Research Explorer

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Researcher

Annelies Van Hecke

Awards & Distinctions

21 Results

2023

GlycoVHH : optimal sites for introducing N-glycans on the camelid VHH antibody scaffold and use for macrophage delivery

Loes van SchieWander Van BreedamCharlotte RoelsBert SchepensMartin FrankAhmadreza MehdipourBram LaukensWim NerinckxFrancis SantensSimon Devos et al.

A1 Journal Article in MABS

2022

GlycoVHH : introducing N-glycans on the camelid VHH antibody scaffold : optimal sites and use for macrophage delivery

Loes van SchieWander Van BreedamCharlotte RoelsBert SchepensMartin FrankAhmadreza MehdipourBram LaukensWim NerinckxFrancis SantensSimon Devos et al.

Validation of a glycomics-based test associated with risk of HCC development in cirrhosis

Xavier VerhelstLeander MeurisRoos ColmanAnnelies Van HeckeAnja GeertsNico CallewaertHans Van Vlierberghe

2021

An affinity-enhanced, broadly neutralizing heavy chain-only antibody protects against SARS-CoV-2 infection in animal models

Bert SchepensLoes van SchieWim NerinckxKenny RooseWander Van BreedamDaria FijalkowskaSimon DevosWannes WeytsSieglinde De CaeSandrine Vanmarcke et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

FRI0304 serum IGG-undergalactosylation profiles reflect cumulative exposure to systemic inflammation in spondyloarthritis patients

Ann-Sophie De CraemerZ. LukasikL. MeurisLiselotte DerooThomas RensonManouk de HoogePhilippe CarronAnnelies Van HeckeNico CallewaertFilip Van den Bosch et al.

2020

Development of a counterselectable transposon to create markerless knockouts from an 18,432-clone ordered Mycobacterium bovis bacillus Calmette-Guérin mutant resource

Katlyn BorgersKristof VandewalleAnnelies Van HeckeGitte MichielsenEvelyn PletsLoes van SchieSandrine VanmarckeLaurent SchindfesselNele FestjensNico Callewaert

A1 Journal Article in MSYSTEMS

Serum IGG-Undergalactosylation profiles reflect cumulative exposure to systemic inflammation in Spondyloarthritis patients

A. S. De CraemerZ. LukasikLeander MeurisL. DerooT. RensonManouk de HoogeP. CarronAnnelies Van HeckeNico CallewaertFilip Van den Bosch et al.

2019

Characterization of human recombinant N-acetylgalactosamine-6-sulfate sulfatase produced in Pichia pastoris as potential enzyme for Mucopolysaccharidosis IVA treatment

Alexander Rodríguez-LópezLuisa N Pimentel-VeraAngela J Espejo-MojicaAnnelies Van HeckePetra TielsShunji TomatsuNico CallewaertCarlos J Alméciga-Díaz

A1 Journal Article in JOURNAL OF PHARMACEUTICAL SCIENCES

Reference genome and comparative genome analysis for the WHO reference strain for Mycobacterium bovis BCG Danish, the present tuberculosis vaccine

Katlyn BorgersJheng-Yang OuPo-Xing ZhengPetra TielsAnnelies Van HeckeEvelyn PletsGitte MichielsenNele FestjensNico CallewaertYao-Cheng Lin

A1 Journal Article in BMC GENOMICS

SapM mutation to improve the BCG vaccine : genomic, transcriptomic and preclinical safety characterization

Nele FestjensKristof VandewalleErica HouthuysEvelyn PletsDieter VanderschaegheKatlyn BorgersAnnelies Van HeckePetra TielsNico Callewaert

A1 Journal Article in VACCINE

2018

Endoglycosidase S enables a highly simplified clinical chemistry procedure for direct assessment of serum IgG undergalactosylation in chronic inflammatory disease

Dieter VanderschaegheLeander MeurisTom RaesHendrik GrootaertAnnelies Van HeckeXavier VerhelstFrederique Van de VeldeBruno LapauwHans Van VlierbergheNico Callewaert

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

2012

A bacterial glycosidase enables mannose-6-phosphate modification and improved cellular uptake of yeast-produced recombinant human lysosomal enzymes

Petra TielsEkaterina BaranovaKathleen PiensCharlotte De VisscherGwenda PynaertWim NerinckxJan StoutFranck FudalejPaco HulpiauSimon Tännler et al.

A1 Journal Article in NATURE BIOTECHNOLOGY

Engineering Yarrowia lipolytica to produce glycoproteins homogeneously modified with the universal Man(3)GlcNAc(2) N-glycan core

Karen De PourcqPetra TielsAnnelies Van HeckeSteven GeysensWouter VerveckenNico Callewaert

A1 Journal Article in PLOS ONE

Engineering the yeast Yarrowia lipolytica for the production of therapeutic proteins homogeneously glycosylated with Man₈GlcNAc₂ and Man₅GlcNAc₂

Karen De PourcqWouter VerveckenIsabelle DewerteAlbena ValevskaAnnelies Van HeckeNico Callewaert

A1 Journal Article in MICROBIAL CELL FACTORIES

2010

Abscisic acid deficiency causes changes in cuticle permeability and pectin composition that influence tomato resistance to Botrytis cinerea

Katrien CurversHamed SeifiGrégory MouilleRiet De RyckeBob AsselberghAnnelies Van HeckeDieter VanderschaegheHerman R HöfteNico CallewaertFrank Van Breusegem et al.

A1 Journal Article in PLANT PHYSIOLOGY

Fed-batch fermentation of GM-CSF-producing glycoengineered Pichia pastoris under controlled specific growth rate

Pieter JacobsM InanNele FestjensJurgen HaustraeteAnnelies Van HeckeRoland ContrerasMM MeagherNico Callewaert

A1 Journal Article in MICROBIAL CELL FACTORIES

2009

Genome sequence of the recombinant protein production host Pichia pastoris

Kristof De SchutterYao-Cheng LinPetra TielsAnnelies Van HeckeS GlinkaJ Weber-LehmannPierre RouzéYves Van de PeerNico Callewaert

A1 Journal Article in NATURE BIOTECHNOLOGY

GlycoFibroTest Is a Highly Performant Liver Fibrosis Biomarker Derived from DNA Sequencer-based Serum Protein Glycomics

Dieter VanderschaegheWouter LaroyErwin SablonPhilippe HalfonAnnelies Van HeckeJoris DelangheNico Callewaert

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

2005

Glycoprofiling of N-linked serum protein: an aging biomarker?

Cuiying ChenL DESMYTERW VAN MOLLEWouter LaroyAnnelies Van HeckeSylviane DewaeleA FEDERICOClaude LibertRoland Contreras

Independent validation and comparison with fibroscan, fibrotest and liver biopsy of clinical glycomics for the non invasive assessment of liver fibrosis in chronic hepatitis C

L CASTERAAnnelies Van HeckeP TRIMOULETNico CallewaertP COUZIGOUV DE LEDINGHENRoland ContrerasWouter Laroy

2004

Noninvasive diagnosis of liver cirrhosis using DNA sequencer-based total serum protein glycomics

Nico CallewaertHans Van VlierbergheAnnelies Van HeckeWouter LaroyJoris DelangheRoland Contreras

A1 Journal Article in NATURE MEDICINE