Research Explorer

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Researcher

Anje Cauwels

Awards & Distinctions

68 Results

2023

A bispecific Clec9A-PD-L1 targeted type I interferon profoundly reshapes the tumor microenvironment towards an antitumor state

Sandra Van LintAlexander Van ParysBram Van Den EeckhoutNiels VandammeStephane PlaisanceAnnick VerheeDominiek CatteeuwElke RoggeJennifer De GeestNele Vanderroost et al.

A1 Journal Article in MOLECULAR CANCER

2022

Direct and indirect anti-leukemic properties of Activity-on-Target interferons for the treatment of T-cell acute lymphoblastic leukemia

Steven GoossensAnje CauwelsTim PietersRenate De SmedtSara T'SasAndré Pedro Pinto De AlmeidaWillem DaneelsPieter Van VlierbergheJan Tavernier

A1 Journal Article in HAEMATOLOGICA

2021

Formatting and gene-based delivery of a human PD-L1 single domain antibody for immune checkpoint blockade

Robin Maximilian AwadQuentin LecocqKatty ZevenThomas ErtveldtLien De BeckHannelore CeuppensKatrijn BroosYannick De VlaeminckCleo GoyvaertsMagali Verdonck et al.

A1 Journal Article in MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT

Microcirculatory function during endotoxemia : a functional citrulline-arginine-NO pathway and NOS3 complex is essential to maintain the microcirculation

Karolina A. P. WijnandsDennis M. MeestersBenjamin VandendriesscheJacob J. BriedeHans M. H. van EijkPeter BrouckaertAnje CauwelsWouter H. LamersMartijn Poeze

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Selective IL-1 activity on CD8+ T cells empowers antitumor immunity and synergizes with neovasculature-targeted TNF for full tumor eradication

Bram Van Den EeckhoutLeander HuygheSandra Van LintElianne BurgStéphane PlaisanceFrank PeelmanAnje CauwelsGilles UzéNiko KleySarah Gerlo et al.

A1 Journal Article in JOURNAL FOR IMMUNOTHERAPY OF CANCER

Targeting IFN activity to both B cells and plasmacytoid dendritic cells induces a robust tolerogenic response and protection against EAE

Anje CauwelsSandra Van LintElke RoggeAnnick VerheeBram Van Den EeckhoutShengru PangMarco PrinzNiko KleyGilles UzeJan Tavernier

A1 Journal Article in SCIENTIFIC REPORTS

2020

Safe eradication of large established tumors using neovasculature-targeted tumor necrosis factor-based therapies

Leander HuygheAlexander Van ParysAnje CauwelsSandra Van LintStijn De MunterJennyfer BultinckLennart ZabeauJeroen HostensAn GoethalsNele Vanderroost et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Teaching an old dog new tricks : activity-on-target interferon to treat T-cell acute lymphoblastic leukemia

Steven GoossensAnje CauwelsTim PietersWillem DaneelsPieter Van VlierbergheJan Tavernier

2019

Targeting interferon activity to dendritic cells enables in vivo tolerization and protection against EAE in mice

Anje CauwelsSandra Van LintDominiek CatteeuwShengru PangFranciane PaulElke RoggeAnnick VerheeMarco PrinzNiko KleyGilles Uzé et al.

A1 Journal Article in JOURNAL OF AUTOIMMUNITY

2018

Delivering type I interferon to dendritic cells empowers tumor eradication and immune combination treatments

Anje CauwelsSandra Van LintFranciane PaulGenevieve GarcinStefaan De KokerAlexander Van ParysThomas WüestSarah GerloJosé Van Der HeydenYan Bordat et al.

A1 Journal Article in CANCER RESEARCH

IL-1β AcTaleukins : towards potent yet safe adjuvants for tumor vaccination

Bram Van Den EeckhoutElianne BurgAnje CauwelsFrank PeelmanSandra Van LintJan TavernierSarah Gerlo

2017

A safe and highly efficient tumor-targeted type I interferon immunotherapy depends on the tumor microenvironment

Anje CauwelsSandra Van LintGeneviève GarcinJennyfer BultinckFranciane PaulSarah GerloJosé Van Der HeydenYann BordatDominiek CatteeuwLode De Cauwer et al.

