Andrea StringerHelen McInnesBronwen MayoRichard LoganBarbara Vanhoecke

2013

Design, synthesis and structure-activity relationships of some novel, highly potent anti-invasive (E)- and (Z)-stilbenes

Bart RomanLaurens De CoenSéverine MortierTine De RyckBarbara VanhoeckeAlan R KatritzkyMarc BrackeChristian Stevens

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

ER stress in diffuse large B cell lymphoma: GRP94 is a possible biomarker in germinal center versus activated B-cell type

Jerina BoelensJean-Philippe JaisBarbara VanhoeckeIlse BeckHeleen Van MelckebekeJan PhilippéMarc BrackeFabrice JardinJosette BrièreKaren Leroy et al.

A1 Journal Article in LEUKEMIA RESEARCH

Unraveling the mechanisms behind the enhanced MTT conversion by irradiated breast cancer cells

Stéphanie BlockhuysBarbara VanhoeckeJoél SmetBoel De PaepeRudy Van CosterMarc BrackeCarlos De Wagter

A1 Journal Article in RADIATION RESEARCH

2012

Angiopoietin-like protein 4 : health effects, modulating agents and structure-function relationships

Charlotte GrootaertTom Van de WieleWilly VerstraeteMarc BrackeBarbara Vanhoecke

A1 Journal Article in EXPERT REVIEW OF PROTEOMICS

Exploration of the SAR of anti-invasive chalcones: synthesis and biological evaluation of conformationally restricted analogues

Bart RomanTine De RyckLaura DierickxBarbara VanhoeckeAlan R KatritzkyMarc BrackeChristian Stevens

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Incorporating a mucosal environment in a dynamic gut model results in a more representative colonization by lactobacilli

Pieter Van den AbbeeleStefaan RoosVenessa EeckhautDonald A MacKenzieMelanie DerdeWilly VerstraeteMassimo MarzoratiSam PossemiersBarbara VanhoeckeFilip Van Immerseel et al.

A1 Journal Article in MICROBIAL BIOTECHNOLOGY

Prenylated chalcone xanthohumol associates with histones in breast cancer cells: a novel target identified by a monoclonal antibody

Ciska WynsKatleen Van SteendamBarbara VanhoeckeDieter DeforceMarc BrackeArne Heyerick

A1 Journal Article in MOLECULAR NUTRITION & FOOD RESEARCH

2011

Adherence and viability of intestinal bacteria to differentiated Caco-2 cells quantified by flow cytometry

Charlotte GrootaertNico BoonFjoralba ZekaBarbara VanhoeckeMarc BrackeWilly VerstraeteTom Van de Wiele

A1 Journal Article in JOURNAL OF MICROBIOLOGICAL METHODS

Bacterial modulation of the fasting-induced adipose factor (FIAF): an example of host-microbe crosstalk related to obesity

Charlotte GrootaertTom Van de WieleIlse Van RoosbroeckSam PossemiersAnne-Sophie Vercoutter-EdouartWilly VerstraeteMarc BrackeBarbara Vanhoecke

Bacterial monocultures, propionate, butyrate and H(2)O(2) modulate the expression, secretion and structure of the fasting-induced adipose factor in gut epithelial cell lines

Charlotte GrootaertTom Van de WieleIlse Van RoosbroeckSam PossemiersAnne-Sophie Vercoutter-EdouartWilly VerstraeteMarc BrackeBarbara Vanhoecke

A1 Journal Article in ENVIRONMENTAL MICROBIOLOGY

Development of a 3D pigmented skin model to evaluate RNAi-induced depigmentation

Mireille Van GeleBarbara GeusensReinhart SpeeckaertPeter DynoodtBarbara VanhoeckeKarolien Van Den BosscheJo Lambert

A1 Journal Article in EXPERIMENTAL DERMATOLOGY

Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells

Samir AttoubAhmed H HassanBarbara VanhoeckeRabah IratniTakashi TakahashiAnne-Marie GabenMarc BrackeSalma AwadAnne JohnHamda Ahmed Kamalboor et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACOLOGY

Microbial reuterin production and its effects on a 3-D model of colonic epithelium

Rosemarie De WeirdtAurélie CrabbéStefan RoosChristophe LacroixWilly VerstraeteBarbara VanhoeckeMarc BrackeCheryl A NickersonTom Van de Wiele

P-cadherin expression reduces melanoma growth, invasion, and responsiveness to growth factors in nude mice

Koen JacobsLynn FeysBarbara VanhoeckeVeerle Van MarckMarc Bracke

A1 Journal Article in EUROPEAN JOURNAL OF CANCER PREVENTION

2010

An innovative in vitro system to study the host-microbiota interaction in the gut under long-term conditions

Massimo MarzoratiBarbara VanhoeckeTom Van de WieleSam PossemiersWilly VerstraetePieter Van den Abbeele

