Research Explorer

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Researcher

Alexander Van Parys

Publications & Research Data

Awards & Distinctions

52 Results

2024

High efficacy of huCD20-targeted AcTaferon in humanized patient derived xenograft models of aggressive B cell lymphoma

Willem DaneelsAlexander Van ParysLeander HuygheElke RoggeSteffi De RouckRuben ChristiaenLennart ZabeauSylvie TaveirneJo Van DorpeNiko Kley et al.

A1 Journal Article in EXPERIMENTAL HEMATOLOGY & ONCOLOGY

Knocking out CD70 rescues CD70-specific nanoCAR T cells from antigen-induced exhaustion

Stijn De MunterJuliane L. BuhlLaurenz De CockAlexander Van ParysWillem DaneelsEva PascalLucas DeseinsJoline IngelsGlenn GoetgelukHanne Jansen et al.

A1 Journal Article in CANCER IMMUNOLOGY RESEARCH

2023

A bispecific Clec9A-PD-L1 targeted type I interferon profoundly reshapes the tumor microenvironment towards an antitumor state

Sandra Van LintAlexander Van ParysBram Van Den EeckhoutNiels VandammeStephane PlaisanceAnnick VerheeDominiek CatteeuwElke RoggeJennifer De GeestNele Vanderroost et al.

A1 Journal Article in MOLECULAR CANCER

Knocking out CD70 rescues CD70-specific nanoCAR T cells from antigen induced exhaustion

Stijn De MunterJuliane BuhlLaurenz De CockAlexander Van ParysWillem DaneelsEva PascalLucas DeseinsJoline IngelsGlenn GoetgelukLore Billiet et al.

2021

Formatting and gene-based delivery of a human PD-L1 single domain antibody for immune checkpoint blockade

Robin Maximilian AwadQuentin LecocqKatty ZevenThomas ErtveldtLien De BeckHannelore CeuppensKatrijn BroosYannick De VlaeminckCleo GoyvaertsMagali Verdonck et al.

A1 Journal Article in MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT

2020

Rapid and effective generation of nanobody based CARs using PCR and Gibson Assembly

Stijn De MunterAlexander Van ParysLayla BralJoline IngelsGlenn GoetgelukSarah BonteMelissa PilleLore BillietKarin WeeningAnnick Verhee et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Safe eradication of large established tumors using neovasculature-targeted tumor necrosis factor-based therapies

Leander HuygheAlexander Van ParysAnje CauwelsSandra Van LintStijn De MunterJennyfer BultinckLennart ZabeauJeroen HostensAn GoethalsNele Vanderroost et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

2018

Delivering type I interferon to dendritic cells empowers tumor eradication and immune combination treatments

Anje CauwelsSandra Van LintFranciane PaulGenevieve GarcinStefaan De KokerAlexander Van ParysThomas WüestSarah GerloJosé Van Der HeydenYan Bordat et al.

A1 Journal Article in CANCER RESEARCH

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes

Lien Van HoeckeSandra Van LintKenny RooseAlexander Van ParysPeter VandenabeeleJohan GrootenJan TavernierStefaan De KokerXavier Saelens

A1 Journal Article in NATURE COMMUNICATIONS

2016

Host stress drives Salmonella recrudescence

Elin VerbruggheMaarten DhaenensBregje LeymanFilip BoyenNeil ShearerAlexander Van ParysRoel HaesendonckWim BertHerman FavoreelDieter Deforce et al.

A1 Journal Article in SCIENTIFIC REPORTS

Host stress drives Salmonella recrudescence (vol 6, 20849, 2016)

Elin VerbruggheMaarten DhaenensBregje LeymanFilip BoyenNeil ShearerAlexander Van ParysRoel HaesendonckWim BertHerman FavoreelDieter Deforce et al.

