Research Explorer

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Researcher

Annekatrien Boel

Awards & Distinctions

72 Results

2025

Prime editing outperforms homology-directed repair as a tool for CRISPR-mediated variant knock-in in zebrafish

Michiel VanhooydonckElyne De NeefHanna De SaffelAnnekatrien BoelAndy WillaertBert CallewaertKathleen Claes

Prime editing outperforms homology-directed repair as a tool for CRISPR-mediated variant knock-in in zebrafish

Michiel VanhooydonckElyne De NeefHanna De SaffelAnnekatrien BoelAndy WillaertBert CallewaertKathleen Claes

U Journal Article in LAB ANIMAL

2024

Early mechanisms of aortic failure in a zebrafish model for thoracic aortic dissection and rupture

Michiel VanhooydonckMaxim VerleeMarta Guerreiro Santana Ramos Da SilvaLore PottieAnnekatrien BoelMatthias Van ImpeHanna De SaffelLisa CaboorPiyanoot TapaneeyaphanAnne Bonnin et al.

Early mechanisms of aortic failure in a zebrafish model for thoracic aortic dissection and rupture

Michiel VanhooydonckMaxim VerleeMarta Guerreiro Santana Ramos Da SilvaLore PottieAnnekatrien BoelMatthias Van ImpeHanna De SaffelLisa CaboorPiyanoot TapaneeyaphanAnne Bonnin et al.

High rate of detected variants in male PLCZ1 and ACTL7A genes causing failed fertilization after ICSI

Arantxa Cardona BarberánRamesh Reddy GuggillaCora ColenbierEmma Van der VeldenAndrei RybouchkinDominic StoopLuc LeybaertPaul CouckeSofie SymoensAnnekatrien Boel et al.

A1 Journal Article in HUMAN REPRODUCTION OPEN

Knock-in of disease-related variants in the zebrafish model organism

Michiel VanhooydonckElyne De NeefHanna De SaffelAnnekatrien BoelKathleen ClaesAndy WillaertBert Callewaert

Pronuclear transfer rescues poor embryo development of in vitro-grown secondary mouse follicles

Antonia ChristodoulakiHaitang HeMin ZhouChloë De RooMachteld BaetensTine De PretreMuhammad Fakhar-I-AdilBjörn MentenAnn Van SoomDominic Stoop et al.

A1 Journal Article in HUMAN REPRODUCTION OPEN

2023

Assisted oocyte activation does not overcome recurrent embryo developmental problems

Arantxa Cardona BarberánDavina BonteAnnekatrien BoelVanessa ThysRuth ParedisFemke MachtelinckxPetra De SutterIlse De CrooLuc LeybaertDominic Stoop et al.

A1 Journal Article in HUMAN REPRODUCTION

CRISPR/Cas9-based correction of infertility-related mutations in the germline : ready or not?

Bieke BekaertBjörn HeindryckxAnnekatrien BoelBjörn Menten

Cathepsin-L secreted by high-quality bovine embryos exerts an embryotrophic effect in vitro

Annelies RaesEline WydoogheKrishna Chaitanya PavaniOsvaldo Américo Bogado PascottiniKatleen Van SteendamMaarten DhaenensAnnekatrien BoelSonia HerasBjörn HeindryckxLuc Peelman et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterization of ovarian tissue oocytes from transgender men reveals poor calcium release and embryo development, which might be overcome by spindle transfer

Antonia ChristodoulakiHaitang HeMin ZhouArantxa Cardona BarberánChloë De RooSusana Marina Chuva de Sousa LopesMachteld BaetensBjörn MentenAnn Van SoomPetra De Sutter et al.

A1 Journal Article in HUMAN REPRODUCTION

Effect of biphasic CAPA-IVM on ovarian tissue oocytes of transgender men

Muhammad Fakhar-I-AdilAntonia ChristodoulakiAnnekatrien BoelSusana Marina Chuva de Sousa LopesBjörn MentenAnn Van SoomDominic StoopChloë De RooBjörn Heindryckx

Monogenic and digenic variants in male PLCZ1, ACTL7A and ACTL9 genes cause fertilization failure after ICSI

Arantxa Cardona BarberánAnnekatrien BoelCora ColenbierEmma Van der VeldenDominic StoopPaul CouckeFrauke Vanden MeerschautBjörn Heindryckx

Reliability of blastomere versus trophectoderm biopsy in preimplantation genetic testing for mitochondrial DNA disorders

Noemi CastelluccioRamesh Reddy GuggillaAndrei RybouchkinDominic StoopSofie SymoensPaul CouckeAnnekatrien BoelBjörn Heindryckx

Retained chromosomal integrity following CRISPR-Cas9-based mutational correction in human embryos

Bieke BekaertAnnekatrien BoelLisa De WitteWinter VandenbergheMina PopovicPanagiotis StamatiadisGwenny CosemansLise TordeursAthina-Maria De LooreSusana Marina Chuva de Sousa Lopes et al.

