Research Explorer

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Researcher

Alexander Panfilov

214 Results

2022

DGM : Directed-Graph Mapping as a novel tool to analyze cardiac arrhythmias

Enid Van NieuwenhuyseNele VandersickelAlexander Panfilov

Dg-mapping as a tool to determine the spatial distribution of the focal sources and the number of reentries during torsade de pointes in the cavb dog model

Robin Van Den AbeeleEnid Van NieuwenhuyseSander HendrickxMarc VosAlexander PanfilovNele Vandersickel

Novel modulators of connexin 43 hemichannel in the heart : from peptides to pathways

Alessio LissoniLuc LeybaertAlexander Panfilov

2021

Anatomical model of rat ventricles to study cardiac arrhythmias under infarction injury

Roman RokeakhTatiana NesterovaKonstantin UsheninEkaterina PolyakovaDmitry SoninMichael GalagudzaTim De CosterAlexander PanfilovOlga Solovyova

A1 Journal Article in MATHEMATICS

Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability

Maarten De SmetAlessio LissoniTimur NezlobinskiiNan WangEef DriesMarta Pérez-HernándezXianming LinMatthew AmoniTim VervlietKatja Witschas et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Determination of dominant loop in dual loop atrial tachycardia with direct graph mapping : an alternative for entrainment mapping?

Lars LowieEnid Van NieuwenhuyseJorge SanchezAlexander PanfilovSebastien KnechtMattias DuytschaeverNele Vandersickel

Directed graph mapping exceeds phase mapping in discriminating true and false rotors detected with a basket catheter in a complex in-silico excitation pattern

Enid Van NieuwenhuyseLaura Martinez-MateuJavier SaizAlexander PanfilovNele Vandersickel

A1 Journal Article in COMPUTERS IN BIOLOGY AND MEDICINE

Directed graph mapping is able to distinguish between the true and false rotors in a complex in-silico excitation pattern

Enid Van NieuwenhuyseLaura Martinez-MateuJavier SaizAlexander PanfilovNele Vandersickel

Electrophysiological characterization of human atria : the understated role of temperature

Rupamanjari MajumderAfnan Nabizath Mohamed NazerAlexander PanfilovEberhard BodenschatzYong Wang

A1 Journal Article in FRONTIERS IN PHYSIOLOGY

Evaluation of directed graph-mapping in complex atrial tachycardias

Enid Van NieuwenhuyseTeresa StrisciuglioGiuseppe LorenzoMilad El HaddadJan GoedgebeurNicolas Van CleemputChristophe LeyAlexander PanfilovJan De PooterYves Vandekerckhove et al.

A1 Journal Article in JACC-CLINICAL ELECTROPHYSIOLOGY

Finding type and location of the source of cardiac arrhythmias from the averaged flow velocity field using the determinant-trace method

Qi-Hao LiEnid Van NieuwenhuyseYuan-Xun XiaJun-Ting PanMattias DuytschaeverSebastien KnechtNele VandersickelChangsong ZhouAlexander PanfilovHong Zhang

A1 Journal Article in PHYSICAL REVIEW E

High-frequency pacing of scroll waves in a three-dimensional slab model of cardiac tissue

Sergei F. Pravdin, Timur NezlobinskyAlexander PanfilovHans Dierckx

A1 Journal Article in PHYSICAL REVIEW E

Mathematical modelling of the mechano-electric coupling in the human cardiomyocyte electrically connected with fibroblasts

Anastasia BazhutinaNathalie A. Balakina-VikulovaAlexander KursanovOlga SolovyovaAlexander PanfilovLeonid B. Katsnelson

A1 Journal Article in PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOG

Minimal functional clusters predict the probability of reentry in cardiac fibrotic tissue

Farhad PashakhanlooAlexander Panfilov

A1 Journal Article in PHYSICAL REVIEW LETTERS

Multiparametric analysis of geometric features of fibrotic textures leading to cardiac arrhythmias

T. NezlobinskyArstanbek OkenovAlexander Panfilov

A1 Journal Article in SCIENTIFIC REPORTS

Period of arrhythmia anchored around an infarction scar in an anatomical model of the human ventricles

Daria MangilevaPavel KonovalovArsenii DokuchaevOlga SolovyovaAlexander Panfilov

A1 Journal Article in MATHEMATICS

Rotational activity around an obstacle in 2D cardiac tissue in presence of cellular heterogeneity

Pavel KonovalovDaria MangilevaArsenii DokuchaevOlga SolovyovaAlexander Panfilov

A1 Journal Article in MATHEMATICS

Scroll wave with negative filament tension in a model of the left ventricle of the human heart and its overdrive pacing

Sergei F. PravdinTimofei EpanchintsevHans DierckxAlexander Panfilov

A1 Journal Article in PHYSICAL REVIEW E

Software for cardiac modelling and patch clamp experiments, and its application to study conduction in the presence of fibrosis

Timur NezlobinskiiAlexander PanfilovLuc Leybaert

2020

An audit of uncertainty in multi-scale cardiac electrophysiology models

Richard H. ClaytonYasser AboelkassemChris D. CantwellCesare CorradoTammo DelhaasWouter HubertsChon Lok LeiHaibo NiAlexander PanfilovCaroline Roney et al.

A1 Journal Article in PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Anisotropic conduction in the myocardium due to fibrosis : the effect of texture on wave propagation

Timur NezlobinskiiO. SolovyovaAlexander Panfilov

A1 Journal Article in SCIENTIFIC REPORTS

Considering discrepancy when calibrating a mechanistic electrophysiology model

Chon Lok LeiSanmitra GhoshDominic G. WhittakerYasser AboelkassemKylie A. BeattieChris D. CantwellTammo DelhaasCharles HoustonGustavo Montes NovaesAlexander Panfilov et al.

