Research Explorer

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Researcher

Andy Willaert

Publications & Research Data

Awards & Distinctions

162 Results

2026

Decoding phenotypic variability in osteogenesis imperfecta : zebrafish as a model for molecular and (ultra)structural insights

Paul CouckAndy WillaertAdelbert De Clercq

Toxicological assessment of cyclopiazonic acid and aflatoxin B1 : EFFECTS on zebrafish development and cardiac physiology

Victor Omondi KagotMarthe De BoevreHanna De SaffelPatrick SipsLimbikani MatumbaSheila OkothSarah De SaegerAndy Willaert

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

2025

Evaluating variants of uncertain significance in adult knock-in zebrafish : a proof of concept with a COL1A2 variant

Michiel VanhooydonckSophie DebaenstEva VanbelleghemHanna De SaffelDelfien SyxPatrick SipsPaul CouckeAndy WillaertBert Callewaert

Evaluating variants of uncertain significance in adult zebrafish via prime editing : a proof of concept with a COL1A2 variant

Michiel VanhooydonckSophie DebaenstEva VanbelleghemHanna De SaffelDelfien SyxPatrick SipsPaul CouckeAndy WillaertBert Callewaert

A1 Journal Article in BMC MEDICAL GENOMICS

Investigating aortic pathology and optimizing precision gene editing in Zebrafish : roles of SMAD3, SMAD6, and GLUT10

Michiel VanhooydonckBert CallewaertPatrick SipsAndy Willaert

Loss of the ubiquitin-associated domain of sqstm1/p62 in zebrafish causes a phenotype resembling Paget’s disease of bone

Yentl HuybrechtsRaphaël De RidderDylan BergenBjörn De SamberEveline BoudinFrancesca TonelliDries KnapenLucia VergauwenDorien SchepersEvelien Van Dijck et al.

A1 Journal Article in CALCIFIED TISSUE INTERNATIONAL

Prime editing outperforms homology-directed repair as a tool for CRISPR-mediated variant knock-in in zebrafish

Michiel VanhooydonckElyne De NeefHanna De SaffelAnnekatrien BoelAndy WillaertBert CallewaertKathleen Claes

Prime editing outperforms homology-directed repair as a tool for CRISPR-mediated variant knock-in in zebrafish

Michiel VanhooydonckElyne De NeefHanna De SaffelAnnekatrien BoelAndy WillaertBert CallewaertKathleen Claes

A1 Journal Article in LAB ANIMAL

Safety evaluation of microbisporicin (NAI-107) using zebrafish (Danio rerio) embryo : a pilot study

Zina GestelsSaïd AbdellatiAndy WillaertChris KenyonSheeba Santhini Manoharan-Basil

A1 Journal Article in FEMS MICROBIOLOGY LETTERS

Variant of uncertain significance testing in zebrafish : a proof of concept using a COL1A2 variant as example

Michiel VanhooydonckSophie DebaenstEva VanbelleghemHanna De SaffelDelfien SyxAndy WillaertPatrick SipsPaul CouckeBert Callewaert

Zebrafish in bone research : a deep dive into fragile bone disorders

Sophie DebaenstPaul CouckeAndy Willaert

2024

Advances in CRISPR-mediated knock-in of disease- and cancer-related variants in zebrafish

Elyne De NeefMichiel VanhooydonckHanna De SaffelBéatrice LintermansAndy WillaertBert CallewaertAnne VralKathleen Claes

Advances in CRISPR-mediated knock-in of disease-related variants in zebrafish

Elyne De NeefMichiel VanhooydonckHanna De SaffelBéatrice LintermansAndy WillaertBert CallewaertAnne VralKathleen Claes

Bmpr1aa modulates the severity of the skeletal phenotype in an fkbp10-deficient Bruck syndrome zebrafish model

Tamara JaraysehSophie DebaenstHanna De SaffelToon RosseelMauro Alessio MilazzoJan Willem BekDavid M HudsonFilip Van NieuwerburghYannick GansemansIván Josipovic et al.

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility

Sophie DebaenstTamara JaraysehHanna De SaffelJan Willem BekMatthieu BooneIván JosipovicPierre KibleurRonald Y KwonPaul CouckeAndy Willaert

A2 Journal Article in ELIFE

Early mechanisms of aortic failure in a zebrafish model for thoracic aortic dissection and rupture

Michiel VanhooydonckMaxim VerleeMarta Guerreiro Santana Ramos Da SilvaLore PottieAnnekatrien BoelMatthias Van ImpeHanna De SaffelLisa CaboorPiyanoot TapaneeyaphanAnne Bonnin et al.

Early mechanisms of aortic failure in a zebrafish model for thoracic aortic dissection and rupture

Michiel VanhooydonckMaxim VerleeMarta Guerreiro Santana Ramos Da SilvaLore PottieAnnekatrien BoelMatthias Van ImpeHanna De SaffelLisa CaboorPiyanoot TapaneeyaphanAnne Bonnin et al.