Subtherapeutic tetracycline concentrations aggravate Salmonella Typhimurium infection by increasing bacterial virulence

Elin VerbruggheAlexander Van ParysRoel HaesendonckBregje LeymanFilip BoyenFreddy HaesebrouckFrank Pasmans

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The probiotic Butyricicoccus pullicaecorum reduces feed conversion and protects from potentially harmful intestinal microorganisms and necrotic enteritis in broilers

Venessa EeckhautJun WangAlexander Van ParysFreddy HaesebrouckMarie JoossensGwen FalonyJeroen RaesRichard DucatelleFilip Van Immerseel

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

2015

Heat-labile enterotoxin of Escherichia coli promotes intestinal colonization of Salmonella enterica

Elin VerbruggheAlexander Van ParysBregje LeymanFilip BoyenSven ArnoutsUrban LundbergRichard DucatelleWim Van Den BroeckMaryam Atef YektaEric Cox et al.

A1 Journal Article in COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

HtpG contributes to Salmonella Typhimurium intestinal persistence in pigs

Elin VerbruggheAlexander Van ParysBregje LeymanFilip BoyenFreddy HaesebrouckFrank Pasmans

A1 Journal Article in VETERINARY RESEARCH

ScsA as a major driver for increased survival of Salmonella during a stress response

Elin VerbruggheMaarten DhaenensBregje LeymanFilip BoyenNeil ShearerAlexander Van ParysRoel HaesendonckWim BertHerman FavoreelDieter Deforce et al.

Subtherapeutic tetracycline concentrations aggravate Salmonella Typhimurium infection by increasing bacterial virulence

Elin VerbruggheAlexander Van ParysBregje LeymanFilip BoyenRoel HaesendonckFreddy HaesebrouckFrank Pasmans

2014

HtpG contributes to persistence of Salmonella in pigs

Elin VerbruggheFilip BoyenAlexander Van ParysBregje LeymanFreddy HaesebrouckFrank Pasmans

LT toxin of Escherichia coli promotes intestinal colonization of pigs with Salmonella

Elin VerbruggheFilip BoyenAlexander Van ParysBregje LeymanRichard DucatelleWim Van Den BroeckEric CoxFreddy HaesebrouckFrank Pasmans

ScsA as a major driver for increased survival of Salmonella during a stress response

Elin VerbruggheMaarten DhaenensBregje LeymanFilip BoyenNeil ShearerAlexander Van ParysRoel HaesendonckWim BertHerman FavoreelDieter Deforce et al.

2013

Induction of seroconversion and persistence of Salmonella Typhimurium in pigs are strain dependent

Alexander Van ParysFilip BoyenBregje LeymanElin VerbruggheDominiek MaesFreddy HaesebrouckFrank Pasmans

A1 Journal Article in COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

2012

A modified glucomannan mycotoxin-adsorbing agent counteracts the reduced weight gain and diminishes cecal colonization of Salmonella Typhimurium in T-2 toxin exposed pigs

Elin VerbruggheSiska CroubelsVirginie VandenbrouckeJoline GoossensPatrick De BackerMia EeckhoutSarah De SaegerFilip BoyenBregje LeymanAlexander Van Parys et al.

A1 Journal Article in RESEARCH IN VETERINARY SCIENCE

Mechanisms of Salmonella Typhimurium persistence in pigs

Alexander Van ParysFreddy HaesebrouckFrank PasmansFilip Boyen

Salmonella Typhimurium induces SPI-1 and SPI-2 regulated and strain dependent downregulation of MHC II expression on porcine alveolar macrophages

Alexander Van ParysFilip BoyenElin VerbruggheBregje LeymanBram FlahouFreddy HaesebrouckFrank Pasmans

A1 Journal Article in VETERINARY RESEARCH

T-2 toxin induced Salmonella Typhimurium intoxication results in decreased Salmonella numbers in the cecum contents of pigs, despite marked effects on Salmonella-host cell interactions

Elin VerbruggheVirginie VandenbrouckeMaarten DhaenensNeil ShearerJoline GoossensSarah De SaegerMia EeckhoutKatharina D'HerdeArthur ThompsonDieter Deforce et al.

