Research Explorer

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Researcher

Ashish Kumar

Publications & Research Data

Awards & Distinctions

52 Results

2025

Comparative analysis of tablet dissolution behavior : batch vs. continuous direct compression

Kensaku MatsunamiAlexander RyckaertHanne VerrecasAna Filipa Tavares da SilvaAndrew AndersonHåkan WikströmMelanie DumareyJames MannThomas De BeerValérie Vanhoorne et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Mathematical models of dissolution testing : challenges and opportunities toward real-time release testing

Kensaku MatsunamiAlexander RyckaertValérie VanhoorneAshish Kumar

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Mechanistic modelling in pharmaceutical product and process development : a review of distributed and discrete approaches

Kensaku MatsunamiPedro Martin SalvadorLuz Naranjo GómezGaia Sofia ComoliIsar CharmchiAshish Kumar

A1 Journal Article in CHEMICAL ENGINEERING RESEARCH & DESIGN

Quality-by-digital-design for the in-process integration of Raman spectroscopy as a PAT tool in continuous manufacturing of pharmaceutical liquids and semi-solids

Tryfon DigkasIsar CharmchiThomas De BeerAshish Kumar

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2024

CFD-DEM model of a cold plasma assisted fluidized bed powder coating process

Pedro Martin SalvadorR. H. VerschuerenThomas De BeerAshish Kumar

A2 Journal Article in FRONTIERS IN CHEMICAL ENGINEERING

Investigating screw-agitator speed ratio impact on feeding performance in pharmaceutical manufacturing using discrete element method

Luz Naranjo GómezKensaku MatsunamiPaul Van LiedekerkeThomas De BeerAshish Kumar

A1 Journal Article in SCIENTIFIC REPORTS

2023

Identification of continuous twin-screw melt granulation mechanisms for different screw configurations, process settings and formulation

Shana Van de SteeneJeroen Van RenterghemValérie VanhoorneChris VervaetAshish KumarThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Linking material properties to 1D-PBM parameters towards a generic model for twin-screw wet granulation

Ana Alejandra Barrera JiménezKensaku MatsunamiDaan Van HauwermeirenMichiel PeetersFanny StaufferEduardo dos Santos SchultzAshish KumarThomas De BeerIngmar Nopens

A1 Journal Article in CHEMICAL ENGINEERING RESEARCH & DESIGN

Partial least squares regression to calculate population balance model parameters from material properties in continuous twin-screw wet granulation

Ana Alejandra Barrera JiménezKensaku MatsunamiDaan Van HauwermeirenMichiel PeetersFanny StaufferEduardo dos Santos SchultzAshish KumarThomas De BeerIngmar Nopens

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2022

Advances in twin-screw granulation

Valérie VanhoorneAshish Kumar

Editorial material

Finite element modeling of powder compaction : mini-tablets in comparison with conventionally sized tablets

Luz Naranjo GómezThomas De BeerAshish Kumar

A1 Journal Article in PHARMACEUTICAL RESEARCH

2021

Development and application of a mechanistic cooling and freezing model of the spin freezing step within the framework of continuous freeze-drying

Gust NuyttenSusan Ríos RevattaPieter-Jan Van BockstalAshish KumarJoris LammensLaurens LeysBrecht VanbillemontJos CorverChris VervaetThomas De Beer

A1 Journal Article in PHARMACEUTICS

Particle-scale modeling to understand liquid distribution in twin-screw wet granulation

Ashish KumarStefan RadlKrist V. GernaeyThomas De BeerIngmar Nopens

A1 Journal Article in PHARMACEUTICS

2020

Characterization of simultaneous evolution of size and composition distributions using generalized aggregation population balance equation

Mehakpreet SinghAshish KumarSaeed ShirazianVivek RanadeGavin Walker

A1 Journal Article in PHARMACEUTICS

Prediction of tablet weight variability in continuous manufacturing

Sonia M. RazaviJames ScicoloneRonald D. SneeAshish KumarJohny BertelsPhilippe CappuynsIvo Van AsscheAlberto M. CuitiñoFernando Muzzio

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Why is batch processing still dominating the biologics landscape? Towards an integrated continuous bioprocessing alternative