Knock-in of disease-related variants in the zebrafish model organism

Michiel VanhooydonckElyne De NeefHanna De SaffelAnnekatrien BoelKathleen ClaesAndy WillaertBert Callewaert

Multi-omics analysis in human retina uncovers ultraconserved cis-regulatory elements at rare eye disease loci

Victor Lopez SorianoAlfredo Dueñas ReyRajarshi MukherjeeFrauke CoppietersMiriam BauwensAndy WillaertElfride De Baere

A1 Journal Article in NATURE COMMUNICATIONS

Prime editing outperforms optimized homology-directed repair as a tool for knock-in generation in zebrafish

Elyne De NeefMichiel VanhooydonckKathleen ClaesBert CallewaertHanna De SaffelBéatrice LintermansAndy WillaertAnne Vral

Prime editing outperforms optimized homology-directed repair as a tool for knock-in generation in zebrafish

Elyne De NeefMichiel VanhooydonckHanna De SaffelAnne VralAndy WillaertBert CallewaertKathleen Claes

Regulation of non-canonical expression of ABCA4 by an RPE-specific enhancer with implications in ABCA4-associated disease

Victor Lopez SorianoAlfredo Dueñas ReyGiulia AscariMünevver Burcu CicekdalEva D'haeneQuinten MahieuHanna De SaffelAndy WillaertKris VleminckxJuan Jesus Tena-Aguilar et al.

Unraveling phenotypic variability and disease manifestations in brittle bone disorders

Tamara JaraysehPaul CouckeAndy Willaert

2023

A tapt1 knock-out zebrafish line with aberrant lens development and impaired vision models human early-onset cataract

Tamara JaraysehBrecht GuillemynHanna De SaffelJan Willem BekDelfien SyxSofie SymoensYannick GansemansFilip Van NieuwerburghSujatha JagadeeshJayarekha Raja et al.

A1 Journal Article in HUMAN GENETICS

Atm deficient zebrafish model reveals conservation of the tumour suppressor function and a role in fertility

Jeroen VierstraeteCharlotte FieuwsDavid CreytensJo Van DorpeAndy WillaertAnne VralKathleen Claes

Editorial material

Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for Osteogenesis Imperfecta

Sophie DebaenstHanna De SaffelJan Willem BekAdelbert De ClercqTamara JaraysehLauren SahdPaul CouckeAndy Willaert

Identification of modifier genes underlying intra-familial phenotypic variability in zebrafish OI models using whole exome sequencing and linkage analysis

Tamara JaraysehAdelbert De ClercqToon RosseelMauro Alessio MilazzoAndy WillaertPaul Coucke

Syntaxin 18 defects in human and zebrafish unravel key roles in early cartilage and bone development

Brecht GuillemynHanna De SaffelJan Willem BekPiyanoot TapaneeyaphanAdelbert De ClercqTamara JaraysehSophie DebaenstAndy WillaertRiet De RyckePeter H. Byers et al.

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

Syntaxin-18 defects in human and zebrafish cause traffic jams and unravel key roles in early bone development

Brecht GuillemynHanna De SaffelJan Willem BekPiyanoot TapaneeyaphanAdelbert De ClercqTamara JaraysehSophie DebaenstAndy WillaertPeter ByersPaul Coucke et al.

The Abcc6a knockout zebrafish model as a novel tool for drug screening for pseudoxanthoma elasticum

Matthias Van GilsAndy WillaertPaul CouckeOlivier Vanakker

The establishment of the first reported zebrafish model for thoracic aortic dissection and rupture

Michiel VanhooydonckMaxim VerleeLore PottieAnnekatrien BoelPiyanoot TapaneeyaphanMarta Guerreiro Santana Ramos Da SilvaAdelbert De ClercqLisa CaboorMatthias Van ImpeDelfien Syx et al.

The establishment of the first reported zebrafish model for thoracic aortic dissection and rupture

Michiel VanhooydonckLore PottieAnnekatrien BoelPiyanoot TapaneeyaphanMarta Guerreiro Santana Ramos Da SilvaAdelbert De ClercqMatthias Van ImpeDelfien SyxAndy WillaertLisa Caboor et al.

The establishment of the first reported zebrafish model for thoracic aortic dissection and rupture

Michiel VanhooydonckMaxim VerleeLore PottieAnnekatrien BoelPiyanoot TapaneeyaphanMarta Guerreiro Santana Ramos Da SilvaAdelbert De ClercqLisa CaboorMatthias Van ImpeDelfien Syx et al.

The pseudoxanthoma elasticum zebrafish model contributes to novel pathophysiological insights and therapeutic strategies in ectopic mineralization

Lisa DangreauLukas NolletMatthias Van GilsAndy WillaertPaul CouckeOlivier Vanakker

Unraveling of the ultrastructural features that determine the variability in phenotypic severity in different dominant forms of OI, using the zebrafish as a model

Lauren SahdCaitlin DebaeneSophie DebaenstTamara JaraysehHanna De SaffelMyriam ClaeysJan Willem BekCharlotte GistelinckFrans RodenburgPhil Salmon et al.

Zebrafish Tric-b is required for skeletal development and bone cells differentiation

Francesca TonelliLaura LeoniValentina DaponteRoberta GioiaSilvia CottiImke A. K. FiedlerDaria LarionovaAndy WillaertPaul CouckeSimona Villani et al.

A1 Journal Article in FRONTIERS IN ENDOCRINOLOGY

2022

A tapt1 knockout zebrafish line with aberrant lens development and impaired vision models human pediatric cataract

Tamara JaraysehBrecht GuillemynHanna De SaffelJan Willem BekSujatha JagadeeshSofie SymoensFransiska MalfaitDelfien SyxFilip Van NieuwerburghYannick Gansemans et al.

A tapt1 knockout zebrafish line with aberrant lens development and impaired vision models human pediatric cataract

Tamara JaraysehBrecht GuillemynHanna De SaffelJan Willem BekSujatha JagadeeshSofie SymoensFransiska MalfaitDelfien SyxFilip Van NieuwerburghYannick Gansemans et al.

