Research Explorer

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Researcher

Annette Caenen

Publications & Research Data

Awards & Distinctions

94 Results

2026

Assessment of myocardial stiffness with new echocardiographic methods

Laurine WoutersAnnette CaenenAhmed YoussefAndressa Araujo Andrade SousaStéphanie BézyJürgen DuchenneJan D’hoogeJens-Uwe Voigt

A1 Journal Article in KOREAN CIRCULATION JOURNAL

2025

3-D high-frame-rate imaging of natural shear waves in the heart

Annette CaenenKonstantina PapangelopoulouLaurine WoutersJens-Uwe VoigtJan D'hooge

A pilot study on midazolam sedation for murine echocardiography : a potential alternative to isoflurane anesthesia and awake imaging

Bart JacobsSarah DerdeLies LangoucheJan D'hoogeNadia SalernoSandro QueirósGreet Van den BergheAnnette CaenenJan Gunst

A2 Journal Article in PHYSIOLOGICAL REPORTS

A pilot study on the effect of intratendinous pressure on shear wave elastography in the Achilles tendon

Ariana CihanClara KeteleLauren PringelsLuc Vanden BosscheHendrik J VosPatrick SegersAnnette Caenen

Artificial intelligence-based model can distinguish patients from healthy volunteers based on natural shear wave properties

K. BampsL. WoutersAnnette CaenenL. MintenA. YoussefJ. D'hoogeJ. U. Voigt

Cardiac shear wave elastography : assessing the performance of different algorithms for shear wave speed estimation

A. Araujo Andrade SousaM. OrlowskaL. WoutersA. YoussefAnnette CaenenJ. D. HoogeJ. U. Voigt

Characterization of SH and SV wave modes in a nonlinear elastic solid with uniaxial stretch using 3D-rotational SWEI

Shruthi SrinivasanAnnette CaenenNed C. RouzeKathryn R. Nightingale

Corrigendum: Effect of interstitial fluid pressure on shear wave elastography : an experimental and computational study (2024 Phys. Med. Biol. 69 075001)

Ariana CihanKristýna HolkováLuxi WeiHendrik J VosCharlotte DebbautAnnette CaenenPatrick Segers

Identifying predictors of shear wave speed in cardiac shear wave elastography using multivariable analysis

Andressa A. A. SousaAnnette CaenenAhmed YoussefLaurine WoutersMiaomiao LiuJan D’HoogeJens-Uwe Voigt

Shear wave velocity exhibits significant beat-to-beat variability in atrial fibrillation

N. SalernoK. PapangelopoulouAnnette CaenenM. OrlowskaA. YoussefL. WoutersJ. D'hoogeJ. U. Voigt

SWE can detect myocardial remodelling in aortic stenosis patients undergoing aortic valve replacement

L. WoutersL. MintenA. YoussefK. PapangelopoulouM. OrlowskaAnnette CaenenJ. DuchenneJ. D'hoogeJ. U. Voigt

The impact of valve stenosis and replacement on wave characteristics in cardiac shear wave elastography

Laurine WoutersLennert MintenMarta OrlowskaAnnette CaenenJürgen DuchenneJens-Uwe VoigtJan D’Hooge

A2 Journal Article in IEEE OPEN JOURNAL OF ULTRASONICS, FERROELECTRICS, AND FREQUENCY CONTROL

Utilizing CNNs on shear wave M-mode data to differentiate cardiac patients from healthy volunteers

Laurine WoutersKobe BampsAnnette CaenenAhmed YoussefJens-Uwe VoigtJan D’Hooge

2024

A robust pipeline including directional filtering and wave propagation zones for mapping shear wave velocity

Ariana CihanPatrick SegersAnnette Caenen

Effect of interstitial fluid pressure on shear wave elastography : an experimental and computational study

Ariana CihanKristýna HolkováLuxi WeiHendrik J VosCharlotte DebbautAnnette CaenenPatrick Segers

A1 Journal Article in PHYSICS IN MEDICINE AND BIOLOGY

Evaluating the performance of automatic wave speed estimators of natural shear waves to assess myocardial stiffness

A. Araujo Andrade SousaM. OrlowskaL. WoutersA. YoussefAnnette CaenenJ. DuchenneJ. D'hoogeJ. U. Voigt

Evolution of natural myocardial shear wave behavior in young hearts : determinant factors and reproducibility analysis

Ahmed S. YoussefAniela PetrescuThomas SalaetsStéphanie BézyLaurine WoutersMarta OrlowskaAnnette CaenenJürgen DuchenneAlexis PuvrezBjorn Cools et al.

