Research Explorer

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Researcher

Annekatrien Boel

47 Results

2022

Distinct genetic impact of CRISPR/Cas9 gene correction in human embryos compared to induced pluripotent stem cells

Bieke BekaertAnnekatrien BoelLisa De WitteGwenny CosemansSusana Marina Chuva de Sousa LopesPetra De SutterDominic StoopPaul CouckeBjörn MentenBjörn Heindryckx

Evaluation of CRISPR/Cas9-induced DNA break repair outcomes in mouse and human embryos

Bieke BekaertAnnekatrien BoelLisa De WitteGwenny CosemansSusana Marina Chuva de Sousa LopesBjörn MentenBjörn Heindryckx

Fertilization failure after human ICSI and the clinical potential of PLCZ1

Arantxa Cardona BarberánAnnekatrien BoelFrauke Vanden MeerschautDominic StoopBjörn Heindryckx

A1 Journal Article in REPRODUCTION

Hatching is modulated by microRNA-378a-3p derived from extracellular vesicles secreted by blastocysts

Krishna PavaniTim MeeseOsvaldo Américo Bogado PascottiniXiaoyuan LinLuc PeelmanFilip Van NieuwerburghDieter DeforceAnnekatrien BoelBjörn HeindryckxKelly TillemanAnn Van SoomBart GadellaAn HendrixKatrien Smits

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human germline nuclear transfer to overcome mitochondrial disease and failed fertilization after ICSI

Maoxing TangAnnekatrien BoelNoemi CastelluccioArantxa Cardona BarberánAntonia ChristodoulakiBieke BekaertMina PopovicFrauke Vanden MeerschautPetra De SutterBjörn MentenSofie SymoensArnaud VanlanderDominic StoopPaul CouckeBjörn Heindryckx

A1 Journal Article in JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

P-802 Distinct genetic impact of CRISPR/Cas9 gene correction in human embryos compared to induced pluripotent stem cells

Bieke BekaertAnnekatrien BoelLisa De WitteGwenny CosemansDominic StoopPaul CouckeBjörn MentenBjörn Heindryckx

U Journal Article in Human Reproduction

TEAD4 regulates trophectoderm differentiation upstream of CDX2 in a GATA3-independent manner in the human preimplantation embryo

Panagiotis StamatiadisGwenny CosemansAnnekatrien BoelBjörn MentenPetra De SutterDominic StoopSusana Marina Chuva de Sousa LopesPaul CouckeBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION

2021

Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells

Swati MishraJasin TaelmanMina PopovicLaurentijn TillemanEvi DuthooMargot Van der JeughtDieter DeforceFilip Van NieuwerburghBjörn MentenPetra De SutterAnnekatrien BoelSusana Marina Chuva de Sousa LopesBjörn Heindryckx

A1 Journal Article in STEM CELLS

Arterial tortuosity syndrome : an ascorbate compartmentalization disorder?

Annekatrien BoelAude BeyensAndy WillaertPaul CouckeBert Callewaert

A1 Journal Article in ANTIOXIDANTS & REDOX SIGNALING

Calcium analysis and embryonic development of in vitro matured oocytes from transgender men

Antonia ChristodoulakiHaitang HeArantxa Cardona BarberánChloë De RooSusana Marina Chuva de Sousa LopesBjörn MentenAnn Van SoomPetra De SutterDominic StoopAnnekatrien BoelBjörn Heindryckx

Comparative analysis of mouse and human preimplantation development following POU5F1 CRISPR/Cas9 targeting reveals interspecies differences

Panagiotis StamatiadisAnnekatrien BoelGwenny CosemansMina PopovicBieke BekaertRamesh GuggillaMaoxing TangPetra De SutterFilip Van NieuwerburghBjörn MentenDominic StoopSusana Marina Chuva de Sousa LopesPaul CouckeBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION

Correcting a PLCζ mutation in the human germ line to overcome hereditary infertility

Bieke BekaertAnnekatrien BoelMina PopovicPanagiotis StamatiadisPetra De SutterBjörn MentenDominic StoopPaul CouckeBjörn Heindryckx

Cutis laxa : a comprehensive overview of clinical characteristics and pathophysiology

Aude BeyensAnnekatrien BoelSofie SymoensBert Callewaert

A1 Journal Article in CLINICAL GENETICS

Digital polymerase chain reaction for assessment of mutant mitochondrial carry-over after nuclear transfer for In Vitro fertilization

Olivier TytgatWillem van SnippenbergAnnekatrien BoelYannick GansemansMichiel Van HerpSofie SymoensWim TrypsteenDieter DeforceBjörn HeindryckxPaul CouckeWard De SpiegelaereFilip Van Nieuwerburgh

A1 Journal Article in CLINICAL CHEMISTRY

Lrp5 mutant and crispant zebrafish faithfully model human osteoporosis, establishing the zebrafish as a platform for CRISPR‐based functional screening of osteoporosis candidate genes