Attenuation of dysfunctional DNA damage response and PARP1 signaling by minocycline reduces ectopic calcification in pseudoxanthoma elasticum

Lukas NolletMatthias Van GilsAndy WillaertPaul CouckeOlivier Vanakker

Crispant screening in zebrafish as a promising approach for rapid functional screening of osteoporosis candidate genes and known genes for Osteogenesis Imperfecta

Sophie DebaenstHanna De SaffelJan Willem BekAdelbert De ClercqTamara JaraysehLauren SahdPaul CouckeAndy Willaert

Minocycline attenuates excessive DNA damage response and reduces ectopic calcification in pseudoxanthoma elasticum

Lukas NolletMatthias Van GilsAndy WillaertPaul CouckeOlivier Vanakker

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

Martin GuilliamsJohnny BonnardelBirthe HaestBart VanderborghtCamille WagnerAnneleen RemmerieAnna BujkoLiesbet MartensTinne ThonéRobin Browaeys et al.

A1 Journal Article in CELL

The Abcc6a knockout zebrafish model as a novel tool for drug screening for pseudoxanthoma elasticum

Matthias Van GilsAndy WillaertPaul CouckeOlivier Vanakker

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

The establishment of the first reported zebrafish model for thoracic aortic dissection and rupture

Michiel VanhooydonckLore PottieAnnekatrien BoelPiyanoot TapaneeyaphanMarta Guerreiro Santana Ramos Da SilvaLisa CaboorAdelbert De ClercqMatthias Van ImpeAndy WillaertPatrick Sips et al.

The establishment of the first reported zebrafish model for thoracic aortic dissection and rupture

Michiel VanhooydonckLore PottieAnnekatrien BoelPiyanoot TapaneeyaphanMarta Guerreiro Santana Ramos Da SilvaAdelbert De ClercqLisa CaboorMatthias Van ImpeAndy WillaertPatrick Sips et al.

The pseudoxanthoma elasticum zebrafish model contributes to novel pathophysiological insights and therapeutic strategies in ectopic mineralization

Lisa DangreauLukas NolletMatthias Van GilsAndy WillaertPaul CouckeOlivier Vanakker

2021

Arterial tortuosity syndrome : an ascorbate compartmentalization disorder?

Annekatrien BoelKrisztina VeszelyiCsilla E. NemethAude BeyensAndy WillaertPaul CouckeBert CallewaertEva Margittai

A1 Journal Article in ANTIOXIDANTS & REDOX SIGNALING

Identification of modifier genes underlying intra-familial phenotypic variability in zebrafish OI models using whole exome sequencing (WES) and linkage analysis

Tamara JaraysehAdelbert De ClercqToon RosseelMauro Alessio MilazzoAndy WillaertPaul Coucke

Identification of skeletal deformities towards deep phenotyping of zebrafish (Danio rerio) connective tissue disease models

Caitlin DebaeneAdelbert De ClercqAndy WillaertPaul Coucke

Lrp5 mutant and crispant zebrafish faithfully model human osteoporosis, establishing the zebrafish as a platform for CRISPR‐based functional screening of osteoporosis candidate genes

Jan Willem BekChen ShochatAdelbert De ClercqHanna De SaffelAnnekatrien BoelJuriaan MetzFrans RodenburgDavid KarasikAndy WillaertPaul Coucke

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

Photoconvertible fluorescent proteins : a versatile tool in zebrafish skeletal imaging

Jan Willem BekAdelbert De ClercqHanna De SaffelMieke SoenensAnn HuysseunePaul Eckhard WittenPaul CouckeAndy Willaert

A1 Journal Article in JOURNAL OF FISH BIOLOGY

The ZE-Tunnel : an affordable, easy-to-assemble, and user-friendly benchtop zebrafish swim tunnel

Jan Willem BekAdelbert De ClercqPaul CouckeAndy Willaert

A1 Journal Article in ZEBRAFISH

The zebrafish in biomedical research : a vertebrate model to study skeletal disorders

Jan Willem BekPaul CouckeAndy Willaert

Welfare and humane endpoints in fish research

Annelies DeclercqMaxime MahuAndy Willaert

Zebrafish as an in vivo screening tool to establish PARP inhibitor efficacy

Jeroen VierstraeteCharlotte FieuwsAndy WillaertAnne VralKathleen Claes

A1 Journal Article in DNA REPAIR

2020

Atm deficient zebrafish model reveals conservation of the tumour suppressor function

Jeroen VierstraeteCharlotte FieuwsDavid CreytensJo Van DorpeAndy WillaertAnne VralKathleen Claes

b3galt6 knock-out zebrafish recapitulate β3GalT6-deficiency disorders in human and reveal a trisaccharide proteoglycan linkage region

Sarah DelbaereAdelbert De ClercqShuji MizumotoFredrik NobornJan Willem BekLien AlluynCharlotte GistelinckDelfien SyxPhil L. SalmonPaul Coucke et al.

b3galt6 Knock-out zebrafish recapitulate β3GalT6-deficiency disorders in human and reveal a trisaccharide proteoglycan linkage region

Sarah DelbaereAdelbert De ClercqShuji MizumotoFredrik NobornJan Willem BekLien AlluynCharlotte GistelinckDelfien SyxPhil L. SalmonPaul Coucke et al.