From clinical observations of intensity-modulated radiotherapy to dedicated in vitro designs

Stéphanie BlockhuysBarbara VanhoeckeCarlos De WagterMarc BrackeWilfried De Neve

A1 Journal Article in MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Incorporation of a mucosal environment in a dynamic gut model results in a more representative colonization by lactobacilli

Pieter Van den AbbeeleVenessa EeckhautMassimo MarzoratiSam PossemiersBarbara VanhoeckeWilly VerstraeteFilip Van ImmerseelTom Van de Wiele

P-cadherin counteracts myosin II-B function : implications in melanoma progression

Koen JacobsMireille Van GeleRamses ForsythLieve BrochezBarbara VanhoeckeOlivier De WeverMarc Bracke

A1 Journal Article in MOLECULAR CANCER

The flavonoid tangeretin activates the unfolded protein response and synergizes with imatinib in the erythroleukemia cell line K562

Sofie LustBarbara VanhoeckeMireille Van GeleJan PhilippéMarc BrackeFritz Offner

A1 Journal Article in MOLECULAR NUTRITION & FOOD RESEARCH

2009

Cell aggregation on agar as an indicator for cell-matrix adhesion: effects of opioids

Delphine DebruyneMarcus MareelBarbara VanhoeckeMarc Bracke

A1 Journal Article in IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Chronic Lymphocytic Leukaemia

Jerina BoelensSofie LustBarbara VanhoeckeFritz Offner

A1 Journal Article in ANTICANCER RESEARCH

Development of in vitro models for investigating spatially fractionated irradiation: physics and biological results

Stéphanie BlockhuysBarbara VanhoeckeLeen PaelinckMarc BrackeCarlos De Wagter

A1 Journal Article in PHYSICS IN MEDICINE AND BIOLOGY

Steroid effects on ZAP-70 and SYK in relation to apoptosis in poor prognosis chronic lymphocytic leukemia

Jerina BoelensSofie LustFemke Van BockstaeleMireille Van GeleAnn JanssensLara DeryckeBarbara VanhoeckeJan PhilippéMarc BrackeFritz Offner

A1 Journal Article in LEUKEMIA RESEARCH

Synthesis, biological evaluation and 2D-QSAR analysis of chalcones as anti-invasive cancer agents

Bart RomanChristian StevensBarbara VanhoeckeMarc Bracke

Xanthohumol activates the proapoptotic arm of the unfolded protein response in chronic lymphocytic leukemia

Sofie LustBarbara VanhoeckeMireille Van GeleJerina BoelensHeleen Van MelckebekeMary KailehWim Vanden BergheGuy HaegemanJan PhilippéMarc Bracke et al.

A1 Journal Article in ANTICANCER RESEARCH

2008

Antioxidant, antiinflammatory and antiinvasive activities of biopolyphenolics

Malhotra ShashwatGaurav ShakyaAjit KumarBarbara VanhoeckeAshok L CholliHanumantharao G RajLuciano SasoBalaram GhoshMarc BrackeAshok K Prasad et al.

A1 Journal Article in ARKIVOC

Enhancement of PDGF-BB mitogenic activity on human dermal fibroblasts by biospecific dextran derivatives

AS VERCOUTTER-EDOUARTG DUBREUCQBarbara VanhoeckeC RIGAUTF RENAUXL DAHRI-CORREIAJ LEMOINEMarc BrackeJC MICHALSKIJ CORREIA

A1 Journal Article in BIOMATERIALS

Plant polyphenolics as anti-invasive cancer agents

Marc BrackeBarbara VanhoeckeLara DeryckeSelin BolcaSam PossemiersArne HeyerickChristian StevensDenis De KeukeleireHerman DepypereWilly Verstraete et al.

A1 Journal Article in ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY

Synthesis, biological evaluation and 2D-QSAR analysis of chalcones as anti-invasive cancer agents

Bart RomanChristian StevensMarc BrackeBarbara Vanhoecke

Synthesis, biological evaluation and 2D-QSAR analysis of chalcones as anti-invasive cancer agents

Bart RomanChristian StevensMarc BrackeBarbara Vanhoecke

The prenylated chalcone xanthohumol induces unfolded protein response, autophagy, and cell death in breast cancer cells by proteasome inhibition

Barbara VanhoeckeMireille Van GeleWim MartinetAnne-Sophie Vercoutter-EdouartSofie LustDelphine DebruyneDenis De KeukeleireFritz OffnerMarc Bracke

2007

Cell motility and breast cancer metastasis.

Marc BrackeDaan De MaeseneerVeerle Van MarckLara DeryckeBarbara VanhoeckeOlivier De WeverHerman Depypere

Bookchapter in Metastasis of Breast Cancer.