A1 Journal Article in PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Creation and application of virtual patient cohorts of heart models

S. A. NiedererY. AboelkassemC. D. CantwellC. CorradoS. CoveneyE. M. CherryT. DelhaasF. H. FentonAlexander PanfilovP. Pathmanathan et al.

A1 Journal Article in PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Drift of scroll waves in a mathematical model of a heterogeneous human heart left ventricle

Sergey PravdinPavel KonovalovHans DierckxOlga SolovyovaAlexander Panfilov

A1 Journal Article in MATHEMATICS

Gap19, a Cx43 hemichannel inhibitor, acts as a gating modifier that decreases main state opening while increasing substate gating

Alessio LissoniNan WangTimur NezlobinskiiMaarten De SmetAlexander PanfilovNele VandersickelLuc LeybaertKatja Witschas

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Heart cells are aMAZEing

Nina KudryashovaAlexander Panfilov

Bookchapter in The art of theoretical biology

In silico optical control of pinned electrical vortices in an excitable biological medium

Rupamanjari MajumderVladimir S. ZykovAlexander Panfilov

A1 Journal Article in NEW JOURNAL OF PHYSICS

Induced drift of scroll waves in the Aliev-Panfilov model and in an axisymmetric heart left ventricle

Sergei F. PravdinI Epanchintsev, TimofeiTimur NezlobinskiiAlexander Panfilov

A1 Journal Article in RUSSIAN JOURNAL OF NUMERICAL ANALYSIS AND MATHEMATICAL MODELLING

Lost in the cells

Nina KudryashovaAlexander Panfilov

Bookchapter in The art of theoretical biology

Mechano-calcium and mechano-electric feedbacks in the human cardiomyocyte analyzed in a mathematical model

Nathalie A. Balakina-VikulovaAlexander PanfilovOlga SolovyovaLeonid B. Katsnelson

A1 Journal Article in JOURNAL OF PHYSIOLOGICAL SCIENCES

Myocardial fibrosis in a 3D model : effect of texture on wave propagation

Arsenii DokuchaevAlexander PanfilovOlga Solovyova

A1 Journal Article in MATHEMATICS

Overdrive pacing of spiral waves in a model of human ventricular tissue

Sergei F. PravdinTimofei I. EpanchintsevAlexander Panfilov

A1 Journal Article in SCIENTIFIC REPORTS

Self-restoration of cardiac excitation rhythm by anti-arrhythmic ion channel gating

Rupamanjari MajumderTim De CosterNina KudryashovaArie O. VerkerkV Kazbanov, IvanBalazs OrdogNiels HarlaarRonald WildersAntoine A. F. de VriesDirk L. Ypey et al.

A1 Journal Article in ELIFE

2019

A quantitative theory for phase-locking of meandering spiral waves in a rotating external field

Tengchao LiBing Wei LiBo ZhengHong ZhangAlexander PanfilovHans Dierckx

A1 Journal Article in NEW JOURNAL OF PHYSICS

Directed networks as a novel way to describe and analyze cardiac excitation : directed graph mapping

Nele VandersickelEnid Van NieuwenhuyseNicolas Van CleemputJan GoedgebeurMilad El HaddadJan De NeveAnthony DemolderTeresa StrisciuglioMattias DuytschaeverAlexander Panfilov

A1 Journal Article in FRONTIERS IN PHYSIOLOGY

Drift of scroll waves in a generic axisymmetric model of the cardiac left ventricle

Sergei F PravdinHans DierckxAlexander Panfilov

A1 Journal Article in CHAOS SOLITONS & FRACTALS

R-from-T as a common mechanism of arrhythmia initiation in long QT syndromes

Michael B. LiuNele VandersickelAlexander PanfilovZhilin Qu

A1 Journal Article in CIRCULATION - ARRHYTHMIA AND ELECTROPHYSIOLOGY

Response function framework for the dynamics of meandering or large-core spiral waves and modulated traveling waves

Hans DierckxAlexander PanfilovHenri VerscheldeVN BiktashevIV Biktasheva

A1 Journal Article in PHYSICAL REVIEW E

The role of adipose tissue in arrhythmogenesis : an in silico study

Tim De CosterAlexander PanfilovPiet Claus

2018

Arrhythmogenicity of fibro-fatty infiltrations

Tim De CosterPiet ClausIvan KazbanovPeter HaemersRik WillemsKarin R SipidoAlexander Panfilov

A1 Journal Article in SCIENTIFIC REPORTS

Dynamical anchoring of distant arrhythmia sources by fibrotic regions via restructuring of the activation pattern

Nele VandersickelMasaya WatanabeQian TaoJan FostierKatja ZeppenfeldAlexander Panfilov

A1 Journal Article in PLOS COMPUTATIONAL BIOLOGY

GEMS : a fully integrated PETSc-based solver for coupled cardiac electromechanics and bidomain simulations

Sander ArensHans DierckxAlexander Panfilov

A1 Journal Article in FRONTIERS IN PHYSIOLOGY

Mechano-electric feedbacks in a new model of the excitation-contraction coupling in human cardiomyocytes

Nathalie Balakina-VikulovaOlga SolovyovaAlexander PanfilovLeonid Katsnelson

Myocyte remodeling due to fibro-fatty infiltrations influences arrhythmogenicity

Tim De CosterPiet ClausGunnar SeemannRik WillemsKarin R SipidoAlexander Panfilov

A1 Journal Article in FRONTIERS IN PHYSIOLOGY

Optogenetics enables real-time spatiotemporal control over spiral wave dynamics in an excitable cardiac system