A1 Journal Article in FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

CRISPR/Cas9 mediated modeling of TP53 and PTEN related malignancies in Xenopus tropicalis

Dionysia DimitrakopoulouKris VleminckxAndy Willaert

Fishing for pathogenic mechanisms underlying rare Ehlers-Danlos syndrome subtypes

Sarah DelbaereFransiska MalfaitAndy Willaert

Hypomorphic zebrafish models mimic the musculoskeletal phenotype of β4GalT7-deficient Ehlers-Danlos syndrome

Sarah DelbaereTim Van DammeDelfien SyxSofie SymoensPaul CouckeAndy WillaertFransiska Malfait

A1 Journal Article in MATRIX BIOLOGY

Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos

Thomas NaertDieter TulkensNicole A. EdwardsMarjolein CarronNikko-Ideen ShaidaniMarcin WlizlaAnnekatrien BoelSuzan DemuynckMarko E. HorbPaul Coucke et al.

A1 Journal Article in SCIENTIFIC REPORTS

Phenomics-based quantification of CRISPR-induced mosaicism in zebrafish

Claire J. WatsonAdrian T. Monstad-RiosRehaan M. BhimaniCharlotte GistelinckAndy WillaertPaul CouckeYi-Hsiang HsuRonald Y. Kwon

A1 Journal Article in CELL SYSTEMS

Slc2a10 knock-out mice deficient in ascorbic acid synthesis recapitulate aspects of arterial tortuosity syndrome and display mitochondrial respiration defects

Annekatrien BoelJoyce BurgerMarine VanhomwegenAude BeyensMarjolijn RenardSander BarnhoornChristophe CasteleynDieter ReinhardtBenedicte DescampsChristian Vanhove et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

Zebrafish : a resourceful vertebrate model to investigate skeletal disorders

Francesca TonelliJan Willem BekRoberta BesioAdelbert De ClercqLaura LeoniPhil SalmonPaul CouckeAndy WillaertAntonella Forlino

A1 Journal Article in FRONTIERS IN ENDOCRINOLOGY

2019

Animal disease modeling of the arterial tortuosity syndrome : advancing the CRISPR/Cas9 system for improved genome editing

Annekatrien BoelPaul CouckeAndy Willaert

Arterial tortuosity syndrome : 40 new families and literature review (vol 20, pg 1236, 2017)

Aude BeyensJuliette AlbuissonAnnekatrien BoelMazen Al-EssaWaheed Al-ManeaDamien BonnetOzlem BostanOdile BouteTiffany BusaNathalie Canham et al.

Beyond the whole-mount phenotype : high-resolution imaging in fluorescence-based applications on zebrafish

Veronika OralovaJoana Teixeira RosaMieke SoenensJan Willem BekAndy WillaertPaul Eckhard WittenAnn Huysseune

A1 Journal Article in BIOLOGY OPEN

Compound screening for PXE using a zebrafish abcc6a CRISPR/Cas9 mutant model : a proof-of-concept study

Matthias Van GilsAndy WillaertPaul CouckeOlivier Vanakker

Compound screening for PXE using zebrafish abcc6a mutant models

Matthias Van GilsAndy WillaertPaul CouckeOlivier Vanakker

Compound screening for PXE using zebrafish abcc6a mutant models

Matthias Van GilsAndy WillaertPaul CouckeOlivier Vanakker

Decreased nuclear ascorbate accumulation accompanied with altered genomic methylation pattern in fibroblasts from arterial tortuosity syndrome patients

Csilla NémethZsófia NemodaPéter LőwPál SzabóErzsébet HorváthAndy WillaertAnnekatrien BoelBert CallewaertPaul CouckeMarina Colombi et al.

A1 Journal Article in OXIDATIVE MEDICINE AND CELLULAR LONGEVITY

Faithfully recapitulating PARP inhibitor efficacy in zebrafish

Jeroen VierstraeteCharlotte FieuwsAndy WillaertAnne VralKathleen Claes

Generation and validation of the first complete knockout model of abcc6a in zebrafish

Matthias Van GilsAndy WillaertEva De VilderPaul CouckeOlivier Vanakker

In-depth characterization of the ultrastructural variability of the vertebral column in a severe, medium and mildly affected Osteogenesis Imperfecta zebrafish model

Adelbert De ClercqHanna De SaffelJan Willem BekMyriam ClaeysPetra VermassenPaul CouckeAndy Willaert

Loss of galactosyltransferase II, encoded by B3GALT6, causes skeletal abnormalities in a zebrafish model for spondylodysplastic Ehlers-Danlos syndrome, the B3GALT6 type

Sarah DelbaereAndy WillaertPhil L SalmonPaul CouckeFransiska Malfait

Purification of high-quality RNA from a small number of fluorescence activated cell sorted zebrafish cells for RNA sequencing purposes

Siebe LoontiensLisa DepestelSuzanne VanhauwaertGivani DewynCharlotte GistelinckKaren VerboomWouter Van LoockeFilip MatthijssensAndy WillaertJo Vandesompele et al.

A1 Journal Article in BMC GENOMICS

Targeted compound screening for PXE using CRISPR/Cas9 abcc6a mutant zebrafish model

Matthias Van GilsAndy WillaertPaul CouckeOlivier Vanakker

The zebrafish as a model for fragile bone disorders

Jan Willem BekHanna De SaffelOsama EssawiAdelbert De ClercqPaul Eckhard WittenAnn HuysseuneJuriaan MetzPhil SalmonPaul CouckeAndy Willaert

The zebrafish as a model for recessive types of osteogenesis imperfecta

Jan Willem BekHanna De SaffelOsama EssawiAdelbert De ClercqPaul Eckhard WittenAnn HuysseunePhil SalmonPaul CouckeAndy Willaert

The zebrafish as a model for recessive types of Osteogenesis Imperfecta.

