Research Explorer

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Researcher

Anne Vral

Awards & Distinctions

240 Results

2025

Fibroblast-based radiosensitivity assays as a clinically valuable tool for (severe) combined immunodeficiency syndromes

Elien BeylsSomara De BeulVictoria BordonAlina FersterFilomeen HaerynckAnne VralAns Baeyens

A1 Journal Article in MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Investigating chromosomal radiosensitivity in inborn errors of immunity : insights from DNA repair disorders and beyond

Elien BeylsEvi DuthooLynn BackersKarlien Claes[missing] RAPID CliniciansTessa KerreB. LambrechtLevi HosteB. MeertensT. Van Genechten et al.

A1 Journal Article in JOURNAL OF CLINICAL IMMUNOLOGY

Replication stress, microcephalic primordial dwarfism, and compromised immunity in ATRIP deficient patients

Evi DuthooElien BeylsLynn BackersThorkell GudjónssonPeiquan HuangLeander JonckheereSebastian RiemannBram PartonLikun DuVeronique Debacker et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2024

Advances in CRISPR-mediated knock-in of disease- and cancer-related variants in zebrafish

Elyne De NeefMichiel VanhooydonckHanna De SaffelBéatrice LintermansAndy WillaertBert CallewaertAnne VralKathleen Claes

Advances in CRISPR-mediated knock-in of disease-related variants in zebrafish

Elyne De NeefMichiel VanhooydonckHanna De SaffelBéatrice LintermansAndy WillaertBert CallewaertAnne VralKathleen Claes

An improved F98 glioblastoma rat model to evaluate novel treatment strategies incorporating the standard of care

Velislava ZotevaValerie De MeulenaereMarthe De BoeckChristian VanhoveLuc LeybaertRobrecht RaedtLeen PietersAnne VralTom BoterbergKarel Deblaere

A1 Journal Article in PLOS ONE

Fructosyl amino oxidase as a therapeutic enzyme in age-related macular degeneration

Joris DelangheJosé Diana Di MavunguKoen BeerensJonas HimpeNezahat BostanMarijn SpeeckaertHenk VrielinckAnne VralCaroline van den BroekeManon Huizing et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Integrating and optimizing tonabersat in standard glioblastoma therapy : a preclinical study

Velislava ZotevaValerie De MeulenaereChristian VanhoveLuc LeybaertRobrecht RaedtLeen PietersAnne VralTom BoterbergKarel Deblaere

A1 Journal Article in PLOS ONE

Peripheral blood lymphocytes differ in DNA damage response after exposure to X-rays with different physical properties

Simon SioenLouise D'hondtFien Van HouteRobin DemuynckKlaus BacherCarlos De WagterAnne VralBarbara VanderstraetenDmitri KryskoAns Baeyens

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Prime editing outperforms optimized homology-directed repair as a tool for knock-in generation in zebrafish

Elyne De NeefMichiel VanhooydonckKathleen ClaesBert CallewaertHanna De SaffelBéatrice LintermansAndy WillaertAnne Vral

Prime editing outperforms optimized homology-directed repair as a tool for knock-in generation in zebrafish

Elyne De NeefMichiel VanhooydonckHanna De SaffelAnne VralAndy WillaertBert CallewaertKathleen Claes

The importance of mechanical and biological cues of tympanic membrane grafts to ensure optimal regeneration

Oriana NobusLaurens ParmentierPieter LivensPieter MuyshondtKrystyna SzewcykChristel JacobsDorien VerdoodtLeen PietersQuinten ThijssenBo Van Durme et al.

A1 Journal Article in BIOMATERIALS ADVANCES

The micronucleus assay on cryopreserved whole blood

Renu DayalElien BeylsAnne VralAns Baeyens

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Variability in chromosomal radiosensitivity of breast cancer patients before and after radiotherapy

Renu DayalLiv VeldemanAnne VralAns Baeyens

2023

A preclinical platform for assessing long-term drug efficacy exploiting mechanically tunable scaffolds colonized by a three-dimensional tumor microenvironment

Elly De VlieghereKoen Van de VijverEva BlondeelNathan CarpentierRouba GhobeiraJarne PauwelsSebastian RiemannManon MinsartCharlotte FieuwsJohanna Mestach et al.

A1 Journal Article in BIOMATERIALS RESEARCH

Atm deficient zebrafish model reveals conservation of the tumour suppressor function and a role in fertility

Jeroen VierstraeteCharlotte FieuwsDavid CreytensJo Van DorpeAndy WillaertAnne VralKathleen Claes

Editorial material

Impact of proton therapy on the DNA damage induction and repair in hematopoietic stem and progenitor cells

Simon SioenOniecha VanhoveBarbara VanderstraetenCarlos De WagterMonique EngelbrechtCharlot VandevoordeEvan De KockMarc-Jan Van GoethemAnne VralAns Baeyens

A1 Journal Article in SCIENTIFIC REPORTS

International comparison exercise for biological dosimetry after exposures with neutrons performed at two irradiation facilities as part of the BALANCE project

David EndesfelderUlrike KulkaMartin BucherUlrich GiesenGuy GartyChristina BeinkeMatthias PortGaetan GruelEric GregoireGeorgia Terzoudi et al.

A1 Journal Article in CYTOGENETIC AND GENOME RESEARCH

RENEB inter-laboratory comparison 2021 : inter-assay comparison of eight dosimetry assays

M PortJ-F BarquineroD EndesfelderJ MoquetU OestreicherG TerzoudiF TrompierAnne VralY AbeL Ainsbury et al.

A1 Journal Article in RADIATION RESEARCH

RENEB inter-laboratory comparison 2021 : the cytokinesis-block micronucleus assay

Anne VralD. EndesfelderJ. BalázsC. BeinkeC. Cuceu PetrenciF. FinotG. GartyL. HadjiiskaR. HristovaI. Ivanova et al.

A1 Journal Article in RADIATION RESEARCH

RENEB inter-laboratory comparison 2021 : the dicentric chromosome assay

D. EndesfelderU. OestreicherM. BucherC. BeinkeC. SiebenwirthE. AinsburyJ. MoquetG. GruelE. GregoireJ.S. Martinez et al.

A1 Journal Article in RADIATION RESEARCH

The variability in chromosomal radiosensitivity of breast cancer patients before and after radiotherapy

Renu DayalAnne VralAns Baeyens

2022

A clinically annotated post-mortem approach to study multi-organ somatic mutational clonality in normal tissues

Tom LuijtsKerryn ElliottJoachim SiawJoris Van de VeldeElien BeylsArne ClaeysTim LammensErik LarssonWouter WillaertAnne Vral et al.

A1 Journal Article in SCIENTIFIC REPORTS

A novel S-micronucleus assay for radiosensitivity detection

Evi DuthooFilomeen HaerynckAnne VralAns Baeyens

An updated view into the cell cycle kinetics of human T lymphocytes and the impact of irradiation

Evi DuthooAnne VralAns Baeyens

A1 Journal Article in SCIENTIFIC REPORTS

DC vaccines loaded with glioma cells killed by photodynamic therapy induce Th17 anti-tumor immunity and provide a four-gene signature for glioma prognosis

Maria VedunovaVictoria TurubanovaOlga VershininaMariia SaviukIuliia EfimovaTatiana MishchenkoRobrecht RaedtAnne VralChristian VanhoveDaria Korsakova et al.