Rupamanjari MajumderIolanda FeolaAlexander S TepleninAntoine AF de VriesAlexander PanfilovDaniel A Pijnappels

A1 Journal Article in ELIFE

Paradoxical onset of arrhythmic waves from depolarized areas in cardiac tissue due to curvature-dependent instability

Alexander S TepleninHans DierckxAntoine AF de VriesDaniël A PijnappelsAlexander Panfilov

A1 Journal Article in PHYSICAL REVIEW X

Response by Feola et al. to letter regarding article, 'Localized optogenetic targeting of rotors in atrial cardiomyocyte monolayers'

Iolanda FeolaLinda VolkersRupamanjari MajumderAlexander TepleninMartin J SchalijAlexander PanfilovAntoine AF de VriesDaniel A Pijnappels

A1 Journal Article in CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY

The fundamental role of cardiac tissue morphology in electrical signal propagation

Nina KudryashovaAlexander PanfilovKonstantin I Agladze

Theory of rotors and arrhythmias

Alexander PanfilovHans Dierckx

Bookchapter in Cardiac electrophysiology : from cell to bedside

2017

Effect of myocyte-fibroblast coupling on the onset of pathological dynamics in a model of ventricular tissue

S SridharNele VandersickelAlexander Panfilov

A1 Journal Article in SCIENTIFIC REPORTS

Effects of early afterdepolarizations on excitation patterns in an accurate model of the human ventricles

Enid Van NieuwenhuyseGunnar SeemannAlexander PanfilovNele Vandersickel

A1 Journal Article in PLOS ONE

Filament tension and phase locking of meandering scroll waves

Hans DierckxIV BiktashevaHenri VerscheldeAlexander PanfilovVN Biktashev

A1 Journal Article in PHYSICAL REVIEW LETTERS

Localized optogenetic targeting of rotors in atrial cardiomyocyte monolayers

Iolanda FeolaLinda VolkersRupamanjari MajumderAlexander TepleninMartin J SchalijAlexander PanfilovAntoine AF de VriesDaniel A Pijnappels

A1 Journal Article in CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY

Measurement and structure of spiral wave response functions

Hans DierckxHenri VerscheldeAlexander Panfilov

A1 Journal Article in CHAOS

Mechanism for mechanical wave break in the heart muscle

Louis WeiseAlexander Panfilov

A1 Journal Article in PHYSICAL REVIEW LETTERS

Short-lasting episodes of torsade de pointes in the chronic atrioventricular block dog model have a focal mechanism, while longer-lasting episodes are maintained by re-entry

Nele VandersickelAlexandre BossuJan De NeveAlbert DunninkVeronique MF MeijborgMarcel AG van der HeydenJet DM BeekmanJacques MT De BakkerMarc A VosAlexander Panfilov

A2 Journal Article in JACC. CLINICAL ELECTROPHYSIOLOGY

Simulation of overdrive pacing in 2D phenomenological models of anisotropic myocardium

Timofei EpanchintsevSergei PravdinAndrey SozykinAlexander Panfilov

Spatial patterns of excitation at tissue and whole organ level due to early afterdepolarizations

Nele VandersickelEnid Van NieuwenhuyseGunnar SeemannAlexander Panfilov

A1 Journal Article in FRONTIERS IN PHYSIOLOGY

Spiral-wave dynamics in a mathematical model of human ventricular tissue with myocytes and Purkinje fibers

Alok Ranjan NayakAlexander PanfilovRahul Pandit

A1 Journal Article in PHYSICAL REVIEW E

Virtual cardiac monolayers for electrical wave propagation

Nina KudryashovaValeriya TsvelayaKonstantin AgladzeAlexander Panfilov

A1 Journal Article in SCIENTIFIC REPORTS

Влияние еормЫ и инизотропии левого желудочка на дрейф трехмерных вихрей

SF PravdinHans DierckxAlexander Panfilov

A2 Journal Article in Биофизика

2016

A mathematical model of neonatal rat atrial monolayers with constitutively active acetylcholine-mediated K+ current

Rupamanjari MajumderWanchana JangsangthongIolanda FeolaDirk L YpeyDaniel A PijnappelsAlexander Panfilov

A1 Journal Article in PLOS COMPUTATIONAL BIOLOGY

Biophysical mechanisms of cardiac arrhythmias due to fibrosis and other pathological conditions

Ivan KazbanovAlexander Panfilov

Drift of scroll waves of electrical excitation in an isotropic model of the cardiac left ventricle

Sergei F PravdinHans DierckxAlexander Panfilov

A1 Journal Article in RUSSIAN JOURNAL OF NUMERICAL ANALYSIS AND MATHEMATICAL MODELLING

Effects of heterogeneous diffuse fibrosis on arrhythmia dynamics and mechanism

Ivan KazbanovKirsten HWJ ten TusscherAlexander Panfilov

A1 Journal Article in SCIENTIFIC REPORTS

Global alternans instability and its effect on non-linear wave propagation : dynamical Wenckebach block and self terminating spiral waves

Nele VandersickelArne DefauwPeter DawyndtAlexander Panfilov

A1 Journal Article in SCIENTIFIC REPORTS

Islands of spatially discordant APD alternans underlie arrhythmogenesis by promoting electrotonic dyssynchrony in models of fibrotic rat ventricular myocardium

Rupamanjari MajumderMarc C EngelsAntoine AF de VriesAlexander PanfilovDaniel A Pijnappels

A1 Journal Article in SCIENTIFIC REPORTS

Mechano-electric heterogeneity of the myocardium as a paradigm of its function

Olga SolovyovaLeonid B KatsnelsonPeter KohlAlexander PanfilovAndrey K TsaturyanPavel B Tsyvian

A1 Journal Article in PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Perpetuation of torsade de pointes in heterogeneous hearts : competing foci or re-entry?