A1 Journal Article in MOLECULAR THERAPY

The establishment of the first reported zebrafish model for thoracic aortic dissection and rupture

Michiel VanhooydonckMaxim VerleeLore PottieAnnekatrien BoelPiyanoot TapaneeyaphanMarta Guerreiro Santana Ramos Da SilvaAdelbert De ClercqLisa CaboorMatthias Van ImpeDelfien Syx et al.

The establishment of the first reported zebrafish model for thoracic aortic dissection and rupture

Michiel VanhooydonckMaxim VerleeLore PottieAnnekatrien BoelPiyanoot TapaneeyaphanMarta Guerreiro Santana Ramos Da SilvaAdelbert De ClercqLisa CaboorMatthias Van ImpeDelfien Syx et al.

The establishment of the first reported zebrafish model for thoracic aortic dissection and rupture

Michiel VanhooydonckLore PottieAnnekatrien BoelPiyanoot TapaneeyaphanMarta Guerreiro Santana Ramos Da SilvaAdelbert De ClercqMatthias Van ImpeDelfien SyxAndy WillaertLisa Caboor et al.

2022

CRISPR/Cas gene editing in the human germline

Bieke BekaertAnnekatrien BoelGwenny CosemansLisa De WitteBjörn MentenBjörn Heindryckx

A1 Journal Article in SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Distinct genetic impact of CRISPR/Cas9 gene correction in human embryos compared to induced pluripotent stem cells

Bieke BekaertAnnekatrien BoelLisa De WitteGwenny CosemansLise TordeursAthina-Maria De LooreSusana Marina Chuva de Sousa LopesPetra De SutterDominic StoopPaul Coucke et al.

Evaluation of CRISPR/Cas9-induced DNA break repair outcomes in mouse and human embryos

Bieke BekaertAnnekatrien BoelLisa De WitteGwenny CosemansSusana Marina Chuva de Sousa LopesBjörn MentenBjörn Heindryckx

Fertilization failure after human ICSI and the clinical potential of PLCZ1

Arantxa Cardona BarberánAnnekatrien BoelFrauke Vanden MeerschautDominic StoopBjörn Heindryckx

A1 Journal Article in REPRODUCTION

Hatching is modulated by microRNA-378a-3p derived from extracellular vesicles secreted by blastocysts

Krishna Chaitanya PavaniTim MeeseOsvaldo Américo Bogado PascottiniXueFeng GuanXiaoyuan LinLuc PeelmanJoachim HamacherFilip Van NieuwerburghDieter DeforceAnnekatrien Boel et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human germline nuclear transfer to overcome mitochondrial disease and failed fertilization after ICSI

Maoxing TangAnnekatrien BoelNoemi CastelluccioArantxa Cardona BarberánAntonia ChristodoulakiBieke BekaertMina PopovicFrauke Vanden MeerschautPetra De SutterBjörn Menten et al.

A1 Journal Article in JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Spindle transfer rescues poor embryo development of in vitro matured ovarian tissue oocytes from transgender men

Antonia ChristodoulakiH. HeM. ZhouArantxa Cardona BarberánChloë De RooS. M. Chuva De Sousa LopesBjörn MentenAnn Van SoomPetra De SutterAnnekatrien Boel et al.

TEAD4 regulates trophectoderm differentiation upstream of CDX2 in a GATA3-independent manner in the human preimplantation embryo

Panagiotis StamatiadisGwenny CosemansAnnekatrien BoelBjörn MentenPetra De SutterDominic StoopSusana Marina Chuva de Sousa LopesFrederic LluisPaul CouckeBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION

The establishment of the first reported zebrafish model for thoracic aortic dissection and rupture

Michiel VanhooydonckLore PottieAnnekatrien BoelPiyanoot TapaneeyaphanMarta Guerreiro Santana Ramos Da SilvaLisa CaboorAdelbert De ClercqMatthias Van ImpeAndy WillaertPatrick Sips et al.

The establishment of the first reported zebrafish model for thoracic aortic dissection and rupture

Michiel VanhooydonckLore PottieAnnekatrien BoelPiyanoot TapaneeyaphanMarta Guerreiro Santana Ramos Da SilvaAdelbert De ClercqLisa CaboorMatthias Van ImpeAndy WillaertPatrick Sips et al.