Ashish KumarIsuru A. UdugamaCarina L. GargaloKrist V. Gernaey

A1 Journal Article in PROCESSES

2019

Evaluation of an in-line NIR spectroscopic method for the determination of the residence time in a tablet press

Fien De LeersnyderValérie VanhoorneAshish KumarChris VervaetThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Impact of material properties and process variables on the residence time distribution in twin screw feeding equipment

Bernd Van SnickAshish KumarMaxim VerstraetenKenny PandelaereJens DhondtG Di PretoroThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Model-based approach to the design of pharmaceutical roller-compaction processes

Peter TosonDiogo G. LopesRaphael PausAshish KumarJeroen GeensSandy StibaleJulian QuodbachPeter KleinebuddeWen-Kai HsiaoJohannes Khinast

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS-X

2017

Continuous direct compression as manufacturing platform for sustained release tablets

Bernd Van SnickJ. HolmanC. CunninghamAshish KumarJurgen VercruysseThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Development of a continuous direct compression platform for low-dose drug products

Bernd Van SnickJ. HolmanValérie VanhoorneAshish KumarThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Twin-screw granulation process development: present approaches, understanding and needs

Ashish KumarK.V. GernaeyIngmar NopensThomas De Beer

Bookchapter in Continuous manufacturing of pharmaceuticals

Visualization of compaction behavior of pharmaceutical powders in solid-dosage manufacturing using finite element analysis

Ashish KumarJens DhondtJhony BertelsDidier KlingeleersKrist V GernaeyIngmar NopensThomas De Beer

2016

Characterization of compaction behaviour of powders in solid-dosage manufacturing using finite element analysis

Ashish KumarJens DhondtJohny BertelsDidier KlingeleersKrist V GernaeyIngmar NopensThomas De Beer

Development of a process map : a step towards a regime map for steady-state high shear wet twin screw granulation

Ashish KumarJens DhondtJurgen VercruysseFien De LeersnyderValérie VanhoorneChris VervaetJean Paul RemonKrist V. GernaeyThomas De BeerIngmar Nopens

A1 Journal Article in POWDER TECHNOLOGY

Linking granulation performance with residence time and granulation liquid distributions in twin-screw granulation : an experimental investigation

Ashish KumarMaija AlakarjulaValérie VanhoorneMaunu ToiviainenFien De LeersnyderJurgen VercruysseMikko JuutiJarkko KetolainenChris VervaetJean Paul Remon et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Methodology and pitfalls when calibrating a PBM : the case of twin-screw wet granulation

Daan Van HauwermeirenThomas De BeerMichael GhijsMaxim VerstraetenAshish KumarKrist V GernaeyKai LeeMary T am EndePankaj DoshiIngmar Nopens

Model-based analysis of a twin-screw wet granulation system for continuous solid dosage manufacturing

Ashish KumarJurgen VercruysseSéverine MortierChris VervaetJean Paul RemonKrist V GernaeyThomas De BeerIngmar Nopens

A1 Journal Article in COMPUTERS & CHEMICAL ENGINEERING

2015

Analysis of a twin-screw granulation process using a combined experimental and computational approach

Ashish KumarJurgen VercruysseKrist V GernaeyThomas De BeerIngmar Nopens

Combined experimental and computational approach to elucidate the twin-screw granulation process

Ashish KumarJurgen VercruysseChris VervaetJean Paul RemonKrist V GernaeyThomas De BeerIngmar Nopens

Conceptual framework for model-based analysis of residence time distribution in twin-screw granulation

Ashish KumarJurgen VercruysseValérie VanhoorneMaunu ToiviainenPierre-Emmanuel PanouillotMikko JuutiChris VervaetJean Paul RemonKrist V GernaeyThomas De Beer et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Detailed simulation of particle and liquid distribution in the mixing zone of a TwinScrew granulator

Ashish KumarStefan RadlJohannes G KhinastKrist V GernaeyThomas De BeerIngmar Nopens

Development of regime map for steady-state high shear wet twin-screw granulation

Ashish KumarJens DhondtJurgen VercruysseFien De LeersnyderValérie VanhoorneKrist V GernaeyThomas De BeerIngmar Nopens