Nele VandersickelTeun P de BoerMarc A VosAlexander Panfilov

A1 Journal Article in JOURNAL OF PHYSIOLOGY-LONDON

Role and contribution of mitochondrial connexin43, complex I and calcium sensitive potassium channels in cardiac ischemia-reperfusion injury

Ashish Kumar GadicherlaLuc LeybaertAlexander PanfilovDmitri Krysko

Scroll wave dynamics in a model of the heterogeneous heart

PV KonovalovSF PravdinOE SolovyovaAlexander Panfilov

A1 Journal Article in JETP LETTERS

Scroll-wave dynamics in the presence of ionic and conduction inhomogeneities in an anatomically tealistic mathematical model for the pig heart

R MajumderR PanditAlexander Panfilov

A1 Journal Article in JETP LETTERS

2015

A comparative study of early afterdepolarization-mediated fibrillation in two mathematical models for human ventricular cells

Soling ZimikNele VandersickelAlok Ranjan NayakAlexander PanfilovRahul Pandit

A1 Journal Article in PLOS ONE

A theory for spiral wave drift in reaction-diffusion-mechanics systems

Hans DierckxSander ArensBingwei LiLouis WeiseAlexander Panfilov

A1 Journal Article in NEW JOURNAL OF PHYSICS

Conditions for waveblock due to anisotropy in a model of human ventricular tissue

Nina KudryashovaIvan KazbanovAlexander PanfilovKonstantin I Agladze

A1 Journal Article in PLOS ONE

Constitutively active acetylcholine-dependent potassium current increases atrial defibrillation threshold by favoring post-shock re-initiation

Brian O BingenSaïd FA AskarZeinab NeshatiIolanda FeolaAlexander PanfilovAntoine AF de VriesDaniël A Pijnappels

A1 Journal Article in SCIENTIFIC REPORTS

Decreased repolarization reserve increases defibrillation threshold by favoring early afterdepolarizations in an in silico model of human ventricular tissue

Nele VandersickelIvan KazbanovArne DefauwDaniel A PijnappelsAlexander Panfilov

A1 Journal Article in HEART RHYTHM

Drift of scroll wave filaments in an anisotropic model of the left ventricle of the human heart

Sergei PravdinHans DierckxVladimir S MarkhasinAlexander Panfilov

A1 Journal Article in BIOMED RESEARCH INTERNATIONAL

Human heart heterogeneity and its role in the onset and perpetuation of cardiac arrhythmias

Arne DefauwAlexander PanfilovPeter Dawyndt

Mathematical modelling of structure and function of the cardiac left ventricle

Sergei PravdinAlexander PanfilovVladimir S MarkhasinVitaly I Berdyshev

2014

A study of early afterdepolarizations in a model for human ventricular tissue

Nele VandersickelIvan KazbanovAnita NuitermansLouis WeiseRahul PanditAlexander Panfilov

A1 Journal Article in PLOS ONE

Chiral selection and frequency response of spiral waves in reaction-diffusion systems under a chiral electric field

Bing-Wei LiMei-Chun CaiHong ZhangAlexander PanfilovHans Dierckx

A1 Journal Article in JOURNAL OF CHEMICAL PHYSICS

Effect of global cardiac ischemia on human ventricular fibrillation : insights from a multi-scale mechanistic model of the human heart

Ivan KazbanovRichard H ClaytonMartyn P NashChris P BradleyDavid J PatersonMartin P HaywardPeter TaggartAlexander Panfilov

A1 Journal Article in PLOS COMPUTATIONAL BIOLOGY

Electrical wave propagation in an anisotropic model of the left ventricle based on analytical description of cardiac architecture

Sergei PravdinHans DierckxLeonid B KatsnelsonOlga SolovyovaVladimir S MarkhasinAlexander Panfilov

A1 Journal Article in PLOS ONE

Light-induced termination of spiral wave arrhythmias by optogenetic engineering of atrial cardiomyocytes

Brian O BingenMarc C EngelsMartin J SchalijWanchana JangsangthongZeinab NeshatiIolanda FeolaDirk L YpeySaïd FA AskarAlexander PanfilovDaniël A Pijnappels et al.

A1 Journal Article in CARDIOVASCULAR RESEARCH

Small size ionic heterogeneities in the human heart can attract rotors

Arne DefauwNele VandersickelPeter DawyndtAlexander Panfilov

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Turbulent electrical activity at sharp-edged inexcitable obstacles in a model for human cardiac tissue

Rupamanjari MajumderRahul PanditAlexander Panfilov

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

2013

A discrete electromechanical model for human cardiac tissue: effects of stretch-activated currents and stretch conditions on restitution properties and spiral wave dynamics

Louis WeiseAlexander Panfilov

A1 Journal Article in PLOS ONE

Action potential duration heterogeneity of cardiac tissue can be evaluated from cell properties using Gaussian Green's function approach

Arne DefauwIvan KazbanovHans DierckxPeter DawyndtAlexander Panfilov

A1 Journal Article in PLOS ONE

Atrium-specific Kir3.x determines inducibility, dynamics, and termination of fibrillation by regulating restitution-driven alternans