Treatment options to overcome impaired fertilization and embryonic development caused by an oocyte-related deficiency in the Patl2-/- mouse model

Arantxa Cardona BarberánAntonia ChristodoulakiJosefien GoethalsVanessa ThysFrauke Vanden MeerschautC. ArnoultDominic StoopAnnekatrien BoelBjörn Heindryckx

2021

Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells

Swati MishraJasin TaelmanMina PopovicLaurentijn TillemanEvi DuthooMargot Van der JeughtDieter DeforceFilip Van NieuwerburghBjörn MentenPetra De Sutter et al.

A1 Journal Article in STEM CELLS

Arterial tortuosity syndrome : an ascorbate compartmentalization disorder?

Annekatrien BoelKrisztina VeszelyiCsilla E. NemethAude BeyensAndy WillaertPaul CouckeBert CallewaertEva Margittai

A1 Journal Article in ANTIOXIDANTS & REDOX SIGNALING

Calcium analysis and embryonic development of in vitro matured oocytes from transgender men

Antonia ChristodoulakiHaitang HeArantxa Cardona BarberánChloë De RooSusana Marina Chuva de Sousa LopesBjörn MentenAnn Van SoomPetra De SutterDominic StoopAnnekatrien Boel et al.

Comparative analysis of mouse and human preimplantation development following POU5F1 CRISPR/Cas9 targeting reveals interspecies differences

Panagiotis StamatiadisAnnekatrien BoelGwenny CosemansMina PopovicBieke BekaertRamesh Reddy GuggillaMaoxing TangPetra De SutterFilip Van NieuwerburghBjörn Menten et al.

A1 Journal Article in HUMAN REPRODUCTION

Correcting a PLCζ mutation in the human germ line to overcome hereditary infertility

Bieke BekaertAnnekatrien BoelMina PopovicPanagiotis StamatiadisS M Chuva de Sousa LopesPetra De SutterBjörn MentenDominic StoopPaul CouckeBjörn Heindryckx

Cutis laxa : a comprehensive overview of clinical characteristics and pathophysiology

Aude BeyensAnnekatrien BoelSofie SymoensBert Callewaert

A1 Journal Article in CLINICAL GENETICS

Digital polymerase chain reaction for assessment of mutant mitochondrial carry-over after nuclear transfer for In Vitro fertilization

Olivier TytgatMX TangWillem van SnippenbergAnnekatrien BoelRR GuggillaYannick GansemansMichiel Van HerpSofie SymoensWim TrypsteenDieter Deforce et al.

A1 Journal Article in CLINICAL CHEMISTRY

Digital polymerase chain reaction for assessment of mutant mitochondrial carry-over after nuclear transfer for in vitro fertilization

Olivier TytgatMaoxing TangWillem van SnippenbergAnnekatrien BoelRamesh Reddy GuggillaYannick GansemansMichiel Van HerpSofie SymoensWim TrypsteenDieter Deforce et al.

A1 Journal Article in CLINICAL CHEMISTRY

Lrp5 mutant and crispant zebrafish faithfully model human osteoporosis, establishing the zebrafish as a platform for CRISPR‐based functional screening of osteoporosis candidate genes

Jan Willem BekChen ShochatAdelbert De ClercqHanna De SaffelAnnekatrien BoelJuriaan MetzFrans RodenburgDavid KarasikAndy WillaertPaul Coucke

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

Prospects of germline nuclear transfer in women with diminished ovarian reserve

Antonia ChristodoulakiAnnekatrien BoelMaoxing TangChloë De RooDominic StoopBjörn Heindryckx

A1 Journal Article in FRONTIERS IN ENDOCRINOLOGY

Sex-specific isolation and propagation of human premeiotic fetal germ cells and germ cell-like cells

Swati MishraJasin TaelmanYolanda W. ChangAnnekatrien BoelPetra De SutterBjörn HeindryckxSusana Marina Chuva de Sousa Lopes

A1 Journal Article in CELLS

TEAD4 regulates trophectoderm differentiation upstream of CDX2 in human preimplantation embryos

Panagiotis StamatiadisAnnekatrien BoelGwenny CosemansFilip Van NieuwerburghBjörn MentenPetra De SutterDominic StoopS. M. Chuva de Sousa LopesF. Lluis

2020

A proof-of-concept study to investigate DNA repair mechanisms in the human embryo after the application of CRISPR/Cas9 gene editing in the germ line

Bieke BekaertAnnekatrien BoelLisa De WitteMina PopovicRamesh Reddy GuggillaSwati MishraGwenny CosemansLise TordeursSusana Marina Chuva de Sousa LopesPetra De Sutter et al.

