Research Explorer

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Researcher

Ahmadreza Mehdipour

Publications & Research Data

Awards & Distinctions

62 Results

2025

Effect of membrane composition on interaction and permeation of a mycobacterial siderophore

Fatemeh SharifianMina EbrahimiAhmadreza Mehdipour

Molecular dynamics of membrane partitioning of nifedipine prior to binding calcium channel Cav1.1

Warre DhondtLouis VanduyfhuysAhmadreza Mehdipour

Stability convergence in natural antibodies with ultra-long hypervariable loops

Marcel Fridolin PassonMatja ZalarThomas NehlsStefaan De SmedtFrederik LermyteAhmadreza MehdipourHristo L. Svilenov

A1 Journal Article in COMMUNICATIONS BIOLOGY

The mycobacterial ABC transporter IrtAB employs a membrane-facing crevice for siderophore-mediated iron uptake

Imre GondaSimona SorrentinoLaura GalazzoNicolas P. LichtiFabian M. ArnoldAhmadreza MehdipourEnrica BordignonMarkus A. Seeger

A1 Journal Article in NATURE COMMUNICATIONS

2024

MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes

Katharina Esther Julia JungnickelOceane GuelleMiharu IguchiWentao DongVadim KotovFlorian GabrielCecile DebackerJulien DairouIsabelle McCort-TranchepainNouf N. Laqtom et al.

A1 Journal Article in NATURE CELL BIOLOGY

Robotic-inspired approach to multi-domain membrane receptor conformation space : theory and SARS-CoV-2 spike protein case study

Alen Thykkoottathil MathewMateusz SikoraGerhard HummerAhmadreza Mehdipour

Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23

Yehudi BlochJan FélixRomain MerceronMathias ProvostRoyan Alipour SymakaniRobin De BackerElisabeth LambertAhmadreza MehdipourSavvas Savvides

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

2023

Dissecting the conformational complexity and mechanism of a bacterial heme transporter

Di WuAhmadreza MehdipourFranziska FinkeHojjat G. GoojaniRoan R. GrohTamara N. GrundThomas M. B. ReichhartRita ZimmermannSonja WelschDirk Bald et al.

A1 Journal Article in NATURE CHEMICAL BIOLOGY

GlycoVHH : optimal sites for introducing N-glycans on the camelid VHH antibody scaffold and use for macrophage delivery

Loes van SchieWander Van BreedamCharlotte RoelsBert SchepensMartin FrankAhmadreza MehdipourBram LaukensWim NerinckxFrancis SantensSimon Devos et al.

A1 Journal Article in MABS

MFSD1 in complex with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes

Katharina Esther Julia JungnickelOcéane GuelleMiharu IguchiWentao DongVadim KotovFlorian GabrielCécile DebackerJulien DairouIsabelle McCort-TranchepainNouf N. Laqtom et al.

Selective killing of the human gastric pathogen Helicobacter pylori by mitochondrial respiratory complex I inhibitors

Clara LettlFranziska SchindeleAhmadreza MehdipourThomas SteinerDiana RingRuth Brack-WernerBärbel StecherWolfgang EisenreichUrsula BilitewskiGerhard Hummer et al.

A1 Journal Article in CELL CHEMICAL BIOLOGY

2022

Cryo-EM structures of pentameric autoinducer-2 exporter from Escherichia coli reveal its transport mechanism

Radhika KheraAhmadreza MehdipourJani R. BollaJoerg KahntSonja WelschUlrich ErmlerCornelia MuenkeCarol RobinsonGerhard HummerHao Xie et al.

A1 Journal Article in EMBO JOURNAL

Evidence for a trap-and-flip mechanism in a proton-dependent lipid transporter

Elisabeth LambertAhmadreza MehdipourAlexander SchmidtGerhard HummerCamilo Perez

A1 Journal Article in NATURE COMMUNICATIONS

Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level

Rong ZhuDaniel CanenaMateusz SikoraMiriam KlausbergerHannah SeferovicAhmadreza MehdipourLisa HainElisabeth LaurentVanessa MonteilGerald Wirnsberger et al.

A1 Journal Article in NATURE COMMUNICATIONS

GlycoVHH : introducing N-glycans on the camelid VHH antibody scaffold : optimal sites and use for macrophage delivery

Loes van SchieWander Van BreedamCharlotte RoelsBert SchepensMartin FrankAhmadreza MehdipourBram LaukensWim NerinckxFrancis SantensSimon Devos et al.

