Research Explorer

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Researcher

Alex Manicardi

Awards & Distinctions

23 Results

2023

A red light-triggered chemical tool for sequence-specific alkylation of G-quadruplex and I-motif DNA

Enrico CadoniLessandro De PaepeGertjan ColpaertRuben TackDries WaegemanAlex ManicardiAnnemieke Madder

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Photo-induced crosslinking uncovers an antiparallel strand orientation in heterodimeric (EIAALEK)(3)/(KIAALKE)(3) and (EIAALEK)(3)/(RIAALRE)(3) coiled-coil systems

Dorien AerssensLaia Miret CasalsD. GomezD. Sousa-NevesY. LevyM. De VleesschouwerAlex ManicardiAnnemieke Madder

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Proximity-induced ligation and one-pot macrocyclization of 1,4-diketone-tagged peptides derived from 2,5-disubstituted furans upon release from the solid support

Alex ManicardiAtiruj TheppawongMarleen Van TroysAnnemieke Madder

A1 Journal Article in ORGANIC LETTERS

2022

Synthesis and structure-activity relationship of peptide nucleic acid probes with improved interstrand-crosslinking abilities: application to biotin-mediated RNA-pulldown

Enrico CadoniFrancesca PennatiPenthip MuangkaewJoke ElskensAnnemieke MadderAlex Manicardi

A2 Journal Article in RSC CHEMICAL BIOLOGY

2021

A tale of furan and nucleic acids : the exploration of furan chemistry as a versatile tool for targeting oligonucleotides

Enrico CadoniAnnemieke MadderAlex Manicardi

Beyond small molecules : targeting G-quadruplex structures with oligonucleotides and their analogues

Enrico CadoniLessandro De PaepeAlex ManicardiAnnemieke Madder

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Exploitation of nucleic acid crosslinking approaches for improved RNA capture and aptamer stabilization

Joke ElskensAnnemieke MadderAlex Manicardi

Hydrolysis of 5-methylfuran-2-yl to 2,5-dioxopentanyl allows for stable bio-orthogonal proximity-induced ligation

Alex ManicardiEnrico CadoniAnnemieke Madder

A1 Journal Article in COMMUNICATIONS CHEMISTRY

Teaching photosensitizers a new trick : red light-triggered G-quadruplex alkylation by ligand co-localization

Enrico CadoniAlex ManicardiMathieu FossepreKaat HeirweghMathieu SurinAnnemieke Madder

A1 Journal Article in CHEMICAL COMMUNICATIONS

2020

Exploiting double exchange Diels-Alder cycloadditions for immobilization of peptide nucleic acids on gold nanoparticles

Enrico CadoniDaniele Rosa-GastaldoAlex ManicardiFabrizio MancinAnnemieke Madder

A1 Journal Article in FRONTIERS IN CHEMISTRY

PNA-based microRNA detection methodologies

Enrico CadoniAlex ManicardiAnnemieke Madder

A1 Journal Article in MOLECULES

Visible-light triggered templated ligation on surface using furan-modified PNAs

Alex ManicardiEnrico CadoniAnnemieke Madder

A1 Journal Article in CHEMICAL SCIENCE

2019

Cu-64 and fluorescein labeled anti-miRNA peptide nucleic acids for the detection of miRNA expression in living cells

Stefania CrociAlex ManicardiSara RubagottiMartina BonaciniMichele IoriPier Cesare CapponiGianfranco CicoriaMaria ParmeggianiCarlo SalvaraniAnnibale Versari et al.

A1 Journal Article in SCIENTIFIC REPORTS

Efficient cell penetration and delivery of peptide nucleic acids by an argininocalix[4]arene

Jessica GasparelloAlex ManicardiAlessandro CasnatiRoberto CorradiniRoberto GambariAlessia FinottiFrancesco Sansone

A1 Journal Article in SCIENTIFIC REPORTS

Physiological expression of miR-130a during differentiation of CD34+ human hematopoietic stem cells results in the inhibition of monocyte differentiation

Fabiana MammoliSandra ParentiMariana LomientoClaudia GemelliClaudio Giacinto AteneAlexis GrandeRoberto CorradiniAlex ManicardiSebastian FantiniTommaso Zanocco-Marani et al.

A1 Journal Article in EXPERIMENTAL CELL RESEARCH

Targeting miR‑155‑5p and miR‑221‑3p by peptide nucleic acids induces caspase‑3 activation and apoptosis in temozolomide‑resistant T98G glioma cells

Roberta MilaniEleonora BrognaraEnrica FabbriAlex ManicardiRoberto CorradiniAlessia FinottiJessica GasparelloMonica BorgattiLucia CosenzaIlaria Lampronti et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF ONCOLOGY

2017

A peptide nucleic acid against microRNA miR-145-5p enhances the expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in calu-3 cells

Enrica FabbriAnna TamaniniTiziana JakovaJessica GasparelloAlex ManicardiRoberto CorradiniGiuseppe SabbioniAlessia FinottiMonica BorgattiIlaria Lampronti et al.

A1 Journal Article in MOLECULES

Building on the peptide nucleic acid (PNA) scaffold : a biomolecular engineering approach

Alex ManicardiAndrea RozziSaša KoromRoberto Corradini

U Journal Article in SUPRAMOLECULAR CHEMISTRY

DNA detection by flow cytometry using PNA-modified metal-organic framework particles

Raquel Mejia-ArizaJessica RosselliChristian BreukersAlex ManicardiLeon W. M. M. TerstappenRoberto CorradiniJurriaan Huskens

A1 Journal Article in CHEMISTRY - A EUROPEAN JOURNAL

Decoration of trastuzumab with short oligonucleotides : synthesis and detailed characterization

Ana Margarida Dias Carvalho Da RochaAlex ManicardiC Véliz MontesSmita GunnooRJ SchneiderAnnemieke Madder

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Optical fiber sensors for label-free DNA detection

Matteo BarozziAlex ManicardiArmando VannucciAlessandro CandianiMichele SozziMaria KonstantakiStavros PissadakisRoberto CorradiniStefano SelleriAnnamaria Cucinotta

A1 Journal Article in JOURNAL OF LIGHTWAVE TECHNOLOGY

Synthesis and improved cross-linking properties of C5-modified furan bearing PNAs

Joke ElskensAlex ManicardiValentina CostiAnnemieke MadderRoberto Corradini

A1 Journal Article in MOLECULES

2016

Furan-PNA : a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA

Alex ManicardiEllen GysselsRoberto CorradiniAnnemieke Madder

A1 Journal Article in CHEMICAL COMMUNICATIONS