Jan Willem BekHanna De SaffelOsama EssawiAdelbert De ClercqPaul Eckhard WittenAnn HuysseunePhil SalmonPaul CouckeAndy Willaert

2018

Arterial tortuosity syndrome : 40 new families and literature review

Aude BeyensJuliette AlbuissonAnnekatrien BoelMazen Al-EssaWaheed Al-ManeaDamien BonnetOzlem BostanOdile BouteTiffany BusaNathalie Canham et al.

A1 Journal Article in GENETICS IN MEDICINE

BATCH-GE : analysis of NGS data for genome editing assessment

Wouter SteyaertAnnekatrien BoelPaul CouckeAndy Willaert

Bookchapter in Xenopus : methods and protocols

BATCH-GE : batch analysis of next-generation sequencing data for genome editing assessment (vol 6, 30330, 2016)

Annekatrien BoelWouter SteyaertNina De RockerBjörn MentenBert CallewaertAnne De PaepePaul CouckeAndy Willaert

CRISPR/Cas9-mediated homology-directed repair by ssODNs in zebrafish induces complex mutational patterns resulting from genomic integration of repair-template fragments

Annekatrien BoelHanna De SaffelWouter SteyaertBert CallewaertAnne De PaepePaul CouckeAndy Willaert

A1 Journal Article in DISEASE MODELS & MECHANISMS

Expressed repetitive elements are broadly applicable reference targets for normalization of reverse transcription-qPCR data in mice

Marjolijn RenardSuzanne VanhauwaertMarine VanhomwegenAli RihaniNiels VandammeSteven GoossensGeert BerxPieter Van VlierbergheJody J HaighBieke Decaesteker et al.

A1 Journal Article in SCIENTIFIC REPORTS

Fishing for the missing link : successful translation of a human disorder in zebrafish

Sarah DelbaereTim Van DammeDelfien SyxSofie SymoensAndy WillaertFransiska Malfait

Generation and validation of a complete knockout model of abcc6a in zebrafish

Matthias Van GilsAndy WillaertEva De VilderPaul CouckeOlivier Vanakker

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Generation and validation of a complete knockout model of abcc6a in zebrafish

Matthias Van GilsAndy WillaertEva De VilderPaul CouckeOlivier Vanakker

Generation and validation of the first complete knockout model of abcc6a in zebrafish

Matthias Van GilsAndy WillaertEva De VilderPaul CouckeOlivier Vanakker

Generation and validation of the first complete knockout model of abcc6a in zebrafish

Matthias Van GilsAndy WillaertEva De VilderPaul CouckeOlivier Vanakker

Generation and validation of the first complete knockout model of abcc6a in zebrafish

Matthias Van GilsAndy WillaertEva De VilderPaul CouckeOlivier Vanakker

Generation and validation of the first complete knockout model of ABCC6A in zebrafish

Matthias Van GilsAndy WillaertPaul CouckeOlivier Vanakker

Genetic analysis of osteogenesis imperfecta in the Palestinian population : molecular screening of 49 affected families

Osama EssawiSofie SymoensMaha FannanaMohammad DarwishMohammad FarrajAndy WillaertTamer EssawiBert CallewaertAnne De PaepeFransiska Malfait et al.

A1 Journal Article in MOLECULAR GENETICS & GENOMIC MEDICINE

Isolation of high-quality RNA from fluorescent activated cell sorted (FACS) zebrafish cells for RNA sequencing purposes

Siebe LoontiensSuzanne VanhauwaertLisa DepestelGivani DewynCharlotte GistelinckKaren VerboomEls JanssensFilip MatthijssensAndy WillaertJo Vandesompele et al.

Knockdown and knockout zebrafish models for the β4GalT7-deficient type of Ehlers-Danlos syndrome reveal distinctive and overlapping phenotypic features

Sarah DelbaereTim Van DammeDelfien SyxSofie SymoensAndy WillaertFransiska Malfait

Knockdown and knockout zebrafish models for the β4GalT7-deficient type of Ehlers-Danlos syndrome reveal distinctive and overlapping phenotypic features

Sarah DelbaereTim Van DammeDelfien SyxSofie SymoensAndy WillaertFransiska Malfait

Loss of galactosyltransferase II, encoded by B3GALT6, causes skeletal abnormalities in a zebrafish model for spondylodysplastic Ehlers-Danlos syndrome, the B3GALT6 type

Sarah DelbaereAndy WillaertPhil L SalmonPaul CouckeFransiska Malfait

Loss of galactosyltransferase II, encoded by B3GALT6, causes skeletal abnormalities in a zebrafish model for spondylodysplastic Ehlers-Danlos syndrome, the B3GALT6 type

Sarah DelbaereAndy WillaertPhil L SalmonPaul CouckeFransiska Malfait

Screening for osteogenic compounds using the zebrafish as a model

Jan Willem BekCharlotte GistelinckHanna De SaffelPaul CouckeAndy Willaert

Uncovering the role of atm in zebrafish

Jeroen VierstraeteAnne VralPaul CouckeAndy WillaertKathleen Claes

Uncovering the role of zebrafish in atm

Jeroen VierstraeteAndy WillaertPaul CouckeAnne VralKathleen Claes

Uncovering the role of zebrafish in atm

Jeroen VierstraeteAndy WillaertPaul CouckeAnne VralKathleen Claes

Zebrafish modeling for spondylodysplastic Ehlers-Danlos syndrome, the B4GALT7 type : mimicking the human hypomorphic phenotype in a validated knock-down model