A1 Journal Article in JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

Shear-wave elastography reflects myocardial stiffness changes in pediatric inflammatory syndrome post COVID-19

Ahmed S. YoussefThomas SalaetsStéphanie BézyLaurine WoutersMarta OrlowskaAnnette CaenenJürgen DuchenneAlexis PuvrezLien De SomerBjorn Cools et al.

A1 Journal Article in JACC-CARDIOVASCULAR IMAGING

Ultrasound shear wave elastography in cardiology

Annette CaenenStéphanie BézyMathieu PernotKathryn R. NightingaleHendrik J. VosJens-Uwe VoigtPatrick SegersJan D’hooge

A1 Journal Article in JACC-CARDIOVASCULAR IMAGING

Uncertainty quantification of the wall thickness and stiffness in an idealized dissected aorta

Lise GheysenLauranne MaesAnnette CaenenPatrick SegersMathias PeirlinckNele Famaey

A1 Journal Article in JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS

2023

Behaviour of natural myocardial shear waves in children and adolescents : determinants and reproducibility

A. YoussefT. SalaetsS. BezyL. WoutersM. OrlowskaAnnette CaenenJ. DuchenneA. PuvrezB. CoolsM. Gewillig et al.

Changes in myocardial operational stiffness in mechanically ventilated sheep can be detected by measuring natural shear wave propagation speed

Bart JacobsAnnette CaenenStephanie BezyLaurine WoutersP. ClausBart MeynsLies LangoucheJan Dhooge

Continuous shear wave measurements for dynamic cardiac stiffness evaluation in pigs

Annette CaenenLana KeijzerStéphanie BézyJürgen DuchenneMarta OrlowskaAntonius F. W. Van Der SteenNico De JongJohan G. BoschJens-Uwe VoigtJan D’hooge et al.

A1 Journal Article in SCIENTIFIC REPORTS

Natural shear wave elastography to assess diastolic function in univentricular hearts : a prospective cohort study

I. CattapanA. YoussefAnnette CaenenB. CoolsW. BudtsM. GewilligA. Van De BruaeneJ. D'hoogeJ. U. Voigt

Natural shear wave measurements detect changes in operational stiffness induced by mechanical ventilation in sheep

B. JacobsAnnette CaenenS. BezyL. WoutersP. ClausB. MeynsL. LangoucheJ. D'hooge

Natural shear waves show sequential changes in myocardial stiffness In paediatric multi-inflammatory systemic syndrome post COVID

A. YoussefT. SalaetsS. BezyL. WoutersM. OrlowskaAnnette CaenenJ. DuchenneA. PuvrezB. CoolsM. Gewillig et al.

Shear wave elastography for assessing interstitial fluid pressure : an in silico study

Ariana CihanAnnette CaenenCharlotte DebbautPatrick Segers

Shear wave elastography using diverging wave imaging with sliding-window coherent compounding

Marta OrlowskaAnnette CaenenKjell KristoffersenJan D'hooge

Transmural wave speed gradient may distinguish intrinsic myocardial stiffening from preload-induced changes in operational stiffness in shear wave elastography

Annette CaenenStephanie BezyAniela PetrescuAnnegret WernerJens-Uwe VoigtJan DhoogePatrick Segers

A1 Journal Article in IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Understanding the biomechanics of cardiac shear wave elastography : an in silico study in a contracting left ventricle

Annette CaenenMathias PeirlinckJan D'hoogePatrick Segers

2022

Assessing cardiac stiffness using ultrasound shear wave elastography

Annette CaenenMathieu PernotKathryn R. NightingaleJens-Uwe VoigtHendrik J. VosPatrick SegersJan D’hooge

