Research Explorer

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Researcher

Aurélie Crabbé

Publications & Research Data

Awards & Distinctions

67 Results

2026

Identification of DksA as a novel pro-inflammatory mediator of <i>Pseudomonas aeruginosa</i> under conditions mimicking chronic cystic fibrosis lung infection

Merel WautersLaura BolléGilles De MeesterSara Van Den BosscheLucia GrassiDelphi Van HaverSara DufourSimon DevosFrancis ImpensEva Van Braeckel et al.

U Journal Article in Virulence

Licence to ill : unravelling pro- and anti-inflammatory mediators of Pseudomonas aeruginosa expressed under in vivo-like conditions in chronic cystic fibrosis lung infection

Merel WautersAurélie CrabbéXavier Saelens

2025

Combination of phages and antibiotics with enhanced killing efficacy against dual-species bacterial communities in a three-dimensional lung epithelial model

Ergun AkturkGraca PintoLisa OstynAurélie CrabbéLuis D. R. MeloJoana AzeredoTom Coenye

A2 Journal Article in BIOFILM

Directed evolution of phages in biofilms enhances Pseudomonas aeruginosa control through improved lipopolysaccharide recognition

Luciana Amorim Perestrelo de MenesesLucie ValentováSílvio B. SantosJelena ErdmannAurélie CrabbéPavel PlevkaSusanne HäusslerDiana P. PiresTom CoenyeJoana Azeredo

A1 Journal Article in NATURE COMMUNICATIONS

Echinacoside reduces intracellular c-di-GMP levels and potentiates tobramycin activity against Pseudomonas aeruginosa biofilm aggregates

Yu-Ming CaiFeng HongAmber De CraemerJacob George MaloneAurélie CrabbéTom Coenye

A1 Journal Article in NPJ BIOFILMS AND MICROBIOMES

Identification of DksA as a novel pro-inflammatory mediator of <i>Pseudomonas aeruginosa</i> under conditions mimicking chronic cystic fibrosis lung infection

Merel WautersLaura BolléSara Van den BosscheLucia GrassiDelphi Van HaverSara DufourSimon DevosFrancis ImpensEva Van BraeckelAnna K.H. Hirsch et al.

Identification of DksA as a novel pro-inflammatory mediator of Pseudomonas aeruginosa under conditions mimicking chronic cystic fibrosis lung infection

Merel WautersAurélie Crabbé

Intranasal exposure to commensal bacterium Rothia mucilaginosa protects against influenza A virus infection

Ana Raquel MaiaLoïc GonzalezBadreddine BounabLucia GrassiCoralie MoussetGaëlle Fromont-HankardAdeline CezardPieter HiemstraThomas BaranekChristophe Paget et al.

A1 Journal Article in ANTIVIRAL RESEARCH

Unraveling the immunosuppressive role of Elastase B produced by cystic fibrosis isolates of Pseudomonas aeruginosa in an organotypic 3-D lung epithelial cell model

Merel WautersLeander MeurisAurélie CrabbéXavier Saelens

Unraveling the immunosuppressive role of Elastase B produced by cystic fibrosis isolates of Pseudomonas aeruginosa in an organotypic 3-D lung epithelial cell model: Mass spectrometry proteomics data

Aurélie CrabbéSara Dufour

Unraveling the immunosuppressive role of Elastase B produced by cystic fibrosis isolates of Pseudomonas aeruginosa in an organotypic 3D lung epithelial cell model

Merel WautersSara Van den BosscheLucia GrassiMariana Fernandes GonçalvesDelphi Van HaverSara DufourSimon DevosLeander MeurisFrancis ImpensXavier Saelens et al.

A1 Journal Article in VIRULENCE

2024

Aggregatibacter is inversely associated with inflammatory mediators in sputa of patients with chronic airway diseases and reduces inflammation in vitro.

Ellen GoeteynSteven L. TaylorAlison DickerLaura BolléMerel WautersMarie JoossensEva Van BraeckelJodie L. SimpsonLucy BurrJames D. Chalmers et al.