A1 Journal Article in CELL DEATH & DISEASE

Fibroblast-based radiosensitivity assessment for primary immunodeficiency patients

Elien BeylsSomara De BeulFilomeen HaerynckVictoria BordonAlina FersterAnne VralAns Baeyens

Preclinical comparative study of [18F]AlF-PSMA-11 and [18F]PSMA-1007 in varying PSMA expressing tumors

Sarah PironJeroen VerhoevenJan CourtynKen KersemansBenedicte DescampsLeen PietersAnne VralChristian VanhoveFilip De Vos

A1 Journal Article in SCIENTIFIC REPORTS

2021

A novel non-coding variant in DCLRE1C results in deregulated splicing and induces SCID through the generation of a truncated ARTEMIS protein that fails to support V(D)J recombination and DNA damage repair

Steven StrubbeMarieke De BruyneUlrich PannickeElien BeylsBart VandekerckhoveGeorges LeclercqElfride De BaereVictoria BordonAnne VralKlaus Schwarz et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

An updated view into the proliferative characteristics of human T lymphocytes and the effects of irradiation

Evi DuthooAnne VralAns Baeyens

Cryopreserved whole blood and isolated peripheral blood mononuclear cells as alternative sample types for the cytokinesis-block micronucleus assay

Elien BeylsSimon SioenAns BaeyensAnne Vral

Impact of the molar activity and PSMA expression level on [18F]AlF-PSMA-11 uptake in prostate cancer

Sarah PironJeroen VerhoevenEmma De CosterBenedicte DescampsKen KersemansLeen PietersAnne VralChristian VanhoveFilip De Vos

A1 Journal Article in SCIENTIFIC REPORTS

Integration of genomics and transcriptomics allows the identification of rare DNA damage defects in PID patients with a cancer predisposition

Lynn BackersBram PartonMattias Van HeetveldeMarieke De BruyneKim De LeeneerSimon TavernierAnne VralFilomeen HaerynckKathleen Claes

Integration of genomics and transcriptomics to identify DNA damage defects in PID patients prone to cancer

Lynn BackersBram PartonMattias Van HeetveldeMarieke De BruyneKim De LeeneerAnne VralFilomeen HaerynckKathleen Claes

Integration of genomics and transcriptomics to identify DNAdamage defects in PID patients with a cancer predisposition

Lynn BackersBram PartonMattias Van HeetveldeMarieke De BruyneKim De LeeneerAnne VralFilomeen HaerynckKathleen Claes

The cytokinesis-block micronucleus assay for cryopreserved whole blood

Elien BeylsAns BaeyensAnne Vral

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

The cytokinesis-block micronucleus assay on human cryopreserved whole blood and isolated peripheral blood mononuclear cells

Simon SioenElien BeylsAnne VralAns Baeyens

Zebrafish as an in vivo screening tool to establish PARP inhibitor efficacy

Jeroen VierstraeteCharlotte FieuwsAndy WillaertAnne VralKathleen Claes

A1 Journal Article in DNA REPAIR

2020

A novel EdU-based protocol for the investigation of cell cycle kinetics of irradiated human lymphocytes

Evi DuthooAnne VralAns Baeyens

Atm deficient zebrafish model reveals conservation of the tumour suppressor function

Jeroen VierstraeteCharlotte FieuwsDavid CreytensJo Van DorpeAndy WillaertAnne VralKathleen Claes

Decreased DNA double‑strand break repair and enhanced chromosomal radiosensitivity in irradiated non‑tumorigenic human breast epithelial cells with a partial BRCA1 or BRCA2 knockdown

Annelot BaertMaria PalermoMattias Van HeetveldeBram VerstraeteJulie DepuydtJeroen VierstraeteJan PhilippéAnna SablinaGianpaolo PerlettiKathleen Claes et al.

A2 Journal Article in WORLD ACADEMY OF SCIENCES JOURNAL

First patient with bloom syndrome caused by a deep intronic variant leading to pseudoexon activation

Lynn BackersBram PartonStephanie VermeulenMarieke De BruyneSimon TavernierKris Van Den BogaertAnne VralAns BaeyensFilomeen HaerynckBart Lambrecht et al.

First patient with bloom syndrome caused by a deep intronic variant leading to pseudoexon activation

Lynn BackersBram PartonStephanie VermeulenMarieke De BruyneKris Van Den BogaertAnne VralAns BaeyensSimon TavernierFilomeen HaerynckKathleen Claes

Fructosamine-3-kinase as a potential treatment option for age-related macular degeneration

Sander De BruyneCaroline Van den BroeckeHenk VrielinckSamira KhelifiOlivier De WeverKen BrackeManon HuizingNezahat BostonJonas HimpeMarijn Speeckaert et al.

A1 Journal Article in JOURNAL OF CLINICAL MEDICINE

Intra-individual dynamic comparison of 18F-PSMA-11 and 68Ga-PSMA-11 in LNCaP xenograft bearing mice

Sarah PironJeroen VerhoevenBenedicte DescampsKen KersemansKathia De ManNick Van LaekenLeen PietersAnne VralChristian VanhoveFilip De Vos

A1 Journal Article in SCIENTIFIC REPORTS

Rad51 foci as biomarkers for HR efficiency and radiosensitivity in individuals with a BRCA1 or BRCA2 mutation

Stephanie VermeulenValerie De MeyEvi DuthooAnne VralAns Baeyens

Radiosensitivity assessment in fibroblasts from patients with a primary immunodeficiency

Elien BeylsAns BaeyensAnne Vral

Study of the time-relationship of the mechano-electrical interaction in an animal model of tetralogy of Fallot : implications for the risk assessment of ventricular arrhythmias

Thierry BovéRahi Alipour SymakaniJonas VerbekeAnne VralMilad El HaddadHans De WildeRoland StroobandtJan De Pooter

A1 Journal Article in INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY

The cytokinesis-block micronucleus assay on human isolated fresh and cryopreserved peripheral blood mononuclear cells

Simon SioenKarlien CloetAnne VralAns Baeyens

A1 Journal Article in JOURNAL OF PERSONALIZED MEDICINE

The cytokinesis-block micronucleus assay on isolated fresh and frozen peripheral blood mononuclear cells

Simon SioenKarlien CloetAnne VralAns Baeyens

Zebrafish as a model to study DNA repair and developmental defects following loss of Brca2 or Atm

Jeroen VierstraeteKathleen ClaesAnne Vral

2019

Absence of genotoxic impact assessed by micronucleus frequency in circulating lymphocytes of workers exposed to cadmium

D LisonG Van Maele-FabryAnne VralStephanie VermeulenP BastinV HaufroidAns Baeyens

A1 Journal Article in TOXICOLOGY LETTERS

Adjuvant therapeutic potential of tonabersat in the standard treatment of glioblastoma : a preclinical F98 glioblastoma rat model study

Valerie De MeulenaereEllen BonteJeroen VerhoevenJean-Pierre Kalala OkitoLeen PietersAnne VralOlivier De WeverLuc LeybaertIngeborg GoethalsChristian Vanhove et al.

A1 Journal Article in PLOS ONE

Assessment of radiation sensitivity in patients with a primary immunodeficiency disease

Anne VralAns BaeyensKathleen ClaesCarolien BonroyVictoria BonroyElien BeylsEvi DuthooLynn BackersStephanie VermeulenFilomeen Haerynck

Chromosomal radiosensitivity of triple negative breast cancer patients

Flavia Zita FranciesOlivia HerdAlan CairnsSarah NietzMarshall MurdochJacobus SlabbertKathleen ClaesAnne VralAns Baeyens

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Comparison of the cytokinesis block micronucleus assay on full blood versus PBMCs

Evi DuthooKarlien CloetSimon SioenAnne VralAns Baeyens

Development of an in vitro radiosensitivity assay on fibroblasts for patients with a primary immunodeficiency

Elien BeylsAns BaeyensAnne Vral

Development of nerve substitutes for peripheral nerve regeneration

Charlot PhilipsMaria CornelissenAnne VralHeidi DeclercqRino Morent

Dynamic changes in hippocampal diffusion and kurtosis metrics following experimental mTBI correlate with glial reactivity

Kim BraeckmanBenedicte DescampsLeen PietersAnne VralKaren CaeyenberghsChristian Vanhove

A1 Journal Article in NEUROIMAGE-CLINICAL

Faithfully recapitulating PARP inhibitor efficacy in zebrafish

Jeroen VierstraeteCharlotte FieuwsAndy WillaertAnne VralKathleen Claes

Fluorescence in situ hybridisation study of micronuclei in C3A cells following exposure to ELF-magnetic fields