Sarah DelbaereTim Van DammeDelfien SyxPaul CouckeAnne De PaepeSofie SymoensAndy WillaertFransiska Malfait

Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies

Charlotte GistelinckRonald Y KwonFransiska MalfaitSofie SymoensMatthew P HarrisKatrin HenkeMichael B HawkinsShannon FisherPatrick SipsBrecht Guillemyn et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2017

Accurate quantification of homologous recombination : a zebrafish brca2-/- model

Jeroen VierstraeteAndy WillaertPetra VermassenLeen PietersPaul CouckeAnne VralKathleen Claes

Accurate quantification of homologous recombination : a zebrafish BRCA2-/- model

Jeroen VierstraeteAndy WillaertPetra VermassenLeen PietersPaul CouckeAnne VralKathleen Claes

Accurate quantification of homologous recombination in zebrafish : brca2 deficiency as a paradigm

Jeroen VierstraeteAndy WillaertPetra VermassenPaul CouckeAnne VralKathleen Claes

A1 Journal Article in SCIENTIFIC REPORTS

Accurate Quantification of Homologous Recombination in Zebrafish: brca2 deficiency as a paradigm

Jeroen VierstraeteAndy WillaertPetra VermassenLeen PietersAnne VralKathleen Claes

Arterial tortuosity syndrome : 37 new families and literature review

Aude BeyensJuliette AlbuissonT BusaN CanhamJM ChopinM DasoukiK DevriendtH DietzBjörn Fischer-ZirnsakAlper Gezdirici et al.

Arterial tortuosity syndrome : 40 new families and literature review

Aude BeyensJuliette AlbuissonAnnekatrien BoelMazen Al-EssaDamien BonnetO BostanOdile BouteT BusaN CanhamErgun Cil et al.

Generation and validation of zebrafish models for heritable skeletal disorders

Charlotte GistelinckPaul CouckeAndy Willaert

GLUT10 - lacking in arterial tortuosity syndrome - is localized to the endoplasmic reticulum of human fibroblasts

Alessandra GamberucciPaola MarcolongoCsilla E NémethNicoletta ZoppiAndrás SzarkaNicola ChiarelliTamás HegedűsMarco RitelliGiulia CariniAndy Willaert et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroCT-based phenomics in the zebrafish skeleton reveals virtues of deep phenotyping in a distributed organ system

M HurCharlotte GistelinckP HuberJ LeeMH ThompsonAT Monstad-RiosCJ WatsonSK McMenaminAndy WillaertDM Parichy et al.

A1 Journal Article in ELIFE

Study of homologous recombination repair in BRCA2 knockout zebrafish embryos

Jeroen VierstraeteAndy WillaertPaul CouckeAnne VralKathleen Claes

Study of homologous recombination repair in BRCA2 knockout zebrafish embryos

Jeroen VierstraeteAndy WillaertPaul CouckeAnne VralKathleen Claes

Zebrafish modeling of the β4GalT7-deficient type of Ehlers-Danlos syndrome

Sarah DelbaereTim Van DammePaul CouckeSofie SymoensDelfien SyxAndy WillaertFransiska Malfait

Zebrafish modeling of the β4GalT7-deficient type of Ehlers-Danlos syndrome

Sarah DelbaereTim Van DammePaul CouckeSofie SymoensDelfien SyxAndy WillaertFransiska Malfait

Zebrafish modeling of the β4GalT7-deficient type of Ehlers-Danlos syndrome

Sarah DelbaereTim Van DammePaul CouckeSofie SymoensDelfien SyxAndy WillaertFransiska Malfait

Zebrafish modeling of the β4GalT7-deficient type of Ehlers-Danlos syndrome

Sarah DelbaereTim Van DammePaul CouckeSofie SymoensAndy WillaertFransiska Malfait

Zebrafish modeling of the β4GalT7-deficient type of Ehlers-Danlos syndrome

Sarah DelbaereTim Van DammePaul CouckeSofie SymoensDelfien SyxAndy WillaertFransiska Malfait

2016

Arterial tortuosity syndrome : 29 novel families

Aude BeyensJuliette AlbuissonT BusaN CanhamJM CM. DasoukiK DevriendtH DietzBjörn Fischer-ZirnsakAlper Gezdirici et al.

BATCH-GE : batch analysis of next-generation sequencing data for genome editing assessment

Annekatrien BoelWouter SteyaertNina De RockerBjörn MentenBert CallewaertAnne De PaepePaul CouckeAndy Willaert

A1 Journal Article in SCIENTIFIC REPORTS

CRISPR-Cas9 modeling of cell lines and zebrafish to study the TLX1-PHF6 cooperative interrelationship in T-cell acute lymphoblastic leukemia

Siebe LoontiensKaat DurinckNina De RockerAnnekatrien BoelEls JanssensSuzanne VanhauwaertPieter RondouCharles De BockInge Van de WalleFinola Moore et al.

CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis

Thomas NaertRobin ColpaertTom Van NieuwenhuysenDionysia DimitrakopoulouJ LJurgen HaustraeteAnnekatrien BoelWouter SteyaertTrees LepezDieter Deforce et al.

A1 Journal Article in SCIENTIFIC REPORTS

Glucose transporter type 10 - lacking in arterial tortuosity syndrome - facilitates dehydroascorbic acid transport

Csilla E NémethPaola MarcolongoAlessandra GamberucciRosella FulceriAngiolo BenedettiNicoletta ZoppiMarco RitelliNicola ChiarelliMarina ColombiAndy Willaert et al.