A1 Journal Article in RESPIRATORY RESEARCH

Antibiofilm activity of Prevotella species from the cystic fibrosis lung microbiota against Pseudomonas aeruginosa

Lucia GrassiKyle L. AsfahlSara Van den BosscheIne MaenhoutAndrea SassEva Van BraeckelBruno VerhasseltJerina BoelensMichael M. Tunney et al.

A2 Journal Article in BIOFILM

Genome-scale model of Rothia mucilaginosa predicts gene essentialities and reveals metabolic capabilities

Nantia LeonidouLisa OstynTom CoenyeAurélie CrabbéAndreas Dräger

A1 Journal Article in MICROBIOLOGY SPECTRUM

Intracellular Pseudomonas aeruginosa : an overlooked reservoir in the lungs of people with cystic fibrosis?

Aurélie Crabbé

Editorial material

Moving beyond antibiotics : exploring the potential of an antivirulence monoclonal antibody against Pseudomonas aeruginosa in Bronchiectasis.

Aurélie Crabbé

Editorial material

Recreating chronic respiratory infections in vitro using physiologically relevant models.

Lucia GrassiAurélie Crabbé

A1 Journal Article in EUROPEAN RESPIRATORY REVIEW

Selective replacement of cholesterol with cationic amphiphilic drugs enables the design of lipid nanoparticles with improved RNA delivery

Bram BogaertAliona DebisschopThomas EhouarneHannelore Van EeckhoutteJoyceline De VolderAn JacobsEline PottieRiet De RyckeAurélie CrabbéPieter Mestdagh et al.

A1 Journal Article in NANO LETTERS

Towards microbiome-based therapies to reduce inflammation in chronic airway diseases

Ellen GoeteynAurélie Crabbé

Understanding the clinical implications of the 'non-classical' microbiome in chronic lung disease : a viewpoint

Steven L. TaylorAurélie CrabbéLuke R. HoffmanJames D. ChalmersGeraint B. Rogers

Editorial material

2023

Combining phages and antibiotic to enhance antibiofilm efficacy against an in vitro dual species wound biofilm

Ergun AkturkLuís D.R. MeloHugo OliveiraAurélie CrabbéTom CoenyeJoana Azeredo

A2 Journal Article in BIOFILM

Commensal bacteria of the lung microbiota synergistically inhibit inflammation in a three-dimensional epithelial cell model

Ellen GoeteynLucia GrassiSara Van den BosscheCharlotte RigautsYannick Vande WeygaerdeEva Van BraeckelTania MaesKen BrackeAurélie Crabbé

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Deciphering the impact of the cystic fibrosis lung microenvironment on antibiotic activity against Pseudomonas aeruginosa

Sara Van den BosscheAurélie CrabbéTom Coenye

Direct lysis of 3D cell cultures for RT-qPCR gene expression quantification

Fien GysensLisa OstynEllen GoeteynEva BlondeelJustine NuytensOlivier De WeverEric de Bony de LavergneAurélie CrabbéPieter Mestdagh

A1 Journal Article in SCIENTIFIC REPORTS

Effect of malate on the activity of ciprofloxacin against Pseudomonas aeruginosa in different in vivo and in vivo-like infection models

Xuerui BaoEllen GoeteynAurélie CrabbéTom Coenye

A1 Journal Article in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High throughput determination of the biofilm prevention concentration for Pseudomonas aeruginosa biofilms using a synthetic cystic fibrosis sputum medium

Amber De BleeckereSara Van den BosschePieter-Jan De SutterTine BeirensAurélie CrabbéTom Coenye

A2 Journal Article in BIOFILM

Modulation of bacterial metabolism to potentiate antibiotic efficacy against Pseudomonas aeruginosa biofilm infections

Xuerui BaoTom CoenyeAurélie Crabbé

Pooling isolates to address the diversity in antimicrobial susceptibility of Pseudomonas aeruginosa in cystic fibrosis

Sara Van den BosscheEmmanuel AbatihLucia GrassiEmma De BroePetra RigoleJerina BoelensJoris Van CaenegemBruno VerhasseltIris JanssensEva Van Braeckel et al.