Luc VerschaeveRoel AntonissenAns BaeyensAnne VralAnnemarie Maes

A1 Journal Article in Caryologia

Green tea catechins for chemoprevention of prostate cancer in patients with histologically-proven HG-PIN or ASAP. Concise review and meta-analysis

Gianpaolo PerlettiVittorio MagriAnne VralKonstantinos StamatiouAlberto Trinchieri

A2 Journal Article in ARCHIVIO ITALIANO DI UROLOGIA E ANDROLOGIA

Radiosensitivity analysis in patients with a primary immunodeficiency disease

Anne VralAns BaeyensKathleen ClaesCarolien BonroyVictoria BordonElien BeylsEvi DuthooLynn BackersStephanie VermeulenFilomeen Haerynck

Receptor mediated radiosensitivity and DNA repair capacity of hormone dependent breast cancer cells

Stephanie VermeulenAnne VralAns Baeyens

Second hits in BRCA1- and BRCA2-associated breast and ovarian cancer : connecting coding to non-coding mechanisms of inactivation

Mattias Van HeetveldeKathleen ClaesAnne VralKim De Leeneer

The H2S-releasing naproxen derivative ATB-346 and the slow-release H2S donor GYY4137 reduce intestinal inflammation and restore transit in postoperative ileus

Jonas Van DingenenLeen PietersAnne VralRomain Lefebvre

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

miRNA expression profiles in BRCA1-associated breast cancers reveal upregulation of specific miRNAs in tumors lacking a clear second hit in a large proportion of the tumour

Mattias Van HeetveldeMieke R Van BockstalJo Van DorpeKim De LeeneerAnne VralKathleen Claes

2018

Accurate detection and quantification of epigenetic and genetic second hits in BRCA1 and BRCA2-associated hereditary breast and ovarian cancer reveals multiple co-acting second hits

Mattias Van HeetveldeMieke Van BockstalBruce PoppeKathleen LambeinToon RosseelLilit AtanesyanDieter DeforceIvo Van Den BergheKim De LeeneerJo Van Dorpe et al.

A1 Journal Article in CANCER LETTERS

Chromosomal radiosensitivity and instability in triple negative and/or young breast cancer and Fanconi Anaemia patients in South Africa

Flavia Zita FranciesAns BaeyensKathleen ClaesAnne Vral

DNA double strand breaks induced by low dose mammography X-rays in breast tissue: A pilot study

Julie DepuydtTanguy ViaenePhillip BlondeelNathalie RocheRudy Van den BroeckeHubert ThierensAnne Vral

A1 Journal Article in ONCOLOGY LETTERS

Diagnosis of Fanconi Anaemia by ionising radiation- or mitomycin C-induced micronuclei

Flavia Zita FranciesRosalind WainwrightJanet PooleKim De LeeneerIlse CoeneGreet WiemeHélène A PoirelBénédicte BrichardStephanie VermeulenAnne Vral et al.

A1 Journal Article in DNA REPAIR

Radiation-induced leukemia : response of hematopoietic stem cells and progenitor cells to clinical therapy beams

Bram VerstraeteAnne VralDmitri KryskoAns Baeyens

Radiotherapy-activated cancer-associated fibroblasts promote tumor progression through paracrine IGF1R activation

Joke TommeleinElly De VlieghereLaurine VersetElodie MelsensJustine LeendersBenedicte DescampsAnnelies DebucquoyChristian VanhovePatrick PauwelsChristian P Gespach et al.

A1 Journal Article in CANCER RESEARCH

Thorough in silico and in vitro cDNA analysis of 21 putative BRCA1 and BRCA2 splice variants and a complex tandem duplication in BRCA2 allowing the identification of activated cryptic splice donor sites in BRCA2 exon 11

Annelot BaertEva MachackovaIlse CoeneCarol CreminKristin TurnerCheryl Portigal-ToddMarie Jill AsratJennifer NukAllison MindlinSean Young et al.

A1 Journal Article in HUMAN MUTATION

Uncovering the role of atm in zebrafish

Jeroen VierstraeteAnne VralPaul CouckeAndy WillaertKathleen Claes

Uncovering the role of zebrafish in atm

Jeroen VierstraeteAndy WillaertPaul CouckeAnne VralKathleen Claes

Uncovering the role of zebrafish in atm

Jeroen VierstraeteAndy WillaertPaul CouckeAnne VralKathleen Claes

miRNA expression profiles in BRCA1-associated breast cancers reveal upregulation of specific miRNAs in tumours lacking a clear second hit in a large proportion of the tumour cells

Mattias Van HeetveldeMieke R Van BockstalJo Van DorpeKim De LeeneerAnne VralKathleen Claes

2017

Accurate Quantification of Homologous Recombination in Zebrafish: brca2 deficiency as a paradigm

Jeroen VierstraeteAndy WillaertPetra VermassenLeen PietersAnne VralKathleen Claes

Accurate quantification of homologous recombination : a zebrafish BRCA2-/- model

Jeroen VierstraeteAndy WillaertPetra VermassenLeen PietersPaul CouckeAnne VralKathleen Claes

Accurate quantification of homologous recombination : a zebrafish brca2-/- model

Jeroen VierstraeteAndy WillaertPetra VermassenLeen PietersPaul CouckeAnne VralKathleen Claes

Accurate quantification of homologous recombination in zebrafish : brca2 deficiency as a paradigm

Jeroen VierstraeteAndy WillaertPetra VermassenPaul CouckeAnne VralKathleen Claes

A1 Journal Article in SCIENTIFIC REPORTS

Analysis of chromosomal radiosensitivity of healthy BRCA2 mutation carriers and non-carriers in BRCA families with the G2 micronucleus assay

Annelot BaertJulie DepuydtTom Van MaerkenBruce PoppeFransiska MalfaitTim Van DammeSylvia De NobeleGianpaolo PerlettiKim De LeeneerKathleen Claes et al.

A1 Journal Article in ONCOLOGY REPORTS

Capabilities of the RENEB network for research and large scale radiological and nuclear emergency situations

Octávia Monteiro GilPedro VazHorst RommCinzia De AngelisAna Catarina AntunesJoan-Francesc BarquineroChristina BeinkeEmanuela BortolinChristopher Ian BurbidgeAlexandra Cucu et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Dose assessment intercomparisons within the RENEB network using G0-lymphocyte prematurely condensed chromosomes (PCC assay)

Georgia I TerzoudiGabriel PanteliasFirouz DarroudiKatarzyna BarszczewskaIwona BuraczewskaJulie DepuydtDimka GeorgievaValeria HadjidekovaVasiliki I HatziIoanna Karachristou et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

From human genetics to radiobiology : in vitro radiosensitivity in individuals with a germline defect in DNA damage response genes

Annelot BaertAnne VralKathleen Claes

Investigation of the influence of calibration practices on cytogenetic laboratory performance for dose estimation

François TrompierMarion BaumannLleonard BarriosEric GregoireMichael AbendElizabeth AinsburyStephen BarnardJoan Francesc BarquineroJuan Antonio BautistaBeata Brzozowska et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Multiparametric magnetic resonance imaging characteristics of normal, benign and malignant conditions in the prostate

Pieter De VisschereAnne VralGianpaolo PerlettiEVA PATTYNMarleen PraetVittorio MagriGeert Villeirs

A1 Journal Article in EUROPEAN RADIOLOGY

RBE variations along the Bragg curve of a 200 MeV proton beam

Charlot VandevoordeAns BaeyensAnne VralJacobus Slabbert

RENEB : running the European network of biological dosimetry and physical retrospective dosimetry

Ulrike KulkaMichael AbendElizabeth AinsburyChristophe BadieJoan Francesc BarquineroLleonard BarriosChristina BeinkeEmanuela BortolinAlexandra CucuAndrea De Amicis et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

RENEB accident simulation exercise

Beata BrzozowskaElizabeth AinsburyAnnelot BaertLindsay Beaton-GreenLeonardo BarriosJoan Francesc BarquineroCeline BassinetChristina BeinkeAnett BenedekPhilip Beukes et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

RENEB intercomparison exercises analyzing micronuclei (Cytokinesis-block Micronucleus Assay)

Julie DepuydtAns BaeyensStephen BarnardChristina BeinkeAnett BenedekPhilip BeukesIwona BuraczewskaFirouz DarroudiStefania De SanctisInmaculada Dominguez et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

RENEB intercomparisons applying the conventional Dicentric Chromosome Assay (DCA)

Ursula OestreicherDaniel SamagaElizabeth AinsburyAna Catarina AntunesAns BaeyensLeonardo BarriosChristina BeinkePhilip BeukesWilliam F. BlakelyAlexandra Cucu et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Second hit landscape in BRCA-associated breast cancer

Mattias Van HeetveldeMieke Van BockstalTrees LepezSteve LefeverLeen PietersKathleen LambeinMarleen PraetIvo Van Den BergheFrauke CoppietersNadine Van Roy et al.