A1 Journal Article in PHYSICS IN MEDICINE AND BIOLOGY

Biomechanical wall thickness and stiffness uncertainty quantification in an idealized model of the pre-stretched dissected aorta

Lise GheysenLauranne MaesMathias PeirlinckAnnette CaenenNele FamaeyPatrick Segers

Cardiac shear wave speed estimation in 3D : an in silico and in vivo study

Ekaterina SeliverstovaAnnette CaenenPedro SantosKonstantina PapangelopoulouJan D'hooge

Comparing myocardial shear wave propagation velocity estimation methods based on tissue displacement, velocity and acceleration data

Ekaterina SeliverstovaAnnette CaenenStephanie BézySjoerd NooijensJens-Uwe VoigtJan D'hooge

A1 Journal Article in ULTRASOUND IN MEDICINE AND BIOLOGY

Externally-induced shear waves in the right ventricular free wall throughout the cardiac cycle

L. WeiR. Alipour SymakaniAnnette CaenenL. B. H. KeijzerD. MerkusB. BarteldsY. TaverneA. F. W. Van Der SteenH. J. VosM. Strachinaru

Full characterization of in vivo muscle as an elastic, incompressible, transversely isotropic material using ultrasonic rotational 3D shear wave elasticity imaging

Anna E. KnightCourtney A. TrutnaNed C. RouzeLisa D. Hobson-WebbAnnette CaenenFelix Q. JinMark L. PalmeriKathryn R. Nightingale

A1 Journal Article in IEEE TRANSACTIONS ON MEDICAL IMAGING

Hemodynamic loading and intrinsic cardiac stiffness affect shear wave measurements : an in silico sensitivity analysis

Annette CaenenStephanie BezyAniela PetrescuAnnegret WernerJens-Uwe VoigtJan D'hoogePatrick Segers

Impact of loading and myocardial mechanical properties on natural shear waves

Stéphanie BézyJürgen DuchenneMarta OrlowskaAnnette CaenenMatthew AmoniSebastian IngelaereLaurine WoutersKeir McCutcheonLennert MintenAlexis Puvrez et al.

A1 Journal Article in JACC-CARDIOVASCULAR IMAGING

Myocardial stiffness assessed by shear wave elastography relates to pressure-volume loop derived measurements of chamber stiffness

S. BezyAnnette CaenenJ. DuchenneM. OrlowskaM. AmoniA. PuvrezJ. D"hoogeJ. U. Voigt

On the interplay of loading, myocardial stiffness and contractility in transthoracic acoustic radiation force induced shear wave measurements in pigs

Annette CaenenLana KeijzerJurgen DuchenneMarta OrlowskaAnton Van Der SteenNico De JongHans BoschJens-Uwe VoigtPatrick SegersJan D'hooge et al.

Phase and group velocities for shear wave propagation in an incompressible, hyperelastic material with uniaxial stretch

Ned C RouzeAnnette CaenenKathryn R Nightingale

A1 Journal Article in PHYSICS IN MEDICINE AND BIOLOGY

Shear wave propagation speed after aortic valve closure is related to myocardial contractility

Stephanie BezyJurgen DuchenneAnnette CaenenMarta OrlowskaJan D'hoogeJens-Uwe Voigt

Systolic shear wave propagation speed as a novel non-invasive marker of myocardial contractility

S. BezyAnnette CaenenJ. DuchenneM. OrlowskaJ. D"hoogeJ. U. Voigt

Transmural shear wave speed gradient distinguishes intrinsic myocardial stiffening from preload-induced changes in functional stiffness : an in silico study

Annette CaenenStephanie BezyAniela PetrescuAnnegret WernerJens-Uwe VoigtJan D'hoogePatrick Segers

2021

Closed-chest measurement of diastolic and systolic shear wave speed to assess myocardial stiffness

Annette CaenenL. KeijzerS. BezyJ. DuchenneM. OrlowskaA. F. W. Van Der SteenN. De JongPatrick SegersJ. G. BoschJ.-U. Voigt et al.

