Research Explorer

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Researcher

Annelies Cannaert

Awards & Distinctions

37 Results

2023

Off-target activity of NBOMes and NBOMe analogs at the mu opioid receptor

Marie DeventerMattias PerssonAntonio LausEline PottieAnnelies CannaertGraziella ToccoHenrik GreenChristophe Stove

A1 Journal Article in ARCHIVES OF TOXICOLOGY

2022

Are the N-demethylated metabolites of U-47700 more active than their parent compound? In vitro mu-opioid receptor activation of N-desmethyl-U-47700 and N,N-bisdesmethyl-U-47700

Frederike NordmeierAnnelies CannaertChristophe StovePeter H. SchmidtMarkus R. MeyerNadine Schaefer

A1 Journal Article in DRUG TESTING AND ANALYSIS

Machine learning to assist in large-scale, activity-based synthetic cannabinoid receptor agonist screening of serum samples

Liesl JanssensDimitri BoeckaertsSimon HudsonDaria MorozovaAnnelies CannaertDavid M. WoodCaitlin WolfeBernard De BaetsMichiel StockPaul, I Dargan et al.

A1 Journal Article in CLINICAL CHEMISTRY

2021

Diagnosing intake and rationalizing toxicities associated with 5F-MDMB-PINACA and 4F-MDMB-BINACA abuse

Wen LieEleanor Jing Yi CheongEvelyn Mei Ling GohHooi Yan MoyAnnelies CannaertChristophe StoveEric Chun Yong Chan

A1 Journal Article in ARCHIVES OF TOXICOLOGY

NNL-3 : a synthetic intermediate or a new class of hydroxybenzotriazole esters with cannabinoid receptor activity?

Adam AmetovskiElizabeth A. CairnsKatharina Elisabeth GrafingerAnnelies CannaertMarie DeventerShuli ChenXinyi WuCaitlin E. SheppersonFelcia LaiRoss Ellison et al.

A1 Journal Article in ACS CHEMICAL NEUROSCIENCE

Report on a new opioid NPS : chemical and in vitro functional characterization of a structural isomer of the MT-45 derivative diphenpipenol

Annelies CannaertFabian HulpiaMartijn RisseeuwKatleen Van UytfangheEric DeconinckSerge Van CalenberghPeter BlanckaertChristophe Stove

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

Shape matters : the application of activity-based in vitro bioassays and chiral profiling to the pharmacological evaluation of synthetic cannabinoid receptor agonists in drug-infused papers seized in prisons

Lysbeth H. AntonidesAnnelies CannaertCaitlyn NormanNiamh NicDaeidOliver B. SutcliffeChristophe StoveCraig McKenzie

A1 Journal Article in DRUG TESTING AND ANALYSIS

Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB-4en-PICA, MDMB-4en-PINACA, ADB-4en-PINACA, and MMB-4CN-BUTINACA using a combination of binding and different CB1 receptor activation assays : part III : The G protein pathway and critical comparison of different assays

Katharina Elisabeth GrafingerMarthe VandeputteAnnelies CannaertAdam AmetovskiEric SparkesElizabeth CairnsPatrick Osamu JuchliBelal HaschimiBenedikt PulverSamuel D. Banister et al.

A1 Journal Article in DRUG TESTING AND ANALYSIS

Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB-4en-PICA, MDMB-4en-PINACA, ADB-4en-PINACA, and MMB-4CN-BUTINACA using a combination of binding and different CB1 receptor activation assays-Part II: Structure activity relationship assessment via a beta-arrestin recruitment assay

Katharina GrafingerAnnelies CannaertAdam AmetovskiEric SparkesElizabeth CairnsSamuel D. BanisterVolker AuwarterChristophe Stove

A1 Journal Article in DRUG TESTING AND ANALYSIS

Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB-4en-PICA, MDMB-4en-PINACA, ADB-4en-PINACA, and MMB-4CN-BUTINACA using a combination of binding and different CB1 receptor activation assays: Part I-Synthesis, analytical characterization, and binding affinity for human CB1 receptors

Edward PikeKatharina GrafingerAnnelies CannaertAdam AmetovskiJia Lin LuoEric SparkesElizabeth A. CairnsRoss EllisonRoy GeronaChristophe Stove et al.