Second hit landscape in BRCA1/2-associated breast cancer

Mattias Van HeetveldeMieke Van BockstalTrees LepezKathleen LambeinDieter DeforceAnne VralBruce PoppeKim De LeeneerJo Van DorpeKathleen Claes

Study of homologous recombination repair in BRCA2 knockout zebrafish embryos

Jeroen VierstraeteAndy WillaertPaul CouckeAnne VralKathleen Claes

Study of homologous recombination repair in BRCA2 knockout zebrafish embryos

Jeroen VierstraeteAndy WillaertPaul CouckeAnne VralKathleen Claes

The RENEB operational basis : complement of established biodosimetric assays

Andrzej WojcikUrsula OestreicherLleonard BarriosAnne VralGeorgia TerzoudiElizabeth AinsburyKai RothkammFrancois TrompierUlrike Kulka

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

The harmonization process to set up and maintain an operational biological and physical retrospective dosimetry network : QA QM applied to the RENEB network

Eric GregoireLiz AinsburyLeonardo BarriosCéline BassinetPaola FattibeneUlrike KulkaUrsula OestreicherGabriel PanteliasGeorgia TerzoudiFrancois Trompier et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

The second gamma-H2AX assay inter-comparison exercise carried out in the framework of the European biodosimetry network (RENEB)

Jayne MoquetStephen BarnardAlbena StaynovaCarita LindholmOctávia Monteiro GilVanda MartinsUte RößlerAnne VralCharlot VandevoordeMaria Wojewódzka et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Uncertainty of fast biological radiation dose assessment for emergency response scenarios

Elizabeth A AinsburyManuel HiguerasPedro PuigJochen EinbeckDaniel SamagaJoan Francesc BarquineroLleonard BarriosBeata BrzozowskaPaola FattibeneEric Gregoire et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

2016

A semi-automated FISH-based micronucleus-centromere assay for biomonitoring of hospital workers exposed to low doses of ionizing radiation

Anne VralVeerle DecorteJulie DepuydtAndré WambersieHubert Thierens

A1 Journal Article in MOLECULAR MEDICINE REPORTS

Chromosomal radiosensitivity of human immunodeficiency virus positive/negative cervical cancer patients in South Africa

Olivia HerdFlavia FranciesJeffrey KotzenTrudy SmithZwide NxumaloXanthene MullerJacobus SlabbertAnne VralAns Baeyens

A1 Journal Article in MOLECULAR MEDICINE REPORTS

In vitro cellular radiosensitivity in relationship to late normal tissue reactions in breast cancer patients : a multi-endpoint case-control study

Charlot VandevoordeJulie DepuydtLiv VeldemanWilfried De NeveNatividad SebastiaGreet WiemeAnnelot BaertSofie De LangheJan PhilippéHubert Thierens et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation

Annelot BaertJulie DepuydtTom Van MaerkenBruce PoppeFransiska MalfaitKatrien StormJenneke van den EndeTim Van DammeSylvia De NobeleGianpaolo Perletti et al.

A1 Journal Article in BREAST CANCER RESEARCH

Radiation sensitivity of human CD34+ cells versus peripheral blood T lymphocytes of newborns and adults: DNA repair and mutagenic effects

Charlot VandevoordeAnne VralBart VandekerckhoveJan PhilippéHubert Thierens

A1 Journal Article in RADIATION RESEARCH

Studying the functionality of the homologous repair pathway in zebrafish embryos : heading for an in vivo functional test to evaluate the pathogenicity of BRCA2 variants

Jeroen VierstraeteAndy WillaertKris VleminckxPetra VermassenLeen PietersPaul CouckeAnne VralKathleen Claes

Studying the functionality of the homologous repair pathway in zebrafish embryos : heading for an in vivo functional test to evaluate the pathogenicity of BRCA2 variants identified in breast/ovarian cancer patients

Jeroen VierstraeteAndy WillaertPetra VermassenLeen PietersPaul CouckeAnne VralKathleen Claes

Studying the functionality of the homologous repair pathway in zebrafish embryos : heading for an in vivo functional test to evaluate the pathogenicity of BRCA2 variants identified in breast/ovarian cancer patients

Jeroen VierstraeteAndy WillaertPetra VermassenLeen PietersPaul CouckeAnne VralKathleen Claes

Studying the functionality of the homologous repair pathway in zebrafish embryos : heading for an in vivo functional test to evaluate the pathogenicity of BRCA2 variants identified in breast/ovarian cancer patients

Jeroen VierstraeteAndy WillaertPetra VermassenLeen PietersPaul CouckeAnne VralKathleen Claes

The cellular response to different radiation qualities in relation to breast cancer screening and treatment

Julie DepuydtAnne VralHubert Thierens

The influence of blood storage time and general anaesthesia on chromosomal radiosensitivity assessment

Ans BaeyensOlivia HerdFlavia Zita FranciesAlan CairnsGary KatzmanMarshall MurdochDineshree PadiachyMike MorfordAnne VralJacobus P Slabbert

A1 Journal Article in MUTAGENESIS

The multiparametric magnetic resonance imaging characteristics of the normal, benign and malignant conditions in the prostate

Pieter De VisschereAnne VralEVA PATTYNMarleen PraetGianpaolo PerlettiVittorio MagriGeert Villeirs

Thorough second hit analysis in BRCA1/2 associated breast cancer

Mattias Van HeetveldeTrees LepezLeen PietersSteve LefeverJo Van DorpeKathleen LambeinMarleen Praetivo Van Den BergheFrauke CoppietersJo Vandesompele et al.

Thorough second-hit analysis in BRCA1/2-associated breast cancer

Mattias Van HeetveldeTrees LepezLeen PietersSteve LefeverJo Van DorpeKathleen LambeinMarleen PraetIvo Van Den BergheFrauke CoppietersJo Vandesompele et al.

2015

Analysis of radiosensitivity in South African cervical and breast cancer patients

Olivia Jayne HerdAns BaeyensAnne Vral

BRCA1, BRCA2 and PALB2 mutations and CHEK2 c. 1100delC in different South African ethnic groups diagnosed with premenopausal and/or triple negative breast cancer

FZ FranciesT WainsteinKim De LeeneerA CairnsM MurdochS NietzH CubaschBruce PoppeTom Van MaerkenBrecht Crombez et al.

A1 Journal Article in BMC CANCER

Operational guidance for radiation emergency response organisations in Europe for using biodosimetric tools developed in EU MULTIBIODOSE project

Alicja JaworskaElizabeth A AinsburyPaola FattibeneCarita LindholmUrsula OestreicherKai RothkammHorst RommHubert ThierensFrancois TrompierPhilippe Voisin et al.

A1 Journal Article in RADIATION PROTECTION DOSIMETRY

Radiation-induced lung damage promotes breast cancer lung-metastasis through CXCR4 signaling

Lynn FeysBenedicte DescampsChristian VanhoveAnne VralLiv VeldemanStefan VermeulenCarlos De WagterMarc BrackeOlivier De Wever

A1 Journal Article in ONCOTARGET

Realising the European network of biodosimetry: RENEB-status quo

U KulkaL AinsburyM AtkinsonS BarnardR SmithJF BarquineroL BarriosC BassinetC BeinkeA Cucu et al.