A1 Journal Article in ONCOIMMUNOLOGY

IL-1β AcTaleukins : towards potent yet safe adjuvants for tumor vaccination

Bram Van Den EeckhoutElianne BurgAnje CauwelsFrank PeelmanSandra Van LintJan TavernierSarah Gerlo

2015

Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice

Robrecht ThoonenAnje CauwelsKelly DecaluwéSandra GeschkaRobert E TainshJoris DelangheTino HochepiedLode De CauwerElke RoggeSofie Voet et al.

A1 Journal Article in NATURE COMMUNICATIONS

Citrulline supplementation improves organ perfusion and arginine availability under conditions with enhanced arginase activity

Karolina AP WijnandsDennis M MeestersKevin WY van BarneveldRuben GJ VisschersJacob J BriedéBenjamin VandendriesscheHans MH van EijkBabs AFM BessemsNadine van den HovenChristian JH von Wintersdorff et al.

A1 Journal Article in NUTRIENTS

2014

A multiscale entropy-based tool for scoring severity of systemic inflammation

Benjamin VandendriesscheHarlinde PeperstraeteElke RoggePeter CauwelsEric HosteOliver StiedlPeter BrouckaertAnje Cauwels

A1 Journal Article in CRITICAL CARE MEDICINE

Extracellular ATP drives systemic inflammation, tissue damage and mortality

Anje CauwelsElke RoggeBenjamin VandendriesscheS ShivaPeter Brouckaert

A1 Journal Article in CELL DEATH & DISEASE

Heme-deficient NO-unresponsive sGC knock-in mice: novel aspects of NO sGC signaling in cardiovascular (patho)physiology

Robrecht ThoonenEmmanuel BuysAnje CauwelsKelly DecaluwéSandra GeschkaRobert TainshJoris DelangheTino HochepiedLode De CauwerElke Rogge et al.

MAPK-activated protein kinase 2-deficiency causes hyperacute tumor necrosis factor-induced inflammatory shock

Benjamin VandendriesscheAn GoethalsAlba SimatsEvelien Van HammePeter BrouckaertAnje Cauwels

A2 Journal Article in BMC PHYSIOLOGY

Nitric oxide production by endotoxin preparations in TLR4-deficient mice

Anje CauwelsJennyfer BultinckRenske De ZwaefBenjamin VandendriesscheStefan MagezPeter Brouckaert

A1 Journal Article in NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock

Tom Vanden BergheDieter DemonPieter BogaertBenjamin VandendriesscheAlain GoethalsBart DepuydtMarnik VuylstekeRia RoelandtElien Van WonterghemJill Vandenbroecke et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

2013

An inactivating caspase-11 passenger mutation muddles sepsis research

Tom Vanden BergheAlain GoethalsDieter DemonPieter BogaertTak W MakAnje CauwelsPeter Vandenabeele

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Complex dynamics in systemic inflammation : quantification of coupling and targeting of the nitric oxide-soluble guanylate cyclase axis

Benjamin VandendriesschePeter BrouckaertAnje Cauwels

Of mice, men, and inflammation

Anje CauwelsBenjamin VandendriesschePeter Brouckaert

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR2 activation causes no morbidity or cardiovascular failure, despite excessive systemic nitric oxide production

Anje CauwelsBenjamin VandendriesscheJennyfer BultinckBenedicte DescampsElke RoggeTom Van NieuwenhuysenMagdalena SipsChristian VanhovePeter Brouckaert

A1 Journal Article in CARDIOVASCULAR RESEARCH

The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems

Benjamin VandendriesscheElke RoggeVera GoossensPeter VandenabeeleJohannes-Peter StaschPeter BrouckaertAnje Cauwels

A1 Journal Article in PLOS ONE

2012

Acute injury in the peripheral nervous system triggers an alternative macrophage response

Elke YdensAnje CauwelsBob AsselberghSofie GoethalsLieve PeeraerGuillaume LornetLeonardo Almeida-SouzaJo A Van GinderachterVincent TimmermanSophie Janssens

A1 Journal Article in JOURNAL OF NEUROINFLAMMATION

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

Nozomi TakahashiLinde DuprezSasker GrootjansAnje CauwelsWim NerinckxJB DuHadawayVera GoossensRia RoelandtFilip Van HauwermeirenClaude Libert et al.

A1 Journal Article in CELL DEATH & DISEASE

Proinflammatory characteristics of SMAC/DIABLO-induced cell death in antitumor therapy

Perpetua U EmeagiSandra Van LintCleo GoyvaertsSarah MaenhoutAnje CauwelsLain A McNeishTomas BosCarlo HeirmanKris ThielennansJoeri L Aerts et al.