2021

Dual nature of human ACE2 glycosylation in binding to SARS-CoV-2 spike

Ahmadreza MehdipourGerhard Hummer

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection

Rukmini MukherjeeAnshu BhattacharyaDenisa BojkovaAhmadreza MehdipourDonghyuk ShinKhadija Shahed KhanHayley Hei-Yin CheungKam-Bo WongWai-Lung NgJindrich Cinatl et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB

Schara SafarianHelen K. Opel-ReadingDi WuAhmadreza MehdipourKiel HardsLiam K. HaroldMelanie RadloffIan StewartSonja WelschGerhard Hummer et al.

A1 Journal Article in NATURE COMMUNICATIONS

The structure of the Aquifex aeolicus MATE family multidrug resistance transporter and sequence comparisons suggest the existence of a new subfamily

Jiangfeng ZhaoHao XieAhmadreza MehdipourSchara SafarianUlrich ErmlerCornelia MuenkeYvonne ThielmannGerhard HummerIngo EbersbergerJingkang Wang et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2020

Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection

Donghyuk ShinAnshu BhattacharyaYi-Lin ChengMarta Campos AlonsoAhmadreza MehdipourGerbrand J. van der Heden van NoortHuib OvaaGerhard HummerIvan Dikic

A1 Journal Article in ELIFE

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

Donghyuk ShinRukmini MukherjeeDiana GreweDenisa BojkovaKheewoong BaekAnshu BhattacharyaLaura SchulzMarek WideraAhmadreza MehdipourGeorg Tascher et al.

A1 Journal Article in NATURE

2019

Conformation space of a heterodimeric ABC exporter under turnover conditions

Susanne HofmannDovile JanulieneAhmadreza MehdipourChristoph ThomasErich StefanStefan BruechertBenedikt T. KuhnEric R. GeertsmaGerhard HummerRobert Tampe et al.

A1 Journal Article in NATURE

Inward-facing conformation of a multidrug resistance MATE family transporter

Sandra ZakrzewskaAhmadreza MehdipourViveka Nand MalviyaTsuyoshi NonakaJuergen KoepkeCornelia MuenkeWinfried HausnerGerhard HummerSchara SafarianHartmut Michel

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of outward-facing PglK and molecular dynamics of lipid-linked oligosaccharide recognition and translocation

Camilo PerezAhmadreza MehdipourGerhard HummerKaspar P. Locher

A1 Journal Article in STRUCTURE

2018

Allosteric control of the K+ uptake system KtrAB

Marina DiskowskiVedrana MikusevicDorith WunnickeAhmadreza MehdipourDeryck J. MillsGerhard HummerKlaus FendlerJanet VonckInga Haenelt

Structural basis of glycan counting in glycosyltransferases

Ana S. RamirezJeremy BoilevinAhmadreza MehdipourGerhard HummerTamis DarbreJean-L ReymondKaspar P. Locher

Structural basis of the molecular ruler mechanism of a bacterial glycosyltransferase

Ana S. RamirezJeremy BoilevinAhmadreza MehdipourGerhard HummerTamis DarbreJean-Louis ReymondKaspar P. Locher

A1 Journal Article in NATURE COMMUNICATIONS

2017

Crystal structure and mechanistic basis of a functional homolog of the antigen transporter TAP

Anne NoellChristoph ThomasValentina HerbringTina ZollmannKatja BarthaAhmadreza MehdipourThomas M. TomasiakStefan BruechertBenesh JosephRupert Abele et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Helical jackknives control the gates of the double-pore K+ uptake system KtrAB

Marina DiskowskiAhmadreza MehdipourDorith WunnickeDeryck J. MillsVedrana MikusevicNatalie BaerlandJan HoffmannNina MorgnerHeinz-Juergen SteinhoffGerhard Hummer et al.

A1 Journal Article in ELIFE

2016

Antigenic peptide recognition on the human ABC transporter TAP resolved by DNP-enhanced solid-state NMR spectroscopy

Elisa LehnertJiafei MaoAhmadreza MehdipourGerhard HummersRupert AbeleClemens GlaubitzRobert Tampe

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cardiolipin puts the seal on ATP synthase

Ahmadreza MehdipourGerhard Hummer

Editorial material

2014

Structure and regulatory interactions of the cytoplasmic terminal domains of serotonin transporter

Cristina Fenollar-FerrerThomas StocknerThomas C. SchwarzAritra PalJelena GotovinaTina HofmaierKumaresan JayaramanSuraj AdhikaryOliver KudlacekAhmadreza Mehdipour et al.