A1 Journal Article in RADIATION PROTECTION DOSIMETRY

The G2 micronucleus-assay for the analysis of in vitro chromosomal radiosensitivity in individuals carrying a BRCA1 mutation

Annelot BaertJulie DepuydtBruce PoppeTom Van MaerkenFransiska MalfaitTim Van DammeSylvia De NobeleKim De LeeneerKathleen ClaesAnne Vral

The first gamma-H2AX biodosimetry intercomparison exercise of the developing European biodosimetry network RENEB

S BarnardEA AinsburyJ Al-hafidhV HadjidekovaR HristovaC LindholmO Monteiro GilJ MoquetM MorenoU Rössler et al.

A1 Journal Article in RADIATION PROTECTION DOSIMETRY

mpMRI-Histopathologic correlation of normal, benign and malignant conditions in the prostate

Pieter De VisschereAnne VralGianpaolo PerlettiEVA PATTYNGeert Villeirs

mpMRI-histopathologic correlation of normal, benign and malignant conditions of the prostate

Pieter De VisschereAnne VralGianpaolo PerlettiEVA PATTYNGeert Villeirs

2014

Induction and disappearance of γH2AX foci and formation of micronuclei after exposure of human lymphocytes to 60Co γ-rays and p(66)+Be(40) neutrons

Veerle VandersickelPhilip BeukesBram Van BockstaeleJulie DepuydtAnne VralJacobus Slabbert

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Inter- and intra-laboratory comparison of a multibiodosimetric approach to triage in a simulated, large scale radiation emergency

Elizabeth AinsburyJenna Al-HafidhAinars BajinskisStephen BarnardJoan Fracesc BarquineroChristina BeinkeVirginie de GelderEric GregoireAlicja JaworskaCarita Lindholm et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Is a semi-automated approach indicated in the application of the automated micronucleus assay for triage purposes?

Hubert ThierensAnne VralCharlot VandevoordeVeerle VandersickelVirginie de GelderH RommU OestreicherK RothkammS BarnardE Ainsbury et al.

A1 Journal Article in RADIATION PROTECTION DOSIMETRY

MRI-guided 3D conformal arc micro-irradiation of a F98 glioblastoma rat model using the Small Animal Radiation Research Platform (SARRP)

Julie BolcaenBenedicte DescampsKarel DeblaereTom BoterbergGiorgio HallaertCaroline Van den BroeckeElke DecrockAnne VralLuc LeybaertChristian Vanhove et al.

A1 Journal Article in JOURNAL OF NEURO-ONCOLOGY

The G2 micronucleus assay for the analysis of in vitro chromosomal radiosensitivity in individuals carrying a BRCA1 or BRCA2 mutation

Annelot BaertJulie DepuydtBruce PoppeTom Van MaerkenFransiska MalfaitTim Van DammeSylvia De NobeleKim De LeeneerKathleen ClaesAnne Vral

The G2-micronucleus assay for the detection of in vitro chromosomal radiosensitivity in BRCA1 and BRCA2 mutation carriers

Annelot BaertJulie DepuydtBruce PoppeTom Van MaerkenFransiska MalfaitTim Van DammeKim De LeeneerKathleen ClaesAnne Vral

Validation of semi-automatic scoring of dicentric chromosomes after simulation of three different irradiation scenarios

H RommE AinsburyS BarnardL BarriosJF BarquineroC BeinkeM DeperasE GregoireA KoivistoinenC Lindholm et al.

A1 Journal Article in HEALTH PHYSICS

Web-based scoring of the dicentric assay, a collaborative biodosimetric scoring strategy for population triage in large scale radiation accidents

H RommE AinsburyA BajinskisS BarnardJF BarquineroL BarriosC BeinkeR Puig-CasanovasM Deperas-KaminskaE Gregoire et al.

A1 Journal Article in RADIATION AND ENVIRONMENTAL BIOPHYSICS

2013

An experimental study on periodontal regeneration after subcutaneous transplantation of rat molar with and without cryopreservation: an in vivo study

SARAH STAELSPeter De CosterAnne VralLiesbeth TemmermanGuy De Pauw

A1 Journal Article in CRYOBIOLOGY

Automatic scoring of dicentric chromosomes as a tool in large scale radiation accidents

H RommE AinsburyS BarnardL BarriosJF BarquineroC BeinkeM DeperasE GregoireA KoivistoinenC Lindholm et al.

A1 Journal Article in MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Comparison of established and emerging biodosimetry assays

K RothkammC BeinkeH RommC BadieY BalagurunathanS BarnardN BernardH Boulay-GreeneM BrenguesA De Amicis et al.

A1 Journal Article in RADIATION RESEARCH

Development of an S-G2 micronucleus assay for the detection of in vitro chromosomal radiosensitivity in high-risk women subjected to early mammography screening for breast cancer

Anne VralJulie DepuydtAnnelot BaertBruce PoppeTom Van MaerkenFransiska MalfaitKim De LeeneerMarc D'HoogheKathleen Claes

Early biomarkers related to secondary primary cancer risk in radiotherapy treated prostate cancer patients: IMRT versus IMAT

Joke WerbrouckPiet OstValérie FonteyneGert De MeerleerWilfried De NeveEvelien BogaertLaurence BeelsKlaus BacherAnne VralHubert Thierens

A1 Journal Article in RADIOTHERAPY AND ONCOLOGY

Heme deficiency of soluble guanylate cyclase induces gastroparesis

Sarah CosynsIngeborg DhaeseRobrecht ThoonenES BuysAnne VralPeter BrouckaertRomain Lefebvre

A1 Journal Article in NEUROGASTROENTEROLOGY AND MOTILITY

Laboratory intercomparison of the cytokinesis-block micronucleus assay

H RommS BarnardH Boulay-GreeneA De AmicisS De SanctisM FrancoF HerodinA JonesU KulkaF Lista et al.

A1 Journal Article in RADIATION RESEARCH

Manual versus automated γ-H2AX foci analysis across five European laboratories: can this assay be used for rapid biodosimetry in a large scale radiation accident?

Kai RothkammStephen BarnardElizabeth A AinsburyJenna Al-HafidhJoan-Francesc BarquineroCarita LindholmJayne MoquetMarjo PeräläSandrine Roch-LefèvreHarry Scherthan et al.

A1 Journal Article in MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Relative biological effectiveness of mammography X-rays at the level of DNA and chromosomes in lymphocytes

Julie DepuydtAnnelot BaertVeerle VandersickelHubert ThierensAnne Vral

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Variant ataxia telangiectasia: clinical and molecular findings and evaluation of radiosensitive phenotypes in a patient and relatives

Kathleen ClaesJulie DepuydtA Malcolm R TaylorJames I LastAnnelot BaertPeter SchietecatteVeerle VandersickelBruce PoppeKim De LeeneerMarc D'Hooghe et al.

A1 Journal Article in NEUROMOLECULAR MEDICINE

2012

Dose-length product of scanners correlates with DNA damage in patients undergoing contrast CT

Laurence BeelsKlaus BacherPeter SmeetsKoenraad VerstraeteAnne VralHubert Thierens

A1 Journal Article in EUROPEAN JOURNAL OF RADIOLOGY

Pulpal regeneration and root development after subcutaneous transplantation of cryopreserved immature teeth in rats

Liesbeth TemmermanAnne VralMaarten MeireRonald VerbeeckEllen DeschepperLuc DermautGuy De Pauw

A1 Journal Article in CRYOBIOLOGY

Realising the European Network of Biodosimetry (RENEB)

U KulkaL AinsburyM AtkinsonJF BarquineroL BarriosC BeinkeG BognarA CucuF DarroudiP Fattibene et al.