Brian O BingenZeinab NeshatiSaïd FA AskarIvan KazbanovDirk L YpeyAlexander PanfilovMartin J SchalijAntoine AF de VriesDaniël A Pijnappels

A1 Journal Article in CIRCULATION

Drift laws for spiral waves on curved anisotropic surfaces

Hans DierckxEvelien BrisardHenri VerscheldeAlexander Panfilov

A1 Journal Article in PHYSICAL REVIEW E

Initiation and dynamics of a spiral wave around an ionic heterogeneity in a model for human cardiac tissue

Arne DefauwPeter DawyndtAlexander Panfilov

A1 Journal Article in PHYSICAL REVIEW E

Mathematical model of the anatomy and fibre orientation field of the left ventricle of the heart

Sergei PravdinVitaly I BerdyshevAlexander PanfilovLeonid B KatsnelsonOlga SolovyovaVladimir S Markhasin

A1 Journal Article in BIOMEDICAL ENGINEERING ONLINE

Negative tension of scroll wave filaments and turbulence in three-dimensional excitable media and application in cardiac dynamics

Sergio AlonsoMarkus BärAlexander Panfilov

A1 Journal Article in BULLETIN OF MATHEMATICAL BIOLOGY

Prolongation of minimal action potential duration in sustained fibrillation decreases complexity by transient destabilization

Brian O BingenSaïd FA AskarMartin J SchalijIvan KazbanovDirk L YpeyAlexander PanfilovDaniël A Pijnappels

A1 Journal Article in CARDIOVASCULAR RESEARCH

Spiral-wave dynamics in a mathematical model of human ventricular tissue with myocytes and fibroblasts

Alok Ranjan NayakTK ShajahanAlexander PanfilovRahul Pandit

A1 Journal Article in PLOS ONE

2012

Emergence of spiral wave activity in a mechanically heterogeneous reaction-diffusion-mechanics system

Louis WeiseAlexander Panfilov

A1 Journal Article in PHYSICAL REVIEW LETTERS

2011

A discrete model to study reaction-diffusion-mechanics systems

Louis WeiseMartyn P NashAlexander Panfilov

A1 Journal Article in PLOS ONE

Effects of reduced discrete coupling on filament tension in excitable media

Sergio AlonsoMarkus BarAlexander Panfilov

A1 Journal Article in CHAOS

Experiment-model interaction for analysis of epicardial activation during human ventricular fibrillation with global myocardial ischaemia

RH ClaytonMP NashCP BradleyAlexander PanfilovDJ PatersonP Taggart

A1 Journal Article in PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Minimum information about a cardiac electrophysiology experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing

TA QuinnS GraniteMA AllessieC AntzelevitchC BollensdorffG BubRAB BurtonE CerbaiPS ChenM Delmar et al.

A1 Journal Article in PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Models of cardiac tissue electrophysiology: progress, challenges and open questions

RH ClaytonOlivier BernusEM CherryHans DierckxFH FentonL MirabellaAlexander PanfilovFB SachseG SeemannH Zhang

A1 Journal Article in PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

New mechanism of spiral wave initiation in a reaction-diffusion-mechanics system

Louis WeiseAlexander Panfilov

A1 Journal Article in PLOS ONE

2010

Anisotropy of wave propagation in the heart can be modeled by a Riemannian electrophysiological metric

Robert J YoungAlexander Panfilov

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anomalous drift of spiral waves in heterogeneous excitable media

S SridharSitabhra SinhaAlexander Panfilov

A1 Journal Article in PHYSICAL REVIEW E

Electromechanical wavebreak in a model of the human left ventricle

RH KeldermannMP NashH GelderblomVY WangAlexander Panfilov

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

2009

A computational study of mother rotor VF in the human ventricles

RH KeldermannKHWJ ten TusscherMP NashCP BradleyR HrenP TaggartAlexander Panfilov

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Modeling cardiac mechano-electrical feedback using reaction-diffusion-mechanics systems

RH KeldermannMP NashAlexander Panfilov

A1 Journal Article in PHYSICA D-NONLINEAR PHENOMENA

Nonlinear waves in excitable media : approaches to cardiac arrhythmias : preface

Olivier BernusArun V HoldenAlexander Panfilov

Editorial material

Organization of ventricular fibrillation in the human heart : experiments and models

KHWJ ten TusscherA MouradMP NashRH ClaytonCP BradleyDJ PatersonR HrenM HaywardAlexander PanfilovP Taggart

A1 Journal Article in EXPERIMENTAL PHYSIOLOGY

2008

A guide to modelling cardiac electrical activity in anatomically detailed ventricles

RH ClaytonAlexander Panfilov

A1 Journal Article in PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Effect of heterogeneous APD restitution on VF organization in a model of the human ventricles

RH KeldermannKHWJ ten TusscherMP NashR HrenP TaggartAlexander Panfilov

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Formation of fast spirals on heterogeneities of an excitable medium

GB Makkes van der DeijlAlexander Panfilov

A1 Journal Article in PHYSICAL REVIEW E

Modelling of the ventricular conduction system

KHWJ Ten TusscherAlexander Panfilov

A1 Journal Article in PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Negative filament tension at high excitability in a model of cardiac tissue

Sergio AlonsoAlexander Panfilov

A1 Journal Article in PHYSICAL REVIEW LETTERS

2007

Drift and breakup of spiral waves in reaction-diffusion-mechanics systems

Alexander PanfilovRH KeldermannMP Nash

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of diffuse fibrosis on wave propagation in human ventricular tissue