Evaluation of an in-line particle imaging tool for monitoring twin-screw granulation performance

Ashish KumarJens DhondtFien De LeersnyderJurgen VercruysseValérie VanhoorneChris VervaetJean Paul RemonKrist V GernaeyThomas De BeerIngmar Nopens

A1 Journal Article in POWDER TECHNOLOGY

Experimental and model-based analysis of twin-screw wet granulation in pharmaceutical processes

Ashish KumarIngmar NopensThomas De BeerKrist V Gernaey

Experimental investigation linking granulation performance with Residence time and granulation liquid distributions in TwinScrew granulation

Ashish KumarMaija AlkarjulaValérie VanhoorneMaunu ToiviainenMikko JuutiChris VervaetJarkko KetolainenKrist V GernaeyIngmar NopensThomas De Beer

Experimental investigation of residence time, granulation liquid and granule size distributions in twin-screw granulation

Ashish KumarMaija AlakarjulaValérie VanhoorneMaunu ToiviainenMikko JuutiChris VervaetJarkko KetolainenKrist V GernaeyThomas De BeerIngmar Nopens

Experimental investigation of the link between granulation performance, residence time and granulation liquid distribution in twin-screw granulation

Ashish KumarMaija AlakarjulaValérie VanhoorneMaunu ToiviainenMikko JuutiChris VervaetJarkko KetolainenKrist V GernaeyThomas De BeerIngmar Nopens

Investigation of twin screw granulation : integrating experimental and computational approaches

Ashish KumarKrist V GernaeyThomas De BeerIngmar Nopens

Model-based characterisation of twin-screw granulation system for continuous solid dosage manufacturing

Ashish KumarKrist V GernaeyThomas De BeerIngmar Nopens

2014

Biochemical engineering parameters for hydrometallurgical processes : steps towards a deeper understanding

Kankana KunduAshish Kumar

A2 Journal Article in JOURNAL OF MINING

Development of a population balance model for continuous twin-screw granulation in pharmaceutical manufacturing

Ashish KumarKrist V GernaeyThomas De BeerIngmar Nopens

Experimental and model-based investigation of twin screw granulation: towards more profound process knowledge

Ashish KumarKrist V GernaeyThomas De BeerIngmar Nopens

Experimental investigation of granule shape and size dynamics in twin-screw granulation

Ashish KumarJurgen VercruysseKrist V GernaeyThomas De BeerIngmar Nopens

Experimental investigation of granule size and shape dynamics in twin-screw granulation

Ashish KumarJurgen VercruysseGiacomo BellandiKrist V GernaeyChris VervaetJean Paul RemonThomas De BeerIngmar Nopens

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Experimental investigation of residence time distribution in twin-screw granulation

Ashish KumarJurgen VercruysseMaunu ToiviainenPierre-Emmanuel PanouillotMikko JuutiValérie VanhoorneKrist V GernaeyThomas De BeerIngmar Nopens

Mixing and transport during pharmaceutical twin-screw wet granulation : experimental analysis via chemical imaging

Ashish KumarJurgen VercruysseMaunu ToiviainenPierre-Emmanuel PanouillotMikko JuutiValérie VanhoorneChris VervaetJean Paul RemonKrist V GernaeyThomas De Beer et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Model-based analysis and experimental validation of residence time distribution in twin-screw granulation

Ashish KumarJurgen VercruysseMaunu ToiviainenPierre-Emmanuel PanouillotMikko JuutiValérie VanhoorneKrist V GernaeyThomas De BeerIngmar Nopens

2013

An experimental study on effect of screw configuration in twin screw wet granulation

Ashish KumarJurgen VercruysseKrist V GernaeyIngmar NopensThomas De Beer

Evaluation of particle shape and size evolution during high-shear wet granulatoin using twin-screw granulator

Ashish KumarJurgen VercruysseKrist V GernaeyThomas De BeerIngmar Nopens

Model-based analysis of high shear wet granulation from batch to continuous processes in pharmaceutical production: a critical review

Ashish KumarKrist V GernaeyThomas De BeerIngmar Nopens

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

One dimensional model of the prediction of residence time distribution granulation in a twin-screw granulator

Ashish KumarKrist V GernaeyThomas De BeerIngmar Nopens