A1 Journal Article in RADIATION PROTECTION DOSIMETRY

Topographic and quantitative relationship between prostate inflammation, proliferative inflammatory atrophy and low-grade prostate intraepithelial neoplasia: a biopsy study in chronic prostatitis patients

Anne VralV MagriE MontanariG GazzanoV GourvasE MarrasG Perletti

A1 Journal Article in INTERNATIONAL JOURNAL OF ONCOLOGY

2011

A semi-automated micronucleus-centromere assay to assess low-dose radiation exposure in human lymphocytes

Ans BaeyensRosemary SwansonOlivia HerdElizabeth AinsburyThulani MabhenguPascale WillemHubert ThierensJacobus P SlabbertAnne Vral

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Combined effect of polymorphisms in Rad51 and XRCC3 on breast cancer risk and chromosomal radiosensitivity

Anne VralPetra WillemsKathleen ClaesBruce PoppeAns BaeyensGianpaolo PerlettiHubert Thierens

A1 Journal Article in MOLECULAR MEDICINE REPORTS

Comparison of the colony formation and crystal violet cell proliferation assays to determine cellular radiosensitivity in a repair-deficient MCF10A cell line

Veerle VandersickelJacobus SlabbertHubert ThierensAnne Vral

A1 Journal Article in RADIATION MEASUREMENTS

Cytokinesis-blocked micronucleus assay and cancer risk assessment

Randa El-ZeinAnne VralCarol J. Etzel

A1 Journal Article in MUTAGENESIS

DNA double-strand breaks induced by low-dose exposure to x-rays used in medical diagnostics

Laurence BeelsHubert ThierensAnne Vral

Review of retrospective dosimetry techniques for external ionising radiation exposures

EA AinsburyE BakhanovaJF BarquineroM BraiV ChumakV CorrecherF DarroudiP FattibeneG GruelI Guclu et al.

A1 Journal Article in RADIATION PROTECTION DOSIMETRY

The micronucleus assay as a biological dosimeter of in vivo ionising radiation exposure

Anne VralMichel FenechHubert Thierens

A1 Journal Article in MUTAGENESIS

2010

Automated micronucleus (MN) scoring for population triage in case of large scale radiation events

Petra WillemsLiezel AugustJacobus SlabbertHorst RommUrsula OestreicherHubert ThierensAnne Vral

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Chromosomal radiosensitivity of HIV positive individuals

Ans BaeyensJacobus P SlabbertPascale WillemSibusiso JozelaDebby Van Der MerweAnne Vral

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Early increase of radiation-induced γH2AX foci in a human Ku70/80 knockdown cell line characterized by an enhanced radiosensitivity

Veerle VandersickelJulie DepuydtBram Van BockstaeleGianpaolo PerlettiJan PhilippéHubert ThierensAnne Vral

A1 Journal Article in JOURNAL OF RADIATION RESEARCH

Inflammation, prostatitis, proliferative inflammatory atrophy: 'Fertile ground' for prostate cancer development?

G PerlettiE MontanariAnne VralG GazzanoE MarrasSylvia MioneV Magri

A1 Journal Article in MOLECULAR MEDICINE REPORTS

Lentivirus-mediated RNA interference of Ku70 to enhance radiosensitivity of human mammary epithelial cells

Veerle VandersickelM ManciniE MarrasP WillemsJ SlabbertJan PhilippéEllen DeschepperHubert ThierensG PerlettiAnne Vral

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Prediction of late normal tissue complications in RT treated gynaecological cancer patients: potential of the γ-H2AX foci assay and association with chromosomal radiosensitivity

Joke WerbrouckKim De RuyckLaurence BeelsAnne VralMarc Van EijkerenWilfried De NeveHubert Thierens

A1 Journal Article in ONCOLOGY REPORTS

Semi-automated micronucleus-centromere scoring in assessing cellular damage in patients exposed to low doses of ionizing radiation

Ans BaeyensJakobus P SlabbertRose SwansonHubert ThierensPetra WillemsAnne Vral

The radiosensitizing effect of Ku70/80 knockdown in MCF10A cells irradiated with X-rays and p(66)+Be(40) neutrons

Veerle VandersickelMonica ManciniJacobus SlabbertEmanuela MarrasHubert ThierensGianpaolo PerlettiAnne Vral

A1 Journal Article in RADIATION ONCOLOGY

The relative biological effectiveness of a high energy neutron beam for micronuclei induction in T-lymphocytes of different individuals

Jacobus P SlabbertL AugustAnne VralJ Symons

A1 Journal Article in RADIATION MEASUREMENTS

The role of the Ku heterodimer in the response of human MCF10A cells to low-and high-LET radiation qualities

Veerle VandersickelAnne VralHubert Thierens

2009

A polymorphism in the promoter region of Ku70/XRCC6, associated with breast cancer risk and oestrogen exposure

Petra WillemsKim De RuyckRudy Van den BroeckeAmin MakarGianpaolo PerlettiHubert ThierensAnne Vral

A1 Journal Article in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Acute normal tissue reactions in head-and-neck cancer patients treated with IMRT: influence of dose and association with genetic polymorphisms in DNA DSB repair genes

Joke WerbrouckKim De RuyckFréderic DuprezLiv VeldemanKathleen ClaesMarc Van EijkerenTom BoterbergPetra WillemsAnne VralWilfried De Neve et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Characterization of the c.190T > C missense mutation in BRCA1 codon 64 (Cys64Arg)

Petra WillemsV. MagriM. CretnikM. FasanoA. JakubowskaS. LevanatJ. LubinskiE. MarasV. MusaniHubert Thierens et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF ONCOLOGY

Polymorphisms in DNA double-strand break repair genes: link with breast cancer susceptibility and in vitro chromosomal radiosensitivity.

Petra WillemsAnne VralHubert Thierens

The micronucleus assay in radiation accidents

Hubert ThierensAnne Vral

A1 Journal Article in ANNALI DELL ISTITUTO SUPERIORE DI SANITA

The radiosensitizing effect of Ku70-80 knockdown by RNA interference in the MCF10A breast epithelial cell line irradiated with low LET X-rays and high LET radiotherapy neutrons

Veerle VandersickelM ManciniJP SlabbertE MarrasHubert ThierensG PerlettiAnne Vral

Virtuele microscopie in morfologisch onderwijs

Sylvia MioneAnne VralMaria CornelissenRichard DucatelleKoen ChiersWim Van Den Broeck

2008

Chromosomal radiosensitivity in head and neck cancer patients: evidence for genetic predisposition?

Kim De RuyckVirginie de GelderMarc Van EijkerenTom BoterbergWilfried De NeveAnne VralHubert Thierens

A1 Journal Article in BRITISH JOURNAL OF CANCER

Discrepancies between in silico and in vitro data in the functional analysis of a breast cancer-associated polymorphism in the XRCC6/Ku70 gene

E MARRASPetra WillemsVeerle VandersickelI CERIANIHubert ThierensAnne VralG PERLETTI

A1 Journal Article in MOLECULAR MEDICINE REPORTS

Polymorphisms in nonhomologous end-joining genes associated with breast cancer risk and chromosomal radiosensitivity

Petra WillemsKathleen ClaesAns BaeyensVeerle VandersickelJoke WerbrouckKim De RuyckBruce PoppeRudy Van den BroeckeAmin MakarEmanuela Marras et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Prevention and modulation of aminoglycoside ototoxicity (Review)

Gianpaolo PerlettiAnne VralMaria Cristina PatrossoEmanuela MarrasIsabella CerianiPetra WillemsMauro FasanoVittorio Magri

A1 Journal Article in MOLECULAR MEDICINE REPORTS

Single-nucleotide polymorphisms in DNA double-strand break repair genes: Association with head and neck cancer and interaction with tobacco use and alcohol consumption

Joke WerbrouckKim De RuyckFréderic DuprezMarc Van EijkerenErnst RietzschelSofie BekaertAnne VralWilfried De NeveHubert Thierens

A1 Journal Article in MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

2007

Abnormal dentin structure in two novel gene mutations [COL1A1, Arg134Cys] and [ADAMTS2, Trp795-to-ter] causing rare type I collagen disorders

Peter De CosterMaria CornelissenAnne De PaepeLuc MartensAnne Vral

A1 Journal Article in ARCHIVES OF ORAL BIOLOGY

Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk

Kim De RuyckMarcin SzaumkesselIsabelle De RudderANNELORE DEHOORNEAnne VralKathleen ClaesAnja VelgheJan Van MeerbeeckHubert Thierens

A1 Journal Article in MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

2006

In vitro radiosensitivity of peripheral blood lymphocytes in multiple sclerosis patients

I PETCUD SAVUHubert ThierensG NAGELSAnne Vral

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Seckel syndrome associated with oligodontia, microdontia, enamel hypoplasia, delayed eruption, and dentin dysmineralization: a new variant?