A1 Journal Article in BIOCHEMISTRY

Substrate bound outward-open state of the symporter PetP : insights into sodium and substrate binding and coupling

Camilo PerezBelinda FaustAhmadreza MehdipourKevin A. FrancesconiLucy R. ForrestChristine Ziegler

Substrate-bound outward-open state of the betaine transporter BetP provides insights into Na+ coupling

Camilo PerezBelinda FaustAhmadreza MehdipourKevin A. FrancesconiLucy R. ForrestChristine Ziegler

A1 Journal Article in NATURE COMMUNICATIONS

2013

Reversal of multidrug resistance in cancer cells by novel asymmetrical 1,4-dihydropyridines

Omidreza FiruziKatayoun JavidniaElham MansourabadiLuciano SasoAhmadreza MehdipourRamin Miri

A1 Journal Article in ARCHIVES OF PHARMACAL RESEARCH

2012

New autocorrelation QTMS-based descriptors for use in QSAM of peptides

S. YousefinejadB. HemmateenejadAhmadreza Mehdipour

A1 Journal Article in JOURNAL OF THE IRANIAN CHEMICAL SOCIETY

Synthesis and calcium channel antagonist activity of novel 1,4-dihydropyridine derivatives possessing 4-pyrone moieties

Aziz ShahrisaRamin MiriSomayeh EsmatiMahnaz SaraeiAhmadreza MehdipourMaryam Sharifi

A1 Journal Article in MEDICINAL CHEMISTRY RESEARCH

Synthesis, cytotoxicity, and QSAR study of new aza-cyclopenta[b]fluorene-1,9-dione derivatives

Ramin MiriOmidreza FiruziPayam PeymaniMeysam ZamaniAhmadreza MehdipourZahra HeydariMaryam Masteri FarahaniAbbas Shafiee

A1 Journal Article in CHEMICAL BIOLOGY & DRUG DESIGN

2011

Cytotoxic effect of some 1,4-dihydropyridine derivatives containing nitroimidazole moiety

Ramin MiriKatayoun JavidniaZahra AmirghofranSeyyed Hossein SalimiZahra SabetghadamSavis MeiliAhmadreza Mehdipour

A1 Journal Article in IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH

Nepetalactones as chemotaxonomic markers in the essential oils of Nepeta species

K. JavidniaAhmadreza MehdipourB. HemmateenejadS. R. RezazadehM. SoltaniA. R. KhosraviR. Miri

A1 Journal Article in CHEMISTRY OF NATURAL COMPOUNDS

Novel amino acids indices based on quantum topological molecular similarity and their application to QSAR study of peptides

Bahram HemmateenejadSaeed YousefinejadAhmadreza Mehdipour

A1 Journal Article in AMINO ACIDS

Synthesis and calcium channel antagonist activity of new symmetrical and asymmetrical 4-[2-chloro-2-(4-chloro-6-methyl-2-oxo-2H-pyran-3-yl)vinyl]-substituted 1,4-dihydropyridines

A. ShahrisaM. ZirakAhmadreza MehdipourR. Miri

A1 Journal Article in CHEMISTRY OF HETEROCYCLIC COMPOUNDS

Synthesis and cytotoxic activity of novel benzopyrano[3,2-c]chromene-6,8-dione derivatives

Abbas ShafieeRadineh MotamediOmidreza FiruziSavis MeiliAhmadreza MehdipourRamin Miri

A1 Journal Article in MEDICINAL CHEMISTRY RESEARCH

2010

Comparative QSAR studies on toxicity of phenol derivatives using quantum topological molecular similarity indices

Bahram HemmateenejadAhmadreza MehdipourRamin MiriMojtaba Shamsipur

A1 Journal Article in CHEMICAL BIOLOGY & DRUG DESIGN

Dihydropyridines and multidrug resistance : previous attempts, present state, and future trends

Abdolhossein ZarrinAhmadreza MehdipourRamin Miri

A1 Journal Article in CHEMICAL BIOLOGY & DRUG DESIGN

The impact of genetic polymorphisms and patient characteristics on warfarin dose requirements : a cross-sectional study in Iran

Soha NamaziNegar AzarpiraFatemeh HendijaniMaryam Banan KhorshidGhazal VessalAhmadreza Mehdipour

A1 Journal Article in CLINICAL THERAPEUTICS

2009

Antihypertensive effects of some new nitroxyalkyl 1,4-dihydropyridine derivatives in rat model of two-kidney, one-clip hypertension