Externally induced shear waves in the right ventricular free wall during the cardiac cycle

Luxi WeiRahi Alipour SymakaniAnnette CaenenLana B. H. KeijzerDaphne MerkusBeatrijs BarteldsYannick TaverneAntonius F. van der SteenHendrik VosMihai Strachinaru

In silico analysis of different methodologies for estimating cardiac shear wave speed

Ekaterin SeliverstovaAnnette CaenenSjoerd NooijensJan D'hooge

Interpretation of transthoracic acoustic radiation force based shear wave elastography measurements to assess myocardial stiffness

Annette CaenenLana KeijzerStephanie BezyJurgen DuchenneMarta OrlowskaAntonius Van Der SteenNico De JongPatrick SegersJohan BoschJens-Uwe Voigt et al.

Myocardial stiffness assessed by natural shear wave elastography is related to pressure-volume loop derived parameters

S. BezyAnnette CaenenJ. DuchenneM. OrlowskaM. AmoniL. B. H. KeijzerR. VosJ. D'hoogeJ. U. Voigt

Myocardial stiffness assessed by natural shear wave elastography is related to pressure-volume loop derived parameters

S. BezyAnnette CaenenJ. DuchenneM. OrlowskaM. AmoniL. B. H. KeijzerR. VosJ. D'hoogeJ. U. Voigt

Natural shear wave propagation speed is influenced by both changes in myocardial structural properties as well as loading conditions

S. BezyJ. DuchenneM. OrlowskaM. AmoniAnnette CaenenL. B. H. KeijzerK. MccutcheonS. IngelaereM. CvijicA. Puvrez et al.

Tapering of the interventricular septum can affect ultrasound shear wave elastography : an in vitro and in silico study

A. SabbadiniAnnette CaenenL. B. H. KeijzerP. L. M. J. van NeerH. J. VosN. de JongM. D. Verweij

A1 Journal Article in JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA

Transmural shear wave speed gradient distinguishes changes in myocardial properties from changes in hemodynamic loading

Annette CaenenPatrick SegersJan D'hooge

2020

A direct comparison of natural and acoustic-radiation-force-induced cardiac mechanical waves

Lana B. H. KeijzerAnnette CaenenJason VoorneveldMihai StrachinaruDaniel J. BowenJens van de WouwOana SoropDaphne MerkusDirk J. DunckerAntonius F. W. van der Steen et al.

A1 Journal Article in SCIENTIFIC REPORTS

Analysis of multiple shear wave modes in a nonlinear soft solid : experiments and finite element simulations with a tilted acoustic radiation force

Annette CaenenAnna E. KnightNed C. RouzeNick B. BottenusPatrick SegersKathryn R. Nightingale

A1 Journal Article in JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS

Demonstration of complex shear wave patterns in skeletal muscle in vivo using 3D SWEI

Anna E. KnightCourtney A. TrutnaNed C. RouzeLisa D. Hobson-WebbMark L. PalmeriAnnette CaenenKathryn R. Nightingale

Numerical model of Lamb wave propagation in the tapered septal wall of the heart

Alberico SabbadiniAnnette CaenenHendrik VosNico de JongMartin D. Verweij

Parasternal versus apical view in cardiac natural mechanical wave speed measurements

Lana B.H. KeijzerMihai StrachinaruDan J. BowenAnnette CaenenAntonius F.W. Van der SteenMartin D. VerweijNico De JongJohan G. BoschHendrik J. Vos

A1 Journal Article in IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL

Shear wave elastography : a non-invasive alternative for multi-axial mechanical testing? Proof of concept in a nonlinear tissue-mimicking phantom

Annette CaenenAnna E. KnightNed C. RouzeNick B. BottenusPatrick SegersKathryn R. Nightingale

Shear wave imaging : what are we looking at?