A1 Journal Article in VETERINARY RESEARCH

Tackling the issue of environmental survival of live Salmonella Typhimurium vaccines: deletion of the lon gene

Bregje LeymanFilip BoyenAlexander Van ParysElin VerbruggheFreddy HaesebrouckFrank Pasmans

A1 Journal Article in RESEARCH IN VETERINARY SCIENCE

The complex interplay between stress and bacterial infections in animals

Elin VerbruggheFilip BoyenWim GaastraLeonie BekhuisBregje LeymanAlexander Van ParysFreddy HaesebrouckFrank Pasmans

A1 Journal Article in VETERINARY MICROBIOLOGY

Vaccination of pigs reduces Salmonella Typhimurium numbers in a model mimicking pre-slaughter stress

Bregje LeymanFilip BoyenElin VerbruggheAlexander Van ParysFreddy HaesebrouckFrank Pasmans

A1 Journal Article in VETERINARY JOURNAL

2011

An update on pathogenesis and control of Salmonella infections in pigs

Filip BoyenFrank PasmansAlexander Van ParysElin VerbruggheBregje LeymanFreddy Haesebrouck

Application of the DIVA principle to Salmonella Typhimurium vaccines in pigs avoids interference with serosurveillance programmes

Bregje LeymanFilip BoyenAlexander Van ParysElin VerbruggheFreddy HaesebrouckFrank Pasmans

Application of the DIVA principle to Salmonella Typhimurium vaccines in pigs avoids interference with serosurveillance programmes

Bregje LeymanFreddy HaesebrouckFilip BoyenAlexander Van ParysElin VerbruggheFrank Pasmans

Double benefit: a modified glucomannan mycotoxin-adsorbing agent counteracts T-2 toxin related reduced weight gain and limits Salmonella Typhimurium infections in pigs

Elin VerbruggheSiska CroubelsVirginie VandenbrouckeJoline GoossensPatrick De BackerMia EeckhoutSarah De SaegerFilip BoyenBregje LeymanAlexander Van Parys et al.

Een gewijzigde glucomannaan mycotoxine binder en T2-toxine in het voeder verminderen de kolonisatie van Salmonella Typhimurium in varkens

Elin VerbruggheSiska CroubelsVirginie VandenbrouckeMia EeckhoutSarah De SaegerJoline GoossensPatrick De BackerBregje LeymanAlexander Van ParysFilip Boyen et al.

Effects of the mycotoxins deoxynivalenol and T-2 toxin on the pathogenesis of a Salmonella TYphimurium infection in pigs

Virginie VandenbrouckeElin VerbruggheSiska CroubelsAn MartelJoline GoossensKim Van DeunFilip BoyenArthur ThompsonNeil ShearerSarah De Saeger et al.

Salmonella Typhimurium interferes with the humoral immune response in pigs

Alexander Van ParysFilip BoyenElin VerbruggheBregje LeymanBram FlahouDominiek MaesFreddy HaesebrouckFrank Pasmans

Salmonella Typhimurium LPS mutations for use in vaccines allowing differentiation of infected and vaccinated pigs

Bregje LeymanFilip BoyenAlexander Van ParysElin VerbruggheFreddy HaesebrouckFrank Pasmans

A1 Journal Article in VACCINE

Stress induced Salmonella Typhimurium re-excretion by pigs is associated with cortisol induced increased intracellular proliferation in porcine macrophages

Elin VerbruggheFreddy HaesebrouckFilip BoyenBregje LeymanKim Van DeunArthur ThompsonNeil ShearerAlexander Van ParysFrank Pasmans

Stress induced Salmonella Typhimurium recrudescence in pigs coincides with cortisol induced increased intracellular proliferation in macrophages

Elin VerbruggheFilip BoyenAlexander Van ParysKim Van DeunSiska CroubelsArthur ThompsonNeil ShearerBregje LeymanFreddy HaesebrouckFrank Pasmans

A1 Journal Article in VETERINARY RESEARCH

T-2 toxin causes decreased intestinal colonization of Salmonella Typhimurium in pigs associated with altered gene expression

Elin VerbruggheVirginie VandenbrouckeSiska CroubelsMia EeckhoutSarah De SaegerJoline GoossensPatrick De BackerArthur ThompsonNeil ShearerBregje Leyman et al.