A1 Journal Article in MICROBIOLOGY SPECTRUM

The development and characterization of in vivo-like three-dimensional models of bronchial epithelial cell lines.

Sara Van den BosscheLisa OstynValerie VandendriesscheCharlotte RigautsHerlinde De KeersmaeckerCheryl A. NickersonAurélie Crabbé

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

2022

Microbial diversity and antimicrobial susceptibility in endotracheal tube biofilms recovered from mechanically ventilated COVID-19 patients

Frits van CharanteAnneleen WiemePetra RigoleEvelien De CanckLisa OstynLucia GrassiDieter DeforceAurélie CrabbéPeter VandammeMarie Joossens et al.

A2 Journal Article in BIOFILM

Rothia mucilaginosa is an anti-inflammatory bacterium in the respiratory tract of patients with chronic lung disease

Charlotte RigautsJuliana AizawaSteven TaylorGeraint B. RogersMatthias GovaertsPaul CosLisa OstynSarah SimsEva VandeplasscheMozes Sze et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

2021

Model system parameters influence the sodium hypochlorite susceptibility of endodontic biofilms

Rosalie SwimbergheAurélie CrabbéRoeland De MoorTom CoenyeMaarten Meire

A1 Journal Article in INTERNATIONAL ENDODONTIC JOURNAL

Model systems to study the chronic, polymicrobial infections in cystic fibrosis : current approaches and exploring future directions

GA O'TooleAurélie CrabbéR KümmerliJJ LiPumaJM BombergerJC DaviesD LimoliVV PhelanJB BliskaWH DePas et al.

A1 Journal Article in MBIO

Porphyrins produced by acneic Cutibacterium acnes strains activate the inflammasome by inducing K+ leakage

Karl-Jan SpittaelsKatleen Van UytfangheChristos C. ZouboulisChristophe StoveAurélie CrabbéTom Coenye

A1 Journal Article in ISCIENCE

The cystic fibrosis lung microenvironment alters antibiotic activity : causes and effects

Sara Van den BosscheEmma De BroeTom CoenyeEva Van BraeckelAurélie Crabbé

A1 Journal Article in EUROPEAN RESPIRATORY REVIEW

The quorum-sensing inhibitor furanone C-30 rapidly loses its tobramycin-potentiating activity against Pseudomonas aeruginosa biofilms during experimental evolution

Mona BovéXuerui BaoAndrea SassAurélie CrabbéTom Coenye

A1 Journal Article in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

2020

Antibiotic susceptibility of cystic fibrosis lung microbiome members in a multispecies biofilm

Eva VandeplasscheAndrea SassLisa OstynMette BurmølleKasper Nørskov KraghThomas BjarnsholtTom CoenyeAurélie Crabbé

A2 Journal Article in BIOFILM (AMSTERDAM)

Bacterial interference with lactate dehydrogenase assay leads to an underestimation of cytotoxicity

Sara Van den BosscheEva VandeplasscheLisa OstynTom CoenyeAurélie Crabbé

A1 Journal Article in FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

Cutibacterium acnes and acne vulgaris : how bad strains ruin it for everyone

Karl-Jan SpittaelsTom CoenyeAurélie Crabbé

Cutibacterium acnes phylotype I and II strains interact differently with human skin cells

Karl-Jan SpittaelsRuben OngenaChristos C. ZouboulisAurélie CrabbéTom Coenye

A1 Journal Article in FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

Exploring the effects of non-pathogenic respiratory microbiome members on inflammation in models of chronic airway disease

Charlotte RigautsAurélie CrabbéTom Coenye

RhIR-regulated acyl-homoserine lactone quorum sensing in a cystic fibrosis isolate of Pseudomonas aeruginosa

Renae L. CruzKyle L. AsfahlSara Van den BosscheTom CoenyeAurélie CrabbéAjai A. Dandekar

A1 Journal Article in MBIO

The anti-microbial peptide (Lin-SB056-1)(2)-K reduces pro-inflammatory cytokine release through Interaction with Pseudomonas aeruginosa lipopolysaccharide