Kirsten HWJ Ten TusscherAlexander Panfilov

A1 Journal Article in EUROPACE

Negative filament tension in the Luo-Rudy model of cardiac tissue

S AlonsoAlexander Panfilov

A1 Journal Article in CHAOS

Organization of ventricular fibrillation in the human heart

Kirsten HWJ Ten TusscherRok HrenAlexander Panfilov

A1 Journal Article in CIRCULATION RESEARCH

Pacemakers in a reaction-diffusion mechanics system

RH KeldermannMP NashAlexander Panfilov

A1 Journal Article in JOURNAL OF STATISTICAL PHYSICS

2006

Alternans and spiral breakup in a human ventricular tissue model

KHWJ ten TusscherAlexander Panfilov

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cell model for efficient simulation of wave propagation in human ventricular tissue under normal and pathological conditions

KHWJ Ten TusscherAlexander Panfilov

A1 Journal Article in PHYSICS IN MEDICINE AND BIOLOGY

Comparison of electrophysiological models for human ventricular cells and tissues

KHWJ Ten TusscherO BernusR HrenAlexander Panfilov

A1 Journal Article in PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Is heart size a factor in ventricular fibrillation? Or how close are rabbit and human hearts?

Alexander Panfilov

Editorial material

Phase singularities and filaments : simplifying complexity in computational models of ventricular fibrillation

RH ClaytonEA ZhuchkovaAlexander Panfilov

A1 Journal Article in PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

2005

Comments on 'A model for human ventricular tissue' : reply

KHWJ ten TusscherD NoblePJ NobleAlexander Panfilov

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Re-entrant waves in contracting excitable ventricular tissue to study mechano-electric feedback and arrhythmias

MP NashRH KeldermannAlexander Panfilov

Re-entrant waves in contracting excitable ventricular tissue to study mechano-electric feedback and arrhythmias

MP NashRH KeldermannAlexander Panfilov

Scroll waves meandering in a model of an excitable medium

A RusakovAB MedvinskyAlexander Panfilov

A1 Journal Article in PHYSICAL REVIEW E

Self-organized pacemakers in a coupled reaction-diffusion-mechanics system

Alexander PanfilovRH KeldermannMP Nash

A1 Journal Article in PHYSICAL REVIEW LETTERS

Wave propagation in excitable media with randomly distributed obstacles

KHWJ ten TusscherAlexander Panfilov

A1 Journal Article in MULTISCALE MODELING & SIMULATION

2004

A model for human ventricular tissue

KHWJ ten TusscherD NoblePJ NobleAlexander Panfilov

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Eikonal formulation of the minimal principle for scroll wave filaments

KHWJ ten TusscherAlexander Panfilov

A1 Journal Article in PHYSICAL REVIEW LETTERS

Electromechanical model of excitable tissue to study reentrant cardiac arrhythmias

MP NashAlexander Panfilov

A1 Journal Article in PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Quantifying ventricular fibrillation : in silico research and clinical implications

Alexander PanfilovPLM Kerkhof

A1 Journal Article in IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

2003

Influence of nonexcitable cells on spiral breakup in two-dimensional and three-dimensional excitable media

KHWJ ten TusscherAlexander Panfilov

A1 Journal Article in PHYSICAL REVIEW E

Reentry in an anatomical model of the human ventricles

Olivier BernusHenri VerscheldeAlexander Panfilov

A1 Journal Article in INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS

Reentry in heterogeneous cardiac tissue described by the Luo-Rudy ventricular action potential model

KHWJ Ten TusscherAlexander Panfilov

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Spiral wave stability in cardiac tissue with biphasic restitution

Olivier BernusHenri VerscheldeAlexander Panfilov

A1 Journal Article in PHYSICAL REVIEW E

The role of Ca2+-channel blockers in the transition from ventricular fibrillation to ventricular tachycardia in an anatomical model of the human ventricles : a simulation study

Olivier BernusHenri VerscheldeAlexander Panfilov

The study of autowave mechanisms of electrocardiogram variability during high-frequency arrhythmias : the result of mathematical modeling

AB MedvinskyAV RusakovAV MoskalenkoMV FedorovAlexander Panfilov

A1 Journal Article in BIOFIZIKA

The unidirectional block of the propagation of a single autowave in a narrow gap and the formation of reentry depend on geometry of the obstacle and medium excitability

AV RusakovAlexander PanfilovAB Medvinsky

A1 Journal Article in BIOFIZIKA

2002

A computationally efficient electrophysiological model of human ventricular cells

Olivier BernusR WildersCW ZemlinHenri VerscheldeAlexander Panfilov

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Instability of three-dimensional linear vortex in a simple model of a heterogeneous excitable medium

AV RusakovAA AlievAlexander PanfilovAB Medvinsky

A1 Journal Article in BIOFIZIKA

Modified ionic models of cardiac tissue for efficient large scale computations

Olivier BernusHenri VerscheldeAlexander Panfilov

A1 Journal Article in PHYSICS IN MEDICINE AND BIOLOGY

Spiral breakup in an array of coupled cells : the role of the intercellular conductance

Alexander Panfilov

A1 Journal Article in PHYSICAL REVIEW LETTERS

Transition from ventricular fibrillation to ventricular tachycardia : a simulation study on the role of Ca2+-channel blockers in human ventricular tissue

Olivier BernusB Van EyckHenri VerscheldeAlexander Panfilov

A1 Journal Article in PHYSICS IN MEDICINE AND BIOLOGY

Wave propagation in an excitable medium with a negatively sloped restitution curve