Tissue-specific Salmonella Typhimurium gene expression during persistence in pigs

Alexander Van ParysFilip BoyenBregje LeymanElin VerbruggheFreddy HaesebrouckFrank Pasmans

A1 Journal Article in PLOS ONE

Vaccination of pigs reduces Salmonella Typhimurium numbers in a model mimicking pre-slaughter stress

Bregje LeymanFilip BoyenElin VerbruggheAlexander Van ParysFreddy HaesebrouckFrank Pasmans

2010

How and why Salmonella Typhimurium circumvents seroconversion in pigs

Alexander Van ParysFilip BoyenElin VerbruggheBregje LeymanFreddy HaesebrouckFrank Pasmans

HtpG and STM4067 contribute to long-term Salmonella Typhimurium persistence in pigs

Alexander Van ParysFilip BoyenElin VerbruggheBregje LeymanFreddy HaesebrouckFrank Pasmans

Salmonella Typhimurium resides largely as an extracellular pathogen in porcine tonsils, independently of biofilm-associated genes csgA, csgD and adrA

Alexander Van ParysFilip BoyenJiri VolfElin VerbruggheBregje LeymanIvan RychlikFreddy HaesebrouckFrank Pasmans

Salmonella Typhimurium resides largely as an extracellular pathogen in porcine tonsils, independently of biofilm-associated genes csgA, csgD and adrA

Alexander Van ParysFilip BoyenJiri VolfElin VerbruggheBregje LeymanIvan RychlikFreddy HaesebrouckFrank Pasmans

A1 Journal Article in VETERINARY MICROBIOLOGY

State of the art: Recent insights in the mechanism of Salmonella persistence in pigs

Bregje LeymanFilip BoyenAlexander Van ParysElin VerbruggheFreddy HaesebrouckFrank Pasmans

The use of tannins to control Salmonella Typhimurium infections in pigs

Alexander Van ParysFilip BoyenJeroen DewulfFreddy HaesebrouckFrank Pasmans

A1 Journal Article in ZOONOSES AND PUBLIC HEALTH

2009

Persistent Salmonella Typhimurium infections in pigs

Filip BoyenAlexander Van ParysJiri VolfElin VerbruggheBregje LeymanIvan RychlikFrank PasmansFreddy Haesebrouck

Stress induced Salmonella Typhimurium excretion by pigs is associated with cortisol induced increased intracellular proliferation in porcine macrophages

Elin VerbruggheFilip BoyenKim Van DeunAlexander Van ParysFilip Van ImmerseelFreddy HaesebrouckFrank Pasmans

2008

Coated fatty acids alter virulence properties of Salmonella Typhimurium and decrease intestinal colonization of pigs

Filip BoyenFreddy HaesebrouckAlexander Van ParysJ VolfMaxime MahuFilip Van ImmerseelI RychlikJeroen DewulfRichard DucatelleFrank Pasmans

A1 Journal Article in VETERINARY MICROBIOLOGY

Salmonella Typhimurium: an extracellular parasite in porcine tonsils and gut-associated lymph nodes

Alexander Van ParysFrank PasmansVolf JiriFilip BoyenFreddy Haesebrouck

Starvation-stress increases the numbers of Salmonella Typhimurium in the gut, intestinal lymph nodes and tonsils of pigs

Elin VerbruggheFilip BoyenFreddy HaesebrouckAlexander Van ParysKim Van DeunFrank Pasmans