Lucia GrassiArianna PompilioEsingul KayaAndrea C. RinaldiEnrico SanjustGiuseppantonio MaisettaAurélie CrabbéGiovanni Di BonaventuraGiovanna BatoniSemih Esin

A1 Journal Article in ANTIBIOTICS-BASEL

2019

Antimicrobial tolerance and metabolic adaptations in microbial biofilms

Aurélie CrabbéPeter Østrup JensenThomas BjarnsholtTom Coenye

A1 Journal Article in TRENDS IN MICROBIOLOGY

Antimicrobial treatment provides a competitive advantage to Mycobacterium abscessus in a dual-species biofilm with Pseudomonas aeruginosa

Graciela Rodríguez-SevillaAurélie CrabbéMarta García-CocaJohn Jairo Aguilera-CorreaJaime EstebanConcepción Pérez-Jorge

A1 Journal Article in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Host metabolites stimulate the bacterial proton motive force to enhance the activity of aminoglycoside antibiotics

Aurélie CrabbéLisa OstynSorien StaelensCharlotte RigautsMartijn RisseeuwMaarten DhaenensSimon DaledHeleen Van AckerDieter DeforceSerge Van Calenbergh et al.

A1 Journal Article in PLOS PATHOGENS

In vitro evolution of Pseudomonas aeruginosa AA2 biofilms in the presence of cystic fibrosis lung microbiome members

Eva VandeplasscheAndrea SassAstrid LemarcqAjai DandekarTom CoenyeAurélie Crabbé

A1 Journal Article in SCIENTIFIC REPORTS

Influence of the lung microbiome on antibiotic susceptibility of cystic fibrosis pathogens

Eva VandeplasscheSarah TavernierTom CoenyeAurélie Crabbé

A1 Journal Article in EUROPEAN RESPIRATORY REVIEW

The antimicrobial peptide lin-SB056-1 and its dendrimeric derivative prevent Pseudomonas aeruginosa biofilm formation in physiologically relevant models of chronic infections

Lucia GrassiGiovanna BatoniLisa OstynPetra RigoleSara Van den BosscheAndrea C RinaldiGiuseppantonio MaisettaSemih EsinTom CoenyeAurélie Crabbé

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

The role of small proteins in Burkholderia cenocepacia J2315 biofilm formation, persistence and intracellular growth

Heleen Van AckerAurélie CrabbéDukas JurėnasLisa OstynAndrea SassSimon DaledMaarten DhaenensDieter DeforceEline TeirlinckHerlinde De Keersmaecker et al.

A2 Journal Article in BIOFILM

Various Evolutionary Trajectories Lead to Loss of the Tobramycin-Potentiating Activity of the Quorum-Sensing Inhibitor Baicalin Hydrate in Burkholderia cenocepacia Biofilms

Andrea SassLisa SlachmuyldersHeleen Van AckerIan VandenbusscheLisa OstynMona BovéAurélie CrabbéLaurent R ChiarelliSilvia BuroniFilip Van Nieuwerburgh et al.

A1 Journal Article in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

2018

Antibiotic susceptibility and evolutionary adaptation of Pseudomonas aeruginosa in a cystic fibrosis multispecies biofilm

Eva VandeplasscheAurélie CrabbéTom Coenye

Coumarin reduces virulence and biofilm formation in Pseudomonas aeruginosa by affecting quorum sensing, type III secretion and C-di-GMP levels

Yunhui ZhangAndrea SassHeleen Van AckerJasper WilleBruno VerhasseltFilip Van NieuwerburghVolkhard KaeverAurélie CrabbéTom Coenye

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

Decreased susceptibility of Streptococcus anginosus to vancomycin in a multispecies biofilm is due to increased thickness of the cell wall

Sarah TavernierAndrea SassMichiel De BruyneFemke BaekeRiet De RyckeAurélie CrabbéIlse VandecandelaereFilip Van NieuwerburghTom Coenye

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Influence of three-dimensional lung epithelial cells and interspecies interactions on antibiotic efficacy against Mycobacterium abscessus and Pseudomonas aeruginosa