The behaviour of natural shear waves under different loading conditions

S. BezyJ. DuchenneM. OrlowskaL. WoutersAnnette CaenenL. B. H. KeijzerM. CvijicJ. D'hoogeJ.-U. Voigt

2019

A comparison of natural and acoustic radiation force induced shear wave propagation speed measurements in open-chest pigs

Lana B.H. KeijzerJason VoorneveldDan J. BowenMihai StrachinaruAntonius F.W. van der SteenNico de JongJohan G. BoschHendrik J. VosAnnette Caenen

Measuring elastic nonlinearity in a soft solid using a tilted acoustic radiation force for shear wave excitation

Annette CaenenAnna E. KnightNed C. RouzeNick B. BottenusPatrick SegersKathryn R. Nightingale

Modeling skin and soft tissue vibrations generated by pressure pulse propagation in the common

Daniela TommasinAnnette CaenenBenedict VerheggheSteve GreenwaldPatrick Segers

Modelling Lamb waves in the septal wall of the heart

Alberico SabbadiniAnnette CaenenHendrik J. VosNico de JongMartin D. Verweij

Physics of within-tissue wave propagation generated by pulse propagation in the carotid artery

Daniela TommasinAnnette CaenenBenedict VerheggheSteve GreenwaldPatrick Segers

A1 Journal Article in APPLIED SCIENCES-BASEL

Wave speeds and Green’s tensors for shear wave propagation in incompressible, hyperelastic materials with uniaxial stretch

Ned C. RouzeAnnette CaenenKathryn R. Nightingale

2018

A biomechanical analysis of shear wave elastography in pediatric heart models

Annette CaenenPatrick SegersAbigail Swillens

An in silico framework to analyze the anisotropic shear wave mechanics in cardiac shear wave elastography

Annette CaenenMathieu PernotMathias PeirlinckLuc MertensAbigail SwillensPatrick Segers

A1 Journal Article in PHYSICS IN MEDICINE AND BIOLOGY

Analyzing the shear wave mechanics in cardiac shear wave elastography using finite element simulations

Annette CaenenMathieu PemotMathias PeirlinckLuc MertensPatrick Segers

Anisotropic constructive shearwave interference measurement of transversely anisotropic materials

Peter HollenderAnna KnightAnnette CaenenNiranjana ShashikumarInje LeeMark PalmeriKathryn NightingaleGregg Trahey

Investigating the degree of shear wave speed anisotropy as a function of studied ventricular zone

Annette CaenenPeter HollenderNick BottenusPatrick SegersGregg TraheyMark Palmeri

Physics of wave propagation underlying skin tissue motion generated by the pressure pulse in the carotid artery

Daniela TommasinAnnette CaenenBenedict VerhegghePatrick Segers

2017

A finite element model to study the effect of tissue anisotropy onex vivoarterial shear wave elastography measurements

Darya ShcherbakovaNic DebusschereAnnette CaenenFrancesco IannacconeM PernotAbigail SwillensPatrick Segers

A1 Journal Article in PHYSICS IN MEDICINE AND BIOLOGY

Effect of ultrafast imaging on shear wave visualization and characterization : an experimental and computational study in a pediatric ventricular model

Annette CaenenMathieu PernotIngvild Kinn EkrollDarya ShcherbakovaLuc MertensAbigail SwillensPatrick Segers

A1 Journal Article in APPLIED SCIENCES-BASEL

Investigating shear wave physics in a generic pediatric left ventricular model via in vitro experiments and finite element simulations

Annette CaenenMathieu PernotDarya ShcherbakovaLuc MertensMathias KersemansPatrick SegersAbigail Swillens

A1 Journal Article in IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL

Shear wave elastography for assessing myocardial material properties : an in vitro, ex vivo and in silico study

Annette CaenenMathieu PernotAbdullah ThabitDarya ShcherbakovaLuc MertensAbigail SwillensPatrick Segers

The effect of stretching on transmural shear wave anisotropy in cardiac shear wave elastography

Annette CaenenAbdullah ThabitAbigail SwillensMathieu PernotDarya ShcherbakovaLuc MertensPatrick Segers

2016

EXPERIMENTAL AND NUMERICAL STUDY OF CIRCUMFERENTIAL AND AXIAL CYLINDRICAL WAVES IN PVA PHANTOMS SURROUNDED BY WATER OR EMBEDDED INTO SOFTER PVA MATERIAL

Darya ShcherbakovaNic DebusschereMathias KersemansAnnette CaenenMathieu PernotPatrick SegersAbigail Swillens

Finite element simulations to support the measurement and analysis of shear wave dispersion

Annette CaenenPatrick SegersAbigail Swillens

How does ultrafast imaging affect shear wave visualization?