A1 Journal Article in DRUG TESTING AND ANALYSIS

The next generation of synthetic cannabinoids : detection, activity, and potential toxicity of pent-4en and but-3en analogues including MDMB-4en-PINACA

Alex J. KrotulskiAnnelies CannaertChristophe StoveBarry K. Logan

A1 Journal Article in DRUG TESTING AND ANALYSIS

2020

Assessment of structure-activity relationships and biased agonism at the Mu opioid receptor of novel synthetic opioids using a novel, stable bio-assay platform

Lakshmi VasudevanMarthe VandeputteMarie DeventerElise WoutersAnnelies CannaertChristophe Stove

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Evidence of enzyme-mediated transesterification of synthetic cannabinoids with ethanol : potential toxicological impact

Orapan ApirakkanIvana GavrilovicGiuseppe FlorestaCheyanne PierreAnnelies CannaertChristophe StovePaul I DarganDavid A CowanLewis CouchmanVincenzo Abbate

A1 Journal Article in FORENSIC TOXICOLOGY

First report on brorphine : the next opioid on the deadly new psychoactive substance horizon?

Nick VerougstraeteMarthe VandeputteCathelijne LyphoutAnnelies CannaertFabian HulpiaSerge Van CalenberghAlain VerstraeteChristophe Stove

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

In vitro activity profiling of Cumyl-PEGACLONE variants at the CB1 receptor : fluorination versus isomer exploration

Liesl JanssensAnnelies CannaertMatthew J. ConnollyHuiling LiuChristophe Stove

A1 Journal Article in DRUG TESTING AND ANALYSIS

In vitro functional characterization of a panel of non-fentanyl opioid new psychoactive substances

Marthe VandeputteAnnelies CannaertChristophe Stove

A1 Journal Article in ARCHIVES OF TOXICOLOGY

In vitro structure-activity relationship determination of 30 psychedelic new psychoactive substances by means of beta-arrestin 2 recruitment to the serotonin 2A receptor

Eline PottieAnnelies CannaertChristophe Stove

A1 Journal Article in ARCHIVES OF TOXICOLOGY

Report on a novel emerging class of highly potent benzimidazole NPS opioids : chemical and in vitro functional characterization of isotonitazene

Peter BlanckaertAnnelies CannaertKatleen Van UytfangheFabian HulpiaEric DeconinckSerge Van CalenberghChristophe Stove

A1 Journal Article in DRUG TESTING AND ANALYSIS

Semiquantitative activity-based detection of JWH-018, a synthetic cannabinoid receptor agonist, in oral fluid after vaping

Annelies CannaertMaria del Mar Ramirez FernandezEef L. TheunissenJohannes G. RamaekersSarah WilleChristophe Stove

A1 Journal Article in ANALYTICAL CHEMISTRY

Synthesis and in vitro cannabinoid receptor 1 activity of recently detected synthetic cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL-CBMICA, ADB-BINACA, APP-BINACA, 4F-MDMB-BINACA, MDMB-4en-PINACA, A-CHMINACA, 5F-AB-P7AICA, 5F-MDMB-P7AICA, and 5F-AP7AICA

Annelies CannaertEric SparkesEdward PikeJia Lin LuoAda FangRichard C. KevinRoss EllisonRoy GeronaSamuel D. BanisterChristophe Stove

A1 Journal Article in ACS CHEMICAL NEUROSCIENCE

Toxicokinetics and toxicodynamics of the fentanyl homologs cyclopropanoyl-1-benzyl-4 '-fluoro-4-anilinopiperidine and furanoyl-1-benzyl-4-anilinopiperidine

Tanja M. GampferLea WagmannYu Mi ParkAnnelies CannaertJennifer HerrmannSvenja FischmannFolker WestphalRolf MuellerChristophe StoveMarkus R. Meyer

A1 Journal Article in ARCHIVES OF TOXICOLOGY

2019

Activity-based reporter assays for the screening of abused substances in biological matrices