Peter De CosterRonald VerbeeckV HOLTHAUSLuc MartensAnne Vral

A1 Journal Article in JOURNAL OF ORAL PATHOLOGY & MEDICINE

TGF beta 1 polymorphisms and late clinical radiosensitivity in patients treated for gynecologic tumors

Kim De RuyckMarc Van EijkerenKathleen ClaesKlaus BacherAnne VralWilfried De NeveHubert Thierens

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

2005

Chromosomal radio sensitivity of breast cancer with a CHEK2 mutation

Ans BaeyensKathleen ClaesPetra WillemsKim De RuyckHubert ThierensAnne Vral

A1 Journal Article in CANCER GENETICS AND CYTOGENETICS

Chromosomal radiosensitivity in breast cancer patients : influence of age of onset of the disease

Ans BaeyensRudy Van den BroeckeAmin MakarHubert ThierensLeo De RidderAnne Vral

A1 Journal Article in ONCOLOGY REPORTS

Cytogenetic biodosimetry of an accidental exposure of a radiological worker using multiple assays

Hubert ThierensKim De RuyckAnne VralVirginie de GelderCA WHITEHOUSEFJ TAWNI BOESMAN

A1 Journal Article in RADIATION PROTECTION DOSIMETRY

Effects of estradiol and progesterone on the variability of the micronucleus assay

Ans BaeyensVeerle VandersickelHubert ThierensLeo De RidderAnne Vral

A1 Journal Article in MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

In vitro chromosomal radiosensitivity in breast cancer patients

Ans BaeyensAnne VralHubert Thierens

Radiation-induced damage to normal tissues after radiotherapy in patients treated for gynecologic tumors: Association with single nucleotide polymorphisms in XRCC1, XRCC3, and OGG1 genes and in vitro chromosomal radiosensitivity in lymphocytes

Kim De RuyckMarc Van EijkerenKathleen ClaesR MORTHIERAnne De PaepeAnne VralLeo De RidderHubert Thierens

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

2004

Biologic dosimetry of Re-188-HDD/lipiodol versus I-131-lipiodol therapy in patients with hepatocellular carcinoma

Kim De RuyckBieke LambertKlaus BacherF GEMMELFILIP DE VOSAnne VralLeo De RidderRudi DierckxHubert Thierens

A1 Journal Article in JOURNAL OF NUCLEAR MEDICINE

Chromosomal aberrations and in vitro radiosensitivity: intra-individual versus inter-individual variability

Anne VralHubert ThierensAns BaeyensLeo De Ridder

A1 Journal Article in TOXICOLOGY LETTERS

Chromosomal radiosensitivity in BRCA1 and BRCA2 mutation carriers

Ans BaeyensHubert ThierensKathleen ClaesBruce PoppeLeo De RidderAnne Vral

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Chromosomal radiosensitivity in secondary-progressive multiple sclerosis patients

Ileana PetcuDiana SavuAnne VralHubert ThierensGuy NagelsLeo De Ridder

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

The use of EBV-transformed cell lines of breast cancer patients to measure chromosomal radiosensitivity

Ans BaeyensHubert ThierensKatia VandenbulckeLeo De RidderAnne Vral

A1 Journal Article in MUTAGENESIS

The use of IL-2 cultures to measure chromosomal radiosensitivity in breast cancer patients

Ans BaeyensKatia VandenbulckeJan PhilippéHubert ThierensLeo De RidderAnne Vral

A1 Journal Article in MUTAGENESIS

2003

Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus project

Stefano BonassiMonica NeriCecilia LandoMarcello CeppiYi-Ping LinWushou P ChangNina HollandMicheline Kirsch-VoldersErrol ZeigerMichael Fenech et al.

A1 Journal Article in MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

In vitro evaluation of Bi-213-rituximab versus external gamma irradiation for the treatment of B-CLL patients: Relative biological efficacy with respect to apoptosis induction and chromosomal damage by the micronucleus assay

K VANDENBULCKEFilip De VosFritz OffnerJan PhilippéC APOSTOLIDISR MOLINETTK NIKULAKlaus BacherVirginie de GelderAnne Vral et al.

In vitro evaluation of Bi-213-rituximab versus external gamma irradiation for the treatment of B-CLL patients: relative biological efficacy with respect to apoptosis induction and chromosomal damage

Katia VandenbulckeFILIP DE VOSFritz OffnerJan PhilippéC APOSTOLIDISR MOLINETTK NIKULAKlaus BacherV DE GELDERAnne Vral et al.

A1 Journal Article in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN project.

M FENECHS BONASSIJ TURNERC LANDOM CEPPIWP CHANGN HOLLANDM KIRSCH-VOLDERSE ZEIGERMP BIGATTI et al.

A1 Journal Article in MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Patient dosimetry for I-131-lipiodol therapy

Myriam MonsieursKlaus BacherB BRANSAnne VralLeo De RidderRudi DierckxHubert Thierens

A1 Journal Article in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

2002

Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition

Ans BaeyensHubert ThierensKathleen ClaesBruce PoppeLudwine MessiaenLeo De RidderAnne Vral

A1 Journal Article in BRITISH JOURNAL OF CANCER

Chromosomal radiosensitivity study of temporary nuclear workers and the support of the adaptive response induced by occupational exposure.

Hubert ThierensAnne VralM BARBEM MEIJLAERSAns BaeyensLeo De Ridder

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Induction and disappearance of G2 chromatid breaks in lymphocytes after low doses of low-LET gamma-rays and high-LET fast neutrons.

Anne VralHubert ThierensAns BaeyensLeo De Ridder

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Micronucleus assay reveals no radiation effects among nuclear power plant workers.

Hubert ThierensAnne VralM BARBELeo De Ridder

A1 Journal Article in HEALTH PHYSICS

The G2 chromosomal radiosensitivity assay.

PE BRYANTL GRAYAC RICHESCM STEELP FINNONO HOWEI KESTERTONAnne VralGB CURWENV SMART et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

The micronucleus and G(2)-phase assays for human blood lymphocytes as biomarkers of individual sensitivity to ionizing radiation: Limitations imposed by intraindividual variability.

Anne VralHubert ThierensAns BaeyensLeo De Ridder

A1 Journal Article in RADIATION RESEARCH

2001

A higher micronucleus yield in B- versus T-cells after low-dose gamma-irradiation is not linked with defective Ku86 protein.

Anne VralHubert ThierensP BRYANTLeo De Ridder

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

HUman MicroNucleus Project: International database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes: I. Effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei.

S BONASSIM FENECHC LANDOYP LINM CEPPIWP CHANGN HOLLANDM KIRSCH-VOLDERSE ZEIGERSY BAN et al.

A1 Journal Article in ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Patient dosimetry after I-131-MIBG therapy for neuroblastoma and carcinoid tumours.

MA MONSIEURSHubert ThierensAnne VralB BRANSLeo De RidderRudi Dierckx

A1 Journal Article in NUCLEAR MEDICINE COMMUNICATIONS

2000

Adaptive response in patients treated with 131I.