Alexander PanfilovCW Zemlin

A1 Journal Article in CHAOS

2001

A realistic and efficient model of excitation propagation in the human atria

CW ZemlinH HerzelSY HoAlexander Panfilov

Realistic modeling of cardiac arrhythmia

C ZemlinH HerzelAlexander Panfilov

Spiral waves in excitable media with negative restitution

CW ZemlinAlexander Panfilov

A1 Journal Article in PHYSICAL REVIEW E

Ventricular fibrillation : evolution of the multiple-wavelet hypothesis

Alexander PanfilovA Pertsov

A1 Journal Article in PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

2000

Dissociation of variability in electrical and mechanical parameters of left ventricular function

PL KerkhofAlexander PanfilovJKJ Li

Elimination of spiral waves in cardiac tissue by multiple electrical shocks

Alexander PanfilovSC MullerVS ZykovJP Keener

A1 Journal Article in PHYSICAL REVIEW E

1999

Migration and thermotaxis of Dictyostelium discoideum slugs, a model study

AFM MareeAlexander PanfilovP Hogeweg

A1 Journal Article in JOURNAL OF THEORETICAL BIOLOGY

Phototaxis during the slug stage of Dictyostelium discoideum : a model study

AFM MareeAlexander PanfilovP Hogeweg

A1 Journal Article in PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Three-dimensional organization of electrical turbulence in the heart

Alexander Panfilov

A1 Journal Article in PHYSICAL REVIEW E

1998

Spiral breakup as a model of ventricular fibrillation

Alexander Panfilov

A1 Journal Article in CHAOS

1997

Models of Dictyostelium discoideum aggregation

JC DallonHG OthmerC Van OssAlexander PanfilovP HogewegT HoferPK Maini

Spiral breakup in excitable tissue due to lateral instability

AFM MareeAlexander Panfilov

A1 Journal Article in PHYSICAL REVIEW LETTERS

1996

A biophysical model for defibrillation of cardiac tissue

JP KeenerAlexander Panfilov

A1 Journal Article in BIOPHYSICAL JOURNAL

A simple two-variable model of cardiac excitation

RR AlievAlexander Panfilov

A1 Journal Article in CHAOS SOLITONS & FRACTALS

Modeling of heart excitation patterns caused by a local inhomogeneity

RR AlievAlexander Panfilov

A1 Journal Article in JOURNAL OF THEORETICAL BIOLOGY

Scroll breakup in a three-dimensional excitable medium

Alexander PanfilovP Hogeweg

A1 Journal Article in PHYSICAL REVIEW E

Spatial pattern formation during aggregation of the slime mould Dictyostelium discoideum

C vanOssAlexander PanfilovP HogewegF SiegertCJ Weijer

A1 Journal Article in JOURNAL OF THEORETICAL BIOLOGY

1995

Dynamics of dissipative structures in reaction-diffusion equations

Alexander PanfilovJP Keener

A1 Journal Article in SIAM JOURNAL ON APPLIED MATHEMATICS

Mechanisms of cardiac fibrillation

RA GrayJ JalifeAlexander PanfilovWT BaxterC CaboJM DavidenkoAM Pertsov

A1 Journal Article in SCIENCE

Mechanisms of cardiac fibrillation

Alexander PanfilovP Hogeweg

A1 Journal Article in SCIENCE

Multiple responses at the boundaries of the vulnerable window in the Belousov-Zhabotinsky reaction

RR AlievAlexander Panfilov

A1 Journal Article in PHYSICAL REVIEW E

Nonstationary vortexlike reentrant activity as a mechanism of polymorphic ventricular tachycardia in the isolated rabbit heart

RA GrayJ JalifeAlexander PanfilovWT BaxterC CaboJM DavidenkoAM Pertsov

A1 Journal Article in CIRCULATION

Re-entry in three-dimensional Fitzhugh-Nagumo medium with rotational anisotropy

Alexander PanfilovJP Keener

A1 Journal Article in PHYSICA D

Reentry in an anatomical model of the heart

Alexander PanfilovJP Keener

A1 Journal Article in CHAOS SOLITONS & FRACTALS

1994

Large pulsating waves in a one-dimensional excitable medium

BN VasievAlexander PanfilovRN Khramov

A1 Journal Article in PHYSICS LETTERS A

Rotating spiral waves created by geometry

K AgladzeJP KeenerSC MullerAlexander Panfilov

A1 Journal Article in SCIENCE

Simulation of Dictyostelium discoideum aggregation via reaction-diffusion model

BN VasievP HogewegAlexander Panfilov

A1 Journal Article in PHYSICAL REVIEW LETTERS

1993

Computer simulation of re-entry sources in myocardium in two and three dimensions

Alexander PanfilovAV Holden

A1 Journal Article in JOURNAL OF THEORETICAL BIOLOGY

Effects of high frequency stimulation on cardiac tissue with an inexcitable obstacle

Alexander PanfilovJP Keener

A1 Journal Article in JOURNAL OF THEORETICAL BIOLOGY

Generation of reentry in anisotropic myocardium

Alexander PanfilovJP Keener

A1 Journal Article in JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Modeling reentry in a finite element model of the heart