Jan Willem BekAdelbert De ClercqHanna De SaffelAnnekatrien BoelAndy WillaertPaul Coucke

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

Prospects of germline nuclear transfer in women with diminished ovarian reserve

Antonia ChristodoulakiAnnekatrien BoelMaoxing TangChloë De RooDominic StoopBjörn Heindryckx

A1 Journal Article in FRONTIERS IN ENDOCRINOLOGY

Sex-specific isolation and propagation of human premeiotic fetal germ cells and germ cell-like cells

Swati MishraJasin TaelmanAnnekatrien BoelPetra De SutterBjörn HeindryckxSusana Marina Chuva de Sousa Lopes

A1 Journal Article in CELLS

TEAD4 regulates trophectoderm differentiation upstream of CDX2 in human preimplantation embryos

Panagiotis StamatiadisAnnekatrien BoelGwenny CosemansFilip Van NieuwerburghBjörn MentenPetra De SutterDominic Stoop

2020

A proof-of-concept study to investigate DNA repair mechanisms in the human embryo after the application of CRISPR/Cas9 gene editing in the germ line

Bieke BekaertAnnekatrien BoelLisa De WitteMina PopovicRamesh GuggillaSwati MishraGwenny CosemansSusana Marina Chuva de Sousa LopesPetra De SutterBjörn MentenDominic StoopPaul CouckeBjörn Heindryckx

Chromosomal mosaicism in human blastocysts : the ultimate diagnostic dilemma

Mina PopovicLien DhaenensAnnekatrien BoelBjörn MentenBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION UPDATE

Chromosomal mosaicism in human blastocysts : the ultimate diagnostic dilemma (vol 26, pg 313, 2020)

Mina PopovicLien DhaenensAnnekatrien BoelBjörn MentenBjörn Heindryckx

Comparative study of preimplantation development following distinct assisted oocyte activation protocols in a PLC-zeta knockout mouse model

Minerva Ferrer BuitragoLaurentijn TillemanVanessa ThysAnnekatrien BoelFilip Van NieuwerburghDieter DeforceLuc LeybaertPetra De SutterBjörn Heindryckx

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Correcting PLCζ mutation in the germ line to overcome transmission of hereditary infertility in mice

Bieke BekaertAnnekatrien BoelVanessa ThysPanagiotis StamatiadisSusana Marina Chuva de Sousa LopesPetra De SutterBjörn MentenDominic StoopPaul CouckeBjörn Heindryckx

Correcting a PLCζ mutation in the human germ line to overcome hereditary infertility

Bieke BekaertAnnekatrien BoelMina PopovicPanagiotis StamatiadisSusana Marina Chuva de Sousa LopesPetra De SutterPaul CouckeBjörn Heindryckx

Diagnosis and treatment of male infertility-related fertilization failure

Arantxa Cardona BarberánAnnekatrien BoelFrauke Vanden MeerschautDominic StoopBjörn Heindryckx

A1 Journal Article in JOURNAL OF CLINICAL MEDICINE

Germline nuclear transfer in mice may rescue poor embryo development associated with advanced maternal age and early embryo arrest

Maoxing TangMina PopovicPanagiotis StamatiadisMargot Van der JeughtRudy Van CosterDieter DeforcePetra De SutterPaul CouckeBjörn MentenDominic StoopAnnekatrien BoelBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION

Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos

Thomas NaertDieter TulkensMarjolein CarronAnnekatrien BoelSuzan DemuynckPaul CouckeAndy WillaertKris Vleminckx

A1 Journal Article in SCIENTIFIC REPORTS

Slc2a10 knock-out mice deficient in ascorbic acid synthesis recapitulate aspects of arterial tortuosity syndrome and display mitochondrial respiration defects

Annekatrien BoelMarine VanhomwegenAude BeyensMarjolijn RenardChristophe CasteleynBenedicte DescampsChristian VanhovePaul CouckeAndy WillaertBert Callewaert

A1 Journal Article in HUMAN MOLECULAR GENETICS

Vitrification negatively affects the Ca2+-releasing and activation potential of mouse oocytes, but vitrified oocytes are potentially useful for diagnostic purposes

Davina BonteVanessa ThysPetra De SutterAnnekatrien BoelLuc LeybaertBjörn Heindryckx

A1 Journal Article in REPRODUCTIVE BIOMEDICINE ONLINE

2019

Animal disease modeling of the arterial tortuosity syndrome : advancing the CRISPR/Cas9 system for improved genome editing

Annekatrien BoelPaul CouckeAndy Willaert

Arterial tortuosity syndrome : 40 new families and literature review (vol 20, pg 1236, 2017)

Aude BeyensAnnekatrien BoelPaul CouckeSofie De SchepperInge De WandeleAndy WillaertBert Callewaert

Assisted oocyte activation significantly increases fertilization and pregnancy outcome in patients with low and total failed fertilization after intracytoplasmic sperm injection : a 17-year retrospective study