A1 Journal Article in CANCER RESEARCH

Severity of sepsis-induced acute kidney injury in a novel mouse model is age dependent

Bert MaddensBenjamin VandendriesscheDieter DemonRaymond VanholderKoen ChiersAnje CauwelsEvelyne Meyer

A1 Journal Article in CRITICAL CARE MEDICINE

2011

Nitrite regulation of shock

Anje CauwelsPeter Brouckaert

A1 Journal Article in CARDIOVASCULAR RESEARCH

RIP Kinase-dependent necrosis drives lethal systemic inflammatory response syndrome

Linde DuprezNozomi TakahashiFilip Van HauwermeirenBenjamin VandendriesscheVera GoossensTom Vanden BergheWim DeclercqClaude LibertAnje CauwelsPeter Vandenabeele

A1 Journal Article in IMMUNITY

TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation

Dmitri KryskoAgnieszka KaczmarekOlga KryskoLiesbeth HeyndrickxJerzy WoznickiPieter BogaertAnje CauwelsNozomi TakahashiS MagezClaus Bachert et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2010

Reactive oxygen species and small-conductance calcium-dependent potassium channels are key mediators of inflammation-induced hypotension and shock

Anje CauwelsElke RoggeBen JanssenPeter Brouckaert

A1 Journal Article in JOURNAL OF MOLECULAR MEDICINE-JMM

2009

Nitrite protects against morbidity and mortality associated with TNF- or LPS-induced shock in a soluble guanylate cyclase-dependent manner

Anje CauwelsEmmanuel S BuysRobrecht ThoonenLisa GearyJoris DelangheSruti ShivaPeter Brouckaert

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

sGCα1β1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models

Emmanuel S BuysAnje CauwelsMichael J RaherJonathan J PasseriIon HobaiSharon M CawleyKristen M RauwerdinkHélène ThibaultPatrick SipsRobrecht Thoonen et al.

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

2008

Critical role for small and large conductance calcium-dependent potassium channels in endotoxemia and TNF toxicity

Anje CauwelsPeter Brouckaert

A1 Journal Article in SHOCK

IL-17 produced by Paneth cells drives TNF-induced shock

N TAKAHASHIIneke VanlaereRiet De RyckeAnje CauwelsLAB JOOSTENE LUBBERTSWB VAN DEN BERGClaude Libert

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Is there NO treatment for severe sepsis?

Amin BredanAnje Cauwels

A1 Journal Article in LIBYAN JOURNAL OF MEDICINE

2007

Excessive endogenous systemic no production is not sufficient to cause shock, morbidity or mortality

Anje CauwelsJennyfer BultinckRenske De ZwaefPeter Brouckaert

Nitric oxide in shock

A1 Journal Article in KIDNEY INTERNATIONAL

Survival of TNF toxicity: Dependence on caspases and NO

Anje CauwelsPeter Brouckaert

A1 Journal Article in ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

2006

Anaphylactic shock depends on PI3K and eNOS-derived NO

Anje CauwelsBen JanssenEmmanuel BuysPatrick SipsPeter Brouckaert

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Anaphylactic shock depends on PI3K, Akt and eNOS-derived NO

Anje CauwelsB JANSSENE BUYSPatrick SipsPeter Brouckaert

High-output systemic NO production during (septic) shock depends on parenchymal cells and is not sufficient to cause shock and lethality

J BULTINCKR DE ZWAEFPeter BrouckaertAnje Cauwels

Systemic NO production during (septic) shock depends on parenchymal and not on hematopoietic cells: in vivo iNOS expression pattern in (septic) shock

Jennyfer BultinckPatrick SipsLuc VakaetPeter BrouckaertAnje Cauwels

A1 Journal Article in FASEB JOURNAL

The in vivo contribution of hematopoietic cells to systemic TNF and IL-6 production during endotoxemia

Jennyfer BultinckPeter BrouckaertAnje Cauwels

A1 Journal Article in CYTOKINE

2005

A model for hyperacute hypotension and shock: Nitric oxide or no nitric oxide ?