Alexander PanfilovJP Keener

Spiral breakup in a modified FitzHugh-Nagumo model

Alexander PanfilovP Hogeweg

A1 Journal Article in PHYSICS LETTERS A

Twisted scroll waves in heterogeneous excitable media

Alexander PanfilovJames P Keener

A1 Journal Article in INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS

1992

Fitzhugh-Nagumo equations are a gradient system

OA MornevAlexander PanfilovRR Aliev

A1 Journal Article in BIOFIZIKA

Structural trend of linalool electrochemical oxidation

Alexander PanfilovGV CherkaevTV MagdesievaNM Przhiyalgovskaya

A1 Journal Article in ZHURNAL ORGANICHESKOI KHIMII

1991

3-Dimensional vortices in active media

Alexander Panfilov

Graphical identification of spatiotemporal chaos

AV HoldenAlexander Panfilov

A1 Journal Article in COMPUTERS & GRAPHICS

Spatiotemporal irregularity in a two-dimensional model of cardiac tissue

Alexander PanfilovAV Holden

A1 Journal Article in INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS

Vortex initiation in a heterogeneous excitable medium

Alexander PanfilovBN Vasiev

A1 Journal Article in PHYSICA D

1990

Self-generation of turbulent vortices in a two-dimensional model of cardiac tissue

Alexander PanfilovAV Holden

A1 Journal Article in PHYSICS LETTERS A

Vortices in a system of two coupled excitable fibers

Alexander PanfilovAV Holden

A1 Journal Article in PHYSICS LETTERS A

1989

2 Regimes of the drift of reverberators in nonhomogenous active media

GR IvanitskyVI KrinskyAlexander PanfilovMA Tsyganov

A1 Journal Article in BIOFIZIKA

An integral invariant for scroll rings in a reaction-diffusion system

Alexander PanfilovRR AlievAV Mushinsky

A1 Journal Article in PHYSICA D

Three-dimensional vortex with a spiral filament in a chemically active medium

KI AgladzeVI KrinskyAlexander PanfilovH LindeL Kuhnert

A1 Journal Article in PHYSICA D

1988

Nonstationary rotation of spiral waves : three-dimensional effect

KI AgladzeAlexander PanfilovAN Rudenko

A1 Journal Article in PHYSICA D

1987

Pulsation mechanism of spatial distribution of population numbers of dividing bioobjects

GR IvanitskyAlexander PanfilovMA Tsyganov

A1 Journal Article in BIOFIZIKA

Two regimes of the scroll ring drift in the three-dimensional active media

Alexander PanfilovAN Rudenko

A1 Journal Article in PHYSICA D

1986

Interaction between spiral and flat periodic autowaves in an active medium

EA ErmakovaVI KrinskyAlexander PanfilovAM Pertsov

A1 Journal Article in BIOFIZIKA

Metabolic regulation of ionosmotic homeostasis of electrounexcitable cells

KB AslanidiAlexander Panfilov

A1 Journal Article in BIOFIZIKA

The Boyle-Conway model including the effect of an electrogenic pump for nonexcitable cells

KB AslanidiAlexander Panfilov

A1 Journal Article in MATHEMATICAL BIOSCIENCES

Turbulent rings in 3-dimensional active media with diffusion by 2 components

Alexander PanfilovAN RudenkoVI Krinsky

A1 Journal Article in BIOFIZIKA

1985

Dynamical simulations of twisted scroll rings in three-dimensional excitable media

Alexander PanfilovAT Winfree

A1 Journal Article in PHYSICA D

Twisted scroll rings in 3-dimensional active media

Alexander PanfilovAN RudenkoAT Winfree

A1 Journal Article in BIOFIZIKA

Twisted scroll waves in active three-dimensional media

AS MikhailovAlexander PanfilovAN Rudenko

A1 Journal Article in PHYSICS LETTERS A

1984

Drift of vortices in heterogeneous active medium (simplified analysis)

RN HramovAN RudenkoAlexander PanfilovVI Krinskij

A1 Journal Article in STUDIA BIOPHYSICA

Rotating spiral waves in a modified Fitz-Hugh-Nagumo model

AM PertsovEA ErmakovaAlexander Panfilov

A1 Journal Article in PHYSICA D

Spiral waves in active media

VI KrinskijAS MikhajlovAlexander PanfilovEA ErmakovaAM Tsyganov

A1 Journal Article in IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII RADIOFIZIKA

Twisted scroll waves in active 3-dimensional media

Alexander PanfilovAN RudenkoAM Pertsov

A1 Journal Article in DOKLADY AKADEMII NAUK SSSR

Vortex ring in 3-dimensional active medium described by reaction diffusion equations

Alexander PanfilovAM Pertsov

A1 Journal Article in DOKLADY AKADEMII NAUK SSSR

1983

Drift and interaction of vortices in two-dimensional heterogeneous active medium

AN RudenkoAlexander Panfilov

A1 Journal Article in STUDIA BIOPHYSICA

Instabilities of autowaves in excitable media associated with critical curvature phenomenon

AM PertsovAlexander PanfilovFU Medvedeva

A1 Journal Article in BIOFIZIKA

1982

Analytical estimation of reverberator period in an arbitrary active medium

Alexander PanfilovOA MornevMA TsyganovVI Krinsky

A1 Journal Article in BIOFIZIKA

Mechanism of spiral waves initiation in active media connected with a critical curvature phenomenon

Alexander PanfilovAM Pertsov

A1 Journal Article in BIOFIZIKA

1981

Increase of heterogeneities at the interface of decrement conduction in a Hodgkin-Huxley model

Alexander PanfilovAM PertsovLI Churikova

A1 Journal Article in BIOFIZIKA

Sharp increase in a refractory period induced by oxidation suppression in a Fitz Hue-Nagumo model : new mechanism of antiarrhythmic drug action

AM PertsovRN KhramovAlexander Panfilov

A1 Journal Article in BIOFIZIKA

Spiral waves in the heart (theoretical analysis)

AK GrenadierAlexander Panfilov

A1 Journal Article in BIOFIZIKA