A1 Journal Article in FEBS LETTERS

Loss of type I collagen telopeptide lysyl hydroxylation causes musculoskeletal abnormalities in a zebrafish model of Bruck syndrome

Charlotte GistelinckPaul Eckhard WittenAnn HuysseuneSofie SymoensFransiska MalfaitDaria LarionovaPascal SimoensManuel DierickLuc Van HoorebekeAnne De Paepe et al.

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

RT-qPCR gene expression analysis in zebrafish : preanalytical precautions and use of expressed repetitive elements for normalization

Suzanne VanhauwaertSteve LefeverPaul CouckeFranki SpelemanAnne De PaepeJo VandesompeleAndy Willaert

A1 Journal Article in Methods in Cell Biology

Studying the functionality of the homologous repair pathway in zebrafish embryos : heading for an in vivo functional test to evaluate the pathogenicity of BRCA2 variants

Jeroen VierstraeteAndy WillaertKris VleminckxPetra VermassenLeen PietersPaul CouckeAnne VralKathleen Claes

Studying the functionality of the homologous repair pathway in zebrafish embryos : heading for an in vivo functional test to evaluate the pathogenicity of BRCA2 variants identified in breast/ovarian cancer patients

Jeroen VierstraeteAndy WillaertPetra VermassenLeen PietersPaul CouckeAnne VralKathleen Claes

Studying the functionality of the homologous repair pathway in zebrafish embryos : heading for an in vivo functional test to evaluate the pathogenicity of BRCA2 variants identified in breast/ovarian cancer patients

Jeroen VierstraeteAndy WillaertPetra VermassenLeen PietersPaul CouckeAnne VralKathleen Claes

Studying the functionality of the homologous repair pathway in zebrafish embryos : heading for an in vivo functional test to evaluate the pathogenicity of BRCA2 variants identified in breast/ovarian cancer patients

Jeroen VierstraeteAndy WillaertPetra VermassenLeen PietersPaul CouckeAnne VralKathleen Claes

Zebrafish collagen type I: molecular and biochemical characterization of the major structural protein in bone and skin

Charlotte GistelinckR GioiaA GagliardiF TonelliL MarcheseL BianchiC LandiL BiniAnn HuysseunePaul Eckhard Witten et al.

A1 Journal Article in SCIENTIFIC REPORTS

Zebrafish modeling of the β4GalT7-deficient type of Ehlers-Danlos syndrome

Sarah DelbaereTim Van DammeAndy WillaertSofie SymoensPaul CouckeFransiska Malfait

Zebrafish modeling of the β4GalT7-deficient type of Ehlers-Danlos syndrome

Sarah DelbaereTim Van DammeAndy WillaertSofie SymoensFransiska Malfait

2015

A zebrafish model for Bruck syndrome caused by PLOD2 mutations

Charlotte GistelinckAndy WillaertPascal SimoensSofie SymoensPaul Eckhard WittenAnn HuysseuneChristian VanhoveFransiska MalfaitAnne De PaepePaul Coucke

Characterization of a col1a1a haploinsufficient zebrafish model for Osteogenesis Imperfecta type I

Pascal SimoensCharlotte GistelinckSofie SymoensChristian VanhoveFransiska MalfaitAnne De PaepePaul CouckeAndy Willaert

Genetic defects in TAPT1 disrupt ciliogenesis and cause a complex lethal osteochondrodysplasia

Sofie SymoensAileen M BarnesCharlotte GistelinckFransiska MalfaitBrecht GuillemynWouter SteyaertDelfien SyxSanne D'hondtMartine BiervlietJulie De Backer et al.

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

Refinement of the critical 2p25.3 deletion region: the role of MYT1L in intellectual disability and obesity

Nina De RockerSarah VergultDavid KoolenEva JacobsAlexander HoischenSusan ZeesmanBirgitte BangFrédérique BénaNele BockaertErnie Bongers et al.

A1 Journal Article in GENETICS IN MEDICINE

RNF216 mutations as a novel cause of autosomal recessive Huntington-like disorder

Patrick SantensTim Van DammeWouter SteyaertAndy WillaertBernard SablonnièreAnne De PaepePaul CouckeBart Dermaut

A1 Journal Article in NEUROLOGY

2014

A zebrafish model for Bruck Syndrome caused by PLOD2 mutations

Andy WillaertCharlotte GistelinckPascal SimoensSofie SymoensChristian VanhoveFransiska MalfaitAnne De PaepePaul Coucke

Characterization of a COL1A1A haploinsufficient zebrafish model for Osteogenesis Imperfecta type I

Charlotte GistelinckPascal SimoensSofie SymoensChristian VanhoveFransiska MalfaitAnne De PaepePaul CouckeAndy Willaert

Defects in TAPT1, involved in axial skeletal patterning, cause a complex lethal recessive disorder of skeletal development

Sofie SymoensAileen BarnesCharlotte GistelinckFransiska MalfaitKris VleminckxBrecht GuillemynDelfien SyxWouter SteyaertEef ParthoensMartine Biervliet et al.

Expressed repeat elements improve RT-qPCR normalization across a wide range of zebrafish gene expression studies

Suzanne VanhauwaertGert Van PeerAli RihaniEls JanssensPieter RondouSteve LefeverAnne De PaepePaul CouckeFranki SpelemanJo Vandesompele et al.