Annelies CannaertMarthe VandeputteSarah WilleChristophe Stove

A1 Journal Article in CRITICAL REVIEWS IN TOXICOLOGY

Application of an activity-based receptor bioassay to investigate the in vitro activity of selected indole- and indazole-3-carboxamide-based synthetic cannabinoids at CB1 and CB2 receptors

Carolina NobleAnnelies CannaertKristian LinnetChristophe Stove

A1 Journal Article in DRUG TESTING AND ANALYSIS

Comprehensive investigation on synthetic cannabinoids : metabolic behavior and potency testing, using 5F-APP-PICA and AMB-FUBINACA as model compounds

David Fabregat-SafontMarie MardalCarolina NobleAnnelies CannaertChristophe StoveJuan V SanchoKristian LinnetFelix HernandezMaria Ibanez

A1 Journal Article in DRUG TESTING AND ANALYSIS

Enantiospecific synthesis, chiral separation, and biological activity of four indazole-3-carboxamide-type synthetic cannabinoid receptor agonists and their detection in seized drug samples

Lysbeth H AntonidesAnnelies CannaertCaitlyn NormanLoelia VivesAidan HarrisonAndrew CostelloNiamh Nic DaeidChristophe StoveOliver B SutcliffeCraig McKenzie

A1 Journal Article in FRONTIERS IN CHEMISTRY

Functional evaluation of carboxy metabolites of synthetic cannabinoid receptor agonists featuring scaffolds based on L‐valine or L‐tert ‐leucine

Elise WoutersLukas MoglerAnnelies CannaertVolker AuwärterChristophe Stove

A1 Journal Article in DRUG TESTING AND ANALYSIS

Hide and seek : overcoming the masking effect of opioid antagonists in activity-based screening tests

Annelies CannaertMarie DeventerMelissa FogartyAmanda LA MohrChristophe Stove

A1 Journal Article in CLINICAL CHEMISTRY

Setup of a serotonin 2A receptor (5-HT2AR) bioassay : demonstration of its applicability to functionally characterize hallucinogenic new psychoactive substances and an explanation why 5-HT2AR bioassays are not suited for universal activity-based screening of biofluids for new psychoactive substances

Eline PottieAnnelies CannaertKatleen Van UytfangheChristophe Stove

A1 Journal Article in ANALYTICAL CHEMISTRY

Validation of activity-based screening for synthetic cannabinoid receptor agonists in a large set of serum samples

Annelies CannaertMarthe VandeputteSimon HudsonDavid M WoodPaul I DarganChristophe Stove

A1 Journal Article in CLINICAL CHEMISTRY

2018

Activity-based concept to screen biological matrices for opiates and (synthetic) opioids

Annelies CannaertLakshmi VasudevanMelissa FrisciaAmanda LA MohrSarah MR WilleChristophe Stove

A1 Journal Article in CLINICAL CHEMISTRY

Activity-based detection and bioanalytical confirmation of a fatal carfentanil intoxication

Annelies CannaertLars AmbachPeter BlanckaertChristophe Stove

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Activity-based detection of cannabinoids in serum and plasma samples

Annelies CannaertJolien StormeCornelius HessVolker AuwärterSarah MR WilleChristophe Stove

A1 Journal Article in CLINICAL CHEMISTRY

Activity-based detection of new psychoactive substances as an alternative screening approach in forensic toxicology

Annelies CannaertChristophe StoveSarah Wille

Molecular dissection of the human A3 adenosine receptor coupling with β-arrestin2

Jolien StormeAnnelies CannaertKathleen Van CraenenbroeckChristophe Stove

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2017

Activity-based detection of consumption of synthetic cannabinoids in authentic urine samples using a stable cannabinoid reporter system

Annelies CannaertFlorian FranzVolker AuwärterChristophe Stove

A1 Journal Article in ANALYTICAL CHEMISTRY

2016

Detection and activity profiling of synthetic cannabinoids and their metabolites with a newly developed bioassay

Annelies CannaertJolien StormeFlorian FranzVolker AuwärterChristophe Stove

A1 Journal Article in ANALYTICAL CHEMISTRY

2014

Development of a new haptoglobin genotyping method by direct PCR on dried blood spots

Nele SadonesLien OnderbekeAnnelies CannaertPieter De KeselJoris DelangheWilly LambertChristophe Stove