Davina BonteMinerva Ferrer BuitragoLien DhaenensMina PopovicVanessa ThysIlse De CrooStefanie De GheselleNathalie SteyaertAnnekatrien BoelFrauke Vanden MeerschautPetra De SutterBjörn Heindryckx

A1 Journal Article in FERTILITY AND STERILITY

Comparative analysis of different nuclear transfer techniques to prevent the transmission of mitochondrial DNA variants

Maoxing TangYannick GansemansMargot Van der JeughtAnnekatrien BoelPanagiotis StamatiadisRudy Van CosterDieter DeforceFilip Van NieuwerburghPetra De SutterBjörn Heindryckx

Comparative analysis of different nuclear transfer techniques to prevent the transmission of mitochondrial DNA variants

Maoxing TangRamesh GuggillaYannick GansemansMargot Van der JeughtAnnekatrien BoelMina PopovicPanagiotis StamatiadisMinerva Ferrer BuitragoVanessa ThysRudy Van CosterDieter DeforcePetra De SutterFilip Van NieuwerburghBjörn Heindryckx

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

De novo and inherited pathogenic variants in KDM3B cause intellectual disability, short stature, and facial dysmorphism

Annekatrien BoelBert Callewaert

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

Decreased nuclear ascorbate accumulation accompanied with altered genomic methylation pattern in fibroblasts from arterial tortuosity syndrome patients

Andy WillaertAnnekatrien BoelBert CallewaertPaul Coucke

A1 Journal Article in OXIDATIVE MEDICINE AND CELLULAR LONGEVITY

Increased primordial germ cell (PGC) specification from human embryonic stem cells (hESC) derived in Activin A

Swati MishraMargot Van der JeughtMina PopovicJasin TaelmanEvi DuthooKatarzyna Joanna Szymańska-VandendriesschePetra De SutterLaurentijn TillemanFilip Van NieuwerburghAnnekatrien BoelBjörn Heindryckx

The use of pronuclear transfer to overcome infertility disorders in mice

Björn HeindryckxAnnekatrien BoelPanagiotis StamatiadisMargot Van der JeughtRamesh GuggillaDieter DeforceRudy Van CosterPetra De Sutter

2018

Arterial tortuosity syndrome : 40 new families and literature review

Aude BeyensAnnekatrien BoelPaul CouckeJulie De BackerAnne De PaepeSofie De SchepperInge De WandeleLaura Muiño MosqueraMarine VanhomwegenAndy WillaertBert Callewaert

A1 Journal Article in GENETICS IN MEDICINE

BATCH-GE : analysis of NGS data for genome editing assessment

Wouter SteyaertAnnekatrien BoelPaul CouckeAndy Willaert

Bookchapter in Xenopus : methods and protocols

CRISPR/Cas9-mediated homology-directed repair by ssODNs in zebrafish induces complex mutational patterns resulting from genomic integration of repair-template fragments

Annekatrien BoelHanna De SaffelWouter SteyaertBert CallewaertAnne De PaepePaul CouckeAndy Willaert

A1 Journal Article in DISEASE MODELS & MECHANISMS

2017

Arterial tortuosity syndrome : 37 new families and literature review

Aude BeyensAnne De PaepeLaura Muiño MosqueraJulie De BackerAnnekatrien BoelAndy WillaertPaul CouckeBert Callewaert

Arterial tortuosity syndrome : 40 new families and literature review

Aude BeyensAnnekatrien BoelPaul CouckeJulie De BackerAnne De PaepeSofie De SchepperInge De WandeleBart LoeysLaura Muiño MosqueraMarine VanhomwegenAndy WillaertBert Callewaert

2016

Arterial tortuosity syndrome : 29 novel families

Aude BeyensAnne De PaepeLaura Muiño MosqueraJulie De BackerAndy WillaertAnnekatrien BoelPaul CouckeBert Callewaert

BATCH-GE : batch analysis of next-generation sequencing data for genome editing assessment

Annekatrien BoelWouter SteyaertNina De RockerBjörn MentenBert CallewaertAnne De PaepePaul CouckeAndy Willaert

A1 Journal Article in SCIENTIFIC REPORTS

CRISPR-Cas9 modeling of cell lines and zebrafish to study the TLX1-PHF6 cooperative interrelationship in T-cell acute lymphoblastic leukemia

Siebe LoontiensKaat DurinckNina De RockerAnnekatrien BoelSuzanne VanhauwaertPieter RondouInge Van de WalleTom TaghonBjörn MentenAndy WillaertPaul CouckePieter Van VlierbergheFranki Speleman

CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis

Thomas NaertRobin ColpaertTom Van NieuwenhuysenDionysia DimitrakopoulouJannick LeoenJurgen HaustraeteAnnekatrien BoelWouter SteyaertTrees LepezDieter DeforceAndy WillaertDavid CreytensKris Vleminckx

A1 Journal Article in SCIENTIFIC REPORTS