Ali Akbar NekooeianAzadeh KhaliliKatayoun JavidniaAhmadreza MehdipourRamin Miri

A1 Journal Article in IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH

Application of MOLMAP approach for QSAR modeling of various biological activities using substituent electronic descriptors

Bahram HemmateenejadAhmadreza MehdipourRamin MiriMojtaba Shamsipur

A1 Journal Article in JOURNAL OF COMPUTATIONAL CHEMISTRY

Brain drug targeting : a computational approach for overcoming blood-brain barrier

Ahmadreza MehdipourMehrdad Hamidi

A1 Journal Article in DRUG DISCOVERY TODAY

Cytotoxic activity and cell cycle analysis of quinoline alkaloids isolated from Haplophyllum canaliculatum Boiss.

Pegah VaraminiKatayoun JavidniaMohammad SoltaniAhmadreza MehdipourAbbas Ghaderi

A1 Journal Article in PLANTA MEDICA

Density functional theory-based quantitative structure activity relationship (QSAR) study of alkanol and alkanthiol derivatives

Ahmadreza MehdipourMohammad Ali SafarpourFariba TaghaviMaryam Jamali

A1 Journal Article in QSAR & COMBINATORIAL SCIENCE

DFT-based QSAR study of alkanols and alkanthiols using the conductor-like polarizable continuum model (CPCM)

Khaled AziziMohammad Ali SafarpourMaryam KeykhaeeAhmadreza Mehdipour

A1 Journal Article in JOURNAL OF MOLECULAR MODELING

Dihydropyridines : evaluation of their current and future pharmacological applications

Najmeh EdrakiAhmadreza MehdipourMehdi KhoshneviszadehRamin Miri

A1 Journal Article in DRUG DISCOVERY TODAY

Semiempirical, ab initio and density functional studies on structural and electronic properties of trans- and cis-cAMPB(H2O)

M. A. SafarpourS. Bagheri NavirM. JamaliAhmadreza Mehdipour

A1 Journal Article in JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM

2008

DFT-based QSAR study of valproic acid and its derivatives

Majid HashemianzadehMohammad Ali SafarpourKiana Gholamjani-MoghaddamAhmadreza Mehdipour

A1 Journal Article in QSAR & COMBINATORIAL SCIENCE

Quantum topological QSAR models based on the MOLMAP approach

Bahram HemmateenejadAhmadreza MehdipourPaul L. A. Popelier

A1 Journal Article in CHEMICAL BIOLOGY & DRUG DESIGN

Synthesis and in vitro dual calcium channel antagonist-agonist activity of some 1,4-Dihydo-2,6-dimethyl-3-nitro and cyano-4-(1-methyl-5-nitro-1H-imidazol-2-yl)-5-pyridinecarboxylates

R. MiriK. JavidniaH. MirkhaniF. KazemiB. HemmateenejadN. EdrakiAhmadreza Mehdipour

A1 Journal Article in DARU-JOURNAL OF FACULTY OF PHARMACY

2007

Dihydropyridine derivatives to overcome atypical multidrug resistance : design, synthesis, QSAR studies, and evaluation of their cytotoxic and pharmacological activities

Ahmadreza MehdipourKatayoun JavidniaBahram HemmateenejadZahra AmirghofranRamin Miri

A1 Journal Article in CHEMICAL BIOLOGY & DRUG DESIGN

QSAR studies on the anesthetic action of some polyhalogenated ethers

Ahmadreza MehdipourBahram HemmateenejadRamin Miri

A1 Journal Article in CHEMICAL BIOLOGY & DRUG DESIGN

Synthesis, QSAR and calcium channel modulator activity of new hexahydroquinoline derivatives containing nitroimidazole

Ramin MiriKatayoun JavidniaHossein MirkhaniBahram HemmateenejadZahra SepeherMasomeh ZalpourTaherh BehzadMehdi KhoshneviszadehNajmeh EdrakiAhmadreza Mehdipour

A1 Journal Article in CHEMICAL BIOLOGY & DRUG DESIGN

2006

Accurate prediction of the blood-brain partitioning of a large set of solutes using ab initio calculations and genetic neural network modeling

Bahram HemmateenejadRamin MiriMohammad A. SafarpourAhmadreza Mehdipour

A1 Journal Article in JOURNAL OF COMPUTATIONAL CHEMISTRY

Composition of the essential oil of Diplotaenia cachrydifolia Boiss. from Iran

K. JavidniaR. MiriM. KamalinejadAhmadreza Mehdipour

A1 Journal Article in JOURNAL OF ESSENTIAL OIL RESEARCH