MA MONSIEURSHubert ThierensAnne VralC VAN DE WIELELeo De RidderRudi Dierckx

A1 Journal Article in JOURNAL OF NUCLEAR MEDICINE

Biomonitoring of radiation workers in Belgium : results of large scale cytogenetic studies using the micronucleus-centromere assay

Hubert ThierensAnne VralB AousalahM BarbéR MorthierLeo De Ridder

Cytogenetic monitoring of hospital workers occupationally exposed to ionizing radiation using the micronucleus centromere assay

Hubert ThierensAnne VralR MorthierB AousalahLeo De Ridder

A1 Journal Article in MUTAGENESIS

1999

A cytogenetic study of nuclear power plant workers using the micronucleus-centromere assay.

Hubert ThierensAnne VralM BARBEB AOUSALAHLeo De Ridder

A1 Journal Article in MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Apoptosis induced by γ irradiation in peripheral blood mononuclear cells is not mediated by cytochrome-c release and only partially involves caspase-3-like proteases

Henk LouagiePeter SchotteAnne VralMaria CornelissenHubert ThierensRudi BeyaertLeo De RidderJan Philippé

A1 Journal Article in CELL BIOLOGY INTERNATIONAL

Cytogenetische studies bij patiënten behandeld met 131I-Nal voor schildklieraandoeningen of 131I-MIBG voor neuroblastoma

Myriam MonsieursHubert ThierensAnne VralChristophe Van De WieleLeo De RidderRudi Dierckx

A2 Journal Article in TIJDSCHRIFT VOOR NUCLEAIRE GENEESKUNDE

Estimation of risk based on biological dosimetry for patients treated with radioiodine.

Myriam MonsieursHubert ThierensChristophe Van De WieleAnne VralIA MEIRLAENHilde De WinterCJ DE SADELEERLeo De RidderJean KaufmanRudi Dierckx

A1 Journal Article in NUCLEAR MEDICINE COMMUNICATIONS

Inter-laboratory comparison of cytogenetic endpoints for the biomonitoring of radiological workers.

Hubert ThierensAnne VralLeo De RidderN TOUILM KIRSCH-VOLDERSV LAMBERTC LAURENT

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

The effect of caspase-inhibitors on radiation induced apoptosis in human peripheral blood lymphocytes: an electron microscopic approach

Maria CornelissenAnne VralHubert ThierensLeo De Ridder

A1 Journal Article in APOPTOSIS

1998

Apoptosis induced by fast neutrons versus Co-60 gamma-rays in human peripheral blood lymphocytes

Anne VralMaria CornelissenHubert ThierensHenk LouagieJan PhilippéKarel StrijckmansLeo De Ridder

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Flow cytometric scoring of apoptosis compared to electron microscopy in γ irradiated lymphocytes

Henk LouagieMaria CornelissenJan PhilippéAnne VralHubert ThierensLeo De Ridder

A1 Journal Article in CELL BIOLOGY INTERNATIONAL

Inductie van micronuclei apoptose in natural killer cellen in vergelijking met T lymfocyten na γ-bestraling

L LouagieJan PhilippéAnne VralMaria CornelissenHubert ThierensLeo De Ridder

A4 Journal Article in TIJDSCHRIFT VAN DE BELGISCHE VERENIGING VAN LABORATORIUM-TECHNOLOGEN = REVUE DE L'ASSOCIATION BELGE DES TECHNOLOGUES DE LABORATOIRE

Induction of micronuclei and apoptosis in natural killer cells compared to T lymphocytes after gamma-irradiation.

H LOUAGIEJan PhilippéAnne VralMaria CornelissenHubert ThierensI DE RIDDER

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Micronucleus frequencies in cytokinesis-blocked human B lymphocytes after low dose gamma-irradiation.

Anne VralHenk LouagieHubert ThierensJan PhilippéMaria CornelissenLeo De Ridder

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

1997

Flow cytometry as a quantitative and sensitive method to evaluate low dose radiation induced apoptosis in vitro in human peripheral blood lymphocytes

Koen HertveldtJan PhilippéHubert ThierensMaria CornelissenAnne VralLeo De Ridder

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

In vitro micronucleus-centromere assay to detect radiation-damage induced by low doses in human lymphocytes

Anne VralHubert ThierensLeo De Ridder

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Quantification of apoptosis in lymphocyte subsets and effect of apoptosis on apparent expression of membrane antigens

Jan PhilippéHenk LouagieHubert ThierensAnne VralMaria CornelissenLeo De Ridder

A1 Journal Article in CYTOMETRY

Semi-automated micronucleus scoring in cytokinesis-blocked lymphocytes after irradiation

Hubert ThierensAnne VralF De ScheerderLeo De RidderA Tates

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

1996

A cytogenetic study of radiological workers: effect of age, smoking and radiation burden on the micronucleus frequency

Hubert ThierensAnne VralLeo De Ridder

A1 Journal Article in MUTATION RESEARCH-ENVIRONMENTAL MUTAGENESIS AND RELATED SUBJECTS

Micronucleus induction by 60Co γ-rays and fast neutrons in ataxia telangiectasia lymphocytes

Anne VralHubert ThierensLeo De Ridder

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Optimalisatie van de in vitro micronucleus methode voor humane lymfocyten via in situ hybridisatie met een centromeer probe

Anne VralHubert ThierensLeo De Ridder

1995

Evaluatie van stralings-geinduceerde chromosomale schade in humane lymfocyten van het perifere bloed met behulp van de cytokinesis-block micronucleus methode

Anne VralL. De RidderH. ThierensP. De Rijcke

Micronucleus induction in peripheral blood lymphocytes of patients under radiotherapy treatment for cervical cancer or Hodgkin's disease.

Hubert ThierensAnne VralMarc Van EijkerenFranki SpelemanLeo De Ridder

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

1994

Micronuclei induced by fast-neutrons versus 60Co γ-rays in human peripheral blood lymphocytes

Anne VralFrans VerhaegenHubert ThierensLeo De Ridder

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Scoring of radiation-induced micronuclei in cytokinesis-blocked human lymphocytes by automated image analysis

Frans VerhaegenAnne VralJ SeuntjensNW SchipperLeo De RidderHubert Thierens

A1 Journal Article in CYTOMETRY

Sensitivity of micronucleus induction in human-lymphocytes to low-LET radiation qualities - RBE and correlation of RBE and LET.

F VERHAEGENAnne Vral

A1 Journal Article in RADIATION RESEARCH

The in vitro cytokinesis-block micronucleus assay : a detailed description of an improved slide preparation technique for the automated detection of micronuclei in human lymphocytes.

Anne VralFrans VerhaegenHubert ThierensLeo De Ridder

A1 Journal Article in MUTAGENESIS

1993

Radiation damage to endothelial cells in vitro, as judged by micronucleus assay

M RaicuAnne VralHubert ThierensLeo De Ridder

A1 Journal Article in MUTAGENESIS

1992

Effects of dose rate on the micronucleus yield in human lymphocytes exposed to X-rays

Anne VralHubert ThierensLeo De Ridder

Lymphocyte labeling with technetium-99M-HPPAO : a radiotoxicity study using the micronucleus assay

Hubert ThierensAnne VralJean P Van HaelstChristophe Van De WieleKarel HG SchelstraeteLeo De Ridder

A1 Journal Article in JOURNAL OF NUCLEAR MEDICINE

Study of dose rate and split dose effects on the in vitro micronucleus yield in human lymphocytes exposed to X-rays

Anne VralHubert ThierensLeo De Ridder

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Study of dose-response and split-dose effects on the micronucleus (MN) yield in human lymphocytes exposed to different radiation qualities

Anne VralHubert ThierensLeo De Ridder

1991

Biological dosimetry using the micronucleus assay for lymphocytes : interindividual differences in dose response

Hubert ThierensAnne VralLeo De Ridder

A1 Journal Article in HEALTH PHYSICS

Evaluatie van stralingsschade door middel van de in vitro micronucleus test in perifere bloedlymfocyten

Anne VralHubert ThierensLeo De Ridder

A4 Journal Article in TIJDSCHRIFT VAN DE BELGISCHE VERENIGING VAN LABORATORIUM-TECHNOLOGEN = REVUE DE L'ASSOCIATION BELGE DES TECHNOLOGUES DE LABORATOIRE