A1 Journal Article in PLOS ONE

Mutations affecting the SAND domain of DEAF1 cause intellectual disability with severe speech impairment and behavioral problems

Anneke T Vulto-van SilfhoutShivakumar RajamanickamPhilip J JensikSarah VergultNina De RockerKathryn J NewhallRamya RaghavanSara N ReardonKelsey JarrettTara McIntyre et al.

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

Phf6 plays a role in hematopoiesis and thymopoiesis in zebrafish

Els JanssensSuzanne VanhauwaertAndy WillaertKaat DurinckAnne De PaepePieter Van VlierberghePieter RondouFranki Speleman

2013

Defective initiation of glycosaminoglycan synthesis due to B3GALT6 mutations causes a pleiotropic Ehlers-Danlos-syndrome-like connective tissue disorder

Fransiska MalfaitAriana KariminejadTim Van DammeCaroline GaucheDelfien SyxFaten Merhi-SoussiSandrine GulbertiSofie SymoensSuzanne VanhauwaertAndy Willaert et al.

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

Zebrafish models for ectopic mineralization disorders : practical issues from morpholino design to post-injection observations

Mohammad Jakir HosenOlivier VanakkerAndy WillaertAnn HuysseunePaul CouckeAnne De Paepe

A2 Journal Article in FRONTIERS IN GENETICS

2012

GLUT10 is required for the development of the cardiovascular system and the notochord and connects mitochondrial function to TGFβ signaling

Andy WillaertSandeep KhatriBert CallewaertPaul CouckeSeth CrosbyJoseph LeeElaine DavisSruti ShivaMichael TsangAnne De Paepe et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

2011

Mutations in FKBP10 cause recessive osteogenesis imperfecta and bruck syndrome

Brian P KelleyFransiska MalfaitLuisa BonafeDustin BaldridgeErica HomanSofie SymoensAndy WillaertNursel ElciogluLionel Van MaldergemChristine Verellen-Dumoulin et al.

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

2010

The RIN2 syndrome: a new autosomal recessive connective tissue disorder caused by deficiency of Ras and Rab interactor 2 (RIN2)

Delfien SyxFransiska MalfaitLut Van LaerJan HellemansT Hermanns-LeAndy WillaertA BenmansourAnne De PaepeA Verloes

A1 Journal Article in HUMAN GENETICS

2009

Recessive osteogenesis imperfecta caused by LEPRE1 mutations: clinical documentation and identification of the splice form responsible for prolyl 3-hydroxylation

Andy WillaertFransiska MalfaitSofie SymoensKris GevaertH. KayseriliA. MegarbaneGeert MortierJ. G. LeroyPaul CouckeAnne De Paepe

A1 Journal Article in JOURNAL OF MEDICAL GENETICS

2008

A genome-wide linkage scan for low spinal bone mineral density in a single extended family confirms linkage to 1p36.3

Andy WillaertInge Van PottelberghHans-Georg ZmierczakStefan GoemaereJean KaufmanAnne De PaepePaul Coucke

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

A Hotspot Splicing Mutation in LEPREI Affects Prolyl 3-hydroxylation and Causes Recessive Osteogenesis Imperfecta

Andy WillaertSofie SymoensFransiska MalfaitKris GevaertPaul CouckeAnne De Paepe

A hotspot splicing mutation in LEPREI affects prolyl 3-hydroxylation and causes recessive osteogenesis imperfecta

Fransiska MalfaitAndy WillaertSofie SymoensPaul CouckeAnne De Paepe

Absence of arterial phenotype in mice with homozygous slc2A10 missense substitutions

Bert CallewaertBart LoeysChristophe CasteleynAndy WillaertPieter DewintJulie De BackerR SedlmeierPaul SimoensAnne De PaepePaul Coucke

A1 Journal Article in GENESIS

Arterial tortuosity syndrome: Clinical and molecular findings in 12 newly identified families

Bert CallewaertAndy WillaertWS KERSTJENS-FREDERIKSEJulie De BackerK DEVRIENDTB ALBRECHTMA RAMOS-ARROYOM DOCO-FENZYRCM HENNEKAMRE PYERITZ et al.

A1 Journal Article in HUMAN MUTATION

2007

Een Belgische patiënt met Arterial Tortuosity Syndrome

Bert CallewaertBart LoeysJulie De BackerAndy WillaertD DevosM GewilligPaul CouckeK DevriendtAnne De Paepe

A2 Journal Article in TIJDSCHRIFT VAN DE BELGISCHE KINDERARTS = JOURNAL DU PEDIATRE BELGE

2006

Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome

Paul CouckeAndy WillaertMW WESSELSBert CallewaertN ZOPPIJulie De BackerJE FOXGMS MANCINIM KAMBOURISR GARDELLA et al.

A1 Journal Article in NATURE GENETICS

2005

Missense mutations in LRP5 are not a common cause of idiopathic osteoporosis in adult men

Patricia CrabbeW BALEMANSAndy WillaertI VAN POTTELBERGHE CLEIRENPaul CouckeMR AIStefan GoemaereW VAN HULAnne De Paepe et al.

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

2004

Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis

Jan HellemansO PREOBRAZHENSKAAndy WillaertP DEBEERPETER VERDONKT COSTAK JANSSENSBjörn MentenNadine Van RoyStefan Vermeulen et al.

A1 Journal Article in NATURE GENETICS

Mutation analysis of the LRP5 gene in men with idiopathic osteoporosis

P CRABBEAndy WillaertI VAN POTTELBERGHPaul CouckeS GOEMAEREAnne De PaepeJ KAUFMAN