Assessment of molecular determinants underlying recurrent embryo developmental arrest and value of assisted oocyte activation as a treatment option

Annekatrien BoelDavina BonteArantxa Cardona BarberánVanessa ThysDominic StoopPetra De SutterPaul CouckeFrauke Vanden MeerschautBjörn Heindryckx

Chromosomal mosaicism in human blastocysts : the ultimate diagnostic dilemma

Mina PopovicLien DhaenensAnnekatrien BoelBjörn MentenBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION UPDATE

Chromosomal mosaicism in human blastocysts : the ultimate diagnostic dilemma (vol 26, pg 313, 2020)

Mina PopovicLien DhaenensAnnekatrien BoelBjörn MentenBjörn Heindryckx

Comparative study of preimplantation development following distinct assisted oocyte activation protocols in a PLC-zeta knockout mouse model

Minerva Ferrer BuitragoLaurentijn TillemanVanessa ThysA HachemAnnekatrien BoelFilip Van NieuwerburghDieter DeforceLuc LeybaertPetra De SutterJ. Parrington et al.

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Correcting PLCζ mutation in the germ line to overcome transmission of hereditary infertility in mice

Bieke BekaertAnnekatrien BoelVanessa ThysPanagiotis StamatiadisSusana Marina Chuva de Sousa LopesPetra De SutterJohn ParringtonBjörn MentenDominic StoopPaul Coucke et al.

Correcting a PLCζ mutation in the human germ line to overcome hereditary infertility

Bieke BekaertAnnekatrien BoelMina PopovicPanagiotis StamatiadisSusana Marina Chuva de Sousa LopesPetra De SutterPaul CouckeBjörn Heindryckx

Diagnosis and treatment of male infertility-related fertilization failure

Arantxa Cardona BarberánAnnekatrien BoelFrauke Vanden MeerschautDominic StoopBjörn Heindryckx

A1 Journal Article in JOURNAL OF CLINICAL MEDICINE

Germline nuclear transfer in mice may rescue poor embryo development associated with advanced maternal age and early embryo arrest

Maoxing TangMina PopovicPanagiotis StamatiadisMargot Van der JeughtRudy Van CosterDieter DeforcePetra De SutterPaul CouckeBjörn MentenDominic Stoop et al.

A1 Journal Article in HUMAN REPRODUCTION

Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos

Thomas NaertDieter TulkensNicole A. EdwardsMarjolein CarronNikko-Ideen ShaidaniMarcin WlizlaAnnekatrien BoelSuzan DemuynckMarko E. HorbPaul Coucke et al.

A1 Journal Article in SCIENTIFIC REPORTS

Slc2a10 knock-out mice deficient in ascorbic acid synthesis recapitulate aspects of arterial tortuosity syndrome and display mitochondrial respiration defects

Annekatrien BoelJoyce BurgerMarine VanhomwegenAude BeyensMarjolijn RenardSander BarnhoornChristophe CasteleynDieter ReinhardtBenedicte DescampsChristian Vanhove et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

Vitrification negatively affects the Ca2+-releasing and activation potential of mouse oocytes, but vitrified oocytes are potentially useful for diagnostic purposes

Davina BonteVanessa ThysPetra De SutterAnnekatrien BoelLuc LeybaertBjörn Heindryckx

A1 Journal Article in REPRODUCTIVE BIOMEDICINE ONLINE

2019

Animal disease modeling of the arterial tortuosity syndrome : advancing the CRISPR/Cas9 system for improved genome editing

Annekatrien BoelPaul CouckeAndy Willaert

Arterial tortuosity syndrome : 40 new families and literature review (vol 20, pg 1236, 2017)

Aude BeyensJuliette AlbuissonAnnekatrien BoelMazen Al-EssaWaheed Al-ManeaDamien BonnetOzlem BostanOdile BouteTiffany BusaNathalie Canham et al.

Assisted oocyte activation significantly increases fertilization and pregnancy outcome in patients with low and total failed fertilization after intracytoplasmic sperm injection : a 17-year retrospective study

Davina BonteMinerva Ferrer BuitragoLien DhaenensMina PopovicVanessa ThysIlse De CrooStefanie De GheselleNathalie SteyaertAnnekatrien BoelFrauke Vanden Meerschaut et al.

A1 Journal Article in FERTILITY AND STERILITY

Comparative analysis of different nuclear transfer techniques to prevent the transmission of mitochondrial DNA variants

Maoxing TangRamesh Reddy GuggillaYannick GansemansMargot Van der JeughtAnnekatrien BoelMina PopovicPanagiotis StamatiadisMinerva Ferrer BuitragoVanessa ThysRudy Van Coster et al.