Deguelin inhibits expression of I kappa B alpha protein and induces apoptosis of B-CLL cells in vitro

Ben GeeraertsBarbara VanhoeckeWim Vanden BergheJan PhilippéFritz OffnerDieter Deforce

A1 Journal Article in LEUKEMIA

QSAR directed design, synthesis and evaluation of anti-invasive chalcones and related heterocyclic compounds

Bart RomanChristian StevensMarc BrackeBarbara Vanhoecke

The anti-invasive and proapoptotic effect of xanthohumol: potential use in cancer.

Barbara VanhoeckeJerina BoelensSofie LustFritz OffnerMarc Bracke

Bookchapter in Beer in Health and Desease Prevention

The endoplasmic reticulum: A target for new anticancer drugs

Jerina BoelensSofie LustFritz OffnerMarc BrackeBarbara Vanhoecke

A1 Journal Article in IN VIVO

Xanthohumol induces in vitro apoptosis in B-CLL cells mediated by non-classical ER stress

Sofie LustBarbara VanhoeckeMireille Van GeleJerina BoelensMary KailehWim Vanden BergheJ PHILLIPESMarc BrackeFritz Offner

Xanthohumol: a new potential proteasome inhibitor that activates the pro-apoptotic arm of the unfolded protein response in B-CLL cells

Sofie LustBarbara VanhoeckeMireille Van GeleJerina BoelensJan PhilippéPetra VinckenMarc BrackeMartine PoelmanFritz Offner

2006

ARE PHYTOESTROGENS OF ANY HELP

Herman DepypereMarc BrackeBarbara VanhoeckeDenis De KeukeleireArne HeyerickSelin BolcaWilly Verstraete

Effects of xanthohumol on human breast cancer cells in vitro : cellular and molecular mechanisms associated with invasion, stress and apoptosis

Barbara VanhoeckeHerman DepypereDenis De Keukeleire

QSAR modeling of anti-invasive activity of organic compounds using structural descriptors

AR KATRITZKYM KUANARDA DOBCHEVBarbara VanhoeckeM KARELSONVS PARMARChristian StevensMarc Bracke

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Soluble N-cadherin in human biological fluids

Lara DeryckeOlivier De WeverVeronique StoveBarbara VanhoeckeJoris DelangheHerman DepypereMarc Bracke

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Tibolone and its metabolites inhibit invasion of human mammary carcinoma cells in vitro

Barbara VanhoeckeMarc BrackeHJ KLOOSTERBOERHerman Depypere

A1 Journal Article in MATURITAS

2005

A proteomic approach to understand the anti-invasive and pro-apoptotic effect of xanthohumol in human breast cancer cells

Barbara VanhoeckeLaurent DolleA Vercoutter-EdouartJ AntolHerman DepypereMarc Bracke

A safety study of oral tangeretin and xanthohumol administration to laboratory mice

Barbara VanhoeckeFEMKE DELPORTEEva Van BraeckelArne HeyerickHerman DepypereM NUYTINCKDenis De KeukeleireMarc Bracke

A1 Journal Article in IN VIVO

Antiinvasive effect of xanthohumol, a prenylated chalcone present in hops (Humulus lupulus L.) and beer

Barbara VanhoeckeLara DeryckeV VAN MARCKHerman DepypereDenis De KeukeleireMarc Bracke

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

New anti-invasive compounds: Results from the Indo-Belgian screening program

Barbara VanhoeckeHerman DepypereA DE BEYTERSK SHARMAVS PARMARDenis De KeukeleireMarc Bracke

A1 Journal Article in PURE AND APPLIED CHEMISTRY

Tangeretin inhibits extracellular-signal-regulated kinase (ERK) phosphorylation

S VAN SLAMBROUCKVS PARMARSK SHARMAB DE BONDTF FOREP COOPMANBarbara VanhoeckeTom BoterbergHerman DepypereGeorges Leclercq et al.

A1 Journal Article in FEBS LETTERS

Tibolone and its metabolites inhibit invasion of human mammary carcinoma cells in vitro

Herman DepypereMarc BrackeBarbara VanhoeckeHJ KLOOSTERBOER

Xanthohumol induces apoptosis in B-CLL mediated by caspase 9 following downregulation of bcL-xL and mcl-1

Barbara VanhoeckeSofie LustAnne JanssensJan PhilippéMarc BrackeFritz Offner

Xanthohumol kills B-chronic lymphocytic leukemia cells by an apoptotic mechanism

Sofie LustBarbara VanhoeckeAnne JanssensJan PhilippéMarc BrackeFritz Offner

A1 Journal Article in MOLECULAR NUTRITION & FOOD RESEARCH

2004

Cellular activities related to growth and invasion: targets for flavonoids

Barbara VanhoeckeHerman DepypereDenis De KeukeleireMarc Bracke

Bookchapter in Recent research developments in cell science

Tangeretin synergizes with imatinib in inhibiting growth of bcr-abl positive K562 Erythroleukemia cells in an Erk-dependent way

Sofie LustBarbara VanhoeckeMarc BrackeFritz Offner