Anje CauwelsB JANSSENPeter Brouckaert

Blood pressure in mice with a targeted deletion of the soluble guanylyl cyclase alpha 1 subunit

Peter BrouckaertE BUYSPatrick SipsElke RoggeM DEWERCHINAnje Cauwels

Dual role of endogenous nitric oxide in tumor necrosis factor shock: induced NO tempers oxidative stress

Anje CauwelsJennyfer BultinckPeter Brouckaert

A1 Journal Article in CMLS-CELLULAR AND MOLECULAR LIFE SCIENCES

2004

Janus faces of caspases and nitric oxide in TNF-induced lethal shock in mice

Anje CauwelsPeter Brouckaert

2003

Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2

Anje CauwelsBen JanssenAnouk WaeytensClaude CuvelierPeter Brouckaert

A1 Journal Article in INFLAMMATION RESEARCH

Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2

Anje CauwelsBen JanssenAnouk WaeytensClaude CuvelierPeter Brouckaert

A1 Journal Article in NATURE IMMUNOLOGY

2000

Protection against TNF-induced lethal shock by soluble guanylate cyclase inhibition requires functional inducible nitric oxide synthase.

Anje CauwelsWim Van MolleB JANSSENBart EveraerdtP HUANGWalther FiersPeter Brouckaert

A1 Journal Article in IMMUNITY

1999

Identification of a Streptococcus pneumoniae gene locus encoding proteins of an ABC phosphate transporter and a two-component regulatory system

R NovakAnje CauwelsE CharpentierE Tuomanen

A1 Journal Article in JOURNAL OF BACTERIOLOGY

The origin and function of soluble CD14 in experimental bacterial meningitis

Anje CauwelsK FreiS SansanoC FearnsR UlevitchW ZimmerliR Landmann

A1 Journal Article in JOURNAL OF IMMUNOLOGY

1997

Coexistence of CD14-dependent and independent pathways for stimulation of human monocytes by gram-positive bacteria

Anje CauwelsE WanM LeismannE Tuomanen

A1 Journal Article in INFECTION AND IMMUNITY

1996

Inhibition of and sensitization to the lethal effects of tumor necrosis factor

Peter BrouckaertClaude LibertAnje CauwelsBart EveraerdtWim Van MollePaul AmelootYannick GansemansBernardo GrijalbaNozomi TakahashiMarie-José Truong et al.

A1 Journal Article in JOURNAL OF INFLAMMATION

Murine IL-12 is involved in Calmette-Guerin Bacillus-induced sensitization and is by itself sufficient to sensitize mice to the lethal effects of human TNF.

Anje CauwelsWalther FiersPeter Brouckaert

A1 Journal Article in JOURNAL OF IMMUNOLOGY

1995

Involvement of IFN-γ in Bacillus Calmette-Guérin-induced but not in tumor-induced sensitization to TNF-induced lethality

Anje CauwelsPeter BrouckaertJohan GrootenSui HuangMichel AguetWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Optimalization and application in TNF-related models of a method to estimate NO production in vivo.

Wim Van MolleBart EveraerdtAnje CauwelsPeter BrouckaertWalther Fiers

Sensitisatie voor hTNF-geïnduceerde letaliteit in de muis : moleculaire dissectie van het mechanisme

Anje CauwelsWalther Fiers

1994

Receptor-selective mutants of tumour necrosis factor in the therapy of cancer : preclinical studies

Peter BrouckaertPaul AmelootAnje CauwelsBart EveraerdtClaude LibertNozomi TakahashiWim Van MolleWalther Fiers

A1 Journal Article in CIRCULATORY SHOCK

Response of interleukin-6-deficient mice to tumor necrosis factor-induced metabolic changes and lethality.

Claude LibertNozomi TakahashiAnje CauwelsPeter BrouckaertH BLUETHMANNWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

1993

Protection against tumor necrosis factor-induced lethality

Claude LibertBart EveraerdtNozomi TakahashiAnje CauwelsPeter BrouckaertWalther Fiers

Strategies to broaden the therapeutic margin of tumor necrosis factor

Peter BrouckaertBart EveraerdtClaude LibertNozomi TakahashiAnje CauwelsWalther Fiers

TUMOR-NECROSIS-FACTOR, ITS RECEPTORS AND THE CONNECTION WITH INTERLEUKIN-1 AND INTERLEUKIN-6.

Peter BrouckaertClaude LibertB EVERAERDTNozomi TakahashiAnje CauwelsWalther Fiers

A1 Journal Article in IMMUNOBIOLOGY

Two pathways of tumor necrosis factor signal transduction: in vitro and in vivo implications

Walther FiersRudi BeyaertPeter BrouckaertAnje CauwelsWim DeclercqDirk De ValckB EveraerdtVera GoossensJohan GrootenGuy Haegeman et al.