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Comparative analysis of different nuclear transfer techniques to prevent the transmission of mitochondrial DNA variants

Maoxing TangR ReddyYannick GansemansMargot Van der JeughtAnnekatrien BoelPanagiotis StamatiadisRudy Van CosterDieter DeforceFilip Van NieuwerburghPetra De Sutter et al.

De novo and inherited pathogenic variants in KDM3B cause intellectual disability, short stature, and facial dysmorphism

Illja J DietsRoos van der DonkKristina BaltrunaiteEsmé WaandersMargot RF ReijndersAlexander JM DingemansRolph PfundtAnneke T Vulto-van SilfhoutLaurens WielChristian Gilissen et al.

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

Decreased nuclear ascorbate accumulation accompanied with altered genomic methylation pattern in fibroblasts from arterial tortuosity syndrome patients

Csilla NémethZsófia NemodaPéter LőwPál SzabóErzsébet HorváthAndy WillaertAnnekatrien BoelBert CallewaertPaul CouckeMarina Colombi et al.

A1 Journal Article in OXIDATIVE MEDICINE AND CELLULAR LONGEVITY

Increased primordial germ cell (PGC) specification from human embryonic stem cells (hESC) derived in Activin A

Swati MishraMargot Van der JeughtMina PopovicJasin TaelmanEvi DuthooKatarzyna Szymańska-VandendriesschePetra De SutterLaurentijn TillemanFilip Van NieuwerburghAnnekatrien Boel et al.

The use of pronuclear transfer to overcome infertility disorders in mice

Björn HeindryckxAnnekatrien BoelPanagiotis StamatiadisMargot Van der JeughtRamesh Reddy GuggillaDieter DeforceRudy Van CosterPetra De Sutter

2018

Arterial tortuosity syndrome : 40 new families and literature review

Aude BeyensJuliette AlbuissonAnnekatrien BoelMazen Al-EssaWaheed Al-ManeaDamien BonnetOzlem BostanOdile BouteTiffany BusaNathalie Canham et al.

A1 Journal Article in GENETICS IN MEDICINE

BATCH-GE : analysis of NGS data for genome editing assessment

Wouter SteyaertAnnekatrien BoelPaul CouckeAndy Willaert

Bookchapter in Xenopus : methods and protocols

BATCH-GE : batch analysis of next-generation sequencing data for genome editing assessment (vol 6, 30330, 2016)

Annekatrien BoelWouter SteyaertNina De RockerBjörn MentenBert CallewaertAnne De PaepePaul CouckeAndy Willaert

CRISPR/Cas9-mediated homology-directed repair by ssODNs in zebrafish induces complex mutational patterns resulting from genomic integration of repair-template fragments

Annekatrien BoelHanna De SaffelWouter SteyaertBert CallewaertAnne De PaepePaul CouckeAndy Willaert

A1 Journal Article in DISEASE MODELS & MECHANISMS

2017

Arterial tortuosity syndrome : 37 new families and literature review

Aude BeyensJuliette AlbuissonT BusaN CanhamJM ChopinM DasoukiK DevriendtH DietzBjörn Fischer-ZirnsakAlper Gezdirici et al.

Arterial tortuosity syndrome : 40 new families and literature review

Aude BeyensJuliette AlbuissonAnnekatrien BoelMazen Al-EssaDamien BonnetO BostanOdile BouteT BusaN CanhamErgun Cil et al.

2016

Arterial tortuosity syndrome : 29 novel families

Aude BeyensJuliette AlbuissonT BusaN CanhamJM CM. DasoukiK DevriendtH DietzBjörn Fischer-ZirnsakAlper Gezdirici et al.

BATCH-GE : batch analysis of next-generation sequencing data for genome editing assessment

Annekatrien BoelWouter SteyaertNina De RockerBjörn MentenBert CallewaertAnne De PaepePaul CouckeAndy Willaert

A1 Journal Article in SCIENTIFIC REPORTS

CRISPR-Cas9 modeling of cell lines and zebrafish to study the TLX1-PHF6 cooperative interrelationship in T-cell acute lymphoblastic leukemia

Siebe LoontiensKaat DurinckNina De RockerAnnekatrien BoelEls JanssensSuzanne VanhauwaertPieter RondouCharles De BockInge Van de WalleFinola Moore et al.

CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis

Thomas NaertRobin ColpaertTom Van NieuwenhuysenDionysia DimitrakopoulouJ LJurgen HaustraeteAnnekatrien BoelWouter SteyaertTrees LepezDieter Deforce et al.

A1 Journal Article in SCIENTIFIC REPORTS