Annette CaenenMathieu PernotDarya ShcherbakovaIngvild EkrollPatrick SegersAbigail Swillens

Investigating the performance of shear wave elastography for cardiac stiffness assessment through finite element simulations

Annette CaenenMathieu PernotDarya ShcherbakovaPascal VerdonckPatrick SegersAbigail Swillens

The effect of ultrafast imaging on shear wave observations

Annette CaenenMathieu PernotDarya ShcherbakovaIngvild EkrollPatrick SegersAbigail Swillens

2015

A versatile and experimentally validated finite element model to assess the accuracy of shear wave elastography in a bounded viscoelastic medium

Annette CaenenDarya ShcherbakovaBenedict VerheggheClement PapadacciMathieu PernotPatrick SegersAbigail Swillens

A1 Journal Article in IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL

Experimental study on the effect of the cylindrical vessel geometry on arterial shear wave elastography

Darya ShcherbakovaAnnette CaenenSimon ChatelinClement PapadacciMathieu PernotAbigail SwillensPatrick Segers

Investigating the accuracy of material characterization algorithms for myocardial Shear Wave Elastography in children

Annette CaenenDarya ShcherbakovaClement PapadacciMathieu PernotLuc MertensPatrick SegersAbigail Swillens

Myocardial stiffness assessment in pediatric cardiology using shear wave imaging an in-vitro and in-silico study

Annette CaenenDarya ShcherbakovaClement PapadacciMathieu PernotLuc MertensPatrick SegersAbigail Swillens

The role of multiphysics modeling in establishing a robust ultrasound-based cardiovascular risk assessment

Abigail SwillensAnnette CaenenDarya ShcherbakovaMathieu PernotBenedict VerheggheJoris DegrooteJan VierendeelsPatrick Segers

2014

Development of an experimentally validated numerical tool to assess the accuracy of shear wave elastography

Annette CaenenDarya ShcherbakovaBenedict VerheggheClement PapadacciMathieu PernotPatrick SegersAbigail Swillens

Effect of geometry and material properties on stiffness characterization with shear wave elastography: a numerical study

Annette CaenenDarya ShcherbakovaBenedict VerheggheClement PapadacciMathieu PernotPatrick SegersAbigail Swillens

Evaluating supersonic shear wave imaging for arterial tissue characterization using numerical simulations

Abigail SwillensAnnette CaenenDarya ShcherbakovaClément PapadacciMathieu PernotBenedict VerhegghePatrick Segers

Supersonic shear wave imaging for the assessment of the nonlinear mechanics and anisotropy of arteries : proof of principle based on ex vivo testing of the horse aorta

Darya ShcherbakovaClement PapadacciAbigail SwillensAnnette CaenenDe Bock SanderVeronique SaeyKoen ChiersMickael TanterStephen E. GreenwaldMathieu Pernot et al.

Supersonic shear wave imaging to assess arterial nonlinear behavior and anisotropy: proof of principle via ex vivo testing of the horse aorta

Darya ShcherbakovaClément PapadacciAbigail SwillensAnnette CaenenSander De BockVeronique SaeyKoen ChiersMickaël TanterStephen GreenwaldMathieu Pernot et al.

A1 Journal Article in ADVANCES IN MECHANICAL ENGINEERING

2013

Supersonic shear wave imaging to assess arterial anisotropy: ex-vivo testing of the horse aorta

Darya ShcherbakovaClément PapadacciAbigail SwillensAnnette CaenenVeronique SaeySander De BockKoen CheirsMickaël TanterMathieu PernotPatrick Segers