Graciela Rodriguez-SevillaCharlotte RigautsEva VandeplasscheLisa OstynIgnacio Mahillo-FernandezJaime EstebanConcepcion Perez-Jorge PeremarchTom CoenyeAurélie Crabbé

A1 Journal Article in PATHOGENS AND DISEASE

Modeling host-pathogen interactions in the context of the microenvironment : three-dimensional cell culture comes of agee

Jennifer BarrilaAurélie CrabbéJiseon YangKarla FrancoSeth D. NydamRebecca J. ForsythRichard R. DavisSandhya GangarajuC. Mark OttCarolyn B. Coyne et al.

A1 Journal Article in INFECTION AND IMMUNITY

2017

Antimicrobial efficacy against Pseudomonas aeruginosa biofilm formation in a three-dimensional lung epithelial model and the influence of fetal bovine serum

Aurélie CrabbéYulong LiuNele MatthijsPetra RigoleCésar De La Fuente-NùñezRichard DavisMaria A LedesmaShameema SarkerRob Van HoudtRobert EW Hancock et al.

A1 Journal Article in SCIENTIFIC REPORTS

Community composition determines activity of antibiotics against multispecies biofilms

Sarah TavernierAurélie CrabbéMayram HaciogluLiesbeth StuerSilke HenryPetra RigoleInne DhondtTom Coenye

A1 Journal Article in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Developing selective media for quantification of multispecies biofilms following antibiotic treatment

Eva VandeplasscheTom CoenyeAurélie Crabbé

A1 Journal Article in PLOS ONE

Evaluation of combination therapy for Burkholderia cenocepacia lung infection in different in vitro and in vivo models

Freija Van den DriesscheBieke VanhoutteGilles BrackmanAurélie CrabbéPetra RigoleJurgen VercruysseGlenn VerstraeteDavie CappoenChris VervaetPaul Cos et al.

A1 Journal Article in PLOS ONE

The effect of interspecies interactions on the antimicrobial susceptibility of multispecies biofilms

Sarah TavernierTom CoenyeAurélie Crabbé

Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to study Salmonella enterica colonization patterns

Jennifer BarrilaJiseon YangAurélie CrabbéShameema F SarkerYulong LiuC Mark OttMayra A Nelman-GonzalezSimon J ClemettSeth D NydamRebecca J Forsyth et al.

A1 Journal Article in NPJ MICROGRAVITY

2016

Effect of shear stress on Pseudomonas aeruginosa isolated from the cystic fibrosis lung

Jozef DingemansPieter MonsieursSung-Huan YuAurélie CrabbéKonrad U FörstnerAnne MalfrootPierre CornelisRob Van Houdt

A1 Journal Article in MBIO

Outpacing infectious disease : mimicking the host-pathogen microenvironment in three-dimensions

Aurélie CrabbéJennifer BarrilaC Mark OttCheryl A Nickerson

Bookchapter in Effect of spaceflight and spaceflight analogue culture on human and microbial cells : novel insights into disease mechanisms

Response of Pseudomonas aeruginosa to spaceflight and spaceflight analogue culture : implications for astronaut health and the clinic

Aurélie CrabbéMaria A LedesmaC Mark OttCheryl A Nickerson

Bookchapter in Effect of spaceflight and spaceflight analogue culture on human and microbial cells : novel insights into disease mechanisms

Spaceflight modulates gene expression in the whole blood of astronauts

Jennifer BarrilaC Mark OttCarly LeBlancSatish K MehtaAurélie CrabbéPhillip StaffordDuane L PiersonCheryl A Nickerson

A1 Journal Article in NPJ MICROGRAVITY

2010

Organotypic 3D cell culture models : using the rotating wall vessel to study host–pathogen interactions

Jennifer BarrilaAndrea L. RadtkeAurélie CrabbéShameema F. SarkerMelissa M. Herbst-KralovetzC. Mark OttCheryl A. Nickerson

A1 Journal Article in NATURE REVIEWS MICROBIOLOGY